scholarly journals Cs2CO3/[bmim]Br as an Efficient, Green, and Reusable Catalytic System for the Synthesis of N-Alkyl Derivatives of Phthalimide under Mild Conditions

2008 ◽  
Vol 2008 ◽  
pp. 1-4 ◽  
Author(s):  
Alireza Hasaninejad ◽  
Abdolkarim Zare ◽  
Ahmad Reza Moosavi-Zare ◽  
Fatemeh Khedri ◽  
Rahimeh Rahimi ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Catalytic System ◽  
Reaction Times ◽  
Catalytic Amount ◽  
Conjugate Addition ◽  
Reaction Conditions ◽  
Mild Conditions ◽  
Alkyl Derivatives ◽  
High Yields ◽  
Derivatives Of

Aza-conjugate addition of phthalimide to α,β-unsaturated esters efficiently achieves in the presence of catalytic amount of Cs2CO3 and ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]Br) under mild reaction conditions (70°C) to afford N-alkyl phthalimides in high yields and relatively short reaction times.

scholarly journals A Task-Specific Ionic-Liquid-Mediated Solvent-Free Protocol for Direct Access to Dimethyl Acetal Protected Benzimidazole 2-Carboxaldehydes

SynOpen ◽  
2020 ◽  
Vol 04 (04) ◽  
pp. 89-95
Author(s):  
Swapan Majumdar ◽  
Barnali Deb ◽  
Ankita Chakraborty ◽  
Jewel Hossain
Keyword(s):  
Ionic Liquid ◽  
Scale Up ◽  
Reaction Times ◽  
Dimethyl Acetal ◽  
Single Step ◽  
Direct Access ◽  
Imidazolium Ionic Liquid ◽  
Reaction Conditions ◽  
High Yields ◽  
Task Specific Ionic Liquid

AbstractA robust and straightforward protocol has been developed for the synthesis of a diverse array of dimethyl acetal protected benz­imidazole-2-carboxaldehydes by reacting various 2-amino aniline derivatives with methyl 4,4-dimethoxy-3-oxobutanoate using the task-specific­ imidazolium ionic liquid (HBIm·TFA) as a promoter for N-C/C-N annulation processes. The present protocol offers several advantages over existing protocols, such as single-step process, short reaction times, very mild reaction conditions, high yields, ease of purification, recovery and reusability of the catalyst, and scale-up of the reaction.

A highly effective and mild protocol for the production of 1-thioamidoalkyl-2-naphthols using 1,3-disulfonic acid imidazolium trifluoroacetate as a dual-functional catalyst

2018 ◽  
Vol 73 (5) ◽  
pp. 289-293 ◽  
Author(s):  
Mostafa Karami ◽  
Abdolkarim Zare
Keyword(s):  
Ionic Liquid ◽  
Reaction Time ◽  
Reaction Times ◽  
Solvent Free ◽  
Disulfonic Acid ◽  
One Pot ◽  
Mild Conditions ◽  
Dual Functional ◽  
Highly Effective ◽  
High Yields

AbstractA solvent-free protocol for the production of 1-thioamidoalkyl-2-naphthols via a one-pot multi-component reaction of arylaldehydes with 2-naphthol and thioacetamide using the ionic liquid 1,3-disulfonic acid imidazolium trifluoroacetate ([Dsim][TFA]) is described. Furthermore, a plausible and attractive mechanism based on the dual functionality of the catalyst is proposed. Because of the dual functionality of [Dsim][TFA] (possessing acidic and basic sites), it is found to be generally highly effective, affording the products in high yields and short reaction times under mild conditions. We claim that this is one of the best protocols for the synthesis of 1-thioamidoalkyl-2-naphthols (in terms of yield, temperature, conditions, and/or the reaction time).

An Efficient Ultrasonic-Assisted Synthesis of Enol Carbamates via Oxidative Coupling of Formamides with 1,3-Dicarbonyl Compounds

2020 ◽  
Vol 17 (7) ◽  
pp. 507-511
Author(s):  
Jafar Akbari ◽  
Alireza Akbari Meyestani
Keyword(s):  
Oxidative Coupling ◽  
Cuo Nanoparticles ◽  
Reaction Conditions ◽  
Dicarbonyl Compounds ◽  
Butyl Hydroperoxide ◽  
Mild Conditions ◽  
Tert Butyl Hydroperoxide ◽  
Ultrasonic Assisted ◽  
High Yields ◽  
Derivatives Of

Sonochemical oxidative-coupling of formamides with 1,3-dicarbonyl compounds in the corresponding carbamates by CuO nanoparticles as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant has been reported. Various derivatives of enol carbamates were synthesized with good to high yields under the optimized reaction conditions. Compared with conventional methods, the main advantage of this method is mild conditions.

Zinc oxide as a new, highly efficient, green, and reusable catalyst for microwave-assisted Michael addition of sulfonamides to α,β-unsaturated esters in ionic liquids

2007 ◽  
Vol 85 (6) ◽  
pp. 438-444 ◽  
Author(s):  
Abdolkarim Zare ◽  
Alireza Hasaninejad ◽  
Ahmad Reza Moosavi Zare ◽  
Abolfath Parhami ◽  
Hashem Sharghi ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Michael Addition ◽  
Catalytic Amount ◽  
Reusable Catalyst ◽  
Efficient Procedure ◽  
Unsaturated Esters ◽  
Microwave Assisted ◽  
Alkyl Derivatives ◽  
High Yields ◽  
Derivatives Of

A simple, clean, and efficient procedure for the green synthesis of some N-alkyl derivatives of sulfonamides is described. Microwave-assisted Michael addition of sulfonamides to α,β-unsaturated esters, in the presence of catalytic amount of zinc oxide (ZnO) in 1-butyl-3-methylimidazolium bromide ([bmim]Br), affords the title compounds in high yields and short reaction times.Key words: zinc oxide, green chemistry, microwave, Michael addition, sulfonamide, ionic liquid.

scholarly journals BIMP Catalyzed 1,3-Prototropic Shift for the Highly Enantioselective Synthesis of Conjugated Cyclohexenones

2020 ◽  
Author(s):  
Jonathan Golec ◽  
Eve Carter ◽  
John W. Ward ◽  
William Whittingham ◽  
Luis Simon ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Linear Regression ◽  
Catalytic System ◽  
Reaction Times ◽  
Multivariate Linear Regression ◽  
Enantioselective Synthesis ◽  
Reaction Conditions ◽  
High Yields ◽  
Experimental Findings ◽  
Good Agreement

<div>A bifunctional iminophosphorane (BIMP) catalyzed enantioselective synthesis of α,β-unsaturated cyclohexenones via a facially selective 1,3-prototropic shift of β,γ-unsaturated prochiral isomers, under mild reaction conditions and in short reaction times, on a range of structurally diverse substrates, is reported. α,β-Unsaturated cyclohexenone products primed for downstream derivatisation were obtained in high yields (up to 99%) and consistently high enantioselectivity (up to 99% ee). In-depth studies into the reaction mechanism and origins of enantioselectivity, including multivariate linear regression of TS energy, were carried out computationally on the catalytic system and the obtained data was found to be in good agreement with experimental findings.</div>

scholarly journals BIMP Catalyzed 1,3-Prototropic Shift for the Highly Enantioselective Synthesis of Conjugated Cyclohexenones

2020 ◽  
Author(s):  
Jonathan Golec ◽  
Eve Carter ◽  
John W. Ward ◽  
William Whittingham ◽  
Luis Simon ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Linear Regression ◽  
Catalytic System ◽  
Reaction Times ◽  
Multivariate Linear Regression ◽  
Enantioselective Synthesis ◽  
Reaction Conditions ◽  
High Yields ◽  
Experimental Findings ◽  
Good Agreement

<div>A bifunctional iminophosphorane (BIMP) catalyzed enantioselective synthesis of α,β-unsaturated cyclohexenones via a facially selective 1,3-prototropic shift of β,γ-unsaturated prochiral isomers, under mild reaction conditions and in short reaction times, on a range of structurally diverse substrates, is reported. α,β-Unsaturated cyclohexenone products primed for downstream derivatisation were obtained in high yields (up to 99%) and consistently high enantioselectivity (up to 99% ee). In-depth studies into the reaction mechanism and origins of enantioselectivity, including multivariate linear regression of TS energy, were carried out computationally on the catalytic system and the obtained data was found to be in good agreement with experimental findings.</div>

Catalyst-Free Three-Component Synthesis of Spirobenzimidazolidines Bearing an Indole Scaffold

Synlett ◽  
2018 ◽  
Vol 29 (17) ◽  
pp. 2301-2305 ◽  
Author(s):  
F. Moghaddam ◽  
A. Moafi ◽  
Z. Zamani ◽  
M. Daneshfar
Keyword(s):  
Reaction Times ◽  
Reaction Conditions ◽  
One Pot ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
New Family ◽  
Three Component Reaction ◽  
High Yields ◽  
First Time ◽  
Derivatives Of

An efficient catalyst-free one-pot three-component reaction was developed for the synthesis of a new family of N- and S-containing spirocyclic compounds. Various derivatives of spirobenzimidazolidine containing an indole scaffold were synthesized for the first time in a modestly toxic solvent and under mild reaction conditions. The reaction times were of the order of several minutes, and all the products were obtained in moderate to high yields (overall yields 58–80%).

Citric acid as a trifunctional organocatalyst for thiocyanation of aromatic and heteroaromatic compounds in aqueous media

2012 ◽  
Vol 90 (5) ◽  
pp. 427-432 ◽  
Author(s):  
Ardeshir Khazaei ◽  
Mohammad Ali Zolfigol ◽  
Mohmmad Mokhlesi ◽  
Mahtab Pirveysian
Keyword(s):  
Citric Acid ◽  
Simple Procedure ◽  
Aqueous Media ◽  
Reaction Times ◽  
Catalytic Amount ◽  
Heteroaromatic Compounds ◽  
Mild Conditions ◽  
High Yields

A green and simple procedure for the thiocynation of aromatic and heteroaromatic rings in the presence of a catalytic amount of citric acid in water are described. The reactions proceed in high yields, with short reaction times and under mild conditions.

Ultrasound-assisted aqua-mediated synthesis of multi-substituted tetrahydropyridine-3-carboxylates using N-carboxymethyl-3-pyridinium hydrogensulfate ([N-CH2CO2H-3-pic]+HSO4−) as a new efficient ionic liquid catalyst

2021 ◽  
Vol 3 (6) ◽  
Author(s):  
Kobra Nikoofar ◽  
Fatemeh Shahriyari
Keyword(s):  
Ionic Liquid ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
H Nmr ◽  
Sonic Waves ◽  
Ft Ir ◽  
High Yields ◽  
Work Up ◽  
C Nmr

AbstractA simple, straightforward, and ultrasound-promoted method for the preparation of some highly functionalized tetrahydropyridines reported via pseudo five-component reaction of (hetero)aromatic aldehydes, different anilines, and alkyl acetoacetates in the presence of [N-CH2CO2H-3-pic]+HSO4−, as a novel ionic liquid, in green aqueous medium. The IL was synthesized utilizing simple and easily-handled substrates and characterized by FT-IR, 1H NMR, 13C NMR, GC-MASS, FESEM, EDX, and TGA/DTG techniques. The procedure contains some highlighted aspects which are: (a) performing the MCR in the presence of aqua and sonic waves, as two main important and environmentally benign indexes in green and economic chemistry, (b) high yields of products within short reaction times, (c) convenient work-up procedure, (d) preparing the new IL via simple substrates and procedure.

Copper-catalyzed 1,6-conjugate addition of para-quinone methides with diborylmethane

2021 ◽  
Author(s):  
Xin Li ◽  
Guoliang Gao ◽  
Songtao He ◽  
Qiuling Song
Keyword(s):  
Catalytic System ◽  
Conjugate Addition ◽  
Quinone Methides ◽  
High Yields

Presented herein is the first 1,6-conjugate addition of diborylmethane, which is promoted by a simple and inexpensive copper catalytic system. This method features high yields, good selectivities and broad functional...

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