scholarly journals Characterization of Phototransduction Gene Knockouts Revealed Important Signaling Networks in the Light-Induced Retinal Degeneration

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Jayalakshmi Krishnan ◽  
Gwang Lee ◽  
Sang-Uk Han ◽  
Sangdun Choi
Keyword(s):  
Transcription Factors ◽  
Late Phase ◽  
Signaling Networks ◽  
Neuronal Function ◽  
Double Knockout ◽  
Retinal Rod ◽  
Rhodopsin Kinase ◽  
Gene Knockouts ◽  
Chip Analysis

Understanding the molecular pathways mediating neuronal function in retinas can be greatly facilitated by the identification of genes regulated in the retinas of different mutants under various light conditions. We attempted to conduct a gene chip analysis study on the genes regulated during rhodopsin kinase (Rhok-/-) and arrestin (Sag-/-) knockout and double knockouts in mice retina. Hence, mice were exposed to constant illumination of 450 lux or 6,000 lux on dilated pupils for indicated periods. The retinas were removed after the exposure and processed for microarray analysis. Double knockout was associated with immense changes in gene expression regulating a number of apoptosis inducing transcription factors. Subsequently, network analysis revealed that during early exposure the transcription factors, p53, c-MYC, c-FOS, JUN, and, in late phase,NF-B, appeared to be essential for the initiation of light-induced retinal rod loss, and some other classical pro- and antipoptotic genes appeared to be significantly important as well.

Characterization of pituitary adenomas by immunohistochemistry of pituitary-specific transcription factors and their correlation with hormonal subtypes

2020 ◽  
Author(s):  
Araceli García-Martínez ◽  
Sandra Silva-Ortega ◽  
Beatriz López-Muñoz ◽  
Óscar Moreno-Pérez ◽  
Irene Monjas ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Pituitary Adenomas

scholarly journals The vrille Gene of Drosophila Is a Maternal Enhancer of decapentaplegic and Encodes a New Member of the bZIP Family of Transcription Factors

Genetics ◽  
1997 ◽  
Vol 146 (4) ◽  
pp. 1345-1363 ◽  
Author(s):  
Hélène George ◽  
Régine Terracol
Keyword(s):  
Transcription Factors ◽  
Signal Transduction Pathway ◽  
Dorsoventral Patterning ◽  
Wing Vein ◽  
Human T Cell ◽  
Tadpole Tail ◽  
Bzip Domain ◽  
Bzip Family ◽  
Mutation Allele

We report here the genetical and molecular characterization of a new Drosophila zygotic lethal locus, vrille (vri). vri alleles act not only as dominant maternal enhancers of embryonic dorsoventral patterning defects caused by easter and decapentaplegic (dpp) mutations, but also as dominant zygotic enhancers of dpp alleles for phenotypes in wing. The vri gene encodes a new member of the bZIP family of transcription factors closely related to gene 9 of Xenopus laevis, induced by thyroid hormone during the tadpole tail resorption program, and NF-IL3A, a human T cell transcription factor that transactivates the interleukin-3 promoter. NF-IL3A shares 93% similarity and 60% identity with Vri for a stretch of 68 amino acids that includes the bZIP domain. Although all the alleles tested behave like antimorphs, the dominant enhancement is also seen with a nonsense mutation allele that prevents translation of the bZIP domain. Because of the strong dominant enhancement of dpp phenotypes by vri alleles in both embryo and wing, and also the similarity between the wing vein phenotypes caused by the vri and shortvein dpp alleles, we postulate that vri interacts either directly or indirectly with certain components of the dpp (a TGFβ homologue) signal transduction pathway.

Functional characterization of two bZIP transcription factors in Verticillium dahliae

Gene ◽  
2017 ◽  
Vol 626 ◽  
pp. 386-394 ◽  
Author(s):  
Yulin Fang ◽  
Dianguang Xiong ◽  
Longyan Tian ◽  
Chen Tang ◽  
Yonglin Wang ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Verticillium Dahliae ◽  
Functional Characterization ◽  
Bzip Transcription Factors

Characterization of Transcription Factors Following Expression Profiling of Medicago truncatula–Botrytis spp. Interactions

2014 ◽  
Vol 32 (5) ◽  
pp. 1030-1040 ◽  
Author(s):  
Ángel M. Villegas-Fernández ◽  
Franziska Krajinski ◽  
Armin Schlereth ◽  
Eva Madrid ◽  
Diego Rubiales
Keyword(s):  
Transcription Factors ◽  
Medicago Truncatula ◽  
Expression Profiling

Characterization of cadmium-responsive transcription factors in wolf spider Pardosa pseudoannulata

Chemosphere ◽  
2021 ◽  
Vol 268 ◽  
pp. 129239
Author(s):  
Juan Wang ◽  
Yuan He ◽  
Xianjin Peng ◽  
Bo lv ◽  
Zhi Wang ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Wolf Spider ◽  
Pardosa Pseudoannulata
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