scholarly journals Statistical Methods for Mapping Multiple QTL

2008 ◽  
Vol 2008 ◽  
pp. 1-8 ◽  
Author(s):  
Wei Zou ◽  
Zhao-Bang Zeng
Keyword(s):  
Statistical Methods ◽  
Bayesian Methods ◽  
Interval Mapping ◽  
Mapping Method ◽  
Research Progress ◽  
Mapping Data ◽  
Tremendous Progress ◽  
Multiple Qtl ◽  
Recent Research Progress ◽  
Made In

Since Lander and Botstein proposed the interval mapping method for QTL mapping data analysis in 1989, tremendous progress has been made in the last many years to advance new and powerful statistical methods for QTL analysis. Recent research progress has been focused on statistical methods and issues for mapping multiple QTL together. In this article, we review this progress. We focus the discussion on the statistical methods for mapping multiple QTL by maximum likelihood and Bayesian methods and also on determining appropriate thresholds for the analysis.

Recent advances in nanostructured metal nitrides for water splitting

2018 ◽  
Vol 6 (41) ◽  
pp. 19912-19933 ◽  
Author(s):  
Ning Han ◽  
Pengyun Liu ◽  
Jing Jiang ◽  
Lunhong Ai ◽  
Zongping Shao ◽  
...  
Keyword(s):  
Water Splitting ◽  
Research Progress ◽  
Metal Nitrides ◽  
Recent Advances ◽  
Chemical Water ◽  
Recent Research Progress ◽  
Nanostructured Metal ◽  
Made In

This review summarizes the recent research progress made in nanostructured metal nitrides for electrochemical and photo(electro)chemical water splitting.

scholarly journals Interval mapping of multiple quantitative trait loci.

Genetics ◽  
1993 ◽  
Vol 135 (1) ◽  
pp. 205-211 ◽  
Author(s):  
R C Jansen
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Interval Mapping ◽  
Inbred Lines ◽  
Mapping Method ◽  
Regression Methods ◽  
Multiple Qtl ◽  
Computational Work ◽  
Trait Loci ◽  
Additional Qtls

Abstract The interval mapping method is widely used for the mapping of quantitative trait loci (QTLs) in segregating generations derived from crosses between inbred lines. The efficiency of detecting and the accuracy of mapping multiple QTLs by using genetic markers are much increased by employing multiple QTL models instead of the single QTL models (and no QTL models) used in interval mapping. However, the computational work involved with multiple QTL models is considerable when the number of QTLs is large. In this paper it is proposed to combine multiple linear regression methods with conventional interval mapping. This is achieved by fitting one QTL at a time in a given interval and simultaneously using (part of) the markers as cofactors to eliminate the effects of additional QTLs. It is shown that the proposed method combines the easy computation of the single QTL interval mapping method with much of the efficiency and accuracy of multiple QTL models.

scholarly journals Forensic Entomology in China and Its Challenges

Insects ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 230
Author(s):  
Yu Wang ◽  
Yinghui Wang ◽  
Man Wang ◽  
Wang Xu ◽  
Yanan Zhang ◽  
...  
Keyword(s):  
Species Identification ◽  
Forensic Entomology ◽  
Research Progress ◽  
Temperature Dependent ◽  
Related Research ◽  
Dependent Development ◽  
Faunal Succession ◽  
Recent Research Progress

While the earliest record of forensic entomology originated in China, related research did not start in China until the 1990s. In this paper, we review the recent research progress on the species identification, temperature-dependent development, faunal succession, and entomological toxicology of sarcosaprophagous insects as well as common applications of forensic entomology in China. Furthermore, the difficulties and challenges forensic entomologists face in China are analyzed and possible countermeasures are presented.

Bayesian Mapping of Multiple Quantitative Trait Loci From Incomplete Inbred Line Cross Data

Genetics ◽  
1998 ◽  
Vol 148 (3) ◽  
pp. 1373-1388
Author(s):  
Mikko J Sillanpää ◽  
Elja Arjas
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Composite Interval Mapping ◽  
Backcross Progeny ◽  
Random Variable ◽  
Interval Mapping ◽  
Mapping Method ◽  
Structure Mapping ◽  
Standard Interval ◽  
Trait Loci

Abstract A novel fine structure mapping method for quantitative traits is presented. It is based on Bayesian modeling and inference, treating the number of quantitative trait loci (QTLs) as an unobserved random variable and using ideas similar to composite interval mapping to account for the effects of QTLs in other chromosomes. The method is introduced for inbred lines and it can be applied also in situations involving frequent missing genotypes. We propose that two new probabilistic measures be used to summarize the results from the statistical analysis: (1) the (posterior) QTL-intensity, for estimating the number of QTLs in a chromosome and for localizing them into some particular chromosomal regions, and (2) the location wise (posterior) distributions of the phenotypic effects of the QTLs. Both these measures will be viewed as functions of the putative QTL locus, over the marker range in the linkage group. The method is tested and compared with standard interval and composite interval mapping techniques by using simulated backcross progeny data. It is implemented as a software package. Its initial version is freely available for research purposes under the name Multimapper at URL http://www.rni.helsinki.fi/~mjs.

scholarly journals A Rank-Based Nonparametric Method for Mapping Quantitative Trait Loci in Outbred Half-Sib Pedigrees: Application to Milk Production in a Granddaughter Design

Genetics ◽  
1998 ◽  
Vol 149 (3) ◽  
pp. 1547-1555 ◽  
Author(s):  
Wouter Coppieters ◽  
Alexandre Kvasz ◽  
Frédéric Farnir ◽  
Juan-Jose Arranz ◽  
Bernard Grisart ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Real Data ◽  
Interval Mapping ◽  
Mapping Method ◽  
Residual Variance ◽  
Data Set ◽  
Wilcoxon Rank Sum Test ◽  
Holstein Friesian ◽  
Trait Loci

Abstract We describe the development of a multipoint nonparametric quantitative trait loci mapping method based on the Wilcoxon rank-sum test applicable to outbred half-sib pedigrees. The method has been evaluated on a simulated dataset and its efficiency compared with interval mapping by using regression. It was shown that the rank-based approach is slightly inferior to regression when the residual variance is homoscedastic normal; however, in three out of four other scenarios envisaged, i.e., residual variance heteroscedastic normal, homoscedastic skewed, and homoscedastic positively kurtosed, the latter outperforms the former one. Both methods were applied to a real data set analyzing the effect of bovine chromosome 6 on milk yield and composition by using a 125-cM map comprising 15 microsatellites and a granddaughter design counting 1158 Holstein-Friesian sires.

Evaluation software for effects produced by MOOC in mediums with different linguistically levels

2018 ◽  
Vol 34 (3) ◽  
pp. 633-645
Author(s):  
Cornel Samoilă ◽  
Doru Ursuţiu ◽  
Vlad Jinga
Keyword(s):  
Statistical Analysis ◽  
Statistical Methods ◽  
Rapid Assessment ◽  
Assessment Method ◽  
Behavioral Changes ◽  
Strong Negation ◽  
Face To Face ◽  
Made In ◽  
The Way

Abstract MOOC appearance has produced, in a first phase, more discussions than contributions. Despite pessimistic opinions or those catastrophic foreseeing the end of the classic education by accepting MOOC, the authors consider that, as it is happening in all situations when a field is reformed, instead of criticism or catastrophic predictions, an assessment should be simply made. MOOC will not be better or worse if it is discussed and dissected but can be tested in action, perfected by results, or abandoned if it has no prospects. Without testing, no decision is valid. A similarity between the MOOC appearance and the appearance of the idea of flying machines heavier than air can be made. In the flight case, the first reaction was a strong negation (including at Academies level) and only performing the first independent flight with an apparatus heavier than air has shifted orientation from denial to contributions. So, practical tests clarified the battle between ideas. The authors of this article encourage the idea of testing–assessment and, therefore, imagined and proposed one software for quickly assess whether MOOC produces changes in knowledge, by simply transferring courses from ‘face-to-face’ environment into the virtual one. Among the methods of statistical analysis for student behavioral changes was chosen the Keppel method. It underpins the assessment method of this work being approached using both the version with one variable and also with three variables. It is intended that this attempts to pave the way for other series of rapid assessment regarding MOOC effects (using other statistical methods). We believe, that this is the only approach that can lead either to improve the system or to renunciation.

Bioapplications of hyperbranched polymers

2015 ◽  
Vol 44 (12) ◽  
pp. 4023-4071 ◽  
Author(s):  
Dali Wang ◽  
Tianyu Zhao ◽  
Xinyuan Zhu ◽  
Deyue Yan ◽  
Wenxin Wang
Keyword(s):  
Biomedical Applications ◽  
Hyperbranched Polymers ◽  
Research Progress ◽  
Recent Research Progress

The recent research progress in biological and biomedical applications of hyperbranched polymers has been summarized in this review.

scholarly journals Supramolecular aggregates as sensory ensembles

2016 ◽  
Vol 52 (88) ◽  
pp. 12929-12939 ◽  
Author(s):  
Qian Wang ◽  
Zhao Li ◽  
Dan-Dan Tao ◽  
Qian Zhang ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Research Progress ◽  
Supramolecular Aggregates ◽  
Supramolecular Aggregation ◽  
Recent Research Progress

Recent research progress in sensing based on induced supramolecular aggregation or disaggregation.

scholarly journals Recent Research Progress in Solar Thermal Conversion Theory and Applications

2015 ◽  
Vol 2015 ◽  
pp. 1-2 ◽  
Author(s):  
Gang Pei ◽  
Yuehong Su ◽  
Sauro Filippeschi ◽  
Hongfei Zheng
Keyword(s):  
Thermal Conversion ◽  
Solar Thermal ◽  
Research Progress ◽  
Recent Research Progress

scholarly journals Senescence in the aging process

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1219 ◽  
Author(s):  
Richard GA Faragher ◽  
Anne McArdle ◽  
Alison Willows ◽  
Elizabeth L. Ostler
Keyword(s):  
Aging Process ◽  
Molecular Mechanisms ◽  
Senescent Cell ◽  
Cell Phenotype ◽  
Direct Demonstration ◽  
Tremendous Progress ◽  
Made In

The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts. Tremendous progress has been made in recent years both in understanding the molecular mechanisms controlling entry into the senescent state and in the direct demonstration that senescent cells act as causal agents of mammalian ageing. The challenges now are to gain a better understanding of how the senescent cell phenotype varies between different individuals and tissues, discover how senescence predisposes to organismal frailty, and develop mechanisms by which the deleterious effects of senescent cells can be ameliorated.

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