scholarly journals A Proposed Method for Thermal Specific Bioimaging and Therapy Technique for Diagnosis and Treatment of Malignant Tumors by Using Magnetic Nanoparticles

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Iddo M. Gescheit ◽  
Moshe Ben-David ◽  
Israel Gannot
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Diagnostic Tool ◽  
Thermal Conduction ◽  
Malignant Tumors ◽  
Low Cost ◽  
Surrounding Tissue ◽  
Thermal Camera ◽  
Irreversible Damage ◽  
Therapy Technique

The objective of this research program is to develop a novel, noninvasive, low-cost infrared (8–12 μm spectral range) imaging technique that would improve upon current methods using nanostructured core/shell magnetic/noble metal-based imaging and therapies. The biocompatible magnetic nanoparticles are able to produce heat under AC magnetic field. This thermal radiation propagates along the tissue by thermal conduction reaching the medium's (tissue's) surface. The surface temperature distribution is acquired by a thermal camera and can be analyzed to retrieve and reconstruct nanoparticles' temperature and location within the tissue. The technique may function as a diagnostic tool thanks to the ability of specific bioconjugation of these nanoparticles to tumor's outer surface markers. Hence, by applying a magnetic field, we could cause a selective elevation of temperature of the targeted nanoparticles up to 5∘C, which detects the tumor. Furthermore, elevating the temperature over 65∘C and up to 100∘C stimulates a thermo ablating interaction which causes a localized irreversible damage to the cancerous site with no harm to the surrounding tissue. While functioning as a diagnostic tool, this procedure may serve as a targeted therapeutic tool under thermal feedback control as well.

scholarly journals Continuous Size-Dependent Sorting of Ferromagnetic Nanoparticles in Laser-Ablated Microchannel

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yiqiang Fan ◽  
Feng Gao ◽  
Huawei Li ◽  
Gang Tang ◽  
Jian Zhuang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Size Distribution ◽  
Rna Virus ◽  
Flow Direction ◽  
Low Cost ◽  
Size Dependent ◽  
Potential Applications ◽  
Size Sorting ◽  
Biological Entities

This paper reports a low-cost method of continuous size-dependent sorting of magnetic nanoparticles in polymer-based microfluidic devices by magnetic force. A neodymium permanent magnet was used to generate a magnetic field perpendicular to the fluid flow direction. Firstly, FeNi3 magnetic nanoparticles were chemically synthesized with diameter ranges from 80 nm to 200 nm; then, the solution of magnetic nanoparticles and a buffer were passed through the microchannel in laminar flow; the magnetic nanoparticles were deflected from the flow direction under the applied magnetic field. Nanoparticles in the microchannel will move towards the direction of high-gradient magnetic fields, and the degree of deflection depends on their sizes; therefore, magnetic nanoparticles of different sizes can be separated and finally collected from different output ports. The proposed method offers a rapid and continuous approach of preparing magnetic nanoparticles with a narrow size distribution from an arbitrary particle size distribution. The proposed new method has many potential applications in bioanalysis field since magnetic nanoparticles are commonly used as solid support for biological entities such as DNA, RNA, virus, and protein. Other than the size sorting application of magnetic nanoparticles, this approach could also be used for the size sorting and separation of naturally magnetic cells, including blood cells and magnetotactic bacteria.

Hepatocyte ultrastructural alterations in perimetastatic areas

1996 ◽  
Vol 54 ◽  
pp. 768-769
Author(s):  
H. J. Finol ◽  
M. E. Correa ◽  
L.A. Sosa ◽  
A. Márquez ◽  
N.L. Díaz
Keyword(s):  
Malignant Tumor ◽  
Malignant Tumors ◽  
Surrounding Tissue ◽  
Ultrastructural Changes ◽  
Pancreas Carcinoma ◽  
Duct Carcinoma ◽  
Tissue Samples ◽  
Primary Malignant Tumor ◽  
Transmission Electron ◽  
Remote Sites

In classical oncological literature two mechanisms for tissue aggression in patients with cancer have been described. The first is the progressive invasion, infiltration and destruction of tissues surrounding primary malignant tumor or their metastases; the other includes alterations produced in remote sites that are not directly affected by any focus of disease, the so called paraneoplastic phenomenon. The non-invaded tissue which surrounds a primary malignant tumor or its metastases has been usually considered a normal tissue . In this work we describe the ultrastructural changes observed in hepatocytes located next to metastases from diverse malignant tumors.Hepatic biopsies were obtained surgically in patients with different malignant tumors which metatastized in liver. Biopsies included tumor mass, the zone of macroscopic contact between the tumor and the surrounding tissue, and the tissue adjacent to the tumor but outside the macroscopic area of infiltration. The patients (n = 5), 36–75 years old, presented different tumors including rhabdomyosarcoma, leiomyosarcoma, pancreas carcinoma, biliar duct carcinoma and colon carcinoma. Tissue samples were processed with routine techniques for transmission electron microscopy and observed in a Hitachi H-500 electron microscope.

scholarly journals Manipulation of light transmission from stable magnetic microrods formed by the alignment of magnetic nanoparticles

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2390-2396
Author(s):  
Yoon Ji Seo ◽  
Hyung Gyu Lee ◽  
Jun Seok Yang ◽  
Hwanyeop Jeong ◽  
Jeonghun Han ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Light Transmission ◽  
Smart Window ◽  
Light Valve

Magnetic microrods were synthesised from magnetic nanoparticles by alignment using a magnetic field. The transparency difference was maximised and the anisotropic features of the rods were used as a light valve to control the transparency of a smart window.

scholarly journals Efficiency of thermal conduction in a magnetized circumgalactic medium

2021 ◽  
Vol 502 (1) ◽  
pp. 1263-1278
Author(s):  
Richard Kooij ◽  
Asger Grønnow ◽  
Filippo Fraternali
Keyword(s):  
Magnetic Field ◽  
Thermal Conduction ◽  
Large Temperature ◽  
Gas Condensation ◽  
Circumgalactic Medium ◽  
Field Lines ◽  
Gas Accretion ◽  
Cloud Evolution ◽  
The Magnetic Field ◽  
Cold Gas

ABSTRACT The large temperature difference between cold gas clouds around galaxies and the hot haloes that they are moving through suggests that thermal conduction could play an important role in the circumgalactic medium. However, thermal conduction in the presence of a magnetic field is highly anisotropic, being strongly suppressed in the direction perpendicular to the magnetic field lines. This is commonly modelled by using a simple prescription that assumes that thermal conduction is isotropic at a certain efficiency f < 1, but its precise value is largely unconstrained. We investigate the efficiency of thermal conduction by comparing the evolution of 3D hydrodynamical (HD) simulations of cold clouds moving through a hot medium, using artificially suppressed isotropic thermal conduction (with f), against 3D magnetohydrodynamical (MHD) simulations with (true) anisotropic thermal conduction. Our main diagnostic is the time evolution of the amount of cold gas in conditions representative of the lower (close to the disc) circumgalactic medium of a Milky-Way-like galaxy. We find that in almost every HD and MHD run, the amount of cold gas increases with time, indicating that hot gas condensation is an important phenomenon that can contribute to gas accretion on to galaxies. For the most realistic orientations of the magnetic field with respect to the cloud motion we find that f is in the range 0.03–0.15. Thermal conduction is thus always highly suppressed, but its effect on the cloud evolution is generally not negligible.

scholarly journals Advantages and Disadvantages of Using Magnetic Nanoparticles for the Treatment of Complicated Ocular Disorders

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1157
Author(s):  
Elena K. Schneider-Futschik ◽  
Felisa Reyes-Ortega
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Therapeutic Efficacy ◽  
Genetic Diseases ◽  
Systemic Exposure ◽  
Drug Carriers ◽  
Three Dimensions ◽  
Target Point ◽  
Advantages And Disadvantages ◽  
Ocular Disorders

Nanomaterials provide enormous opportunities to overcome the limitations of conventional ocular delivery systems, such as low therapeutic efficacy, side effects due to the systemic exposure, or invasive surgery. Apart from the more common ocular disorders, there are some genetic diseases, such as cystic fibrosis, that develop ocular disorders as secondary effects as long as the disease progresses. These patients are more difficult to be pharmacologically treated using conventional drug routes (topically, systemic), since specific pharmacological formulations can be incompatible, display increased toxicity, or their therapeutic efficacy decreases with the administration of different kind of chemical molecules. Magnetic nanoparticles can be used as potent drug carriers and magnetic hyperthermia agents due to their response to an external magnetic field. Drugs can be concentrated in the target point, limiting the damage to other tissues. The other advantage of these magnetic nanoparticles is that they can act as magnetic resonance imaging agents, allowing the detection of the exact location of the disease. However, there are some drawbacks related to their use in drug delivery, such as the limitation to maintain efficacy in the target organ once the magnetic field is removed from outside. Another disadvantage is the difficulty in maintaining the therapeutic action in three dimensions inside the human body. This review summarizes all the application possibilities related to magnetic nanoparticles in ocular diseases.

scholarly journals Magnetoviscosity of a Magnetic Fluid Based on Barium Hexaferrite Nanoplates

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1870
Author(s):  
Dmitry Borin ◽  
Robert Müller ◽  
Stefan Odenbach
Keyword(s):  
Magnetic Field ◽  
Experimental Study ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Shear Flow ◽  
Magnetic Fluid ◽  
Barium Hexaferrite ◽  
Dipole Interaction ◽  
Field Dependent ◽  
Fluid Behaviour

This paper presents the results of an experimental study of the influence of an external magnetic field on the shear flow behaviour of a magnetic fluid based on barium hexaferrite nanoplates. With the use of rheometry, the magnetoviscosity and field-dependent yield-stress in the fluid are evaluated. The observed fluid behaviour is compared to that of ferrofluids with magnetic nanoparticles having high dipole interaction. The results obtained supplement the so-far poorly studied topic of the influence of magnetic nanoparticles’ shape on magnetoviscous effects. It is concluded that the parameter determining the observed magnetoviscous effects in the fluid under study is the ratio V2/l3, where V is the volume of the nanoparticle and l is the size of the nanoparticle in the direction corresponding to its orientation in the externally applied magnetic field.

An application of high-temperature superconductors YBCO to magnetic separation

2017 ◽  
Vol 31 (25) ◽  
pp. 1745001 ◽  
Author(s):  
Qiudong Guo ◽  
Peng Zhang ◽  
Lin Bo ◽  
Guibin Zeng ◽  
Dengqian Li ◽  
...  
Keyword(s):  
Magnetic Field ◽  
High Temperature ◽  
Magnetic Separation ◽  
High Magnetic Field ◽  
Low Cost ◽  
Rapid Development ◽  
High Temperature Superconductors ◽  
New Approach ◽  
Industrial Areas ◽  
Ybco Tape

With the rapid development of manufacturing technology of high temperature superconductive YB[Formula: see text]Cu3O[Formula: see text] YBCO materials and decreasing in cost of production, YBCO is marching into industrial areas with its good performances as source of high-magnetic field and rather low cost in reaching superconductivity. Based on analysis of the performance of high temperature superconductors YBCO and development of technology in superconductive magnetic separation both home and abroad, we propose a new approach of taking YBCO tape to make a solenoid as the source of a high magnetic field of magnetic separatior of ores. The paper also looks into the future of the YBCO high temperature superconductive magnetic separation from the perspective of technology and cost, as well as its applications in other industries.

Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging

Nanoscale ◽  
2015 ◽  
Vol 7 (19) ◽  
pp. 9004-9012 ◽  
Author(s):  
Jinghua Li ◽  
Yan Hu ◽  
Yanhua Hou ◽  
Xinkun Shen ◽  
Gaoqiang Xu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Phase Change ◽  
Phase Change Material ◽  
Alternating Magnetic Field ◽  
Change Material

An alternating magnetic field triggered nanocarrier for drug delivery is fabricated for dual modal imaging-guided thermo-chemo cancer therapy.

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