scholarly journals The Cold Contact Method as a Simple Drug Interaction Detection System

2008 ◽  
Vol 2008 ◽  
pp. 1-4 ◽  
Author(s):  
Ilma Nugrahani ◽  
Sukmadjaja Asyarie ◽  
Sundani Nurono Soewandhi ◽  
Slamet Ibrahim
Keyword(s):  
Simple Technique ◽  
Detection System ◽  
Drug Dosage ◽  
Dosage Forms ◽  
Physical Interaction ◽  
Contact Method ◽  
Melting Point Determination ◽  
Interaction Detection ◽  
Amoxicillin Clavulanate ◽  
Point Determination

The physical interaction between 2 substances frequently occurs along the mixing and manufacturing of solid drug dosage forms. The physical interaction is generally based on coarrangement of crystal lattice of drug combination. The cold contact method has been developed as a simple technique to detect physical interaction between 2 drugs. This method is performed by observing new habits of cocrystal that appear on contact area of crystallization by polarization microscope and characterize this cocrystal behavior by melting point determination. Has been evaluated by DSC, this method is proved suitable to identify eutecticum interaction of pseudoephedrine HCl-acetaminophen, peritecticum interaction of methampyrone-phenylbutazon, and solid solution interaction of amoxicillin-clavulanate, respectively.

The Cold Contact Method as a Simple Drug Interaction Detection System

2011 ◽  
pp. 92-97
Author(s):  
Ilma Nugrahani ◽  
Sukmadjaja Asyarie ◽  
Sundani Soewandhi ◽  
Slamet Ibrahim
Keyword(s):  
Drug Interaction ◽  
Detection System ◽  
Contact Method ◽  
Interaction Detection

scholarly journals The role of fathers in the postpartum period: experiences with skin to skin method

2012 ◽  
Vol 25 (6) ◽  
pp. 914-920 ◽  
Author(s):  
Joaquín Jesús Blanca Gutiérrez ◽  
María del Rosario Ábalos Pérez ◽  
Maria Victoria Montes Aguilera ◽  
Soledad González Moreno
Keyword(s):  
Health Professionals ◽  
Qualitative Method ◽  
Simple Technique ◽  
Contact Method ◽  
Skin Contact ◽  
Father’S Role ◽  
Skin To Skin ◽  
Depth Interviews ◽  
Positive Results

OBJECTIVE: This study aimed at investigating the significance of the skin-to-skin contact method with fathers, looking at their own experiences with their newborns. METHODS: The information was collected through in-depth interviews with 14 fathers who had used the skin-to-skin contact method with their newborns, after a cesarean delivery. The technique utilized for data analysis was the qualitative method of content analysis. RESULTS: Four principal themes emerged from the data: the preparation for the skin-to-skin method, the experiences of the fathers, the father's role, and effects of the method on the baby. CONCLUSIONS: The investigations performed highlighted the importance of the involvement of health professionals in the use of this method, which leads to a series of positive results for the organization related to satisfaction. We conclude that the skin-to-skin method is a simple technique, recommended for positive results for fathers and their babies.

scholarly journals Synthesis of 3-Ferrocenyl Isocoumarins

2020 ◽  
Vol 36 (05) ◽  
pp. 976-979
Author(s):  
Neeta Sinha
Keyword(s):  
Spectral Analysis ◽  
Melting Point ◽  
Phosphoric Acid ◽  
Polyphosphoric Acid ◽  
Aluminium Chloride ◽  
Melting Point Determination ◽  
Anhydrous Aluminium Chloride ◽  
Point Determination ◽  
Derivatives Of

The derivatives of 3-ferrocenyl isocoumarin were synthesized by the condensation of substituted homothphalic anhydride with ferrocene using phosphoric acid or anhydrous aluminium chloride as cyclising agent. Substituted homophthalic acid did not condense with ferrocene so homophthalic acids were converted into their anhydride and then allowed to react with ferrocene in the presence of polyphosphoric acid or in the presence of anhydrous aluminium chloride using dichloromethane as the solvent to give 3-ferrocenyl isocoumarins. 7-Methoxy, 6-methyl, 5,7-dihydroxy, 6,7-dimethoxy and 5,7-dimethoxy derivatives of 3-ferrocenyl isocoumarin were synthesized. All the compounds were characterised by melting point determination, elemental and spectral analysis.

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