scholarly journals Refractory Crohn’s Disease of the Vulva Treated with Infliximab: A Case Report

2007 ◽  
Vol 21 (12) ◽  
pp. 835-837 ◽  
Author(s):  
Sapna Makhija ◽  
Martin Trotter ◽  
Elizabeth Wagner ◽  
Sylvain Coderre ◽  
Remo Panaccione
Keyword(s):  
Weight Loss ◽  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Case Report ◽  
Crohn's Disease ◽  
Inflammatory Disorder ◽  
Extraintestinal Manifestations ◽  
Common Presentation ◽  
The Common ◽  
Systemic Symptoms

Crohn’s disease (CD) is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract. The common presentation includes abdominal pain, abdominal cramping and diarrhea. Many patients may exhibit systemic symptoms of fever and weight loss. Approximately 20% to 40% of patients will experience extraintestinal manifestations that involve the eyes, skin and joints. Women may experience a variety of gynecological manifestations, including vulvovaginal involvement, which is often not recognized and also difficult to treat. A case of refractory vulvovaginal CD is presented and the literature of gynecological manifestations of CD and its treatment are reviewed.

scholarly journals P168 Isolated terminal ileitis: when capsule endoscopy is key for Crohn’s disease diagnosis

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S222-S222
Author(s):  
M FREITAS ◽  
T Cúrdia Gonçalves ◽  
P Boal Carvalho ◽  
F Dias de Castro ◽  
B Rosa ◽  
...  
Keyword(s):  
Weight Loss ◽  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Capsule Endoscopy ◽  
Disease Diagnosis ◽  
Inflammatory Activity ◽  
Extraintestinal Manifestations ◽  
Terminal Ileitis ◽  
Proximal Small Bowel

Abstract Background Terminal ileitis (TI) is a common condition in clinical practice and may be associated with a wide variety of diseases, mostly Crohn’s disease (CD). Data regarding predictors of CD diagnosis in isolated TI are lacking, particularly concerning small bowel capsule endoscopy (SBCE) findings. Aim To evaluate predictive factors for CD diagnosis in patients with isolated TI detected during ileocolonoscopy, submitted to SBCE. Methods Retrospective study including consecutive patients undergoing SBCE after diagnosis of TI without colonic mucosal abnormalities on ileocolonoscopy between January 2016 and September 2019. Demographic, clinical, biochemical, endoscopic and imaging data were collected. The diagnosis of CD was based on clinical evaluation, endoscopic, histological, radiological, and/or biochemical investigations. Results One hundred and two patients with isolated ileitis on ileocolonoscopy were included. After performing SBCE, 34.3% of the patients had a diagnosis of CD. All CD diagnosed patients had positive SBCE findings. Extraintestinal manifestations (p = 0.003), weight loss (p = 0.01), abnormal imaging (p = 0.04) and positive SBCE findings (p = 0.005) were independently associated with CD diagnosis. Regarding SBCE, presence of proximal small-bowel disease (p = 0.02), diffuse findings (p = 0.002) and presence of moderate to severe inflammatory activity (Lewis Score≥790) (p < 0.001) were independently associated with CD diagnosis. Conclusion SBCE is a valuable tool that should be systematically used in patients presenting with isolated TI, since it enabled CD diagnosis in approximately one-third of patients. A diagnosis of CD should be considered when a patient with TI shows extraintestinal manifestations, weight loss, abnormal imaging and positive SBCE findings, especially proximal involvement, diffuse findings and the presence of moderate to severe inflammatory activity.

scholarly journals Infliximab for the Treatment of Crohn'S Disease: Review and Indications for Clinical Use in Canada

2001 ◽  
Vol 15 (6) ◽  
pp. 371-375 ◽  
Author(s):  
Remo Panaccione
Keyword(s):  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Activity Index ◽  
Significant Risk ◽  
Inflammatory Disorder ◽  
Aminosalicylic Acid ◽  
Onset Of Action ◽  
Necrosis Factor Alpha

Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract. It may affect any portion of the gastrointestinal tract from the mouth to the anus. Symptoms typically include cramping abdominal pain, diarrhea (which may be bloody) and nausea. As the severity of the illness worsens, patients may experience constant abdominal pain, vomiting, weight loss and fever. From the perspective of the patient, disease symptoms significantly impair quality of life, and interfere with their work environment and activities of daily living. Unfortunately, there is no cure for Crohn's disease. Patients experience a chronic, relapsing course characterized by recurrent flares of their disease. Conventional medical treatment of Crohn's disease includes the use of non-specific anti-inflammatory drugs (5-aminosalicylic acid agents, prednisone, budesonide), immunosuppressives (6-mercaptopurine, azathioprine, methotrexate) and antibiotics. A variable onset of action, incomplete response rates and a significant risk of adverse effects characterize current therapies. Although surgery is frequently used to treat complications or medically refractory disease, postoperative recurrence is a common problem. Infliximab, a murine chimeric monoclonal antibody directed toward tumour necrosis factor-alpha, is a highly effective treatment of active Crohn's disease. In randomized, placebo-controlled clinical trials, 33% of patients treated with infliximab 5 mg/kg achieved remission (Crohn's Disease Activity Index score less than 150), compared with only 4% of those receiving placebo (P<0.001). Additionally, infliximab is the only drug therapy shown to be effective for the treatment of fistulizing Crohn's disease. In studies done to date, infliximab appears to be well tolerated and has a favourable side effect profile.

Crohn’s disease

2018 ◽  
Vol 11 (8) ◽  
pp. 435-442
Author(s):  
James Franklin
Keyword(s):  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Terminal Ileum ◽  
Bowel Disease ◽  
Rare Condition ◽  
Inflammatory Bowel

Crohn’s disease is a chronic relapsing gastrointestinal condition. It is an inflammatory bowel disease that can affect any part of the gastrointestinal tract from mouth to anus, but most commonly affects the terminal ileum and colon. Individuals can present with a wide variety of symptoms, but diarrhoea, abdominal pain and weight loss are the most common. It is a rare condition, but GPs play an important role in recognising Crohn’s disease and supporting patients through their lifelong treatment.

scholarly journals S0838 Diarrhea, Abdominal Pain, and Weight Loss in Crohn’s Disease: A Patient’s Perspective

2020 ◽  
Vol 115 (1) ◽  
pp. S432-S433
Author(s):  
Dawn Beaulieu ◽  
Nicole Zaleski ◽  
Sara Horst ◽  
Robin Dalal ◽  
Elizabeth Scoville ◽  
...  
Keyword(s):  
Weight Loss ◽  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Crohn's Disease ◽  
Patient’S Perspective

scholarly journals An atypical cause of right lower abdominal pain: amoebiasis, a family cluster

2021 ◽  
Vol 84 (2) ◽  
pp. 362-364
Author(s):  
T De Somer ◽  
D Baert ◽  
M Deceuninck ◽  
C Van Steenkiste ◽  
D Marichal ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Case Report ◽  
Crohn's Disease ◽  
Maintenance Therapy ◽  
Lower Abdominal Pain ◽  
Close Relative ◽  
Histopathologic Examination ◽  
Family Cluster ◽  
Micro Organisms

In this case report we present a family cluster of amoebiasis in a nonendemic region. A 46-year-old women, diagnosed with Crohn’s disease for which she received no maintenance therapy, was evaluated for the suspicion of a flare. At colonoscopy however, atypical findings for Crohn’s disease were seen. Histopathologic examination revealed micro-organisms compatible with amoebiasis. Interestingly, 4 years before this event she started a new relationship with a 38-year-old man who was diagnosed with liver-amoebiasis 3 months after the start of their relationship. On top of this, her 18-year-old daughter was diagnosed with amoebiasis 2 years after her diagnosis. The source of the infection remains unknown, but we speculate that the infection was transmitted feco-orally between the different members of this family. These cases illustrate that we should be aware of parasitological causes of colitis, especially in patients with atypical endoscopic images or when a close “relative” is diagnosed with amoebiasis.

scholarly journals Can mild abdominal pain be the only sign of developing Crohn’s disease? A case report

2016 ◽  
Vol 12 (4) ◽  
pp. 445-450
Author(s):  
Agnieszka Sakson-Słomińska ◽  
◽  
Zuzanna Wasielewska ◽  
Anna Szaflarska-Popławska ◽  
Aneta Krogulska ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Case Report ◽  
Crohn's Disease ◽  
Mild Abdominal Pain

scholarly journals EPIDIDYMOORCHITIS AS AN EXTRAINTESTINAL MANIFESTATION OF CROHN’S DISEASE (case report)

2019 ◽  
Vol 18 (3(69)) ◽  
pp. 99-103
Author(s):  
D. A. Khubezov ◽  
S. N. Trushin ◽  
A. Y. Ogoreltsev ◽  
E. I. Semionkin
Keyword(s):  
Crohn’S Disease ◽  
Case Report ◽  
Ankylosing Spondylitis ◽  
Crohn's Disease ◽  
Biological Therapy ◽  
Ileocecal Resection ◽  
Extraintestinal Manifestations ◽  
Extraintestinal Manifestation ◽  
Disease Case ◽  
Penetrating Crohn’S Disease

Extraintestinal manifestations are found at least in a quarter of patients with Crohn's disease. In contrast to eyes lesions, joints and skin, epididymoorchitis caused by Crohn's disease is extremely rare and is described in few papers. However, orchitis and epididymitis are described in another autoimmune disease, ankylosing spondylitis and, although the incidence of asymptomatic orchitis in ankylosing spondylitis is unknown, it is often diagnosed during examinations for male infertility. A clinical case report of a 26-year-old patient suffering from Crohn's disease with extraintestinal manifestations in the form of orchiepididymitis is presented. While receiving treatment in the urological unit, the patient underwent several procedures, including a right-side orchiectomy, but the inflammatory process progressed with the risk of losing the only remaining testicle. Only after ileocecal resection for the penetrating Crohn's disease with ileosigmoid fistula and following biological therapy, it was possible to achieve remission and preserve a single testicle.

scholarly journals Pneumatosis intestinalis as a presentation of Crohn’s disease: a case report

2020 ◽  
Vol 40 (2) ◽  
pp. 188
Author(s):  
Rómulo Vargas Rubio ◽  
Janeth Bejarano Rengifo ◽  
Esteban Ardila Silva
Keyword(s):  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Case Report ◽  
Crohn's Disease ◽  
Rare Condition ◽  
Pneumatosis Intestinalis ◽  
Intestinal Wall ◽  
Chronic Abdominal Pain ◽  
Diagnostic Approach ◽  
Balloon Enteroscopy

Pneumatosis intestinalis (PI) is defined as presence of gas within the intestinal wall. It is a rare condition, usually associated with a wide variety of pathologies. It requires a special diagnostic approach to determine underlying etiology. We present the case of a 18 year old woman with chronic abdominal pain, who presents with peritoneal signs and pneumoperitoneum. Laparoscopy showed NI. Thereafter, Crohn´s disease was diagnosed by balloon enteroscopy.

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