scholarly journals Protective Role of Genistein in Acute Liver Damage Induced by Carbon Tetrachloride

2007 ◽  
Vol 2007 ◽  
pp. 1-6 ◽  
Author(s):  
Nalan Kuzu ◽  
Kerem Metin ◽  
Adile Ferda Dagli ◽  
Fatih Akdemir ◽  
Cemal Orhan ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Protective Role ◽  
Acute Liver Damage

Role of L-carnitine in the prevention of acute liver damage induced by carbon tetrachloride in rats

2004 ◽  
Vol 19 (3) ◽  
pp. 333-338 ◽  
Author(s):  
KUTBEDDIN DEMIRDAG ◽  
IBRAHIM HALIL BAHCECIOGLU ◽  
IBRAHIM HANIFI OZERCAN ◽  
MEHMET OZDEN ◽  
SEVAL YILMAZ ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Acute Liver Damage

scholarly journals Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Luciano Rezende Vilela ◽  
Lindisley Ferreira Gomides ◽  
Bruna Araújo David ◽  
Maísa Mota Antunes ◽  
Ariane Barros Diniz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Damage ◽  
Acute Liver Injury ◽  
Endocannabinoid System ◽  
Protective Role ◽  
Acute Liver Damage ◽  
Protective Actions ◽  
Cocaine Toxicity ◽  
Hepatotoxic Drug

Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. Considering the protective role of the endocannabinoid system against cell toxicity, we hypothesized that treatment with an anandamide hydrolysis inhibitor, URB597, or with a phytocannabinoid, cannabidiol (CBD), protects against cocaine toxicity. URB597 (1.0 mg/kg) abolished cocaine-induced seizure, yet it did not protect against acute liver injury. Using confocal liver intravital microscopy, we observed that CBD (30 mg/kg) reduced acute liver inflammation and damage induced by cocaine and prevented associated seizure. Additionally, we showed that previous liver damage induced by another hepatotoxic drug (acetaminophen) increased seizure and lethality induced by cocaine intoxication, linking hepatotoxicity to seizure dynamics. These findings suggest that activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine, supporting its further clinical application in the treatment of cocaine abuse.

The Hepatoprotective Role of Warburgia salutaris and Iso-Mukaadial Acetate on Carbon tetrachloride Intoxicated Rats Model

2021 ◽  
Vol 17 ◽  
Author(s):  
Gideon Ayeni ◽  
Mthokozisi Blessing Cedric Simelane ◽  
Shahidul Islam ◽  
Ofentse Jacob Pooe
Keyword(s):  
Carbon Tetrachloride ◽  
Hepatic Injury ◽  
Antioxidant Properties ◽  
Hepatic Necrosis ◽  
Protective Role ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Isolated Compound

Background: Medicinal plants together with their isolated bioactive compounds are known for their antioxidant properties which constitute therapeutic agents that are routinely employed in the treatment of liver diseases. Aims of the Study: The current study sought to explore the protective role of Warburgia salutaris and its isolated compound, iso-mukaadial acetate against carbon tetrachloride (CCl4)-induced hepatic injury. Methods: Thirty-five male Sprague Dawley rats were divided into seven groups of five animals each and injected with CCl4 to induce hepatic injury. Results: Treatment with the crude extract of W. salutaris and of iso-mukaadial acetate significantly reduced the levels of alkaline phosphatase, alanine and aspartate aminotransaminases, total bilirubin and malondialdehyde in a dose dependent manner, when compared to untreated groups. Liver histology revealed a reduction in hepatic necrosis and inflammation. Conclusion: The current investigation has demonstrated that W. salutaris extract and iso-mukaadial acetate could mitigate the acute liver injury inflicted by a hepatotoxic inducer in rats.

scholarly journals Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae)

2018 ◽  
Vol 29 (6) ◽  
pp. 609-619 ◽  
Author(s):  
Lucky Legbosi Nwidu ◽  
Yibala I. Oboma ◽  
Ekramy Elmorsy ◽  
Wayne Grant Carter
Keyword(s):  
Carbon Tetrachloride ◽  
Leaf Extract ◽  
Protective Role ◽  
Lipid Peroxidation Product ◽  
Hematological Indices ◽  
Hepatocellular Damage ◽  
Antioxidant Parameters ◽  
Mechanistic Basis ◽  
Histopathological Studies

Abstract Background Glyphae brevis leaf is reported in ethnomedicine as a treatment for hepatitis and jaundice; however, no studies have hitherto investigated the mechanistic basis of these claims. Methods A hepato-protective role of G. brevis hydromethanolic (GBH) leaf extract was established against carbon tetrachloride (CCl4)-induced hepatotoxicity. Twenty-four hours after a CCl4 challenge, rats were sacrificed and serum hematological indices, lipid profile, and biochemical parameters were determined. The antioxidant enzymes parameters (glutathione, catalase, and superoxide dismutase) and lipid peroxidation product (thiobarbituric reactive substances) levels in liver homogenates were evaluated. Changes in the liver cyto-architecture of different treatment groups were also investigated. Results The GBH extract produced no significant impact on weight and hematological indices. Intoxication with CCl4 significantly (p<0.001–0.05) increased total cholesterol (TC) and low-density lipoproteins (LDL) compared with control rats. Pretreatment with GBH leaf extract significantly reduced triglycerides, TC, and LDL to approaching control levels (p<0.001–0.05). The GBH leaf extract significantly alleviated CCl4-induced elevation of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and the CCl4-induced depression of total protein, and albumin. Liver antioxidant parameters were significantly increased in plant extract-treated rats, and this antagonized the pro-oxidant effect of CCl4. Histopathological studies also supported a hepato-protective effect of GBH. Collectively, the GBH leaf extract alleviated the CCl4-induced hepatotoxicity through improvement of innate antioxidant enzyme levels and lipid metabolism and stabilized the hepatocyte cyto-architecture of intoxicated rats. Conclusions This study establishes the ethnomedicinal role of G. brevis leaf in hepatitis and the mechanistic basis of hepato-protection against CCl4-induced hepatotoxicity.

Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat

2008 ◽  
Vol 31 (9) ◽  
pp. 1160-1165 ◽  
Author(s):  
Hee Seung Lee ◽  
Kyung-Hee Jung ◽  
Sang-Won Hong ◽  
In-Suh Park ◽  
Chongmu Lee ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Acute Liver Damage

Protective and Therapeutic Effects of Curcuma xanthorrhiza on Hepatotoxin-induced Liver Damage

1995 ◽  
Vol 23 (03n04) ◽  
pp. 243-254 ◽  
Author(s):  
Song-Chow Li ◽  
Chun-Ching Lin ◽  
Yun-Ho Lin ◽  
S. Supriyatna ◽  
Chao-Wei Teng
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Intraperitoneal Administration ◽  
Therapeutic Effects ◽  
Acute Liver Damage ◽  
Liver Injuries ◽  
Acute Elevation ◽  
Serum Transaminases ◽  
Hepatoprotective Agent ◽  
Curcuma Xanthorrhiza

Curcuma xanthorrhiza Roxb. (Zingiberaceae family, commonly known as temu lawak or Javanese turmeric in Indonesia), which is found both wild and cultivated in Indonesia, has been traditionally used for medicinal purposes. C. xanthorrhiza is also used as a tonic in Indonesia. The aim of the present study is to clarify whether C. xanthorrhiza treatment may prevent acute liver damage induced by acetaminophen and carbon tetrachloride in mice. The results clearly indicated that extract of C. xanthorrhiza could reduce significantly the acute elevation of serum transaminases levels induced by the two kinds of hepatotoxins, and alleviated the degree of liver damage at 24 hours after the intraperitoneal administration of two hepatotoxins. It may be concluded that C. xanthorrhiza can protect the liver from various hepatotoxins, hence C. xanthorrhiza could be useful in the treatment of liver injuries and has promise as a kind of broad spectrum hepatoprotective agent.

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