scholarly journals Synthesis and Characterization of 9-Phenyl-9H-purin-6-amines from 5-Amino-1-phenyl-1H-imidazole-4-carbonitriles

2007 ◽  
Vol 4 (3) ◽  
pp. 372-375 ◽  
Author(s):  
Asieh Yahyazadeh ◽  
Fatemah Habibi
Keyword(s):  
Synthesis And Characterization ◽  
High Yields

9-Phenyl-9H-purin-6-amine derivatives have been synthesized in high yields by reaction between 5-amino-1-phenyl-1H-imidazole-4-carbonitrile with HC(OEt)3and Ac2O followed by reaction with ammonia.

Synthesis and characterization of novel optically active poly(ester-imide-imine)s

e-Polymers ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Abdol Reza Hajipour ◽  
Parniyan Roosta ◽  
Saeed Zahmatkesh ◽  
Arnold E. Ruoho
Keyword(s):  
Amino Acids ◽  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Optically Active ◽  
Synthesis And Characterization ◽  
Interfacial Polycondensation ◽  
Thermal Stabilities ◽  
Amino Phenol ◽  
High Yields

Abstract N,N´-(3,3´,4,4´-Benzophenonetetracarboxylic)-3,3´,4,4´-diimido-di-Lamino acids (1a-1d) and N,N´-pyromelliticdiimido-di-L-amino acids (2a-2d) are prepared from the reaction of 3,3´,4,4´-benzenetetracarboxylic-3,3´,4,4´- dianhydride or pyromellitic dianhydride with the corresponding L-amino acids in a solution of glacial acetic acid/pyridine (3:2) at refluxing temperature. 4-(4-((4- Hydroxyphenylimino)methyl)benzylidene amino) phenol (3) is prepared from 4- amino phenol and terephthaldialdehyde in refluxing ethanol. Interfacial polycondensation method was used to prepare the corresponding polymers (PEII1-8) in two immiscible solvents (water/dichloromethane). The resulting poly(esterimide- imine)s (PEIIs) having good inherent viscosities (0.13-1.25 dl g-1), optical activity and thermal stabilities is obtained in high yields.

scholarly journals Synthesis and Characterization of New Diiron and Diruthenium μ-Aminocarbyne Complexes Containing Terminal S-, P- and C-Ligands

2007 ◽  
Vol 62 (3) ◽  
pp. 427-438 ◽  
Author(s):  
Vincenzo G. Albano ◽  
Luigi Busetto ◽  
Fabio Marchetti ◽  
Magda Monari ◽  
Stefano Zacchini ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Diffraction Study ◽  
Coordination Mode ◽  
Bond Cleavage ◽  
Synthesis And Characterization ◽  
X Ray Diffraction ◽  
X Ray ◽  
Dithiocarbamate Ligand ◽  
High Yields

The diiron aminocarbyne complexes [Fe2{μ-CN(Me)(R)}(μ-CO)(CO)(NCMe)(Cp)2][SO3CF3] (R = Xy1, 1a; R = Me, 1b; R = CH2Ph, 1c; Xy1 = 2,6-Me2C6H3) undergo replacement of the coordinated nitrile by halides, diethyldithiocarbamate, and dicyanomethanide to give [Fe2{μ-CN(Me) (R)}(μ-CO)(CO)(X)(Cp)2] complexes (R = Me, X = Br, 4a; R = Me, X = I, 4b; R = CH2Ph, X = Cl, 4c; R = CH2Ph, X = Br, 4d; R = CH2Ph, X = I, 4e; R = Xy1, X = SC(S)NEt2, 5a; R = Me, X = SC(S)NEt2, 5b; R = Xy1, X = CH(CN)2, 7), in good yields. The molecular structure of 5a shows an unusual η1 coordination mode of the dithiocarbamate ligand. Similarly, treatment of [M2{μ-CN(Me) (R)}(μ-CO)(CO)(NCMe)(Cp)2][SO3CF3] (M = Fe, R = Xy1, 1a; M = Fe, R = Me, 1b; M = Ru, R = Xy1, 2a; M = Ru, R = Me, 2b) with a series of phosphanes generates the cationic complexes [M2{μ- CN(Me)(R)}(μ-CO)(CO)(P)(Cp)2][SO3CF3] (M = Fe, R = Xy1, P = PPh2H, 6a; M = Fe, R = Xy1, P = PPh3, 6b; M = Fe, R = Xy1, P = PMe3, 6c; M = Fe, R = Me, P = PMe2Ph, 6d; M = Fe, R = Me, P = PPh3, 6e; M = Fe, R = Me, P = PMePh2, 6f; M = Ru, R = Xy1, P = PPh2H, 6g; M = Ru, R = Me, P = PPh2H, 6h), in high yields. The molecular structure of 6a has been elucidated by an X-ray diffraction study. The reactions of [Fe2{μ-CN(Me)(Xyl)}(μ-CO)(CO)(NCR′)(Cp)2][SO3CF3] [R′ = Me, 1a; R′ = tBu, 3] with PhLi and PPh2Li yield [Fe2{μ-CN(Me)(Xy1)}(μ-CO)(CO)(Ph)(Cp)2] (8) and [Fe2{μ-CN(Me)(Xy1)}(μ-CO)(CO)(PPh2)(Cp)2] (9), respectively. The molecular structure of 8 has been ascertained by X-ray diffraction. Conversely, the reaction of 1a with MeLi generates the aminoalkylidene compound [Fe2{C(Me)N(Me)(Xy1)}(μ-CO)2(CO)(Cp)2] (10).Finally, the acetone complex [Fe2{μ-CN(Me)(Xy1)}(μ-CO)(CO)(OCMe2)(Cp)2][SO3CF3] (12) reacts with lithium acetylides to give complexes [Fe2{μ-CN(Me)(Xy1)}(μ-CO)(CO)(C≡CR)(Cp)2] (R = p-C6H4Me, 11a; R = Ph, 11b; R = SiMe3, 11c), in high yields. Filtration through alumina of a solution of 11a in CH2Cl2 results in hydration of the acetylide group and C-Si bond cleavage, affording [Fe2{μ-CN(Me)(Xy1)}(μ-CO)(CO){C(O)Me}(Cp)2] (12).

scholarly journals Synthesis and Characterization of Novel 1,3-Thiazole and 2-Amino-1,3,4-Thiadiazole Derivatives

2014 ◽  
Vol 33 (2) ◽  
pp. 189 ◽  
Author(s):  
Mustafa Er ◽  
Ayşe Şahin ◽  
Hakan Tahtacı
Keyword(s):  
Biological Activities ◽  
High Yield ◽  
Synthesis And Characterization ◽  
Hantzsch Reaction ◽  
H Nmr ◽  
Thiadiazole Derivatives ◽  
High Yields ◽  
Mass Spectrometric Techniques ◽  
C Nmr

<p>Thiosemicarbazone derivatives <strong>3a–e</strong> were synthesized by the reaction of various aldehydes<strong> 1a–e</strong> with 4-methyl thiosemicarbazide <strong>2</strong> in 78% to 90% yield. Then, the thiazole moieties of the target materials <strong>5a–e</strong> were obtained in high yields (71–93%) using the Hantzsch reaction utilizing thiosemicarbazone derivatives <strong>3a–e</strong> with ethyl-2-chloroacetoacetic ester. The substituted nitrile derivatives <strong>7a–e</strong> were obtained in moderate to high yield (58–84%) from the reaction of compounds <strong>5a–e</strong> with chloroacetonitrile by the nucleophilic aliphatic substitution reaction in the presence of anhydrous potassium carbonate. Finally, substituted 2-amino-1,3,4-thiadiazole compounds <strong>9a–e</strong> were obtained in moderate to good yields (51–62%) from the reaction of thiosemicarbazide with substituted nitrile derivatives <strong>7a–e</strong>. As a result, compounds that all share a high disposition for biological activities were obtained. The structures of the newly synthesized compounds were confirmed by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, elemental analysis, and mass spectrometric techniques.</p>

Synthesis and Characterization of Triazole-Linked Bistetrahydrobenzofuran Derivatives as Anti-Ulcer Agents

2014 ◽  
Vol 997 ◽  
pp. 128-131
Author(s):  
Quan Li Yang ◽  
Chun Xue Chen ◽  
Wu Li ◽  
Wan Liu ◽  
Hu Biao Fang ◽  
...  
Keyword(s):  
Elemental Analysis ◽  
Click Reaction ◽  
Bioactive Compound ◽  
Inhibitory Effect ◽  
Synthesis And Characterization ◽  
Mild Conditions ◽  
Inhibitory Activities ◽  
High Yields

A pair of triazole-linked bistetrahydrobenzofuran derivatives were prepared in high yields through Cu (II)-catalyzed click reaction under mild conditions. All of the intermediates and target compounds were characterized by NMR, IR, ESI-MS and elemental analysis. Thein vitroH+/K+-ATPase inhibitory effect for the target compounds were also evaluated by MTT methods, and the (E)-isomer of the bistetrahydrobenzofurans exhibited the better H+/K+-ATPase inhibitory activities than the commercial omeprazole with the IC50of 37.90 μM. The bioactive compound might be potentially used as anti-ulcer agents in the treatment of acid-related diseases.

Synthesis and Characterization of Iso E Super®

2011 ◽  
Vol 396-398 ◽  
pp. 1115-1118 ◽  
Author(s):  
Yue Lin Zhu ◽  
Ji Ne Wang ◽  
Chang Jian Xiong
Keyword(s):  
Industrial Production ◽  
Diels Alder ◽  
Synthesis And Characterization ◽  
Reaction Conditions ◽  
High Yields ◽  
Alder Adduct

A three-step route was used in the study to synthesize the Iso E Super®. Firstly, acetaldehyde was reacted with butanone to obtain 3-methyl-3pentene-2-one, which, in turn, was reacted with myrcene to form a subsitiuted acyl cyclohexene. Finally, the so called Diels-Alder adduct was cyclized. The structure of the products was confirmed by NMR, IR, GC-MS and Roman analysis. The method used has the advantages of readily availability of starting materials, mild reaction conditions, convenient manipulation and moderately high yields, so it has a promising prospect in industrial production

scholarly journals Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin

2008 ◽  
Vol 5 (1) ◽  
pp. 114-119 ◽  
Author(s):  
K. H. Hemakumar ◽  
A. D. Sathisha ◽  
Y. B. Basavaraju
Keyword(s):  
Anticancer Activity ◽  
Synthesis And Characterization ◽  
Naturally Occurring ◽  
High Yields ◽  
New Compounds

The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-2,3-dimethoxy-9-chloro–11bH benzo[C]-fluoren-5,7-dione and 6,6a-dihydro-2,3-dimethoxy-9-fluoro–11bH benzo[C]-fluoren-5,7- dione were synthesized in high yields. They are analogues of naturally occurring lignan podophyllotoxin which exhibits anticancer activity. They are very essential to study anticancer activity.

Synthese und Charakterisierung von 1,3,5-Hexahydrotriazin-Komplexen des Moo und MoVI / Synthesis and Characterization of 1,3,5-Hexahydrotriazine Complexes of Mo0 and M oVI

1995 ◽  
Vol 50 (7) ◽  
pp. 1038-1044 ◽  
Author(s):  
Hans Schumann
Keyword(s):  
Mass Spectroscopy ◽  
Spectroscopic Properties ◽  
Macrocyclic Ligands ◽  
Synthesis And Characterization ◽  
Controlled Conditions ◽  
Ligand Displacement ◽  
High Yields

Organo-substituted 1,3,5-hexahydrotriazine complexes of the type (RNCH2)3Mo(CO)3 (R = CH3, i - C3H7 and CH2C6H5) are obtained by ligand displacement from η6-C7H8Mo(CO)3 in high yields. These products have been characterized by 1H, 13C, 95Mo NMR, IR as well as mass spectroscopy and contain an electron-rich Mo(C O)3 center bonded to the 1,3,5-hexahydrotriazine 6e donor via three Mo -N bonds. Oxidation of the Mo0 complex 1,3,5-(CH3NCH2)3Mo(CO)3 with H2O2 under carefully controlled conditions allows isolation of 1,3,5-(CH3NCH2)3MoO3 containing a MoVI center. Chemical and spectroscopic properties of these complexes are compared with those of related Mo complexes with neutral macrocyclic ligands containing N3 donor sets.

scholarly journals Identification and Efficient Synthetic Method for Preparation of Cyclopentane-1,3-diol Impurity in Tafluprost Drug

2020 ◽  
Vol 33 (1) ◽  
pp. 210-214
Author(s):  
Muvvala Venkatanarayana
Keyword(s):  
Aluminum Hydride ◽  
Synthesis And Characterization ◽  
Synthetic Method ◽  
High Yields

In present work, the isolation, synthesis and characterization of the identified triol impurity present in tafluprost is described. This investigation helps to avoid formation of impurity by control the reaction and its leads to improving high yields of tafluprost. The source of impurity was identified, due to over-reduction of lactone with diisobutyl aluminum hydride (DIBAL-H).

One-pot synthesis and characterization of chalcopyrite CuInS2 nanoparticles

2014 ◽  
Vol 2 (27) ◽  
pp. 10629-10633 ◽  
Author(s):  
Chivin Sun ◽  
Zehra Cevher ◽  
Jin Zhang ◽  
Bo Gao ◽  
Kai Shum ◽  
...  
Keyword(s):  
Reaction Times ◽  
Synthesis And Characterization ◽  
Single Source ◽  
One Pot ◽  
Single Source Precursors ◽  
Mercaptopropionic Acid ◽  
One Pot Synthesis ◽  
High Yields

We synthesized tetragonal chalcopyrite CuInS2 (CIS) nanoparticles from molecular single source precursors, (Ph3P)2Cu-(μ-SEt)2In(SEt)2, by a one-pot reaction in the presence of 3-mercaptopropionic acid at reaction times of 3 hours or less with high yields.

scholarly journals A Rapid, Convient and Diversified-Multicomponent Synthesis and Characterization of Pyrano[2,3-b]Indoles

2014 ◽  
Vol 26 ◽  
pp. 69-76
Author(s):  
H.B. Ghodasara ◽  
P.M. Singala ◽  
Viresh H. Shah
Keyword(s):  
Chromatographic Method ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Synthesis And Characterization ◽  
Basic Catalyst ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
High Yields ◽  
Work Up

A series of pyrano[2,3-b]indoles, was efficiently synthesized via one-pot, multi component reaction (MCRs) of 1,3-bifunctional synthon(malononitrile/ethylcyano acetate), aromatic aldehydes and oxiindole in the presence of various basic catalyst. The key advantages of this process are high yields, shorter reaction times, easy work-up, and purification of products by non-chromatographic method.

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