scholarly journals Oral Corticosteroids in Asthma: A Review of Benefits and Risks

2007 ◽  
Vol 14 (suppl c) ◽  
pp. 1C-7C ◽  
Author(s):  
Robert Schellenberg ◽  
Jonathan D R Adachi ◽  
Dennis Bowie ◽  
Jacques Brown ◽  
Lyn Guenther ◽  
...  

Oral corticosteroids (OCS) play an integral role in the pharmacological management of asthma, as well as a number of other inflammatory and autoimmune disorders. However, although their broad spectrum of effect is beneficial in controlling inflammation, it can also lead to undesirable effects on other cells, resulting in adverse effects. The purpose of the present review is to discuss the particular benefits of OCS and to outline the optimal role of these agents in the management of asthma, drawing on evidence-based medicine and current clinical practice guidelines. The mandate for the present review also covers an analysis of the risk:benefit ratio as it pertains to OCS use in asthma. The more common adverse effects will be discussed and weighed against the possible benefits.

Author(s):  
Robyn Bluhm

Both evidence-based medicine (EBM) and biological psychiatry aim to improve clinical practice by basing it more firmly on the results of scientific research. In this chapter, however, I show that the two approaches have very different views on what kinds of research will improve practice. This is because EBM is a form of medical empiricism – it focuses solely on whether treatments work, while biological psychiatry is a form of medical rationalism – it seeks to understand the causes that give rise to observed clinical outcomes. I argue that EBM’s empiricism is ultimately shortsighted and that it should integrate some of the rationalist concerns with pathophysiology. I then use this analysis to draw some lessons for research based on the NIMH’s new Research Domain Criteria.


2019 ◽  
Vol 110 (1) ◽  
Author(s):  
Abhishek Sharma ◽  
Nidhi Madan

2011 ◽  
Vol 33 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Bob Wilffert ◽  
◽  
Jesse Swen ◽  
Hans Mulder ◽  
Daan Touw ◽  
...  

2016 ◽  
pp. 34-37
Author(s):  
Olha Puzanovа

The objective: was to study the international experience of evidence based preventive medicine development as well as to estimate its perspectives in Ukraine. Patients and methods. Main principles and methods of scientific knowledge and research have been used including universal ones, methods of systemic approach, quantitative and qualitative information analysis, classification and systematization of theoretical and empirical data, hystorical and logical methods, health statistics as well). In total 529 scientific information sources have been studied, particularly a number of evidence based medicine (EBM) computer databases, special task forces recommendations and Cochrane reviews on prevention, Register of medical and technological documents for health care standards in Ukraine et al. Results. The contribution of foreign scientific schools in the development of EBM has been determined, as well as the crucial role of scientific works carried out in the US and Great Britain in 1930–80s as to the development of evidence based preventive medicine. The international experience of the development and functioning of evidence based practice centers’ and special task forces on prevention has been summarized, as the experience of the development and implementation of recommendations on prevention in primary health care (PHC) in high income countries acceptable for Ukraine. The concept of evidence based prevention has been first proposed. It is revealed, that EBM implementation in Europe has been prioritized in both the field of infectious diseases prevention and PHC, while there are both the development of differentiated evidence based prevention and early evidence based diagnosis in PHC in the US. Conclusion. The results proved importance of taking into consideration of international experience while evidence based PHC is being developed as a priority in Ukraine.


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