scholarly journals Synthesis of Novel Azetidinone and Thiazolidinones Derivatives and Evaluation of Their Antimicrobial Efficacy

2006 ◽  
Vol 3 (2) ◽  
pp. 103-109 ◽  
Author(s):  
K. H. Patel ◽  
A. G. Mehta
Keyword(s):  
Acetic Acid ◽  
Schiff Base ◽  
Glycolic Acid ◽  
Acetyl Chloride ◽  
Aromatic Aldehydes ◽  
Antimicrobial Efficacy ◽  
Cyclocondensation Reaction

2-Amino-4-(2-naphthalenyl) thiazole (1) was prepared from 2-acetylnapthalene. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a-h). These anils on cyclocondensation reaction with chloro acetyl chloride and thio glycolic acid (i.e. mercapto acetic acid) yields 2-azetidinones and 4-thiazolidinones respectively. The prepared compounds have been screened on some stains of bacteria.

scholarly journals Synthesis and Antifungal Activity of Azetidinone and Thiazolidinones Derivatives of 2-Amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole

2006 ◽  
Vol 3 (4) ◽  
pp. 267-273 ◽  
Author(s):  
K. H. Patel ◽  
A. G. Mehta
Keyword(s):  
Acetic Acid ◽  
Schiff Base ◽  
Antifungal Activity ◽  
Glycolic Acid ◽  
Acetyl Chloride ◽  
Aromatic Aldehydes ◽  
Cyclocondensation Reaction ◽  
Derivatives Of

2-Amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole [1] was prepared by treatment of KCNS and Br2on 2-Amino-4-(2-naphthalenyl) thiazole. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a-h). These anils on cyclocondensation reaction with chloro acetyl chloride and thio glycolic acid (i.e. mercapto acetic acid) afford 2-azetidinones and 4-thiazolidinones respectively. The prepared compounds have been screened on some stains of fungai.

scholarly journals Synthesis and Biological Activity of 3-Chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-one

2009 ◽  
Vol 6 (s1) ◽  
pp. S91-S96 ◽  
Author(s):  
Dinesh R. Panchasara ◽  
Subhash Pande
Keyword(s):  
Acetic Acid ◽  
Biological Activity ◽  
Schiff Base ◽  
Good Yield ◽  
Acetyl Chloride ◽  
Acid Hydrazide ◽  
Aromatic Aldehydes ◽  
Antibacterial And Antifungal Activities ◽  
Schiff Base Derivatives ◽  
Antibacterial And Antifungal

Perimidine-1-acetic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding azomethine (i.e. Schiff base) derivatives (2a-h) in good yield. Cyclocondensation of compounds (2a-h) with chloro acetyl chloride affords 3-chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-ones (3a-h). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

scholarly journals Synthesis and Characterization of 3 - Substituted Coumarin

2016 ◽  
Vol 13 (1) ◽  
pp. 89-96
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Schiff Bases ◽  
1H Nmr ◽  
Acetyl Chloride ◽  
Aromatic Aldehydes ◽  
Synthesis And Characterization ◽  
Carbonyl Chloride ◽  
Ft Ir

The reaction of(2-oxo-2H-chromen-3-Carbonyl chloride)(k1) with hydrazine in boiling ethanol gives the hydrazide(K2).When compound (k2) reacts with various aromatic aldehydes ,the corres ponding Schiff bases(k3–k4) achieve new series of thiazotidines (k5–k6) and azetidinones (k7–k8) obtained from the reactions of appropriate Schiff bases with mercapto acetic acid and chloro acetyl chloride respectively. All the compounds are characterized by FT-IR,1H-NMR and GC-Ms.

scholarly journals Environ-Economic Synthesis and Characterization of Some New 1,2,4-Triazole Derivatives as Organic Fluorescent Materials and Potent Fungicidal Agents

2013 ◽  
Vol 2013 ◽  
pp. 1-19 ◽  
Author(s):  
Harshita Sachdeva ◽  
Rekha Saroj ◽  
Sarita Khaturia ◽  
Diksha Dwivedi
Keyword(s):  
Aromatic Aldehydes ◽  
New Drugs ◽  
Fluorescence Study ◽  
One Pot ◽  
Triazole Derivatives ◽  
Fluorescent Materials ◽  
Cyclocondensation Reaction ◽  
Practical Tool ◽  
High Yields

A multicomponent one-pot clean cyclocondensation reaction of 4-chloro-2-nitro aniline/amino acids and aromatic aldehydes/indole-2,3-diones with thiosemicarbazide in water yielding triazole/spiro indole-triazole derivatives in high yields and shorter reaction time and displaying excellent florescent property is reported. The developed MCR may provide a valuable practical tool for the synthesis of new drugs containing the title core fragment. All the newly synthesized compounds have been characterized by IR, 1HNMR, 13CNMR, and fluorescence study and also been screened for antimicrobial activity.

Acetylation and Formylation of 3-Ferrocenylpyrroles

1999 ◽  
Vol 64 (1) ◽  
pp. 99-106
Author(s):  
Battsengel Gotov ◽  
Štefan Toma ◽  
Eva Solčániová
Keyword(s):  
Acetic Acid ◽  
Acetic Anhydride ◽  
Aluminum Chloride ◽  
Acetyl Chloride ◽  
Trifluoroacetic Anhydride ◽  
Acid Mixture ◽  
Chloride Method

Acetylations of 3-ferrocenyl-1-methylpyrrole as well as 3-cyano-4-ferrocenylpyrrole and 3-cyano-4-ferrocenyl-1-methylpyrrole were performed. The course of the acylation is highly dependent on the acylation agent, that is acetyl chloride/aluminum chloride (method A), trifluoroacetic anhydride-acetic acid mixture (method B) or acetic anhydride/Sc(OTf)3 (method C). Method A gives the acetylation on ferrocene moiety, method B affords the trifluoroacetylation on pyrrole moiety and method C affords pyrrole moiety acetylation. Vielsmeier-Haack formylation gives the products of substitution on pyrrole moiety.

scholarly journals Synthesis and Antimicrobial Activities of Some New Synthesized Imide and Schiff's Base Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Nermien M. Sabry ◽  
Eman M. Flefel ◽  
Mohamed A. Al-Omar ◽  
Abd El-Galil E. Amr
Keyword(s):  
Acetic Acid ◽  
Fusidic Acid ◽  
Spectroscopic Data ◽  
Glacial Acetic Acid ◽  
Aromatic Aldehydes ◽  
Antimicrobial Activities ◽  
Schiff’S Bases ◽  
Schiff’S Base ◽  
Antimicrobial Screening ◽  
Positive Controls

A series of 2,6-bis(substituted thiazolopyrimi-dinyl) pyridine(2a,b)and corresponding Schiff's bases(3a–j)were synthesized from 2,6-bis-(3-amino-2-methyl-4-oxo-9-substituted-3,4-dihydropyrido-[30,20 : 4,5]-thieno[3,2-d]pyrimidin-7-yl)pyridines(1a,b)as starting materials. The compounds1a,bwere reacted with 2,3,4,5-tetrachlorophthalic anhydride in glacial acetic acid to give the corresponding bis-imides(2a,b). But they are treated with aromatic aldehydes in refluxing ethanol to afford the Schiff’s base derivatives(3a–j). The antimicrobial screening showed that many of these newly synthesized compounds had good antimicrobial activities comparable to streptomycin and fusidic acid as positive controls. The detailed synthesis, spectroscopic data, and antimicrobial activities of the synthesized compounds were reported.

Steroid and bile acids amide conjugates with D-glucosamine

2011 ◽  
Vol 76 (1) ◽  
pp. 65-74
Author(s):  
Zdena Nováková ◽  
Jana Tomanová ◽  
Lucie Štěrbová ◽  
Pavel Drašar
Keyword(s):  
Acetic Acid ◽  
Bile Acids ◽  
Acid Chloride ◽  
Acetyl Chloride ◽  
Glucosamine Hydrochloride ◽  
Negative Results ◽  
Step Procedure ◽  
One Step ◽  
New Type

New type of amide conjugates of steroid and bile acids with D-glucosamine 1 and 2 were prepared. Title compounds are prepared via acid chloride or using N-[({[(1E)-1-cyano-2-ethoxy-2-oxoethylidene]amino}oxy)(dimethylamino)methylidene]-N-methylmethanaminium tetrafluoroborate as condensation agent. They were examined for gelation properties with negative results. Per-O-acetylated D-glucosamine hydrochloride was prepared in one step procedure from D-glucosamine hydrochloride by acetylation in a mixture of acetyl chloride and acetic acid.

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