scholarly journals Long-Term Survival in a Patient with Pulmonary Lymphangioleiomyomatosis

2002 ◽  
Vol 9 (5) ◽  
pp. 342-346 ◽  
Author(s):  
John K Reid ◽  
Henrike Rees ◽  
Donald Cockcroft
Keyword(s):  
High Resolution ◽  
Lung Function ◽  
Symptom Onset ◽  
Exercise Tolerance ◽  
Lung Biopsy ◽  
Term Survival ◽  
Pulmonary Lymphangioleiomyomatosis ◽  
Long Time ◽  
Minimal Reduction

A patient with pulmonary lymphangioleiomyomatosis was diagnosed more than 22 years after the onset of symptoms by a thoracoscopic lung biopsy, after a high resolution computerized tomogram of the chest was highly suggestive of the disease. After nearly 30 years since the onset of her symptoms, the patient leads a relatively normal life with only mildly abnormal lung function and has minimal reduction in her exercise tolerance. There have been few reports of patients surviving for such a long time after the onset of this disease; the literature suggests that most patients die within 15 years of symptom onset.

scholarly journals Analysis of the relationship between corporate identity, image and reputation of the company

Tehnika ◽  
2021 ◽  
Vol 76 (4) ◽  
pp. 499-505
Author(s):  
Milovan Vuković ◽  
Aleksandra Vuković ◽  
Ivana Mladenović-Ranisavljević ◽  
Snežana Urošević
Keyword(s):  
Corporate Reputation ◽  
Relevant Literature ◽  
Corporate Identity ◽  
Corporate Image ◽  
Economic Downturn ◽  
Competitive Advantages ◽  
Term Survival ◽  
Whole Process ◽  
Long Time

For a long time, corporate identity, corporate image and corporate reputation have been studied from a number of academic perspectives, due to their intangibility and their significant role in gaining an organization's competitive advantages. Recent business circumstances (for example, the economic downturn due to the Covid-19 pandemy) bring new challenges for companies and their long-term survival. The aim of this paper is to review the constructs of corporate identity, corporate image and corporate reputation, and, thus, to remove or reduce the misunderstanding of the three constructs in the relevant literature. After a thorough theoretical review, some influential conceptual models were examined, pointing out the role of communication in the whole process of corporate marketing.

scholarly journals Long-Term Survival of Shiga Toxin-ProducingEscherichia coli O26, O111, and O157 in Bovine Feces

1999 ◽  
Vol 65 (11) ◽  
pp. 5177-5181 ◽  
Author(s):  
Hiroshi Fukushima ◽  
Ken Hoshina ◽  
Manabu Gomyoda
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Term Survival ◽  
Long Term Survival ◽  
Low Concentration ◽  
Long Time ◽  
High Concentrations ◽  
Bovine Feces

ABSTRACT Cattle are an important reservoir of Shiga toxin-producingEscherichia coli (STEC) O26, O111, and O157. The fate of these pathogens in bovine feces at 5, 15, and 25°C was examined. The feces of a cow naturally infected with STEC O26:H11 and two STEC-free cows were studied. STEC O26, O111, and O157 were inoculated into bovine feces at 101, 103, and 105 CFU/g. All three pathogens survived at 5 and 25°C for 1 to 4 weeks and at 15°C for 1 to 8 weeks when inoculated at the low concentration. On samples inoculated with the middle and high concentrations, O26, O111, and O157 survived at 25°C for 3 to 12 weeks, at 15°C for 1 to 18 weeks, and at 5°C for 2 to 14 weeks, respectively. Therefore, these pathogens can survive in feces for a long time, especially at 15°C. The surprising long-term survival of STEC O26, O111, and O157 in bovine feces shows that such feces are a potential vehicle for transmitting not only O157 but also O26 and O111 to cattle, food, and the environment. Appropriate handling of bovine feces is emphasized.

Unrelated Donor T-Cell Depleted (TCD) Hematopoietic Stem Cell Transplantation (HSCT) for Patients with Advanced Myelodysplastic Syndromes (MDS): The MSKCC Experience

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 1996-1996
Author(s):  
Stephen S. Chung ◽  
Jenna D Goldberg ◽  
Esperanza B. Papadopoulos ◽  
Ann A. Jakubowski ◽  
Sean Devlin ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
High Resolution ◽  
Chronic Gvhd ◽  
Hla Typing ◽  
Refractory Anemia ◽  
Term Survival ◽  
Long Term Survival ◽  
Poor Risk

Abstract Abstract 1996 The outcomes of unrelated HSCT have markedly improved with the advent of high resolution HLA-typing. However, graft-versus host disease (GvHD) remains a limiting factor, particularly in mismatched transplants. Several studies have demonstrated that TCD reduces the incidence of acute and chronic GvHD, potentially allowing for improved outcomes in the mismatched setting. We have observed excellent long term survival in our early experience performing matched related TCD HSCT in patients with advanced MDS, particularly in patients who achieve a complete remission (CR) or second refractory cytopenia phase (RCy2) prior to transplant. We report here our experience performing unrelated TCD HSCT in 85 consecutive patients with advanced MDS. From 1989–2011, 85 patients with advanced MDS (IPSS Intermediate risk [IR]-1 or higher) and AML transformed from MDS underwent TCD HSCT (18 bone marrow [BM], 67 mobilized peripheral blood [PB]) from unrelated donors following conditioning with a total body irradiation-based (25 patients) or a busulfan-based (60 patients) myeloablative regimen. 49 donors were fully matched and 36 were partially matched (9/10 HLA matched: 23; 8/10 HLA matched: 8; 7/10 HLA matched: 1; and 5/6 HLA matched: 4 [before high resolution typing]). The median age was 55 (range 4–73). Prior to conditioning, 80 patients received chemotherapy (28 with a hypomethylating agent, 65 with intensive chemotherapy, and nine with both) and five patients did not receive chemotherapy. Prior to transplant, 34 of the 80 patients who received chemotherapy were in CR, 30 were in RCy2, and 15 failed to achieve remission (10 with RAEB, 5 with AML). Of the five patients who did not receive chemotherapy, two had refractory anemia and three had RAEB. The BM grafts were depleted of T-cells using the soybean agglutinin method followed by sheep RBC rosetting, and the G-CSF mobilized PB stem cell grafts were depleted of T-cells using immunomagnetic CD34+ selection (Isolex initially and CliniMACS after 09/2011). Rejection prophylaxis with ATG was used in all patients. No post-transplant pharmacologic prophylaxis for GvHD was given. 82 of 85 patients engrafted (92%). Three died before engraftment (3.5%, all <28 d after transplant) and two developed late graft failure (2.4%). The day-100 cumulative incidence (CI) of grade II-IV aGVHD was 19% (95% confidence interval [95%CI] 11%-28%), and the 1-year CI of aGvHD, including the late onset form, was 28% (95%CI 18%-38%). When only including grade III-IV aGVHD, the day-100 CI was 9.4% (95%CI 4.3%-17%) and the 1-year CI was 16% (95%CI 9.4%-25%). The 2-year CI of cGVHD was only 3.5% (95%CI 0.9%-9.1%). The overall survival (OS) was 53% (95%CI 43%-63%) at two years and 44% (95%CI 35%-75%) at five years. The relapse free survival (RFS) was 46% (95%CI 36%-57%) at two years and 41% (95%CI 31%-52%) at five years. There was no significant difference in OS/RFS among patients transplanted with fully HLA-matched, 9/10 HLA-matched, or 7–8/10 HLA-matched grafts. There was a trend towards worse OS in patients who had a poor risk (HR) IPSS score at any time prior to transplant; the 2-year OS in this group was 43% (95%CI 32%-60%) versus 64% (95%CI 49%-82%) in the IR-1/IR-2 IPSS groups (p=0.08). Likewise, there was a trend towards worse OS in patients who failed to achieve CR or RCy2 prior to transplant (2-year OS 32% [95%CI 16%-64%]), as compared with patients who achieved CR or RCy2 (2-year OS 58% [95%CI 48%-71%], p=0.25). The overall 1-year CI of relapse was low at 13% (95%CI 7%-21%). The 1-year CI of relapse was significantly higher in patients with IPSS poor risk cytogenetics (27%, 95%CI 5.2%-55%) as compared with intermediate (18%, 95%CI 0.1%-65%) and good (8.4%, 95%CI 0.04%-45%) risk cytogenetics (p=0.03). The 1-year NRM was 36% (95%CI 23%-49%) in those with HR disease and only 18% (95%CI 7%-33%) in those with IR-1/IR-2 risk disease. 5-year OS was superior in transplants done from 2000–2011 (48%, 95%CI 36%-59%) compared with 1989–1999 (25%, 95%CI 6%-50%, p=0.01), reflecting the availability of high resolution HLA-typing and improvements in supportive care. These results indicate that patients with advanced MDS can achieve durable remissions and long term survival after unrelated TCD HSCT with low rates of acute and chronic GVHD even with mismatched donors. Selecting patients for HSCT before progression to IPSS HR disease and induction into CR or RCy2 prior to transplant may maximize the efficacy of this approach. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Salvatore Parisi ◽  
Pietro Corsa ◽  
Arcangela Raguso ◽  
Antonio Perrone ◽  
Sabrina Cossa ◽  
...  
Keyword(s):  
Combined Treatment ◽  
Haematological Toxicity ◽  
High Grade ◽  
Term Survival ◽  
Long Time ◽  
Radiotherapy Alone ◽  
High Grade Gliomas ◽  
Time Basis ◽  
Grade 3

Temozolomide (TMZ) is the first line drug in the care of high grade gliomas. The combined treatment of TMZ plus radiotherapy is more effective in the care of brain gliomas then radiotherapy alone. Aim of this report is a survival comparison, on a long time (>10 years) span, of glioma patients treated with radiotherapy alone and with radiotherapy + TMZ.Materials and Methods. In this report we retrospectively reviewed the outcome of 128 consecutive pts with diagnosis of high grade gliomas referred to our institutions from April 1994 to November 2001. The first 64 pts were treated with RT alone and the other 64 with a combination of RT and adjuvant or concomitant TMZ.Results. Grade 3 (G3) haematological toxicity was recorded in 6 (9%) of 64 pts treated with RT and TMZ. No G4 haematological toxicity was observed. Age, histology, and administration of TMZ were statistically significant prognostic factors associated with 2 years overall survival (OS). PFS was for GBM 9 months, for AA 11.Conclusions. The combination of RT and TMZ improves long term survival in glioma patients. Our results confirm the superiority of the combination on a long time basis.

scholarly journals Feeding behaviour and pugmark analysis of elephants in Sarguja, Chhattisgarh

2016 ◽  
Vol 8 (4) ◽  
pp. 2060-2065 ◽  
Author(s):  
A. K. Thakur ◽  
D. K. Yadav ◽  
M. K. Jhariya
Keyword(s):  
Cynodon Dactylon ◽  
Crop Raiding ◽  
Aegle Marmelos ◽  
Forest Department ◽  
Term Survival ◽  
Dendrocalamus Strictus ◽  
Long Time ◽  
Four Blocks ◽  
Palatable Species

The pugmark analysis of the elephants offers basic information to track the wild elephant migratory route, identification and census. For its study, four blocks viz, Sitapur, Lundra, Batouli (Sarguja district) and Farsabahar (Jashpur district) of northern Chhattisgarh were selected because these blocks are commonly visited by elephants and a major path route of movement of heard in inter/intra state. The most commonly consumed species belongs to family poaceae (22.58%) followed by fabaceae (19.35%) but their diet was mainly dependent on availability of seasonal food round the year and on their migration. Elephants extensively fed on Artocarpus heterophyllus, Syzygium cumini, Acacia nilotica, A. catechu, Dalbergia sissoo, Zizyphus mauritiana, Aegle marmelos and Ficus species, besides these elephants also utilized various grasses and shrubs as their food, which mainly included Dendrocalamus strictus, Cynodon dactylon etc. Elephants sometimes spent long time to feed on some particular plant species like D. strictus and Ficus species. Crop raiding, which was sporadic during the rainy season, gradually increased with more area being cultivated with the onset of monsoon. Analysis of pugmark revealed that the circumference varied from 63.80 cm to 172.70 cm whereas length x width varied from 22x20 cm to 60x55 cm, which reflects a substantial variation/differentiation of individual in heard in respect of their age, sex, size etcTherefore, management implications are needed to conserve the corridors for their long term survival and reduction of HEC. The study will be helpful to provide key information and facilitate better understating of the scenario to the forest department, policy maker and conservationist to plan, manage and improve the habitat towards the restoration and afforestation of suitable palatable species preferred by elephants of northern corridors of Chhattisgarh.

Factors Associated To Long-Term Survival In Patients With Low Lung Function Undergoing Presumably Curative Surgery

2011 ◽  
Author(s):  
Luis Puente-Maestu ◽  
Javier de Miguel ◽  
Mª Carmen Juarez ◽  
Elena Ojeda ◽  
Yolanda Martinez ◽  
...  
Keyword(s):  
Lung Function ◽  
Curative Surgery ◽  
Term Survival ◽  
Long Term Survival ◽  
Factors Associated

The development and overwintering survival of free-living larvae of Haemonchus contortus in Sweden

2005 ◽  
Vol 79 (4) ◽  
pp. 373-379 ◽  
Author(s):  
K. Troell ◽  
P. Waller ◽  
J. Höglund
Keyword(s):  
Haemonchus Contortus ◽  
Practical Significance ◽  
Southern Sweden ◽  
Free Living ◽  
Term Survival ◽  
Commercial Flock ◽  
Long Time ◽  
Overwintering Survival ◽  
Eggs And Larvae

AbstractFive complimentary studies were undertaken with the overall aim to examine the ability of free-living stages of Haemonchus contortus to over-winter and tolerate cold stress. Two studies deal with the development and long-term survival of eggs and infective larvae of two geographically different isolates (Kenya and Sweden). Eggs and larvae were monitored in climatic chambers at temperatures that fluctuated daily between −1°C and 15°C, or at constant temperatures of 5°C and 15°C. The development from egg to larvae was dependent on temperatures over 5°C. The long time survival was favoured at lower temperatures. Furthermore, the overwintering capacity of the free-living stages of these isolates was estimated under Swedish field conditions. Two groups of lambs were experimentally infected with different isolates, and kept separated on previously ungrazed plots. In early May the following year, two parasite-naive tracer lambs were turned out on each of the plots to estimate the pick up of overwintered larvae. This experiment was replicated in central and southern Sweden. In addition, two experiments were performed in 2003 on pasture previously grazed by naturally infected sheep. One trial was on a pasture in southern Sweden grazed by a commercial flock, where extreme numbers of H. contortus were found towards the end of the grazing season 2002. The other study was on a pasture plot in central Sweden grazed by a hobby flock in 2002, where three of six lambs died due to haemonchiasis. Overwintered H. contortus was recorded on three of four experimental sites. Worm burdens were in all instances extremely low. No differences in development and survival were found between the isolates. Consequently, overwintering on pasture is of no practical significance in the transmission of H. contortus between grazing-seasons in Sweden.

scholarly journals Idiopathic pleuroparenchymal fibroelastosis confirmed by pathology: a case report

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052199221
Author(s):  
Min Cao ◽  
Hui Li ◽  
Hou-Rong Cai
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
High Resolution ◽  
Lung Function ◽  
Lung Biopsy ◽  
High Resolution Computed Tomography ◽  
Pleuroparenchymal Fibroelastosis ◽  
Pleural Thickening ◽  
New Type ◽  
The Right

The case of a patient with cough and asthma after activity that each had a 1-month duration is reported. Chest high-resolution computed tomography (HRCT) showed visceral pleural thickening in both upper lungs (especially the right lung), which was accompanied by fibrous strips and patches near the pleura, and these were accompanied by distraction bronchiectasis. Idiopathic pleuropulmonary elastosis was confirmed by thoracoscopic lung biopsy. The patient was treated with acetylcysteine, but their asthma worsened after activity and their lung function decreased significantly after 10 months. Idiopathic pleuroparenehymal fibroelastosis is a rare new type of idiopathic interstitial pneumonia, which has no effective treatment except for lung transplantation.

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