scholarly journals Osteonecrosis in a Patient with Crohn's Disease Unrelated to Corticosteroid Use

2001 ◽  
Vol 15 (11) ◽  
pp. 765-768 ◽  
Author(s):  
Ali Khan ◽  
Gerald Illiffe ◽  
Donald S Houston ◽  
Charles N Bernstein
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Present Report ◽  
Vascular Thrombosis ◽  
Inflammatory Disorders ◽  
Direct Association

Osteonecrosis is a feared complication of corticosteroid use. However, a direct association between corticosteroid use and osteonecrosis has never been proven. The present report examines the case of a patient with longstanding Crohn's disease who had never been treated with corticosteroids and who developed osteonecrosis of the talus. The association of systemic inflammatory disorders with osteonecrosis and the possible association with vascular thrombosis are discussed.

scholarly journals Anticipation in an Indo-Canadian Family with Crohn's Disease

2001 ◽  
Vol 15 (10) ◽  
pp. 695-698 ◽  
Author(s):  
Hugh J Freeman ◽  
Noel B Hershfield
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Neurological Disorders ◽  
Molecular Basis ◽  
Present Report ◽  
Phenotypic Expression ◽  
Apparent Increase ◽  
The Family ◽  
Perianal Sepsis ◽  
Common Environmental Factor

Genetic anticipation, associated elsewhere with monogenic neurological disorders, has been hypothesized to be present in familial forms of Crohn's disease. Usually, with studies of parent-child pairs, the parent who is initially diagnosed is older at the onset of disease than the child. With each successive generation, an apparent increase in disease severity or behaviour occurs. This phenomenon is believed to have a molecular basis. In the present report, an Indo-Canadian family with Crohn's disease is described. In all members of the family, disease was diagnosed only after prolonged residence in Canada, supporting the view that Crohn's disease arises in individuals with a genetic predisposition following exposure to some, as yet unknown, common environmental factor. Three siblings with Crohn's disease, first diagnosed between ages 15 and 27 years, or six to 11 years after arrival in Canada, had phenotypically concordant disease localized in the ileum and colon, with fistulizing complications, including perianal sepsis. Crohn's disease was only diagnosed in the father at the age of 76 years, almost three decades after his arrival in Canada. His disease was localized to the ileum and had a fibrostenosing behaviour. This is the first reported instance of familial Crohn's disease in an immigrant population, illustrating potential biases in genetically based studies of Crohn's disease that rely solely on phenotypic expression.

scholarly journals Crohn's Disease Defined in Three Elderly Disters

2005 ◽  
Vol 19 (4) ◽  
pp. 251-252
Author(s):  
Hugh J Freeman
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Environmental Factor ◽  
Present Report ◽  
Granulomatous Inflammation ◽  
Disease Clustering ◽  
Endoscopic Biopsies ◽  
Unusual Occurrence ◽  
Shared Environmental Factor

Three elderly sisters presented with symptomatic Crohn's disease. All had ileocolic involvement, and granulomatous inflammation was documented in endoscopic biopsies or surgically resected intestinal specimens. The present report documents the unusual occurrence of very late phenotypical expression of familial ileocolic Crohn's disease. The observations presented here reflect a possible gene-based predisposition to Crohn's disease or, alternatively, disease clustering related to a commonly shared environmental factor.

scholarly journals Crohn’s Disease and Cheilitis

2003 ◽  
Vol 17 (7) ◽  
pp. 445-447 ◽  
Author(s):  
Abdulrahman A Al-Hussaini ◽  
Helen M Machida ◽  
J Decker Butzner
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Cell ◽  
Present Report ◽  
Inflammatory Cell Infiltrate ◽  
Chronic Inflammatory Cell ◽  
Colonoscopic Examination ◽  
One Year ◽  
Fissure Formation ◽  
Colonic Biopsies

A five-year-old boy presented to his family physician with painless swelling of both lips. One year later he developed abdominal pain, nonbloody diarrhea, weight loss and joint pains. Colonoscopic examination demonstrated patchy erythema, friability and multiple aph-thous ulcers consistent with the appearance of Crohn’s colitis, and treatment with prednisone was initiated. Colonic biopsies displayed a chronic inflammatory cell infiltrate, focal cryptitis and fissure formation. The patient’s lip swelling relapsed on multiple occasions when steroids were tapered, despite minimal intestinal symptoms of Crohn’s disease. The objective of the present report is to alert physicians to this unusual presentation of Crohn’s disease and that cheilitis may run a protracted course.

scholarly journals Dicrocoelium DendriticumInfection in a Patient with Crohn’s Disease

2008 ◽  
Vol 22 (6) ◽  
pp. 571-573 ◽  
Author(s):  
Franzjosef Schweiger ◽  
Magdalena Kuhn
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Medical Literature ◽  
Present Report ◽  
Land Snail ◽  
Human Infection ◽  
Complex Life Cycle ◽  
Intermediate Hosts ◽  
Animal Liver ◽  
Second Intermediate Host

Infection withDicrocoelium dendriticumin humans is rarely reported in the medical literature. This liver fluke, which commonly infects ruminants, has a complex life cycle with two intermediate hosts – the land snail and the ant. True human infection occurs by ingestion of the second intermediate host, but spurious infections have occurred after consumption of undercooked animal liver. The present report describes a patient with active Crohn’s disease whose stool containedD dendriticumeggs. A brief discussion of the medical literature is presented.

scholarly journals Laparoscopic versus Open Bowel Resection for Crohn's Disease

2001 ◽  
Vol 15 (4) ◽  
pp. 237-242 ◽  
Author(s):  
Jeanine Tabet ◽  
Dennis Hong ◽  
Cei-Whan Kim ◽  
Jason Wong ◽  
Robert Goodacre ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Laparoscopic Resection ◽  
Bowel Resection ◽  
Present Report ◽  
Laparoscopic Group ◽  
Elective Resection ◽  
Disease Free Interval ◽  
Free Interval ◽  
Disease Free

BACKGROUND: Laparoscopic bowel resection is an alternative to open surgery for patients with Crohn's disease requiring surgical resection. The present report describes a seven-year experience with the laparoscopic treatment of Crohn's disease compared with the open technique in a tertiary Canadian centre.PATIENTS AND METHODS: A retrospective analysis of 61 consecutive patients undergoing elective resection for Crohn's disease was carried out between October 1992 and June 1999. This analysis included 32 laparoscopic resections (mean age 33 years) and 29 open resections (mean age 42 years). Patient demographics were compared, as well as short and long term outcomes after surgery (mean follow-up 39 months).RESULTS: Patients in the laparoscopic group were younger and had fewer previous bowel surgeries than patients who had open resections. Indications for surgery and operative times were similar between the groups. Patients who underwent laparoscopic resections required fewer doses of narcotic analgesics. The resumption of bowel function after surgery, and tolerance of a clear liquid and solid diet was quicker in the laparoscopic group. Patients who underwent laparoscopic resections had significantly shorter hospital stays than those who underwent open resections. Fifteen patients (48.4%) in the laparoscopic group experienced recurrence of disease compared with 13 patients (44.8%) in the open group. In both groups, the most common site of recurrence was at the anastomosis. The disease-free interval was the same length for both groups (23.9±17.3 months for the laparoscopic resection patients compared with 23.9±20.2 months for the open resection patients; P=1.00).CONCLUSIONS: Laparoscopic resection for Crohn's disease can be performed safely and effectively. Quicker resumption of oral feeds, less postoperative pain and earlier discharge from hospital are advantages of the laparoscopic method. No differences in the recurrence rate or the disease-free interval were noted.

scholarly journals Perioperative Use of Vedolizumab in Crohn’s Disease Patients and Surgical Outcomes

2021 ◽  
pp. 144-154
Author(s):  
Mohammed Alfawaz
Keyword(s):  
Risk Factors ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Postoperative Complication ◽  
Surgical Outcomes ◽  
Surgical Intervention ◽  
Considerable Proportion ◽  
Complication Rates ◽  
Postoperative Results ◽  
Direct Association

Despite advancement in managing Crohn’s disease (CD), a considerable proportion of cases still need surgical intervention, which is an essential means in therapy algorithms. Other drugs of the biologics are recently available, while most CD cases having operations have previously received a drug of this class. This class of agents has a direct association with higher postoperative complication rates, which raises a lot of controversies. In this review summarize the essential data concerning the vedolizumab effect on CD’s postoperative results. The previous data did not demonstrate a cause-effect absolute connection between the increased postoperative morbidities and vedolizumab. Many routing factors unquestionably affect CD’s postoperative outcomes and complications, like malnutrition, unsuitable abdominal settings, and steroids’ previous use. Using vedolizumab perioperatively seems safe. Nevertheless, a definitive relationship from the available data is controversial. Personalized, multidisciplinary evaluations and decisions should be made for each case independently, adjusting the surgical plan regarding the involved risk factors.

On-table endoscopy to define strictures and resection margins: experience from 178 operations for Crohn's disease using intraoperative endoscopy

2001 ◽  
Vol 3 (Supplement 2) ◽  
pp. 58-62
Author(s):  
G. Olaison ◽  
P. Andersson ◽  
P. Myrelid ◽  
K. Smedh ◽  
J. Soderholm ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Resection Margins ◽  
Intraoperative Endoscopy
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