scholarly journals Spontaneous Peritonitis from Perforation of the Colon in Collagenous Colitis

2001 ◽  
Vol 15 (4) ◽  
pp. 265-267 ◽  
Author(s):  
HJ Freeman ◽  
D James ◽  
CJ Mahoney
Keyword(s):  
Inflammatory Bowel Disease ◽  
Sigmoid Colon ◽  
Bowel Disease ◽  
Clinical Course ◽  
Collagenous Colitis ◽  
Watery Diarrhea ◽  
Colon Perforation ◽  
Life Threatening ◽  
Inflammatory Bowel ◽  
Sigmoid Colon Perforation

A 37-year-old woman presented with an acute abdomen following the onset of watery diarrhea. Spontaneous peritonitis was detected, along with evidence of a focal sigmoid colon perforation. Subsequent postoperative colonoscopic studies revealed collagenous colitis with a focal, deep, nongranulomatous ulcer in the sigmoid colon. Although the literature suggests that collagenous colitis tends to have a relatively 'benign' clinical course characterized by chronic or episodic watery diarrhea. Potentially serious and life- threatening complications may occur in this microscopic form of inflammatory bowel disease.

scholarly journals Synchronous Occurrence of Collagenous and Pseudomembranous Colitis

2000 ◽  
Vol 14 (4) ◽  
pp. 353-358 ◽  
Author(s):  
Z Vesoulis ◽  
G Lozanski ◽  
T Loiudice
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Pseudomembranous Colitis ◽  
Collagenous Colitis ◽  
Watery Diarrhea ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Unique Association ◽  
Idiopathic Inflammatory Bowel Disease

Synchronous collagenous and pseudomembranous colitis has not been previously reported. A 73-year-old woman presented with chronic watery diarrhea and abdominal cramping of six weeks’ duration. Biopsies of the colon revealed findings of collagenous colitis involving the endoscopically normal right colon, and superimposed collagenous and pseudomembranous colitis involving the rectosigmoid colon. Endoscopically, the left colon revealed discrete ulcerative plaques, andClostridium difficiletoxin A assay was positive. The patient partially responded to a three-week regimen of metronidazole, and symptoms resolved completely with subsequent steroid therapy. At follow-up endoscopy four months later, colon biopsies demonstrated persistence of subepithelial collagen but no pseudomembranes. The patient remained asymptomatic during this interval. Collagenous colitis has been reported in association with other inflammatory bowel diseases, including lymphocytic colitis, sprue and idiopathic inflammatory bowel disease. This unique association of collagenous colitis with an endotoxigenic inflammatory bowel disease is presented with a review of related disease features.

scholarly journals Mo1343 Inflammatory Bowel Disease Unclassified in Real Practice: Prevalence, Clinical Course and Therapy Requirements

2013 ◽  
Vol 144 (5) ◽  
pp. S-642
Author(s):  
Fernando Bermejo ◽  
Alicia Algaba ◽  
José Luis Cuño ◽  
Belén Botella ◽  
Carlos Taxonera ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Clinical Course ◽  
Inflammatory Bowel ◽  
Real Practice

scholarly journals Influence of a Positive Family History on the Clinical Course of Inflammatory Bowel Disease

2016 ◽  
Vol 10 (9) ◽  
pp. 1024-1032 ◽  
Author(s):  
Sung Wook Hwang ◽  
Min Seob Kwak ◽  
Wan Soo Kim ◽  
Jeong-Mi Lee ◽  
Sang Hyoung Park ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Family History ◽  
Bowel Disease ◽  
Clinical Course ◽  
Positive Family History ◽  
Inflammatory Bowel

Expanding Contributions of Monogenic Very Early Onset Inflammatory Bowel Disease

2021 ◽  
Author(s):  
Jodie Ouahed
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Early Onset ◽  
Current Issue ◽  
Epithelial Barrier ◽  
Mevalonate Kinase Deficiency ◽  
Bowel Diseases ◽  
Life Threatening ◽  
Mucosal Homeostasis ◽  
Inflammatory Bowel

Abstract Currently over 70 genes known to be causative in very early onset inflammatory bowel disease (VEOIBD) have been identified. In the current issue of Inflammatory Bowel Diseases, 2 articles describing monogenetic forms of VEOIBD are highlighted. One describes a patient with life-threatening VEOIBD and a mutation in ITGA6, illustrating the importance of the epithelial barrier in maintaining mucosal homeostasis. The other describes the presentation and management of 10 patients with VEOIBD secondary to damaging mutations in MVK, resulting in mevalonate kinase deficiency. Though most monogenic causes of VEOIBD remain “private,” understanding the different categories of pathways affected in children with VEOIBD is critical and has already resulted in invaluable insight in the management of patients with VEOIBD and may hold strong implications for the care of IBD overall.

scholarly journals Epidemiology and clinical course of inflammatory bowel disease in the Central Province of Sri Lanka: A hospital-based study

JGH Open ◽  
2018 ◽  
Vol 2 (4) ◽  
pp. 129-133 ◽  
Author(s):  
Udaya Kalubowila ◽  
Tharanga Liyanaarachchi ◽  
K B Galketiya ◽  
Palitha Rathnayaka ◽  
I N A P Piyasena ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Sri Lanka ◽  
Bowel Disease ◽  
Clinical Course ◽  
Central Province ◽  
Inflammatory Bowel

scholarly journals Clinical Course and Dietary Patterns Among Patients Incorporating the Autoimmune Protocol for Management of Inflammatory Bowel Disease (P12-010-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Joy Lee ◽  
Christian Pedretti ◽  
Gauree Konijeti
Keyword(s):  
Inflammatory Bowel Disease ◽  
Support Groups ◽  
Dietary Patterns ◽  
Bowel Disease ◽  
Online Survey ◽  
Clinical Course ◽  
Immunosuppressive Agents ◽  
Food Group ◽  
Dietary Interventions ◽  
Inflammatory Bowel

Abstract Objectives The aim was to examine the clinical course and dietary patterns among patients incorporating autoimmune protocol (AIP) for management of inflammatory bowel disease (IBD). Methods An anonymous online survey was sent through electronic newsletters and support groups utilizing AIP. The survey assessed demographics, IBD disease activity, and medication use. Participants were asked about AIP utilization and food group reintroductions. Abdominal pain (AP), stool frequency (SF), and rectal bleeding (RB) were compared at baseline (BL, prior to starting AIP), week 6 (after starting AIP), and present, for both Crohn's disease (CD) and ulcerative colitis (UC). Results There were 78 respondents. Mean age was 39.4 years, with mean IBD duration 13.2 years. 78% had prior steroid exposure. 35% currently on immunosuppressive agents. 73% perceived achieving clinical remission due to AIP. This was more common among patients not on immunosuppression (76% vs. 24% on immunosuppression, P < 0.001). After starting AIP, 32% reported discontinuing steroids. AIP was initiated according to protocol by 73%, while 27% modified it. Food group reintroductions were started within 0–4 weeks of starting AIP among 8%, while 23% reintroduced within 5–8 weeks, 24% within 2–6 months, 23% within 6–12 months, and 13% after 12 months. Success of food group reintroductions varied (Table 1). Among patients with CD, improvement by ≥1 levels of symptoms by week 6 was reported by 77% for AP, 57% for SF, and 57% for RB. Compared to BL, reported symptoms improved by ≥1 levels in 70% for AP, 53% for SF, and 57% for RB. In contrast, disease worsening by ≥1 levels at week 6 was reported by 7% for AP and none for SF and RB. Among patients with UC, improvement by ≥1 levels by week 6 was reported by 72% for AP, 79% for SF, and 65% for RB. Compared to BL, reported symptoms improved by ≥1 levels in 65% for AP, 67% for SF, and 58% for RB. In contrast, disease worsening by ≥1 levels at week 6 was reported by 2% for AP, 2% for SF, and 5% for RB. Conclusions Patients utilizing AIP for management of IBD report clinical benefit of AIP, reduction of steroid use, and successful food group reintroduction. Dietary interventions could be another form of treatment in patients with IBD to improve symptoms and maintain remission. Funding Sources Not applicable. Supporting Tables, Images and/or Graphs

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