scholarly journals Adenoma of the Papillae of Vater. Report of Eleven Cases

HPB Surgery ◽  
2000 ◽  
Vol 11 (5) ◽  
pp. 339-344 ◽  
Author(s):  
Heikki Kiviniemi ◽  
Jyrki Mäkelä ◽  
Jukka Palm ◽  
Arto Saarela
Keyword(s):  
Histological Examination ◽  
Preoperative Diagnosis ◽  
University Hospital ◽  
Operative Risk ◽  
Resection Margins ◽  
Low Grade ◽  
Endoscopic Biopsies ◽  
High Operative Risk ◽  
Low Grade Dysplasia ◽  
Transduodenal Excision

Eleven patients with a preoperative diagnosis of adenoma of the papillae of Vater were followed up during the fifteen-year period from 1984 till 1998 in the Oulu University Hospital. Seven patients were treated primarily by transduodenal excision without any recurrences so far. One of these seven patients was found to have adenocarcinoma in a histological examination.Active surgery for adenoma of the papillae of Vater is recommended because of the precancerous nature of the lesion, and because malignancy cannot always be detected by endoscopic biopsies. Transduodenal excision could be recommend for patients at high operative risk, especially in cases with small adenomas and low-grade dysplasia, where histologically free resection margins can be achieved, but pancreaticoduodenectomy should still be performed on patients at low operative risk.

scholarly journals Well-differentiated adenocarcinoma associated with ulcerative colitis

2017 ◽  
Vol 5 ◽  
pp. 2050313X1769290 ◽  
Author(s):  
Tomoko Yamamoto ◽  
Atsuko Hiroi ◽  
Hiroko Itagaki ◽  
Yoichiro Kato ◽  
Bunei Iizuka ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Tumor Cells ◽  
Preoperative Diagnosis ◽  
Aurora B ◽  
Low Grade ◽  
Biopsy Specimens ◽  
Tnf Α ◽  
Low Grade Dysplasia ◽  
Well Differentiated ◽  
A Disintegrin And Metalloproteinase

Objectives: Adenocarcinoma is known to be associated with ulcerative colitis, but the diagnosis is sometimes challenging, both clinically and pathologically. Methods and Results: We present a case of extremely well-differentiated adenocarcinoma associated with ulcerative colitis, in which preoperative diagnosis was not possible. Glands in biopsy specimens showed a serrated appearance that looked like low-grade dysplasia or regenerative mucosa. After an operation due to severe symptoms of stenosis, carcinoma was diagnosed. Tumor cells, especially in invasive glands, tended to show stronger immunoreactivity against anti-CK7, TNF-α and Aurora B antibodies compared to cells of mucosal lesion. Interestingly, CD44v6, one of the adhesion molecules, was less expressed in invasive glands, while those glands exhibited stronger expression of a disintegrin and metalloproteinase 17 (ADAM 17), one of the sheddases that cleaves an extracellular domain of CD44. Conclusions: These observations appear interesting to consider the pathogenesis and to diagnose extremely well-differentiated adenocarcinoma in ulcerative colitis, although further investigation is needed.

scholarly journals Diagnosis of Barrett’s esophagus in University Hospital Centre Zagreb between 2012 and 2017

2019 ◽  
Author(s):  
Luka Franolic ◽  
Pave Markos ◽  
Nadan Rustemovic
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Early Cancer ◽  
Demographic Data ◽  
High Grade Dysplasia ◽  
University Hospital ◽  
Low Grade ◽  
High Grade ◽  
Tertiary Referral Centre ◽  
Low Grade Dysplasia

Abstract AIM To evaluate epidemiology and demographic data of patients diagnosed with Barrett’s esophagus in University Hospital Centre Zagreb between January 2012 and December 2017. MATERIALS AND METHODS In a 6 year period, upper GI endoscopy was performed in 19950 patients. We have analysed endoscopy and hospital database regarding pathohistological confirmation and demographic data of patients diagnosed with Barrett’s esophagus . RESULTS Endoscopy suspicion of esophageal metaplasia (ESEM) was made in 592 patients. Pathohistological confirmation of Barrett’s esophagus was established in 163 patients (0.8%). Intestinal metaplasia without dysplasia was diagnosed in 137 patients, low grade dysplasia in 20 patients, high grade dysplasia in three and early cancer in three patients. In the group of 163 patients with confirmed Barrett’s esophagus 116 (71%) were male and 47 (29%) were female with median age of 58 years. Hiatal hernia was observed during endoscopy in 92 patients (56%). Patients with high grade dysplasia and early cancer have been treated with bandEMR and then radio frequency ablation (RFA), and all the patients with confirmed low grade dysplasia have been treated with RFA. CONCLUSION Barrett’s esophagus still has a low incidence in Croatia, even in a high volume tertiary referral Centre.

Is the diagnosis of low-grade dysplasia in ulcerative colitis consistent?

2001 ◽  
Vol 120 (5) ◽  
pp. A733-A733
Author(s):  
C LIM ◽  
A AXON ◽  
A VAIL ◽  
D FORMAN ◽  
M DIXON
Keyword(s):  
Ulcerative Colitis ◽  
Low Grade ◽  
Low Grade Dysplasia

ENDOSCOPIC RESECTION OF LOW GRADE DYSPLASIA IN BARRETT’S OESOPHAGUS: A RETROSPECTIVE STUDY ABOUT 61 PATIENTS

2020 ◽  
Author(s):  
Fabrice Caillol ◽  
Arthur Falque ◽  
Margherita Pizzicannella ◽  
Christian Pesenti ◽  
Jean Philippe Ratone ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Endoscopic Resection ◽  
Barrett’S Oesophagus ◽  
Low Grade ◽  
Barrett's Oesophagus ◽  
Low Grade Dysplasia

Clinical case of breast tumor relapse in domestic cat

2020 ◽  
pp. 29-32
Author(s):  
Viktor V. Grechko ◽  
◽  
Lyudmila F. Bodrova ◽  
Dmitriy K. Ovchinnikov ◽  
Keyword(s):  
Histological Examination ◽  
Breast Tumor ◽  
Abdominal Ultrasound ◽  
Liver Parenchyma ◽  
Mammary Glands ◽  
Blood Analysis ◽  
Domestic Cat ◽  
Biological Behavior ◽  
Breast Adenocarcinoma ◽  
Low Grade

Domestic shorthair 10-year-old cat, not sterilized, not vaccinated, feeding from the table. We went to the clinic with breast cancer. General and special research methods were performed: blood analysis, x-ray examination of the lungs and abdominal ultrasound. Based on anamnesis and clinical examination, the diagnosis was made: a malignant breast tumor. The operation was performed. The operating material is sent for histological examination. Chemotherapy was prescribed. After the fi rst chemotherapy and monitoring of the animal's condition, it was necessary to perform a second unilateral mastoectomy of the remaining mammary glands, but the animal's owners refused to perform the operation. Chemotherapy was performed twice. Re-applied, after a year and a half with a sharp deterioration in the General condition and the appearance of a new tumor on the non-removed mammary glands. The owners refused the necessary treatment and decided to euthanize the cat. At the autopsy, breast neoplasms are presented as tubercles of various sizes. There are pronounced signs of inflammation, ulceration and necrosis foci. In the chest cavity, the lungs are enlarged, there were single and multiple formations of white and brown color, round shape of different diameters, dense consistency. There is a large number of metastases in the liver parenchyma. The organ is enlarged in size, dark brown in color, irregularly colored, with an uneven (bumpy) surface. In General, there are many dense nodes of a round-oval shape of white color, of various diameters. Histological examination of the tumor revealed foci of necrosis, atypical glandular complexes with frequently occurring mitosis figures. This structure indicates a low-grade breast adenocarcinoma. In the lungs, there is an expansion of the alveoli and bronchioles, thinning and rupture of the interalveolar partitions. There is a complex of tumor cells. In the liver, there is a lack of structural units of the liver, hepatocytes disperse chaotically, liver triads do not have a clear localization, atrophy and necrosis are expressed. Metastases in the liver, various forms. In a cat, a breast tumor interpreted as an adenocarcinoma had different biological behavior. At the initial diagnosis-adenocarcinoma of medium differentiation, and a year and a half later-low-grade adenocarcinoma.

scholarly journals Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer

2021 ◽  
Vol 22 (16) ◽  
pp. 8479
Author(s):  
Tilman L. R. Vogelsang ◽  
Aurelia Vattai ◽  
Elisa Schmoeckel ◽  
Till Kaltofen ◽  
Anca Chelariu-Raicu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Epithelial Ovarian Cancer ◽  
Tnm Classification ◽  
Rank Correlation ◽  
University Hospital ◽  
Cancer Tissue ◽  
Low Grade ◽  
High Grade ◽  
Trace Amine

Trace amine-associated receptor 1 (TAAR1) is a Gαs- protein coupled receptor that plays an important role in the regulation of the immune system and neurotransmission in the CNS. In ovarian cancer cell lines, stimulation of TAAR1 via 3-iodothyronamine (T1AM) reduces cell viability and induces cell death and DNA damage. Aim of this study was to evaluate the prognostic value of TAAR1 on overall survival of ovarian carcinoma patients and the correlation of TAAR1 expression with clinical parameters. Ovarian cancer tissue of n = 156 patients who were diagnosed with epithelial ovarian cancer (serous, n = 110 (high-grade, n = 80; low-grade, n = 24; unknown, n = 6); clear cell, n = 12; endometrioid, n = 21; mucinous, n = 13), and who underwent surgery at the Department of Obstetrics and Gynecology, University Hospital of the Ludwig-Maximilians University Munich, Germany between 1990 and 2002, were analyzed. The tissue was stained immunohistochemically with anti-TAAR1 and evaluated with the semiquantitative immunoreactive score (IRS). TAAR1 expression was correlated with grading, FIGO and TNM-classification, and analyzed via the Spearman’s rank correlation coefficient. Further statistical analysis was obtained using nonparametric Kruskal-Wallis rank-sum test and Mann-Whitney-U-test. This study shows that high TAAR1 expression is a positive prognosticator for overall survival in ovarian cancer patients and is significantly enhanced in low-grade serous carcinomas compared to high-grade serous carcinomas. The influence of TAAR1 as a positive prognosticator on overall survival indicates a potential prognostic relevance of signal transduction of thyroid hormone derivatives in epithelial ovarian cancer. Further studies are required to evaluate TAAR1 and its role in the development of ovarian cancer.

scholarly journals A urine-based DNA methylation assay to facilitate early detection and risk stratification of bladder cancer

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Weimei Ruan ◽  
Xu Chen ◽  
Ming Huang ◽  
Hong Wang ◽  
Jiaxin Chen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Bladder Cancer ◽  
Risk Stratification ◽  
Early Stage ◽  
Operative Risk ◽  
Low Grade ◽  
Single Center ◽  
Detection Model ◽  
Methylation Assay ◽  
Muscle Invasive

Abstract Background Current non-invasive tests have limited sensitivities and lack capabilities of pre-operative risk stratification for bladder cancer (BC) diagnosis. We aimed to develop and validate a urine-based DNA methylation assay as a clinically feasible test for improving BC detection and enabling pre-operative risk stratifications. Methods A urine-based DNA methylation assay was developed and validated by retrospective single-center studies in patients of suspected BC in Cohort 1 (n = 192) and Cohort 2 (n = 98), respectively. In addition, a prospective single-center study in hematuria patient group (Cohort 3, n = 174) was used as a second validation of the model. Results The assay with a dual-marker detection model showed 88.1% and 91.2% sensitivities, 89.7% and 85.7% specificities in validation Cohort 2 (patients of suspected BC) and Cohort 3 (patients of hematuria), respectively. Furthermore, this assay showed improved sensitivities over cytology and FISH on detecting low-grade tumor (66.7–77.8% vs. 0.0–22.2%, 0.0–22.2%), Ta tumor (83.3% vs. 22.2–41.2%, 44.4–52.9%) and non-muscle invasive BC (NMIBC) (80.0–89.7% vs. 51.5–52.0%, 59.4–72.0%) in both cohorts. The assay also had higher accuracies (88.9–95.8%) in diagnosing cases with concurrent genitourinary disorders as compared to cytology (55.6–70.8%) and FISH (72.2–77.8%). Meanwhile, the assay with a five-marker stratification model identified high-risk NMIBC and muscle invasive BC with 90.5% sensitivity and 86.8% specificity in Cohort 2. Conclusions The urine-based DNA methylation assay represents a highly sensitive and specific approach for BC early-stage detection and risk stratification. It has a potential to be used as a routine test to improve diagnosis and prognosis of BC in clinic.

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