scholarly journals Short Course Monotherapy with Clarithromycin for LocalizedMycobacterium MarinumSkin Infection

1997 ◽  
Vol 8 (3) ◽  
pp. 164-166 ◽  
Author(s):  
Mitchell R Weinstein ◽  
Donald E Low ◽  
Tony Mazzulli
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Mycobacterium Marinum ◽  
In Vitro Studies ◽  
Published Data ◽  
Clinical Use ◽  
Review Of The Literature ◽  
Short Course

In vitro studies have shown thatMycobacterium marinumis usually susceptible to clarithromycin. However, there are limited published data on the clinical use of clarithromycin for the treatment ofM marinuminfections. This report describes a previously healthy 58-year-old man who developed a chronic soft tissue infection of his right hand caused byM marinum.He responded to four weeks’ therapy with clarithromycin. Follow-up at six months showed no relapse. Our experience and review of the literature suggest that short course monotherapy with clarithromycin may be quite effective for uncomplicated soft issue infections caused byM marinum.

scholarly journals Scedosporium apiospermumcatheter-related soft-tissue infection: a case report and review of the literature

2012 ◽  
Vol 50 (6) ◽  
pp. 627-630 ◽  
Author(s):  
Carole Eldin ◽  
Laurent Chiche ◽  
Guillemette Thomas ◽  
Marie Pierre Dicostanzo ◽  
Jean Marc Durand ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Review Of The Literature

Titanium dioxide-based scanning powder can modulate cell activity of oral soft tissue - Insights from in vitro studies with L929 cells and periodontal fibroblasts

2020 ◽  
Vol 64 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Gunpreet Oberoi ◽  
Anna Müller ◽  
Andreas Moritz ◽  
Hassan Ali Shokoohi-Tabrizi ◽  
Christoph Kurzmann ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Soft Tissue ◽  
Cell Activity ◽  
In Vitro Studies ◽  
L929 Cells ◽  
Oral Soft Tissue

Cost-utility analysis of surveillance strategies for soft tissue sarcoma recurrence.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 11565-11565
Author(s):  
Bonny Chau ◽  
Marita Zimmermann ◽  
Michael Wagner ◽  
Lee D. Cranmer
Keyword(s):  
Cost Effectiveness ◽  
Soft Tissue ◽  
Imaging Modality ◽  
Soft Tissue Sarcomas ◽  
Definitive Treatment ◽  
Published Data ◽  
X Rays ◽  
Life Years ◽  
Screening Intervals

11565 Background: Soft tissue sarcomas (STS) are uncommon malignancies with significant biological and clinical variation. After primary curative therapy, patients enter a program of surveillance for recurrence with periodic chest x-rays (CXR) or computed tomography (CT). We compared costs and health outcomes of CXR and CT at a range of frequencies and durations of follow-up. Methods: We used a Markov model to simulate a cohort of 10,000 STS patients through their surveillance experience for lung metastasis after completion of definitive treatment for stage II or III primary disease. Health states in the model were no evidence of disease, recurrence, and death. We assessed the method of chest imaging, duration of follow-up, and interval (every 3 months or 6 months) of surveillance in the first 3 years. Cost effectiveness was assessed for each screening modality and screening frequency. Recurrence probabilities, utilities, treatment costs, and other parameters were from previously published data. Outcomes were costs, quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICER). Results: The initial evaluation comparing screening every 3 months for 3 years, every 6 months for years 4 and 5, and annually from years 6 to 10 resulted in 632,264 QALYs and $1,038,351,481 costs for CT, compared to 631,834 QALYs and $746,019,937 for CXR, resulting in an ICER of $679,322/QALY. In comparing screening intervals, less frequent screening intervals of every 6 months compared to every 3 months for the first three years using CT resulted in an ICER of $690,527/QALY and for CXR, the ICER was $271,423/QALY. In comparing screening duration between 6 years and 10 years of follow-up, strategies with longer follow-up resulted in slightly higher QALYs in each of the comparison scenarios, at a much higher cost. Conclusions: In our evaluation, more frequent screening the first 3 years and longer duration of surveillance resulted in higher QALYs in both screening modalities. However, in the comparisons the ICERs exceed common willingness to pay thresholds of $150,000/QALY gained; CXR is the more cost-effective imaging modality. Limitation of this model includes the simplification of disease progression and heterogeneity in STS.

scholarly journals A case of infection caused by the basidiomycete Phellinus undulatus

2011 ◽  
Vol 60 (2) ◽  
pp. 256-258 ◽  
Author(s):  
Deborah Williamson ◽  
Sushil Pandey ◽  
Susan Taylor ◽  
Karen Rogers ◽  
Louanne Storey ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Molecular Analysis ◽  
Soft Tissue Infection ◽  
Human Infection ◽  
Morphological Features ◽  
Tissue Infection

We present a case of soft tissue infection caused by the basidiomycete Phellinus undulatus. To our knowledge, this is the first reported case of human infection caused by this fungus. Definitive identification was only possible through molecular analysis as the isolate failed to produce any distinct morphological features in vitro.

scholarly journals Mycobacterium marinum: MR imaging and clinical course of a rare soft tissue infection

2004 ◽  
Vol 33 (7) ◽  
Author(s):  
E. Cauzza ◽  
E. Stauffer ◽  
S. Zimmerli ◽  
U. B�chler ◽  
E. Voegelin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Mr Imaging ◽  
Soft Tissue Infection ◽  
Clinical Course ◽  
Mycobacterium Marinum ◽  
Tissue Infection

scholarly journals CRISPR-Cas9 modified bacteriophage for treatment of Staphylococcus aureus induced osteomyelitis and soft tissue infection

2019 ◽  
Author(s):  
Leah K. Horstemeyer ◽  
JooYoun Park ◽  
Elizabeth A. Swanson ◽  
Mary Catherine Beard ◽  
Emily M. McCabe ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Bone Infection ◽  
Tissue Infection ◽  
Fluorescent Imaging ◽  
Alginate Hydrogel ◽  
Antibiotic Resistant

AbstractOsteomyelitis, or bone infection, is often induced by antibiotic resistant Staphylococcus aureus strains of bacteria. Although debridement and long-term administration of antibiotics are the gold standard for osteomyelitis treatment, the increase in prevalence of antibiotic resistant bacterial strains limits the ability of clinicians to effectively treat infection. Bacteriophages (phages), viruses that effectively lyse bacteria, have gained recent attention for their high specificity, non-toxicity, and the low likelihood of resistance development by pathogens. Previously, we have shown that CRISPR-Cas9 genomic editing techniques could be utilized to expand bacteriophage host range and enhance bactericidal activity through modification of the tail fiber protein, as well as improve safety with removal of major virulence genes. In a dermal infection study, these CRISPR-Cas9 phages reduced bacterial load relative to unmodified phage. Thus, we hypothesized this bacteriophage would be effective to mitigate infection from a biofilm forming S. aureus strain in vitro and in vivo. In vitro, qualitative fluorescent imaging demonstrated superiority of phage to conventional vancomycin and fosfomycin antibiotics against S. aureus biofilm. Quantitative antibiofilm effects increased over time for fosfomycin, phage, and fosfomycin-phage (dual) therapeutics delivered via alginate hydrogel. We developed an in vivo rat model of osteomyelitis and soft tissue infection that was reproducible and challenging and enabled longitudinal monitoring of infection progression. Using this model, phage (with and without fosfomycin) delivered via alginate hydrogel were successful in reducing soft tissue infection but not bone infection, based on bacteriological, histological, and scanning electron microscopy analyses. Notably, the efficacy of phage at mitigating soft tissue infection was equal to that of high dose fosfomycin. Future research may utilize this model as a platform for evaluation of therapeutic type and dose, and alternate delivery vehicles for osteomyelitis mitigation.

scholarly journals Rabbits as Animal Models in Contemporary Implant Biomaterial Research

2011 ◽  
Vol 2 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Himanshu Arora ◽  
Anil Nafria ◽  
Anup Kanase
Keyword(s):  
Animal Models ◽  
Dental Implants ◽  
Dental Implant ◽  
Mechanical Stability ◽  
In Vitro Studies ◽  
Clinical Use ◽  
Essential Step ◽  
Rigorous Testing

ABSTRACT Development of an optimal interface between bone and orthopedic or dental implants has taken place for many years. In order to determine whether a newly developed implant material conforms to the requirements of biocompatibility, mechanical stability and safety, it must undergo rigorous testing both in vitro and in vivo. Results from in vitro studies can be difficult to extrapolate to the in vivo situation. For this reason the use of animal models is often an essential step in the testing of orthopedic and dental implants prior to clinical use in humans. This review discusses the reasons, the importance, and the research carried out in rabbits in our quest to develop a dental implant ideally suited for human bone.

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