scholarly journals Streptococcus suisMeningitis: First Case Reported in Quebec

1996 ◽  
Vol 7 (5) ◽  
pp. 329-331 ◽  
Author(s):  
Sophie Michaud ◽  
Raymond Duperval ◽  
Robert Higgins
Keyword(s):  
Hearing Loss ◽  
Clinical Manifestation ◽  
Streptococcus Suis ◽  
Swine Production ◽  
Severe Hearing Loss ◽  
Occupational Illness ◽  
First Case ◽  
Swine Workers ◽  
Streptococcal Meningitis

Very fewStreptococcus suisinfections in humans have been reported in Canada, although the condition is frequent in pigs. Meningitis, often accompanied by severe hearing loss, is the most common clinical manifestation. The disease is an occupational illness affecting persons in contact with pigs and may be underdiagnosed because of misidentification of the responsible bacterium. Since Quebec is the leading province for swine production in Canada, physicians and microbiologists should be aware of this infection, especially when a streptococcal meningitis is diagnosed in swine workers. The first case ofS suistype 2 meningitis reported in Quebec is described.

scholarly journals Streptococcal infection in young pigs: IV. An outbreak of streptococcal meningitis in weaned pigs

1975 ◽  
Vol 75 (1) ◽  
pp. 69-78 ◽  
Author(s):  
R. S. Windsor ◽  
S. D. Elliott
Keyword(s):  
Streptococcal Infection ◽  
Streptococcus Suis ◽  
Human Infants ◽  
Young Pigs ◽  
Similar Disease ◽  
Streptococcal Meningitis ◽  
Group B ◽  
Group D

SUMMARYTwenty-eight pigs died in an outbreak of streptococcal meningitis in an East Anglian herd. Most were 10–14 weeks old. The outbreak lasted from January to April and was finally controlled by antibiotic therapy. A similar number of losses had occurred in the previous year though no diagnosis had then been made.The causal agent appeared to be a haemolytic streptococcus belonging to group D and provisionally designatedStreptococcus suistype 2. It is probably identical with de Moor's group R streptococcus which causes a similar disease in the Netherlands. It is serologically distinct fromStreptococcus suistype 1 which causes meningitis in piglets. Type 2 infection in pigs appears to be widespread in England and Wales and to occur in animals up to the age of at least 14 weeks.A comparison is drawn betweenStr. suismeningitis in pigs and group B streptococcal meningitis in human infants.

scholarly journals Streptococcal infection in young pigs. V. An immunogenic polysaccharide from Streptococcus suis type 2 with particular reference to vaccination against streptococcal meningitis in pigs

1980 ◽  
Vol 85 (2) ◽  
pp. 275-285 ◽  
Author(s):  
S. D. Elliott ◽  
Felicity Clifton-Hadley ◽  
Joseph Tai
Keyword(s):  
Capsular Polysaccharide ◽  
Streptococcal Infection ◽  
Streptococcus Suis ◽  
Booster Injection ◽  
Young Pigs ◽  
Unvaccinated Control ◽  
Streptococcal Meningitis ◽  
Late Bleeding

SUMMARYOf 17 pigs vaccinated with Streptococcus suis type-2 capsular polysaccharide plus Freund's Incomplete Adjuvant, all developed opsonizing antibody against Str. suis type 2. Of 14 pigs vaccinated with type-2 polysaccharide alone, 4 (possibly 6) developed opsonizing antibody. It is possible that some pigs vaccinated with polysaccharide plus Freund's Incomplete Adjuvant developed opsonizing antibody in response to a ‘booster’ injection of polysaccharide alone. Of 21 unvaccinated control pigs, late bleeding from 3 showed opsonizing activity against Str. suis type 2.

scholarly journals Inherited and de novo biallelic pathogenic variants in COL11A1 result in type 2 Stickler syndrome with severe hearing loss

2020 ◽  
Vol 8 (9) ◽  
Author(s):  
Thomas Nixon ◽  
Allan J. Richards ◽  
Adrian Lomas ◽  
Stephen Abbs ◽  
Pradeep Vasudevan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
De Novo ◽  
Stickler Syndrome ◽  
Severe Hearing Loss ◽  
Pathogenic Variants

Otoacoustic Emissions in an Adult With Severe Hearing Loss

1991 ◽  
Vol 34 (3) ◽  
pp. 703-703
Author(s):  
B. A. Prieve ◽  
M. Gorga ◽  
S. T. Neely
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Severe Hearing Loss

Intestinal Heterotopic Pancreas Involved by Simultaneous PanIN-2 Lesion and Endocrine Microadenoma: a Unique Case

2017 ◽  
Vol 26 (2) ◽  
pp. 199-202
Author(s):  
Remus Cornea ◽  
Sorina Taban ◽  
Cristian Suciu ◽  
Codruta Lazureanu ◽  
Alis Dema
Keyword(s):  
Histopathological Examination ◽  
Intraepithelial Neoplasia ◽  
Heterotopic Pancreas ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Unique Case ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Pancreatic Endocrine Neoplasm ◽  
First Case ◽  
Mucinous Neoplasms

We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. In this area, two pathological distinct lesions were identified, one histologically compatible with pancreatic intraepithelial neoplasia (PanIN) type 2 lesion and the other with morphologic criteria for endocrine microadenoma. To our knowledge, this is the first case that evidences the presence of a concomitant premalignant exocrine lesion and benign endocrine lesion in a heterotopic pancreas (HP).Abbreviations: HP: heterotopic pancreas; IPMN: Intraductal Papillary Mucinous Neoplasms; PanIN: Pancreatic Intraepithelial Neoplasia; PEN: pancreatic endocrine neoplasm.

scholarly journals A novel case of concurrent occurrence of demyelinating-polyneuropathy-causing PMP22 duplication and SOX10 gene mutation producing severe hypertrophic neuropathy

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nozomu Matsuda ◽  
Koushi Ootsuki ◽  
Shunsuke Kobayashi ◽  
Ayaka Nemoto ◽  
Hitoshi Kubo ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Neuromuscular Disorders ◽  
Whole Body ◽  
Congenital Hearing Loss ◽  
Severe Phenotype ◽  
Demyelinating Neuropathy ◽  
Magnetic Resonance Neurography ◽  
Peripheral Myelin Protein 22 ◽  
Hypertrophic Neuropathy

Abstract Background Hereditary motor and sensory neuropathy, also referred to as Charcot–Marie–Tooth disease (CMT), is most often caused by a duplication of the peripheral myelin protein 22 (PMP22) gene. This duplication causes CMT type 1A (CMT1A). CMT1A rarely occurs in combination with other hereditary neuromuscular disorders. However, such rare genetic coincidences produce a severe phenotype and have been reported in terms of “double trouble” overlapping syndrome. Waardenburg syndrome (WS) is the most common form of a hereditary syndromic deafness. It is primarily characterized by pigmentation anomalies and classified into four major phenotypes. A mutation in the SRY sex determining region Y-box 10 (SOX10) gene causes WS type 2 or 4 and peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, WS, and Hirschsprung disease. We describe a 11-year-old boy with extreme hypertrophic neuropathy because of a combination of CMT1A and WS type 2. This is the first published case on the co-occurrence of CMT1A and WS type 2. Case presentation The 11-year-old boy presented with motor developmental delay and a deterioration in unstable walking at 6 years of age. In addition, he had congenital hearing loss and heterochromia iridis. The neurological examination revealed weakness in the distal limbs with pes cavus. He was diagnosed with CMT1A by the fluorescence in situ hybridization method. His paternal pedigree had a history of CMT1A. However, no family member had congenital hearing loss. His clinical manifestation was apparently severe than those of his relatives with CMT1A. In addition, a whole-body magnetic resonance neurography revealed an extreme enlargement of his systemic cranial and spinal nerves. Subsequently, a genetic analysis revealed a heterozygous frameshift mutation c.876delT (p.F292Lfs*19) in the SOX10 gene. He was eventually diagnosed with WS type 2. Conclusions We described a patient with a genetically confirmed overlapping diagnoses of CMT1A and WS type 2. The double trouble with the genes created a significant impact on the peripheral nerves system. Severe phenotype in the proband can be attributed to the cumulative effect of mutations in both PMP22 and SOX10 genes, responsible for demyelinating neuropathy.

Streptococcus suis type 2 in British pig herds

In Practice ◽  
1984 ◽  
Vol 6 (3) ◽  
pp. 69-71 ◽  
Author(s):  
Terry Heard
Keyword(s):  
Streptococcus Suis

scholarly journals Recessive mutations of TMC1 associated with moderate to severe hearing loss

Neurogenetics ◽  
2016 ◽  
Vol 17 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Ayesha Imtiaz ◽  
Azra Maqsood ◽  
Atteeq U. Rehman ◽  
Robert J. Morell ◽  
Jeffrey R. Holt ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Severe Hearing Loss ◽  
Recessive Mutations
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