scholarly journals Diagnostic Value of Serum Lactate Dehydrogenase Isoenzyme and Amino Acid Patterns in Several Schistosomal and Non-Schistosomal Disorders as Compared to other Biochemical Parameters

1996 ◽  
Vol 13 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Samia A. Ahmed ◽  
Mohamed Z. Gad
Keyword(s):  
Bladder Cancer ◽  
Amino Acid ◽  
Lactate Dehydrogenase ◽  
Biochemical Parameters ◽  
Elevated Serum ◽  
Diagnostic Value ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Control Group ◽  
Ldh Isoenzyme

Serum lactate dehydrogenase (LDH) isoenzyme and amino acid (a. a) patterns were evaluated in comparison to several other biochemical parameters for liver and renal function with the objective of clarifying the differential diagnosis of hepatic disorders and predicting the outcome of schistosomal infection in Egyptian patients. Patients examined included those with complicated hepatic disorders and others with different stages of schistosomal infestation, hepatoma or bladder cancer, in addition to a normal control group. Several biochemical parameters appeared to be useful in establishing consistent differences or similarities between the studied groups. Examples are; elevated serum AST/ AL T ratio and methionine content in chronic schistosomiasis, elevated serum urea/creatinine ratio and leucine content in all schistosomal patients and extremely high levels of N-acetyl-β-D-glucosaminidase (NAG) in the urine of non-schistosomal bladder cancer patients. In addition, characteristic LDH isoenzyme profiles distinguish between the studied groups, in particular separating chronic schistosomiasis from schistosomal bladder cancer and hepatoma from other hepatic disorders.

Prognostic Significance of Elevated Serum Lactate Dehydrogenase (LDH) in Patients with Severe Sepsis

CHEST Journal ◽  
2004 ◽  
Vol 126 (4) ◽  
pp. 873S ◽  
Author(s):  
Joe G. Zein ◽  
Gregory L. Lee ◽  
Maroun Tawk ◽  
Mohammed Dabaja ◽  
Gary T. Kinasewitz
Keyword(s):  
Severe Sepsis ◽  
Lactate Dehydrogenase ◽  
Prognostic Significance ◽  
Elevated Serum ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase

The effect of respiratory diseases on serum lactate dehydrogenase and its isoenzyme patterns in calves

2013 ◽  
Vol 16 (2) ◽  
pp. 211-218 ◽  
Author(s):  
O. Nagy ◽  
Cs. Tóthová ◽  
I. Paulíková ◽  
G. Kováčl ◽  
H. Seidel
Keyword(s):  
Lactate Dehydrogenase ◽  
Respiratory Diseases ◽  
Clinical Signs ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Control Group ◽  
Diagnostic Significance ◽  
Organ Systems ◽  
Isoenzyme Patterns

AbstractIn this study we examined the serum activity of lactate dehydrogenase (LDH) and its isoenzyme patterns in 28 calves of a lowland black spotted breed and its crossbreeds at the age of 2-6 months suffering from clinically noticeable manifested respiratory diseases - bronchopneumonia (BRD Group). As a control group we used 35 clinically healthy calves of the same age, breed and nutrition (Healthy Group). The sick calves did not show clinical signs or pathological lesions on other organ systems. The results found in sick calves showed a significantly higher total activity of LDH than in clinically healthy animals (P<0.01). The mean activity of LDH was 2012 U/l in healthy calves and in calves with respiratory diseases 2529 U/l. The differences in all LDH isoenzyme patterns between both groups of animals were significant (P<0.001) and in calves with respiratory diseases are characterized by a marked increase of the LDH 1 fraction and a decrease in the proportion of the other four LDH isoenzymes. Our results differ from those observed and presented in respiratory diseases in human medicine or in sheep. The explanation for the obtained results in calves and the determination of their diagnostic significance needs further studies and investigations using more animals with various severity of clinical signs and pathological changes, including analysis and determination of lactate dehydrogenase isoenzyme patterns in healthy and affected cattle lung tissue.

Serum Lactate Dehydrogenase is Elevated in Ischemic Acute Tubular Necrosis but Not in Acute Rejection in Kidney Transplant Patients

2016 ◽  
Vol 27 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Hefziba Green ◽  
Ana Tobar ◽  
Anat Gafter-Gvili ◽  
Leonard Leibovici ◽  
Tirza Klein ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Lactate Dehydrogenase ◽  
Acute Rejection ◽  
Acute Tubular Necrosis ◽  
Elevated Serum ◽  
Graft Function ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Antibody Mediated Rejection ◽  
Tubular Necrosis

Background: Serum lactate dehydrogenase (LDH) levels may help to distinguish ischemic acute tubular necrosis (ATN) from acute rejection after kidney transplantation. Methods: All kidney biopsies performed in the years 2010 to 2012 were reviewed. Serum LDH, creatinine level, clinical variables, and presence of donor-specific antibodies were recorded before the biopsy. Results: Overall 150 biopsies were included. Ischemic ATN was diagnosed in 45 biopsies and acute cellular-mediated rejection and/or antibody-mediated rejection in 59 biopsies, 38 of which were accompanied by ATN. Serum LDH was elevated in 23 (51%) of 45 cases with ischemic ATN versus 15 (14%) of 105 cases with other diagnoses ( P < .0001). Median serum LDH was 478 U/L (range 277-2018) for ischemic ATN and 372 U/L (range 191-748) for all other diagnoses ( P < .001). When delayed graft function or primary nonfunctioning grafts were caused by ischemic ATN, serum LDH was elevated in 58% of cases, but when caused by acute rejection, LDH was normal in 88% of cases ( P = .02). Conclusions: There is a strong association between elevated serum LDH 1 to 3 days before performing kidney biopsy and the diagnosis of ischemic ATN after kidney transplantation, especially at the immediate posttransplantation period. Normal serum LDH at this period should raise a suspicion of acute rejection.

An Elevated Serum Lactate Dehydrogenase-to-albumin Ratio Is a Useful Poor Prognostic Predictor of Nivolumab in Patients With Gastric Cancer

2021 ◽  
Vol 41 (8) ◽  
pp. 3925-3931
Author(s):  
NOBUHIRO NAKAZAWA ◽  
MAKOTO SOHDA ◽  
ARISA YAMAGUCHI ◽  
TAKAYOSHI WATANABE ◽  
HIDEYUKI SAITO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lactate Dehydrogenase ◽  
Elevated Serum ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Albumin Ratio ◽  
Prognostic Predictor

scholarly journals Serum lactate dehydrogenase (LDH) level in mild and severe preeclampsia as a prognostic marker

2018 ◽  
Vol 7 (10) ◽  
pp. 3969
Author(s):  
Radheshyam Bairwa ◽  
Suhail Iqbal
Keyword(s):  
Lactate Dehydrogenase ◽  
Laboratory Data ◽  
Elevated Serum ◽  
Serum Lactate ◽  
Severe Preeclampsia ◽  
Serum Lactate Dehydrogenase ◽  
Close Monitoring ◽  
Intracellular Enzyme ◽  
Potential Marker ◽  
Control Serum

Background: Lactate Dehydrogenase (LDH) is mainly an intracellular enzyme. Its level is an useful biomarker for cellular injury which may suggested as a potential marker to predict the severity of preeclampsia and indicator for multi-organ involvement have significant role in management of preeclampsia. We conducted this study to examine the relationship between lactate dehydrogenase concentration and the severity of the disease and occurrence of complications. The objective of the present study was to assess role of serum LDH level in mild and severe preeclamptic womenMethods: This prospective study was conducted in the Department of obstetrics and gynecology in Jhalawar medical college from Jan 2017 to Oct 2017 Total 120 pregnant women during third trimester (32-40 weeks) aged 18 to 35 years were selected. Among them 40 were severe preeclampsia and 40 were mild preeclampsia patients and 40 were healthy normotensive control. Serum LDH level was estimated by continuous spectrophotometric method. Demographic, hemodynamic, and laboratory data were compared among the three groups. The symptoms and complications of severe pre-eclampsia along with foetal outcome were analyzed according to the levels of LDH.Results: In this study, serum LDH level was significantly higher (P<0.001) in preeclamptic compared to those of control. Again, this value was significantly higher in severe preeclamptic than those of mild preeclamptic. The symptoms and complications of preeclampsia along with perinatal mortality were increased significantly in patents with LDH> 800IU/I compared with those who had lower levels.Conclusions: From this study, it can be concluded that elevated serum LDH level is associated with severity of preeclampsia. LDH has been evaluated as a biochemical marker for preeclampsia and as a prognosticator of the disease severity. Detection of high-risk patients with increased levels of LDH mandate close monitoring and management to prevent maternal and fetal morbidity and mortality.

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