scholarly journals Aphthous Esophagael Ulceration: A Novel Presentation of Crohn’s Disease?

1994 ◽  
Vol 8 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Paul L Beck ◽  
Philip K Blustein ◽  
Melvin A Andersen
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Giant Cells ◽  
Distal Ileum ◽  
Cell Hyperplasia ◽  
The Past ◽  
Bacterial Cultures ◽  
Aphthous Ulcers ◽  
Lymphoid Aggregates

Crohn’s disease (CD) commonly presents as involvement of the small bowel or colon - the esophagus is rarely involved. The authors describe the case of a 45-year-old woman who presented with odynophagia and was found to have aphthous ulcers of the esophagus. On questioning, she admitted to three to four episodes of nonbloody diarrhea, each lasting less than one week, over the past two years. The patient denied other symptoms of gastrointestinal, collagen-vascular, respiratory or cardiovascular disease. Viral, fungal and bacterial cultures of blood, stool and tissue biopsies were all negative. A small bowel enema showed inflammation of the distal ileum. Colonoscopy revealed patchy areas of inflammation of the colon and distal ileum. Biopsies from the esophagus, duodenum, terminal ileum and colon showed chronic inflammation, lymphoid aggregates, goblet cell hyperplasia (in the colon) and crypt abscesses. Giant cells, granulomas and fissures were not evident in any of the biopsies. The patient failed to respond to a three-week course of omeprazole, but her symptoms resolved within three days of starting prednisone. The exact cause of the esophageal ulcerations is unknown but most likely is CD of the esophagus.

Capsule endoscopy in small bowel Crohn’s disease and Tuberculosis

2017 ◽  
Vol 47 (2) ◽  
pp. 113-118 ◽  
Author(s):  
Surinder Singh Rana ◽  
Vishal Sharma ◽  
Ravi Sharma ◽  
Ritambhra Nada ◽  
Rajesh Gupta ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Capsule Endoscopy ◽  
Ileocecal Valve ◽  
Final Diagnosis ◽  
Diagnostic Challenge ◽  
Large N ◽  
Aphthous Ulcers

Differentiation of small bowel tuberculosis (SBTB) from Crohn’s disease (CD) is a diagnostic challenge. We studied 52 patients with suspected SBTB or CD with terminal ileal involvement, who were prospectively enrolled. After confirming patency of the gastrointestinal tract, 26 patients underwent capsule endoscopy (CE). A final diagnosis of CD was found in 18 patients and SBTB in eight patients. All SBTB patients had involvment of the ileocecal valve (ICV) with large (n = 6) and aphthous (n = 2) ulcers in the ileal segment. In CD, ICV involvement was seen in five (33%) patients. Large and aphthous ulcers were observed in seven (47%) and 15 (100%) patients, respectively. On comparison with CD, patients with SBTB had increased frequency of ICV involvement ( P = 0.002) and lesser frequency of aphthous ulcers ( P = 0.007). CE can help in differentiating CD from SBTB by the position of its involvement and the type of ulcers present.

Colon Adenocarcinoma Metastasis Through Ileocolic Fistula to Small Bowel in the Setting of Crohn’s Disease

2021 ◽  
Author(s):  
Michael Tseng ◽  
Taseen Ahmed Syed ◽  
Patricija Zot ◽  
Ravi Vachhani
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Unusual Case ◽  
Colon Adenocarcinoma ◽  
Fistula Tract ◽  
Gastrointestinal Fistula ◽  
The Past ◽  
Pathology Reports

Abstract Purpose: Patients with Crohn’s disease (CD) are at higher risk of developing colorectal cancer (CRC) and gastrointestinal fistula. We report an unusual case of sigmoid colon adenocarcinoma in a CD patient that metastasized to the small bowel through an ileocolic fistula tract.Methods: This case report was written after patient was seen in the clinic and reviewing overall hospitalization including clinically relevant data including imaging and pathology reports associated to our focus and presentation. Prior cases of metastatic CRC via fistula tract were reviewed and compared as well. Results: We described an unprecedented case of a sigmoid adenocarcinoma metastasized to ileum via ileal-sigmoid fistula. Patient received surgical treatment and systemic chemotherapy and currently in remission. Conclusion: CD is associated with a higher risk of fistula development. Few cases in the past described CRC metastasized within the gastrointestinal tract through a fistula. Intriguingly in our case, sigmoid adenocarcinoma developed and further metastasized to the ileum via the ileal-sigmoid fistula in the setting of CD. In addition to presenting a unique pathological phenomenon in these patients, this case raises awareness of the importance of regular follow-up and early initiation of IBD therapies.

Small-bowel lymphoma complicating long-standing Crohn's disease.

1997 ◽  
Vol 169 (5) ◽  
pp. 1462-1463 ◽  
Author(s):  
H E Woodley ◽  
J A Spencer ◽  
K A MacLennan
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease

Apex Score: Predicting Flares in Small-Bowel Crohn’s Disease After Mucosal Healing

2021 ◽  
Author(s):  
Vítor Macedo Silva ◽  
Marta Freitas ◽  
Pedro Boal Carvalho ◽  
Francisca Dias de Castro ◽  
Tiago Cúrdia Gonçalves ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Mucosal Healing

scholarly journals Infliximab: A Review of its use in the Treatment of Pediatric Crohn's Disease

2010 ◽  
Vol 2 ◽  
pp. CMT.S2840
Author(s):  
Arkady Broder ◽  
Joel R. Rosh
Keyword(s):  
Monoclonal Antibodies ◽  
Crohn’S Disease ◽  
Chronic Disease ◽  
Crohn's Disease ◽  
Tumor Necrosis ◽  
Immune Dysregulation ◽  
Necrosis Factor Alpha ◽  
The Past ◽  
Factor Alpha ◽  
Necrosis Factor

The past decade has brought great change to the treatment of pediatric Crohn's disease. The majority of affected patients now receive therapy directed at the underlying immune dysregulation that is associated with this chronic disease. The monoclonal antibodies directed against tumor necrosis factor alpha play an increasing role in such therapy. Infliximab is the prototype of this class of biologic based therapy. This review covers the basic pharmacokinetics of infliximab while reviewing the data on its efficacy in pediatric Crohn's disease patients. Current issues related to infliximab dosing and safety are also reviewed.

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