scholarly journals Eosinophilic Gastroenteritis in a Patient with Ehlers-Danlos Syndrome - A Rare Combination

1992 ◽  
Vol 6 (3) ◽  
pp. 129-132
Author(s):  
I Al-Traif ◽  
L Jewell ◽  
ABR Thomson
Keyword(s):  
Weight Loss ◽  
Abdominal Pain ◽  
Elemental Diet ◽  
Eosinophilic Gastroenteritis ◽  
Treatment Modalities ◽  
Ehlers Danlos Syndrome ◽  
Gastrointestinal Manifestations ◽  
Rare Combination ◽  
Danlos Syndrome

A case of eosinophilic gastroenteritis in a patient with Ehlers-Danlos syndrome who presented with abdominal pain, vomiting, diarrhea and profound weight loss is presented. Because of inability to tolerate glucocorticosteroids, symptoms were treated with sodium chromoglycate and an elemental diet given by jejunostomy. The patient did well on this program. The gastrointestinal manifestations of eosinophilic gastroenteritis and Ehlers-Danlos syndrome are reviewed as well as the treatment modalities available for eosinophilic gastroenteritis.

scholarly journals Pelvic Girdle Pain, Hypermobility Spectrum Disorder and Hypermobility-Type Ehlers-Danlos Syndrome: A Narrative Literature Review

2020 ◽  
Vol 9 (12) ◽  
pp. 3992
Author(s):  
Ahmed Ali ◽  
Paul Andrzejowski ◽  
Nikolaos K. Kanakaris ◽  
Peter V. Giannoudis
Keyword(s):  
Pelvic Ring ◽  
Patient Reported Outcome Measures ◽  
Pelvic Girdle ◽  
Spectrum Disorder ◽  
Pelvic Girdle Pain ◽  
Treatment Modalities ◽  
Ehlers Danlos Syndrome ◽  
Ongoing Research ◽  
Patient Reported ◽  
Danlos Syndrome

Pelvic girdle pain (PGP) refers specifically to musculoskeletal pain localised to the pelvic ring and can be present at its anterior and/or posterior aspects. Causes such as trauma, infection and pregnancy have been well-established, while patients with hypermobile joints are at greater risk of developing PGP. Research exploring this association is limited and of varying quality. In the present study we report on the incidence, pathophysiology, diagnostic and treatment modalities for PGP in patients suffering from Hypermobility Spectrum Disorder (HSD) and Hypermobility-Type Ehlers-Danlos Syndrome (hEDS). Recommendations are made for clinical practice by elaborating on screening, diagnosis and management of such patients to provide a holistic approach to their care. It appears that this cohort of patients are at greater risk particularly of mental health issues. Moreover over, they may require a multidisciplinary approach for their management. Ongoing research is still required to expand our understanding of the relationship between PGP, HSD and hEDS by appropriately diagnosing patients using the latest updated terminologies and by conducting randomised control trials to compare outcomes of interventions using standardised patient reported outcome measures.

7143 Gastrointestinal manifestations in patients with classical and hypermobile ehlers-danlos syndrome.

2000 ◽  
Vol 51 (4) ◽  
pp. AB278
Author(s):  
Somprak Boonpongmanee ◽  
Thian Lok Tio ◽  
Richard S. Zubarick ◽  
William Mayoral ◽  
vICTOR Nwakwakwawa ◽  
...  
Keyword(s):  
Ehlers Danlos Syndrome ◽  
Gastrointestinal Manifestations ◽  
Danlos Syndrome

Ehlers Danlos syndrome and gastrointestinal manifestations: a 20-year experience at Mayo Clinic

2015 ◽  
Vol 27 (11) ◽  
pp. 1657-1666 ◽  
Author(s):  
A. D. Nelson ◽  
M. A. Mouchli ◽  
N. Valentin ◽  
D. Deyle ◽  
P. Pichurin ◽  
...  
Keyword(s):  
Mayo Clinic ◽  
Ehlers Danlos Syndrome ◽  
Gastrointestinal Manifestations ◽  
Danlos Syndrome

scholarly journals Ehlers-Danlos Syndrome: An Analysis of the Current Treatment Options

2020 ◽  
Vol 4;23 (7;4) ◽  
pp. 429-438
Author(s):  
Bo Song
Keyword(s):  
Physical Therapy ◽  
Occupational Therapy ◽  
Current Treatment ◽  
Treatment Modalities ◽  
Comprehensive Treatment ◽  
Alternative Treatments ◽  
Ehlers Danlos Syndrome ◽  
Care Clinic ◽  
Treatment Methods ◽  
Danlos Syndrome

Background: Ehlers-Danlos syndrome (EDS) is a multifaceted disease that can present with a variety of types of pain. Unfortunately, both the mechanisms and treatments for pain are poorly understood. The proposed treatments for the various musculoskeletal pain syndromes in EDS have had variable success, and it becomes much more imperative to better define and evaluate the current treatment modalities in treating this debilitating disease. Objectives: The purpose of this study was to investigate the currently available treatment modalities for patients with EDS and their efficacies in pain and symptom relief. Study Design: Retrospective cohort study. Setting: Institutional physical medicine and rehabilitation primary care clinic. Methods: All patients were seen between January 2015 and April 2019, in which 98 patients with EDS were identified through retrospective chart review. Institutional review board approval was obtained, and all patients provided written consent to be included in the study. We reviewed various treatment modalities, including complimentary/alternative treatments, opioids/opioid-like medications, nonsteroidal antiinflammatory drugs, physical therapy, occupational therapy, muscle relaxants, neuropathic modulators, steroids, surgery/procedures, and acetaminophen. Treatment methods were extracted from individual patient charts, and efficacy was grouped into 3 categories: improvement, no effect, or worsened symptoms. Results: The most common treatments used were complimentary/alternative treatments (n = 88). Occupational therapy and bracing were the most effective options with 70% of patients reporting improvement. Neuropathic modulators were the least well tolerated with 47% of patients reporting adverse effects. Limitations: Men were a small percentage of the study. Patients were not randomized, and pain score reporting was subjective. Patient data were extracted from a single practice setting. Timing and symptom onset were not measured. Conclusions: There is a relative paucity of published literature regarding the various treatment methods for EDS. Although our study is able to identify positive and negative trends with certain modalities, it is vital to understand that EDS is not a uniform diagnosis among patients, and that a combination of several different treatments usually is needed for optimal symptom control. Further research and investigation are necessary to develop a comprehensive treatment database for this complex condition. Key words: Ehlers-Danlos syndrome, pain, hypermobility, arthralgia, subluxation, genetic, physical therapy, interventional pain

Mo1599 - Abdominal Pain in Hypermobility-Type Ehlers Danlos Syndrome is Associated with Proliferation and Hypersensitivity of Colonic Nociceptive Nerve Endings

2018 ◽  
Vol 154 (6) ◽  
pp. S-765-S-766
Author(s):  
Rubina Aktar ◽  
Paulo Watanabe ◽  
Vincent Cibert-Goton ◽  
Madusha Peiris ◽  
Asma Fikree ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Nerve Endings ◽  
Ehlers Danlos Syndrome ◽  
Danlos Syndrome

scholarly journals A123 GASTROINTESTINAL SYMPTOMS AND DISORDERS OF GUT BRAIN INTERACTION ARE COMMON IN PATIENTS WITH EHLERS-DANLOS SYNDROME (EDS) IN TERTIARY REFERRAL CENTER

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 143-144
Author(s):  
E Abu-Farhaneh ◽  
Y Tse ◽  
C H Parker ◽  
L W Liu
Keyword(s):  
Abdominal Pain ◽  
Fecal Incontinence ◽  
Gastrointestinal Symptoms ◽  
Retrospective Chart Review ◽  
Final Analysis ◽  
Ehlers Danlos Syndrome ◽  
Early Satiety ◽  
Tertiary Referral Center ◽  
Gi Symptoms ◽  
Danlos Syndrome

Abstract Background Ehlers Danlos Syndrome (EDS) is a group of rare connective tissue disorders. Gastrointestinal (GI) symptoms such as abdominal pain, nausea, vomiting, bloating and altered bowel habits are common in patients with EDS. Specifically, disorders of gut brain interaction (DGBI) appear to be more common in this patient population. The University Health Network (UHN) has the first and only multi-disciplinary clinic, including specialized gastroenterology services, in Canada for the management of EDS. Aims The aim of this study is to describe the GI symptoms and DGBI that are present in our cohort of EDS patients. Methods A retrospective chart review of all EDS who were seen in the gastroenterologist clinic of the GoodHope EDS clinic at UHN were reviewed from November 1, 2017 to September 26, 2019. Demographic information including age, sex and EDS subtype were collected. GI symptoms that were collected include constipation, diarrhea, fecal incontinence, nausea, vomiting, bloating, abdominal pain, early satiety, heart burn, dysphagia and regurgitation. A physician made diagnosis of irritable bowel syndrome (IBS) was recorded. Descriptive statistics were performed. Results The charts of 79 EDS patients were reviewed; 4 were excluded due to missing data. 75 patients were included in the final analysis. 93.3% of patients were female with a mean age of 36.4 +/- 12.5 years. Of these 75 patients, 43 (57.3%) had EDS-hypermobile subtype, 13 (17.3%) EDS-classic, 3 (4%) EDS-vascular, 3 (4%) unknown EDS subtype and 13 (17.3%) were categorized as having a hypermobile spectrum disorder. The most common GI symptoms observed in this patient group included abdominal pain in 85.5%, bloating in 64.4%, heartburn in 61.8%, constipation in 57.9%, nausea in 50%, diarrhea 43.4%, dysphagia in 43.4%, regurgitation in 34.2%, early satiety in 32.89%, vomiting in 30.2%,and fecal incontinence in 13.1%. It was also observed that 50.7% (n=38) had a physician made diagnosis of IBS. Of these patients with IBS, 16 (42.1%) had IBS constipation, 12 (31.5%) had IBS mixed, and 10 (26.3%) had IBS diarrhea. Conclusions Our study demonstrated that GI symptoms are common in patients with EDS. In our cohort, abdominal pain is the most commonly reported GI symptom, though other various GI symptoms are also reported in high numbers. DGBI are also common, with IBS being much more common than what has been reported in the general population. Further studies are needed to better understand the pathophysiology and impact of these GI symptoms and DGBI in patients with EDS. Funding Agencies UNH Foundation Goodhope Fund

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