scholarly journals Therapeutic Options in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulceration

1990 ◽  
Vol 4 (3) ◽  
pp. 113-119
Author(s):  
Malcolm C Champion
Keyword(s):  
Therapeutic Options ◽  
Gastric Mucosal Damage ◽  
Current Status ◽  
Gastric Ulcers ◽  
Receptor Antagonists ◽  
Drug Induced ◽  
Duodenal Ulcers ◽  
Inflammatory Drug ◽  
Ulcer Disease ◽  
Anti Inflammatory

This article reviews the current status of H2receptor antagonists, omeprazole, sucralfate and misoprostol as therapeutic options for the prophylaxis and treatment of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal ulceration. The efficacy of the Hz receptor antagonists appears to be restricted to prophylaxis and treatment of NSAID-induced duodenal ulcer disease. Omeprazole may have a place in the future treatment of NSAID-induced gastric ulcers. However, more studies are necessary to examine this drug's efficacy in both the prophylaxis and treatment of NSAID-induced ulceration. Sucralface improves symptoms, but does not appear to have any effect on improving gastric mucosal damage when compared to placebo. It may, however, be useful in the treatment of NSAID-induced duodenal ulcers. Misoprostol is effective in both the prophylaxis and treatment of NSAID-induced gastric ulcers; however, its exact role in the prophylaxis and treatment of NSAlD-induced duodenal ulcers remains to be defined.

scholarly journals Toxicoproteomic analysis of a mouse model of nonsteroidal anti-inflammatory drug-induced gastric ulcers

2012 ◽  
Vol 420 (1) ◽  
pp. 210-215 ◽  
Author(s):  
Kaname Ohyama ◽  
Akina Shiokawa ◽  
Kosei Ito ◽  
Ritsuko Masuyama ◽  
Tomoko Ichibangase ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gastric Ulcers ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Heme Oxygenase-1 Is Protective Against Nonsteroidal Anti-inflammatory Drug–induced Gastric Ulcers

2012 ◽  
Vol 54 (4) ◽  
pp. 471-476 ◽  
Author(s):  
Aliye Uc ◽  
Xiaoyan Zhu ◽  
Brett A. Wagner ◽  
Garry R. Buettner ◽  
Daniel J. Berg
Keyword(s):  
Heme Oxygenase ◽  
Gastric Ulcers ◽  
Heme Oxygenase 1 ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals NSAID-induced damage to the gastrointestinal tract: new opportunities for the prevention of gastro- and enteropathies

2020 ◽  
pp. 166-174 ◽  
Author(s):  
V. N. Drozdov ◽  
Yu. V. Meshcheryakov ◽  
S. Yu. Serebrova ◽  
E. V. Shikh
Keyword(s):  
Gastrointestinal Tract ◽  
Medical Personnel ◽  
Histamine Receptor ◽  
Cytochrome P450 Enzyme ◽  
Drug Induced ◽  
Duodenal Ulcers ◽  
Additional Advantage ◽  
Inflammatory Drug ◽  
Cytokines And Chemokines ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drug is one of the most commonly prescribed drugs for the treatment of inflammatory and pain syndromes in the clinical practice of doctors of various specialties. The popularity of this pharmacological group is increasing due to over-the-counter dispensing condition, but at the same time, the significance of issues of likelihood, prevention and treatment of severe adverse drug reactions during intake that is controlled and uncontrolled by medical personnel is increasing. This review is devoted to the issue of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract and to the current possibilities to prevent and manage such damage. The drugs that can increase the production of prostaglandins and mucus in the digestive tract and have a general anti-inflammatory effect raise significant hopes. Rebamipide draws particular attention due to numerous pleiotropic effects, including stimulation of secretion of newly formed prostaglandins and glycoproteins in the mucous membranes, inhibition of synthesis of oxidative stress products, inflammatory cytokines and chemokines by intestinal epithelial cells. The authors considered the effectiveness of prophylactic use of rebamipide in comparison with other strategies for the use of drugs to prevent the development of stomach ulcers, duodenal ulcers and distal small bowel ulcers. They described the mechanisms of prophylactic action and its debatable aspects for proton pump inhibitors, H2-histamine receptor blockers, misoprostol. The clinical efficacy of rebamipide is illustrated by a clinical example. The absence of effects on cytochrome P450 enzyme activity, which minimizes the risks of drug interactions and changes in bioavailability, biotransformation and excretion of the drug itself during its course use is an additional advantage of rebamipide.

Dietary fibers prevent ethanol and nonsteroidal anti-inflammatory drug–induced gastric mucosal damage in rats

2007 ◽  
Vol 27 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Luciana Di Pietro Magri ◽  
Leônia Maria Batista ◽  
Ana Beatriz Albino Almeida ◽  
Elisângela Farias-Silva ◽  
Miguel Arcanjo Areas ◽  
...  
Keyword(s):  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Dietary Fibers ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Non Steroidal Anti-Inflammatory Drug Induced Damage on Lower Gastro-Intestinal Tract: Is There an Involvement of Microbiota?

2014 ◽  
Vol 9 (3) ◽  
pp. 196-204 ◽  
Author(s):  
Lucia Montenegro ◽  
Giuseppe Losurdo ◽  
Raffaele Licinio ◽  
Maria Zamparella ◽  
Floriana Giorgio ◽  
...  
Keyword(s):  
Intestinal Tract ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Gastro Intestinal Tract
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