scholarly journals Type A Behaviours and Heart Disease: Epidemiological and Experimental Foundations

1990 ◽  
Vol 3 (4) ◽  
pp. 261-277 ◽  
Author(s):  
Paul Bennett ◽  
Douglas Carroll
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
High Risk ◽  
Environmental Factors ◽  
Strong Evidence ◽  
Type A ◽  
Structured Interview ◽  
Epidemiological Studies ◽  
The Other ◽  
The Relationship

This paper critically examines three strands of evidence that concern the relationship between type A behaviours and coronary heart disease; prospective epidemiological studies of healthy populations, studies of those at high risk for coronary heart disease, and angiographic studies of atherosclerosis. The first of these would seem to provide the strongest test. Methodological and conceptual issues mean that the results of studies using the other methods should be interpreted with care. It is concluded that there is relatively strong evidence of an association between Type A behaviour as measured by Structured Interview and coronary heart disease. Hostility and anger appear to be the most powerful determinants of CHD. However, it is likely that they interact with other type A behaviours and related environmental factors in determining risk.

scholarly journals C-Reactive Protein and Coronary Heart Disease: All Said—Is Not It?

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Frederik Strang ◽  
Heribert Schunkert
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
Experimental Investigations ◽  
C Reactive Protein ◽  
Genetic Studies ◽  
Reactive Protein ◽  
The Relationship

C-reactive protein (CRP) and coronary heart disease (CHD) have been the subject of intensive investigations over the last decades. Epidemiological studies have shown an association between moderately elevated CRP levels and incident CHD whereas genetic studies have shown that polymorphisms associated with elevated CRP levels do not increase the risk of ischemic vascular disease, suggesting that CRP might be a bystander rather than a causal factor in the progress of atherosclerosis. Beside all those epidemiological and genetic studies, the experimental investigations also try to reveal the role of CRP in the progress of atherosclerosis. This review will highlight the complex results of genomic, epidemiological, and experimental studies on CRP and will show why further studies investigating the relationship between CRP and atherosclerosis might be needed.

An Investigation into the Relationship between Coronary Risk Factors and Coronary Heart Disease among the Pietermaritzburg Asian Population

1996 ◽  
Vol 26 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Timothy A. Barry ◽  
Douglas R. Wassenaar
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Asian Population ◽  
Type A ◽  
Behaviour Pattern ◽  
Coronary Risk Factors ◽  
Coronary Risk ◽  
The Relationship

This study investigated the relationship between coronary heart disease and a number of established coronary risk factors among Indian males. Included were factors such as Type A behaviour pattern (sometimes referred to as the coronary-prone behaviour pattern). The study investigated whether the following coronary risk factors were able to distinguish those with myocardial infarction from controls: Type A behaviour pattern, stress levels, anger levels, diabetes, previous coronary heart disease, hypertension, obesity, family history of coronary heart disease, physical exercise, cigarette smoking and alcohol consumption. Statistical analysis indicated that none of the risk factors, except Type A behaviour pattern, were able to significantly distinguish the myocardial infarction group from controls.

The Relationship Between Cognition and Mortality in Patients with Stroke, Coronary Heart Disease, or Cancer

2006 ◽  
Vol 11 (3) ◽  
pp. 182-195 ◽  
Author(s):  
Kaarin J. Anstey ◽  
Holly A. Mack ◽  
Chwee von Sanden
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cognitive Impairment ◽  
Health Outcomes ◽  
Cognitive Performance ◽  
Mortality Risk ◽  
Epidemiological Studies ◽  
Increased Risk ◽  
And Control ◽  
The Relationship

Numerous studies have reported an association between cognitive impairment and an increased risk for mortality. Most results are from large epidemiological studies and control for medical conditions that may relate to cognitive decline, as well as an increased mortality risk. The aim of this review was to evaluate the association between cognitive performance and mortality within patient samples of stroke, cancer, or coronary heart disease. After reviewing the PubMed literature for articles on stroke, cancer, and cardiovascular related illnesses, 47 longitudinal studies were identified that met the cognition/mortality search criteria. In general, the results demonstrated that within the clinical groups studied, cognitive performance and cognitive impairment both predict mortality, although results were less consistent for coronary heart disease. This study adds further support for the ubiquity of the association of cognitive performance with health outcomes and mortality. Optimizing health has implications for both cognitive performance and longevity.

The Preventive Effect of Alprostadil on the Contrast-Induced Nephropathy of Coronary Heart Disease Treated by Percutaneous Coronary Intervention in Moderate and High-Risk Population Stratified by Mehran Score

Angiology ◽  
2021 ◽  
pp. 000331972110155
Author(s):  
Xiaogang Liu ◽  
Peng Zhang ◽  
Jing Zhang ◽  
Xue Zhang ◽  
Shicheng Yang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
High Risk ◽  
Risk Groups ◽  
Coronary Intervention ◽  
Preventive Effect ◽  
Moderate Risk ◽  
Contrast Induced Nephropathy ◽  
Percutaneous Coronary

The Mehran risk score (MRS) was used to classify patients with coronary heart disease and evaluate the preventive effect of alprostadil on contrast-induced nephropathy (CIN) after percutaneous coronary intervention. The patients (n = 1146) were randomized into an alprostadil and control group and then divided into 3 groups on the basis of the MRS: low-risk, moderate-risk, and high-risk groups. The primary end point was the occurrence of CIN (alprostadil + hydration vs simple hydration treatment); secondary end points included serum creatinine, blood urea nitrogen, creatinine clearance rate, cystatin C, interleukin-6, C-reactive protein, proteinuria, and differences in the incidence of major adverse events. In the low-risk, moderate-risk, and high-risk groups, the incidence of CIN in the control and alprostadil group was 2.9 versus 2.6% ( P = .832), 11.4 versus 4.9% ( P = .030), 19.1 versus 7.7% ( P = .041), respectively. Multivariate logistic regression analysis showed that alprostadil treatment was a favorable protective factor for moderate-risk and high-risk CIN patients (OR = 0.343, 95% CI: 0.124-0.951, P = .040). Alprostadil can be used as a preventive treatment for moderate- and high-risk CIN patients classified by the MRS. The reduction of CIN by alprostadil may be related to an anti-inflammatory effect.

scholarly journals Statin Underuse and Low Prevalence of LDL-C Control Among U.S. Adults at High Risk of Coronary Heart Disease

2014 ◽  
Vol 348 (2) ◽  
pp. 108-114 ◽  
Author(s):  
Christopher M. Gamboa ◽  
Monika M. Safford ◽  
Emily B. Levitan ◽  
Devin M. Mann ◽  
Huifeng Yun ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
High Risk ◽  
Low Prevalence

Mortality and associated risk factors in diabetics

1985 ◽  
Vol 110 (4_Suppl) ◽  
pp. S21-S26 ◽  
Author(s):  
R. J. Jarrett ◽  
M. J. Shipley
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Mortality Risk ◽  
Mortality Rates ◽  
Potential Risk Factors ◽  
Diabetic Population ◽  
Associated Risk Factors ◽  
The Relationship

Summary. In 168 male diabetics aged 40-64 years participating in the Whitehall Study, ten-year age adjusted mortality rates were significantly higher than in non-diabetics for all causes, coronary heart disease, all cardiovascular disease and, in addition, causes other than cardiovascular. Mortality rates were not significantly related to known duration of the diabetes. The predictive effects of several major mortality risk factors were similar in diabetics and non-diabetics. Excess mortality rates in the diabetics could not be attributed to differences in levels of blood pressure or any other of the major risk factors measured. Key words: diabetics; mortality rates; risk factors; coronary heart disease. There are many studies documenting higher mortality rates - particularly from cardiovascular disease -in diabetics compared with age and sex matched diabetics from the same population (see Jarrett et al. (1982) for review). However, there is sparse information relating potential risk factors to subsequent mortality within a diabetic population, information which might help to explain the increased mortality risk and also suggest preventive therapeutic approaches. In the Whitehall Study, a number of established diabetics participated in the screening programme and data on mortality rates up to ten years after screening are available. We present here a comparison of diabetics and non-diabetics in terms of relative mortality rates and the influence of conventional risk factors as well as an analysis of the relationship between duration of diabetes and mortality risk.

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