scholarly journals Injection Therapy for Nonvariceal Gastrointestinal Bleeding

1990 ◽  
Vol 4 (9) ◽  
pp. 650-652 ◽  
Author(s):  
Paul Kortan
Keyword(s):  
High Risk Group ◽  
Controlled Trials ◽  
Recurrent Bleeding ◽  
Mortality And Morbidity ◽  
Ulcer Disease ◽  
Number Of Patients ◽  
Significant Difference ◽  
Endoscopic Sclerosis ◽  
Additional Therapy ◽  
The Ideal

Gastrointestinal hemorrhage is a common and serious problem - its average mortality of 10% has changed little over the past 40 years. In 80% of patients the bleeding stops spontaneously. In patients with continuous or recurrent bleeding (20%), mortality and morbidity are high, and emergency surgery is often required, which has a higher mortality than the same operation performed electively. Successful therapeutic endoscopic intervention in this high risk group is necessary to improve outcome. For injection treatment of nonvariceal bleeding lesions, the author has been using the Soehendra method (1:10,000 adrenaline and polidocanol) with success in 90% of actively bleeding patients. Three controlled trials of endoscopic sclerosis in bleeding peptic ulcer disease showed decreased blood transfusions, surgery and hospital stay, but did not find any significant difference in mortality. The ideal solution and the usefulness of additional therapy are questions which must be addressed via prospective controlled trials of a large number of patients.

scholarly journals Trans-bronchial lung cryobiopsy in patients at high-risk of complications

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Benjamin Bondue ◽  
Pascal Schlossmacher ◽  
Nathalie Allou ◽  
Virgile Gazaille ◽  
Olivier Taton ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Lung Biopsy ◽  
Risk Group ◽  
High Risk Group ◽  
Low Risk ◽  
Systolic Pulmonary Artery Pressure ◽  
Mortality And Morbidity ◽  
Number Of Patients ◽  
Significant Difference

Abstract Background The surgical lung biopsy (SLB) is the recommended sampling technique when the pathological analysis of the lung is required in the work-up of an interstitial lung disease (ILD) but trans-bronchial lung cryobiopsy (TBLC) is increasingly recognized as an alternative approach. As TBLCs have lower mortality and morbidity risks than SLB, this study aimed to investigate the safety of TBLCs in patients at higher risk of complications and for whom SLB was not considered as an alternative. Method This prospective study was conducted in two hospitals in which TBLCs were performed in patients with body mass index (BMI) > 35, and/or older than 75 years, and/or with severely impaired lung function (FVC < 50% or DLCO < 30%), and/or systolic pulmonary artery pressure > 45 mmHg, and/or a clinically significant cardiac disease. Patients with any of these risk factors constituted the high-risk group. Clinical outcomes were compared with those obtained in patients without these risk factors (low-risk group). Results Ninety-six patients were included between April 2015 and April 2020, respectively 38 and 58 in the high-risk or the low-risk group. No statistically significant difference was observed between both groups in terms of severity and rate of bleeding, pneumothorax, or duration of hospital stay (p value ranging from 0.419 to 0.914). Conclusion This preliminary study on a limited number of patients suggests that TBLC appears safe in those in whom lung biopsy is at high-risk of complications according to their age, BMI, lung impairment, and cardiac comorbidities.

Acoustic neuroma (schwannoma) surgery 1978–1990

1991 ◽  
Vol 105 (3) ◽  
pp. 165-173 ◽  
Author(s):  
J. E. M. Dutton ◽  
R. T. Ramsden ◽  
R. H. Lye ◽  
K. Morris ◽  
A. O. Keith ◽  
...  
Keyword(s):  
Tumour Size ◽  
Hearing Preservation ◽  
Royal Infirmary ◽  
Perioperative Mortality ◽  
Neurophysiological Mechanism ◽  
Mortality And Morbidity ◽  
Number Of Patients ◽  
Normal Functional ◽  
Unusual Type ◽  
The Ideal

AbstractA series of 151 patients with 154 acoustic schwannomas have been operated upon in Manchester Royal Infirmary by a joint Otological and Neurosurgical team, employing either the translabynnthine or the sub-occipital approach. The perioperative mortality rate was 3 per cent. Anatomical preservation of the facial nerve was achieved in 89 per cent of tumour removals and a good to normal functional result in 79 per cent of cases. Attempts at hearing preservation have been unsuccessful, largely because of the small number of patients in the series in whom useful hearing was present preoperatively. Complications included major brain stem ischaemia (1.2 per cent), CSF fistula (5 per cent) and facial dysaesthesia (7 per cent). The incidence of mortality and morbidity is directly related to tumour size and to the experience of the surgeons. A number of patients experienced an unusual type of post-operative dreamlike state which appeared to be a form of hypnagogic hallucination, and the possible neurophysiological mechanism responsible for this phenomenon is discussed. The continuing failure to attain the ideal of early diagnosis is lamented, and the importance of a flexible bidisciplinary surgical approach emphasized.

Metastases resection after FOLFIRI-aflibercept (FA) in oxaliplatin-refractory colorectal cancer patients (ORF-CRC).

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 862-862 ◽  
Author(s):  
Andres J. Muñoz Martín ◽  
Silvia Garcia Adrian ◽  
Carles Pericay ◽  
Ana Ruíz ◽  
Patricia Ibeas ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Real Life ◽  
Colorectal Metastases ◽  
Second Line ◽  
Surgical Mortality ◽  
Wild Type ◽  
Mortality And Morbidity ◽  
Number Of Patients ◽  
Significant Difference ◽  
The Impact

862 Background: Recent data suggest resection of colorectal metastases after second-line chemotherapy offers similar overall survival (OS) benefit compared to what described in first-line. The improvement in response rate with FA in second-line may increase the number of patients eventually undergo metastases resection. Methods: We performed a retrospective analysis of 32 patients from 26 Spanish hospitals who underwent surgical resection after FA in ORF-CRC in real-life setting. Our aim was to analyze the impact of metastases resection in different organs (liver, lung, etc.) in terms of OS and progression-free survival (PFS) and post-surgical mortality and morbidity. Results: Clinical characteristics: Median age: 65 years (43-83). Sex: 78.1% male, 21.9% female. ECOG 0/1 53.1/46.9%. Ras: wild-type/mutated 25/75%. Type of tumor: colon 75.0%, rectal 25.0%. Location: right 28.1%, transverse 9.4%, and left-side 62.5%. Previous treatment: oxaliplatin combinations (100%), bevacizumab 37.5%, cetuximab 21.97%. Ras wild-type patients received previous anti-EGFR therapy. FA in second-line 93.7% and beyond second-line 6.3%. Median FA cycles before surgery: 6.5 (range 3-44). Type of surgery: liver metastases 46.9%, lung metastases 25.0%, cytoreductive surgery for peritoneal carcinomatosis 15.6%, supraadrenalectomy 3.1%, simultaneous liver and peritoneal carcinomatosis 9.4%. Better tumor response with FA (RECIST1.1): partial response 56.3%, complete response 3.1%, stable disease 40.6%. Median follow-up: 20.9 months [m] (range 3.8-57.3 m). Median PFS from surgery: 8.0 m (confidence interval [CI] 95% 2.5-13.5 m). Median OS from surgery: 37.3 m (CI 95% 23.3-51.4 m). No significant difference between right and left-side tumors in OS or PFS were observed. 90-day postoperative mortality/morbidity: 18.8/0% Reoperation rate: 9.4%. Resection rates: R0 75.0%, R1 15.6%, R2 9.4%. Aflibercept after surgery: 22% patients. Conclusions: Metastases resection following FA in ORF-CRC offers encouraging OS with favorable surgical mortality and morbidity. Salvage surgery should be considered in highly selected patients in second-line setting with oligometastatic disease.

scholarly journals Role of a multidisciplinary program in improving outcomes in cognitively impaired heart failure older patients

2015 ◽  
Vol 78 (1) ◽  
Author(s):  
Donatella Del Sindaco ◽  
Giovanni Pulignano ◽  
Andrea Di Lenarda ◽  
Luigi Tarantini ◽  
Giovanni Cioffi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cognitive Impairment ◽  
Relative Effectiveness ◽  
Intervention Group ◽  
Cognitive Status ◽  
High Risk Group ◽  
Mortality And Morbidity ◽  
Entire Cohort ◽  
Multidisciplinary Program ◽  
Significant Difference

Background: Cognitive impairment (CI) frequently complicates Heart failure (HF) and is associated with increased mortality and morbidity. Previous studies reported that nurse-lead home-based multidisciplinary program (MP) may not improve the prognosis of this high-risk group. In the present study, we analysed the relative effectiveness of an integrated hospital-based MP in patients with cognitive impairment. Methods: Consecutive (n=173) community-living outpatients aged &gt;70 years (mean 77+6, 48% women) randomized to a MP (n=86) or usual care (UC) (n=87) were enrolled in stable clinical conditions. Cognitive status was assessed by means of Folstein Mini Mental State Examination (MMSE). Results: CI (MMSE&lt;24) was present in 41.6% (42,5% UC vs 40.7% MP p=ns). The variables independently associated to CI were: older age, education level &lt;5 years, anemia and severe renal dysfunction. During a 2-year follow-up, 59 patients died (31.4%) with no significant difference between intervention group. At multivariate analysis, in the entire cohort, CI was independently associated to death (HR 2,077[95%CI 1,097- 3,931]), HF admissions (2,133[1,346-3,381]), death/HF admissions (1,784[1,132-2,811]) and all-cause admissions (1,473[1,008-2,153]. When considered according to intervention groups, CI was independently associated to all-cause death (3,603 [1,553-8,358], death/HF admissions (2,029[1,200-3,432]) and HF admissions (2,474[1,406-4,353]) but not to all-cause admissions. The assignment of patients with CI to MP was associated to a significant reduction in HF admissions vs UC (0,503[0,253-0,999] (all interaction tests p=ns). Conclusions: This study suggests that CI is very common and associated to worse prognosis in heart failure and that hospital-based MP seems to improve outcomes in these patients through reduction of heart failure hospital admission.

scholarly journals Epidemiological analysis of demographic characteristics and type of injuries in patients with multiple trauma with respect to conclusive treatment outcome

2008 ◽  
Vol 136 (3-4) ◽  
pp. 136-140 ◽  
Author(s):  
Slavisa Zagorac ◽  
Marko Bumbasirevic ◽  
Aleksandar Lesic ◽  
Ivan Milosevic
Keyword(s):  
Treatment Outcome ◽  
Multiple Trauma ◽  
Traffic Accidents ◽  
Injury Severity ◽  
Injury Mechanism ◽  
Organic System ◽  
Mortality And Morbidity ◽  
Number Of Patients ◽  
Significant Difference ◽  
Presentation Methods

Introduction Multiple trauma is one of the leading causes of mortality and morbidity in the population of people under 45 years of age. The consequences of multiple trauma have huge epidemiological, social and economic significance. Objective The aim of the paper was to analyze the conclusive treatment outcome of multiply traumatized patients with respect to their sex, age, injury mechanism and type. METHOD This retrospective study included 100 patients with multiple injuries (ISS>16) treated in the Emergency Room of the Clinical Centre of Serbia in the course of 2004. Clinical, X-ray, laboratory and numerical presentation methods - scores (ISS and GCS) were used to show the injury severity. Results Most of the injured were males (80%), and the average age was 40?20 (5-83). Out of the total number of patients who died, 23 (82%) were males, and 5 (18%) were females. The average age of the patients with fatal outcomes was 48?21 (8-86). Traffic accidents were the leading cause of injury (59%). The median GCS was 10?3 (3-15). The average ISS was 30 (20-66) in the surviving patients, and 53 (27-77) in those who died. Conclusion With respect to sex, in most cases multiple trauma affects males (p<0.01), with the average age of about 40. With respect to injury mechanism, the main cause of the occurrence of multiple trauma is traffic accidents (p<0.01). There is a statistically significant difference in the values of GCS and ISS relative to the definitive outcome (p<0.01). Statistical data processing indicated that there was a statistically significant correlation between mortality and type of injury in a given organic system (p<0.01), but that there was no statistically significant correlation between mortality and age. .

scholarly journals Effects of Periosteal Elevation Before Lateral Osteotomy in Rhinoplasty: A Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 13 (3) ◽  
pp. 268-273 ◽  
Author(s):  
Ji-Sun Kim ◽  
Sun Hong Kim ◽  
Hyesook Lee ◽  
Byung Guk Kim ◽  
Se Hwan Hwang
Keyword(s):  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Subconjunctival Hemorrhage ◽  
Randomized Controlled ◽  
Eyelid Edema ◽  
Lateral Osteotomy ◽  
Rigorous Research ◽  
Number Of Patients ◽  
Significant Difference

Objectives. Although osteotomy is an important part of rhinoplasty, it is known to be closely related to postoperative eyelid edema and ecchymosis. We aimed to evaluate the effects of periosteal elevation prior to osteotomy on eyelid edema and ecchymosis.Methods. Two authors reviewed studies in the Medline, Scopus, and Cochrane databases published through May 2019. Randomized controlled trials comparing periosteal elevation (subperiosteal tunneling) with periosteal preservation that reported eyelid edema or ecchymosis or subconjunctival hemorrhage as outcomes of interest were included. From each study, the baseline characteristics of the study subjects, the quality of the study, the number of patients in the treatment and control groups, and outcomes were extracted.Results. Data for meta-analysis were identified in six studies with a total of 208 patients. Eyelid ecchymosis and edema within 3 days postoperatively were significantly more common in the periosteal elevation group than in the preservation group, although such an association was not found for edema on postoperative day 7 (standardized mean difference [SMD], 0.21; 95% confidence interval [CI], –0.09 to 0.50; I<sup>2</sup> =0%). There was no significant difference in subconjunctival hemorrhage on day 1 (SMD, 0.31; 95% CI, –0.09 to 0.72; I<sup>2</sup> =0%).Conclusion. Periosteal preservation during lateral osteotomy may reduce eyelid edema and ecchymosis compared to periosteal elevation. Further studies with rigorous research methods should be carried out to determine the effectiveness of different techniques in lateral osteotomy.

scholarly journals Separation and pain perception of Elastomeric, Kesling and Kansal separators

2019 ◽  
Vol 24 (2) ◽  
pp. 42-48
Author(s):  
Tulika Tripathi ◽  
Navneet Singh ◽  
Priyank Rai ◽  
Neha Khanna
Keyword(s):  
Pain Perception ◽  
The Other ◽  
Single Patient ◽  
Number Of Patients ◽  
Significant Difference ◽  
Different Types ◽  
Maximum Pain ◽  
Single Blind ◽  
Optimum Separation ◽  
The Ideal

Abstract Introduction: Various types of separators have been advocated, but the ideal separator should produce optimum separation with minimal pain and discomfort. Objective: The objective of this study was to evaluate and compare the amount of separation achieved by three different types of separators (Elastomeric, Kesling and Kansal), and to assess the associated pain and discomfort. Methods: A random single-blind split-mouth study was conducted on 108 patients seeking fixed orthodontic treatment, in which two different separators were used on each side in both the arches for a single patient. After five days, the amount of separation was measured with a feeler gauge. Visual Analogue Scale (VAS) scoring was performed by the patient on each day, to evaluate pain perception. Discomfort was evaluated by questionnaire filled by the patient at the time of separator removal. Results: The greatest amount of separation was seen with the elastomeric separators, while the smallest separation was seen with Kansal separators. VAS scoring showed maximum pain at day 1 with all the three separator types. Highest pain was perceived in the Elastomeric separators group, followed by Kesling and Kansal separators, respectively. Statistically significant difference was found in VAS score of Elastomeric separators, when compared to both Kesling and Kansal, on day 1 and 2 (p= 0.001). Analysis of the questionnaires revealed that a greater number of patients experienced discomfort with elastomeric separators placement (69.4%), which was statistically significant (p< 0.01) when compared to the other two types of separators. Answers to the other questions were comparable, except for the need for medications, which was reportedly highest with elastomeric separators. Conclusion: Kesling separators produce adequate separation with minimal discomfort and pain, compared to Elastomeric and Kansal separators.

scholarly journals Bleeding oesophageal varices: Therapeutic options

2007 ◽  
Vol 54 (1) ◽  
pp. 139-144
Author(s):  
A.R. Pavlovic ◽  
M.N. Krstic ◽  
S. Djuranovic ◽  
D. Popovic ◽  
I. Jovanovic ◽  
...  
Keyword(s):  
Esophageal Varices ◽  
Oesophageal Varices ◽  
Recurrent Bleeding ◽  
Endoscopic Sclerotherapy ◽  
Absolute Alcohol ◽  
Esophageal Variceal Bleeding ◽  
Vasoactive Substances ◽  
Bleeding Esophageal Varices ◽  
Number Of Patients ◽  
Additional Therapy

Introduction: Emergency endoscopy plays the most important role in diagnosis and treatment of patients with esophageal variceal bleeding. Endoscopic sclerotherapy (EST), placement of esophageal band ligatures (EVL), medicamentous treatment using somatostatin and its derivatives and balloon tamponade are the methods most frequently applied in treatment of the bleeding esophageal varices. Patients and methods: Endoscopic reports on the patients with bleeding esophageal and gastric varices were retrospectively analyzed in the emergency unit of the Clinic of Gastroenterology and Hepatology, Clinical Center of Serbia over the five-year period - since January 2001 till December 2005. Results: The total of approximately 3, 954 emergency upper endoscopies were performed due to the upper gastrointestinal tract bleeding. Out of the total number of patients, bleeding was diagnosed in 324 (8.2%) patients due to the esophageal varices. In the group of patients with bleeding esophageal varices, the total of 252 (77.8%) males and 72 (22.2%) females averagely aged 56.8+7.5 years (range 24 - 80 years) were examined. The primary sclerosant therapy with absolute alcohol was applied in 118 (36.4%) patients, while Blakemore probe tamponade was performed in 145 (44.8%) patients with bleeding esophageal varices. The total of 240 (74.1%) patientswere treated with vasoactive substances (somatostatin and its analogues), as additional therapy and control of the primary hemostasis. It was evidenced that out of 118 patients intra and paravariceally treated with the sclerosant agent (absolute alcohol) hemostasis was achieved in 47 (39.8%). Out of 145 patients subjected to Blakemore probe placement, bleeding was successfully arrested in 117 (80.7%) patients. Somatostatin and its analogues as primary and only treatment of the bleeding esophageal varices were applied in 71 (29.6%) patients, while in the remaining 169 (70.4%) patients, they were applied as additional therapy to the endoscopic sclerotherapy and mechanical treatment of bleeding. Out of 71 patients treated with somatostatin preparations as the only therapeutic option, 45 (63.4%) responded positively by arrest of bleeding for 72 hours. Conclusion: Treatment of the acute bleeding esophageal varices is focused on the arrest of bleeding, prevention of early recurrent bleeding and reduction of mortality. Based on the most recent studies, efficacy of the modern endoscopic therapy in the form of sclerotherapy and band ligature placement, as well as application of vasoactive substances reaches up to 90%. Our results evidence minimal efficacy of the sclerotherapy (approximately 40%), which indicates the need of better preparation of patients for the intervention itself and additional education of the personnel.

scholarly journals The pandemic of COVID-19 decreased adherence to treatment among hypertension patients at Dr. Zainoel Abidin Hospital

2021 ◽  
Vol 1 (2) ◽  
pp. 58-65
Author(s):  
Ghina Salsabila Rahman ◽  
Muhammad Ridwan ◽  
Hilwah Nora ◽  
Maimun Syukri ◽  
Fitri Dewi Ismida
Keyword(s):  
Treatment Adherence ◽  
Patient Adherence ◽  
Positive Association ◽  
Bivariate Analysis ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Mortality And Morbidity ◽  
Number Of Patients ◽  
Significant Difference

Hypertension is one of the leading causes of mortality and morbidity worldwide. Treatment adherence is an essential factor in controlling blood pressure among hypertensive patients. This study aimed to evaluate the effect of the Coronavirus disease 2019 (COVID-19) pandemic on treatment adherence among hypertensive patients at Dr. Zainoel Abidin Hospital, Aceh, Indonesia, as well as to determine its associated factors. A cross-sectional study was conducted at the Cardiac Center by utilizing medical records of hypertensive patients visiting during the period of April-July 2019 and December 2020-March 2021. Bivariate analysis using the Kruskal-Wallis test was employed to examine the effect of the COVID-19 pandemic on patients’ adherence. The results showed that the number of patients adhering to treatment significantly decreased (p=0.000) by 22.7%, from 179 patients in 2019 to 64 patients in 2020. The data also suggested a significant positive association between residential and patient adherence before the pandemic (p=0.006); however, no significant difference was observed between residential and patients’ adherence after the pandemic (p=0.282). Furthermore, our study found no association between age and adherence before and after the pandemic (p=0.690 in 2019 and p=0.125 in 2020). In conclusion, the pandemic of COVID-19 significantly affected treatment adherence among patients with hypertension at Aceh provincial hospital, with a decreased number in patient visits up to 22.7%.  

Perbedaan sensitivitas tetes telinga antibiotik terhadap Pseudomonas aeruginosa pada otitis media supuratif kronik

2012 ◽  
Vol 42 (2) ◽  
Author(s):  
Anton Budhi Darmawan ◽  
Dwi Utami Anjarwati
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Otitis Media ◽  
Chronic Suppurative Otitis Media ◽  
Test Results ◽  
Sectional Study ◽  
Suppurative Otitis Media ◽  
Number Of Patients ◽  
Significant Difference ◽  
Cochran Test ◽  
Post Hoc

Background: Chronic suppurative otitis media (CSOM) is one infectious disease of the middle ear, most commonly caused by Pseudomonas aeruginosa. A high number of patients come to the ENT outpatient clinic with active benign type of CSOM. The bacteria Pseudomonas aeruginosa is capable of producing biofilm which protects itself from penetration of antibiotics, and therefore creates resistance towards antibiotics and difficult to eradicate. Objective: The aim of this study was to compare the sensitivity levels of chloramphenicol, polymyxin-neomycin, cyprofloxacin and ofloxacine against Pseudomonas aeruginosa in patients with active benign type CSOM in ENT clinic. Method: The method used was across sectional study on 25 patients, from August 2010 until December 2010. Samples were taken withear swab and then put on sensitivity test to chloramphenicol, polymyxin-neomycin, cyprofloxacin andofloxacine using the diffusion disc method. The analysis used in this study was Cochran test. Results: Results showed a significant difference in sensitivity among chloramphenicol (38,70%), polymyxinneomycin(83,87%),cyprofloxacin(90,32%)andofloxacin(58,06%)withp=0,000(p<0,05).PostHocanalysisusing the Mc Nemar indicated that there were significant differences in sensitivity betweenpolymyxin-neomycin to chloramphenicol with p=0,000 (p<0,05), ciprofloxacin to chloramphenicol andciprofloxacin to ofloxacine with p= 0,002, but there were no significant differences between cyprofloxacinto polymyxin-neomycin with p=0,687, polymyxin-neomycin to ofloxacin p=0.057 and ofloxacin tochloramphenicol p=0,109.   There were significant differences in antibiotic ear dropssensitivity to Pseudomonas aeruginosa in patients with active benign type of CSOM. Cyprofloxacin andpolymyxin-neomycin were more sensitive than ofloxacin and chloramphenicol. Keywords: Pseudomonas aeruginosa, active benign type of chronic suppurative otitis media, antibioticear drops.  Abstrak :  Latar belakang: Otitis media supuratif kronik (OMSK) merupakan penyakit infeksi kronik telinga tengah yang sering dijumpai di klinik THT. Penyebab tersering OMSK adalah bakteri Pseudomonasaeruginosa. Pseudomonas aeruginosa mempunyai kemampuan untuk membentuk biofilm yangmelindunginya dari penetrasi antibiotik sehingga menimbulkan resistensi terhadap antibiotik dan sulituntuk eradikasinya. Tujuan: Untuk mengetahui perbandingan tingkat sensitivitas kloramfenikol,polimiksin-neomisin, ciprofloksasin dan ofloksasin terhadap isolat Pseudomonas aeruginosa padapasien OMSK benigna aktif di klinik THT RSMS. Metode: Metode yang digunakan adalah crosssectional terhadap 29 pasien OMSK di klinik THT RSMS periode bulan Agustus 2010 - Desember2010. Pengambilan sampel dilakukan dengan swab telinga. Uji sensitivitas terhadap kloramfenikol,polimiksin-neomisin, ciprofloksasin dan ofloksasin dilakukan dengan metode cakram secara difusi.Analisis yang digunakan dalam penelitian ini adalah Cochran dan analisis post hoc. Hasil: Didapatkansensitivitas kloramfenikol sebesar 38,70%, polimiksin-neomisin sebesar 83,87%, ciprofloksasin sebesar90,32% dan ofloksasin sebesar 58,06% dengan p=0,01 (P<0,05), yang menunjukkan adanya perbedaansensitivitas yang bermakna antara kloramfenikol, polimiksin-neomisin, ciprofloksasin dan ofloksasinterhadap Pseudomonas aeruginosa. Analisis post hoc menggunakan Mc Nemar menunjukkan bahwaterdapat perbedaan sensitivitas yang bermakna antara tetes telinga polimiksin-neomisin terhadapkloramfenikol, dan ciprofloksasin terhadap kloramfenikol p=0,000 (p<0,05), serta terdapat perbedaanyang bermakna antara tetes telinga ciprofloksasin terhadap ofloksasin, p=0,002, tetapi tidak terdapatperbedaan yang bermakna antara ciprofloksasin terhadap polimiksin-neomisin, p=0,687, polimiksinneomisinterhadap ofloksasin p=0,057, dan kloramfenikol terhadap ofloksasin p=0,109. Kesimpulan:Terdapat perbedaan sensitivitas yang bermakna tetes telinga antibiotik terhadap Pseudomonas aeruginosa pada pasien OMSK benigna aktif. Ciprofloksasin dan polimiksin-neomisin tetes telinga mempunyai sensitivitas yang lebih baik dibanding ofloksasin dan kloramfenikol. Kata kunci: Pseudomonas aeruginosa, otitis media supuratif kronik, tetes telinga antibiotik 

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