Cellular mechanisms of inorganic phosphate transport in kidney

1986 ◽  
Vol 66 (1) ◽  
pp. 36-70 ◽  
Author(s):  
P. Gmaj ◽  
H. Murer
Keyword(s):  
Inorganic Phosphate ◽  
Phosphate Transport ◽  
Cellular Mechanisms

scholarly journals The Complexities of Organ Crosstalk in Phosphate Homeostasis: Time to Put Phosphate Sensing Back in the Limelight

2021 ◽  
Vol 22 (11) ◽  
pp. 5701
Author(s):  
Lucile Figueres ◽  
Sarah Beck-Cormier ◽  
Laurent Beck ◽  
Joanne Marks
Keyword(s):  
Molecular Mechanisms ◽  
Dominant Role ◽  
Fibroblast Growth Factor 23 ◽  
Hormone Secretion ◽  
Phosphate Transport ◽  
Phosphate Homeostasis ◽  
Cellular Mechanisms ◽  
Exact Function ◽  
Phosphate Sensing ◽  
Significant Research

Phosphate homeostasis is essential for health and is achieved via interaction between the bone, kidney, small intestine, and parathyroid glands and via intricate processes involving phosphate transporters, phosphate sensors, and circulating hormones. Numerous genetic and acquired disorders are associated with disruption in these processes and can lead to significant morbidity and mortality. The role of the kidney in phosphate homeostasis is well known, although it is recognized that the cellular mechanisms in murine models and humans are different. Intestinal phosphate transport also appears to differ in humans and rodents, with recent studies demonstrating a dominant role for the paracellular pathway. The existence of phosphate sensing has been acknowledged for decades; however, the underlying molecular mechanisms are poorly understood. At least three phosphate sensors have emerged. PiT2 and FGFR1c both act as phosphate sensors controlling Fibroblast Growth Factor 23 secretion in bone, whereas the calcium-sensing receptor controls parathyroid hormone secretion in response to extracellular phosphate. All three of the proposed sensors are expressed in the kidney and intestine but their exact function in these organs is unknown. Understanding organ interactions and the mechanisms involved in phosphate sensing requires significant research to develop novel approaches for the treatment of phosphate homeostasis disorders.

Sodium, potassium, and intestinal transport of glucose, l-tyrosine, phosphate, and calcium

1963 ◽  
Vol 205 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Harold E. Harrison ◽  
Helen C. Harrison
Keyword(s):  
Small Intestine ◽  
Calcium Transport ◽  
Inorganic Phosphate ◽  
Choline Chloride ◽  
Sodium Concentration ◽  
Phosphate Transport ◽  
Metabolic Energy ◽  
Transport Systems ◽  
Bicarbonate Buffer ◽  
Distal Small Intestine

Everted loops of rat small intestine were incubated in media varying in their concentrations of sodium and potassium. Reduction of sodium concentration was effected by substitution of choline chloride in equimolar amounts for sodium chloride in the saline-bicarbonate buffer. Concentrative transport of glucose, l-tyrosine, inorganic phosphate, and calcium was measured by determination of the final ratio of the concentrations of the solute in serosal and mucosal fluids, and the increment of the solute in serosal fluid during incubation. Ca45 was used as an indicator of calcium distribution. The glucose, l-tyrosine, and inorganic phosphate transport systems require sodium, and at a submaximal concentration of sodium an increased concentration of potassium is inhibitory. The calcium transport system does not require sodium and in loops from the distal small intestine calcium transport is enhanced by reduction of sodium concentration in the medium. It is postulated that there is a common sodium-requiring system which is necessary for the linkage of metabolic energy to glucose, amino acid, and inorganic phosphate transport.

HOMEOSTATIC ADJUSTMENT IN THE RENAL TUBULAR TRANSPORT OF INORGANIC PHOSPHATE IN THE DOG

1955 ◽  
Vol 33 (1) ◽  
pp. 638-650 ◽  
Author(s):  
James G. Foulks
Keyword(s):  
Inorganic Phosphate ◽  
Renal Tubule ◽  
Phosphate Transport ◽  
Sodium Sulphate ◽  
Tubular Transport ◽  
Renal Tubular Transport ◽  
Transport Of Inorganic Phosphate ◽  
Renal Tubular ◽  
Filtered Load

By means of the infusion of small amounts of sodium sulphate it has been possible to elevate the filtered load of inorganic phosphate to the renal tubule in fasted dogs without the administration of exogenous phosphate. Under these circumstances, the reabsorption of phosphate remains virtually complete, even when filtered loads are reached which result in a substantial phosphaturia when phosphate has been administered. By comparing phosphate reabsorption and excretion in fasted animals, and in animals at various intervals after feeding, the existence of homeostatic adjustments in the renal tubular transport of inorganic phosphate has been demonstrated. The available evidence suggests that the intracellular disposition of phosphate itself may be an important factor in determining the rate of renal tubular phosphate transport at filtered loads in the physiological range. The limitations of the determination of the phosphate "Tm" as a device for studying homeostatic processes have been discussed.

Does Availability of Inorganic Phosphate Regulate Cellular Oxidative Metabolism?

Physiology ◽  
1986 ◽  
Vol 1 (3) ◽  
pp. 100-103 ◽  
Author(s):  
PC Brazy ◽  
LJ Mandel
Keyword(s):  
Solute Transport ◽  
Oxidative Metabolism ◽  
Inorganic Phosphate ◽  
Phosphate Transport ◽  
Renal Tubules ◽  
Metabolic Processes

Cells require inorganic phosphate for formation of ATP and a variety of other metabolic and transport functions. Studies of renal tubules indicate that availability of phosphate does regulate rates of oxidative metabolism and solute transport, that intracellular metabolic processes compete for inorganic phosphate, and that transepithelial phosphate transport provides inorganic phosphate for use within the cell.

HOMEOSTATIC ADJUSTMENT IN THE RENAL TUBULAR TRANSPORT OF INORGANIC PHOSPHATE IN THE DOG

1955 ◽  
Vol 33 (4) ◽  
pp. 638-650 ◽  
Author(s):  
James G. Foulks
Keyword(s):  
Inorganic Phosphate ◽  
Renal Tubule ◽  
Phosphate Transport ◽  
Sodium Sulphate ◽  
Tubular Transport ◽  
Renal Tubular Transport ◽  
Transport Of Inorganic Phosphate ◽  
Renal Tubular ◽  
Filtered Load

By means of the infusion of small amounts of sodium sulphate it has been possible to elevate the filtered load of inorganic phosphate to the renal tubule in fasted dogs without the administration of exogenous phosphate. Under these circumstances, the reabsorption of phosphate remains virtually complete, even when filtered loads are reached which result in a substantial phosphaturia when phosphate has been administered. By comparing phosphate reabsorption and excretion in fasted animals, and in animals at various intervals after feeding, the existence of homeostatic adjustments in the renal tubular transport of inorganic phosphate has been demonstrated. The available evidence suggests that the intracellular disposition of phosphate itself may be an important factor in determining the rate of renal tubular phosphate transport at filtered loads in the physiological range. The limitations of the determination of the phosphate "Tm" as a device for studying homeostatic processes have been discussed.

A putative membrane protein, Pho88p, involved in inorganic phosphate transport in

1996 ◽  
Vol 251 (5) ◽  
pp. 580 ◽  
Author(s):  
Chulee Yompakdee ◽  
Nobuo Ogawa ◽  
Satoshi Harashima ◽  
Y. Oshima
Keyword(s):  
Membrane Protein ◽  
Inorganic Phosphate ◽  
Phosphate Transport ◽  
Putative Membrane Protein

How Renal Phosphate Transport Is Regulated

Physiology ◽  
1987 ◽  
Vol 2 (2) ◽  
pp. 45-48
Author(s):  
H Murer ◽  
M Kerstin
Keyword(s):  
Protein Synthesis ◽  
Inorganic Phosphate ◽  
Apical Membrane ◽  
Phosphate Transport ◽  
Short Term ◽  
Transcellular Transport ◽  
Sodium Dependent ◽  
Transport Of Inorganic Phosphate ◽  
Cotransport System

Transcellular transport of inorganic phosphate (Pi) in the renal proximal tubule is sodium dependent. The entry step across the apical membrane involves a Na-Pi cotransport system and is subject to short-term and long-term regulation. This regulation can be protein synthesis independent (short term) as well as protein synthesis dependent (long term).

Sign in / Sign up

Export Citation Format

Share Document