scholarly journals The Sleep-Immune Crosstalk in Health and Disease

2019 ◽  
Vol 99 (3) ◽  
pp. 1325-1380 ◽  
Author(s):  
Luciana Besedovsky ◽  
Tanja Lange ◽  
Monika Haack
Keyword(s):  
Immune System ◽  
Sleep Duration ◽  
Time Course ◽  
Future Research ◽  
Low Grade ◽  
Immune Functions ◽  
Short Sleep Duration ◽  
Immune Parameters ◽  
Immune System Activation ◽  
Health And Disease

Sleep and immunity are bidirectionally linked. Immune system activation alters sleep, and sleep in turn affects the innate and adaptive arm of our body’s defense system. Stimulation of the immune system by microbial challenges triggers an inflammatory response, which, depending on its magnitude and time course, can induce an increase in sleep duration and intensity, but also a disruption of sleep. Enhancement of sleep during an infection is assumed to feedback to the immune system to promote host defense. Indeed, sleep affects various immune parameters, is associated with a reduced infection risk, and can improve infection outcome and vaccination responses. The induction of a hormonal constellation that supports immune functions is one likely mechanism underlying the immune-supporting effects of sleep. In the absence of an infectious challenge, sleep appears to promote inflammatory homeostasis through effects on several inflammatory mediators, such as cytokines. This notion is supported by findings that prolonged sleep deficiency (e.g., short sleep duration, sleep disturbance) can lead to chronic, systemic low-grade inflammation and is associated with various diseases that have an inflammatory component, like diabetes, atherosclerosis, and neurodegeneration. Here, we review available data on this regulatory sleep-immune crosstalk, point out methodological challenges, and suggest questions open for future research.

594 Sleep Trajectories Between the Age of 2 and 5 are Associated with Blood Cytokine Levels at Age 5 in the EDEN Birth-Cohort Study

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A234-A234
Author(s):  
Masihullah Radmanish ◽  
Olfa Khalfallah ◽  
Nicolas Glaichenhaus ◽  
Anne Forhan ◽  
Barbara Heude ◽  
...  
Keyword(s):  
Immune System ◽  
Birth Cohort ◽  
Sleep Duration ◽  
Independent Study ◽  
Tnf Alpha ◽  
Low Grade ◽  
Reference Trajectory ◽  
Night Sleep ◽  
Ifn Gamma ◽  
Immune System Activation

Abstract Introduction There is a reciprocal interaction between sleep and the immune system. Activation of the immune system changes the quality of sleep, and sleep regulates innate and adaptive immune responses. While these interactions have been studied in adults and adolescents, only a few studies have focused on school age children and none on preschoolers. Here, we have studied the association between night sleep trajectories between the age of 2 and 5 and serum levels of four cytokines in 5-year-old children. Methods A total of 687 children (44% girls) from the EDEN French birth cohort were included. Information on night sleep trajectories between 2 and 5 was available in all included individuals, as well as the levels of Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, interferon gamma (IFN-gamma), and IL-10 in 5-year-old children. The associations between sleep trajectories and cytokines were assessed by multivariate linear regressions adjusted for socioeconomic, familial, maternal, perinatal and child factors. Results A shorter sleep duration trajectory (<10h/night, 4.5% of children) was associated with higher levels of IL-6 when compared to the reference trajectory (≈11h30/night, 37.4% of children). A longer sleep duration trajectory (≥11h3/night, 40.9% of children) was associated with higher levels of IL-10. A changing sleep duration trajectory (≥11h30/night followed by 10h30/night, 5.6% of children) was associated with increased levels of TNF-alpha. No statically significant association was observed between sleep duration trajectories and IFN-gamma. Conclusion This first longitudinal study in preschoolers demonstrates an association between sleep duration trajectories and blood levels of IL-6, IL-10 and TNF-alpha. While association does not imply causation, our results are compatible with an impact of sleep duration on low-grade inflammation in preschool children. Should our results be replicated in an independent study sample, it would pave the way for a better understanding of the interactions between sleep and the immune system. Support (if any):

scholarly journals Impact of Dietary Flavanols on Microbiota, Immunity and Inflammation in Metabolic Diseases

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 850
Author(s):  
María Ángeles Martín ◽  
Sonia Ramos
Keyword(s):  
Immune System ◽  
Fruits And Vegetables ◽  
Metabolic Diseases ◽  
Nuclear Factor Κb ◽  
Low Grade ◽  
Beneficial Effects ◽  
Health And Disease ◽  
Immunological Reactions ◽  
And Function ◽  
Positive Properties

Flavanols are natural occurring polyphenols abundant in fruits and vegetables to which have been attributed to beneficial effects on health, and also against metabolic diseases, such as diabetes, obesity and metabolic syndrome. These positive properties have been associated to the modulation of different molecular pathways, and importantly, to the regulation of immunological reactions (pro-inflammatory cytokines, chemokines, adhesion molecules, nuclear factor-κB [NF-κB], inducible enzymes), and the activity of cells of the immune system. In addition, flavanols can modulate the composition and function of gut microbiome in a prebiotic-like manner, resulting in the positive regulation of metabolic pathways and immune responses, and reduction of low-grade chronic inflammation. Moreover, the biotransformation of flavanols by gut bacteria increases their bioavailability generating a number of metabolites with potential to affect human metabolism, including during metabolic diseases. However, the exact mechanisms by which flavanols act on the microbiota and immune system to influence health and disease remain unclear, especially in humans where these connections have been scarcely explored. This review seeks to summarize recent advances on the complex interaction of flavanols with gut microbiota, immunity and inflammation focus on metabolic diseases.

scholarly journals Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 699
Author(s):  
Cielo García-Montero ◽  
Oscar Fraile-Martínez ◽  
Ana M. Gómez-Lahoz ◽  
Leonel Pekarek ◽  
Alejandro J. Castellanos ◽  
...  
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Mediterranean Diet ◽  
Inflammatory Disorder ◽  
Immune Functions ◽  
Treatment And Prevention ◽  
Nutritional Components ◽  
Westernized Diet ◽  
Prevention And Health Promotion ◽  
Health And Disease

The most prevalent diseases of our time, non-communicable diseases (NCDs) (including obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising worldwide. All of them share the condition of an “inflammatory disorder”, with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have in common malnutrition related to physiopathology. In this context, diet is the greatest modulator of immune system–microbiota crosstalk, and much interest, and new challenges, are arising in the area of precision nutrition as a way towards treatment and prevention. It is a fact that the westernized diet (WD) is partly responsible for the increased prevalence of NCDs, negatively affecting both gut microbiota and the immune system. Conversely, other nutritional approaches, such as Mediterranean diet (MD), positively influence immune system and gut microbiota, and is proposed not only as a potential tool in the clinical management of different disease conditions, but also for prevention and health promotion globally. Thus, the purpose of this review is to determine the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.

scholarly journals Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiuqing Zhu ◽  
Jinqing Hu ◽  
Shuhua Deng ◽  
Yaqian Tan ◽  
Chang Qiu ◽  
...  
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Citation Analysis ◽  
Mood Disorders ◽  
Bibliometric Analysis ◽  
The United States ◽  
Kynurenine Pathway ◽  
Current Status ◽  
Future Research ◽  
Low Grade

Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system.Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field.Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16).Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, “quinolinic acid.” All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analysis revealed that the top four most important research focuses were “kynurenine pathway,” “psychoneuroimmunology,” “indoleamine 2,3-dioxygenase,” and “proinflammatory cytokines,” and the most recent focus was “gut-brain axis,” thus indicating the role of the KP in bridging the GM and the host immune system, and together reflecting the field’s research foundations. Overlap analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics “Alzheimer’s disease,” “prefrontal cortex,” and “acid,” were research frontiers.Conclusion: This comprehensive bibliometric study provides an updated perspective on research associated with the KP in MD, with a focus on the current status of GM research in this field. This perspective may benefit researchers in choosing suitable journals and collaborators, and aid in the further understanding of the field’s hotspots and frontiers, thus facilitating future research.

scholarly journals Comparisons of lung and gluteus transcriptome profiles between yaks at different ages

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jin-Wei Xin ◽  
Zhi-Xin Chai ◽  
Cheng-Fu Zhang ◽  
Qiang Zhang ◽  
Yong Zhu ◽  
...  
Keyword(s):  
Immune System ◽  
Immune Function ◽  
Muscle Injury ◽  
Tibet Plateau ◽  
Immune Functions ◽  
Immune System Activation ◽  
System Activation ◽  
Qinghai Tibet Plateau ◽  
Activation Status

Abstract The yak, Bos grunniens, is the only large mammal in the Qinghai-Tibet Plateau and has been bred to provide meat, milk, and transportation. Previous studies indicate that the immune system contributes to the yak’s adaptation to high-altitude environments. In order to further investigate changes in immune function during yak development, we compared the transcriptome profiles of gluteus and lung tissues among yaks at 6, 30, 60, and 90 months of age. Analyses of significantly differentially expressed genes (DEGs) in lung tissues revealed that immune function was more activated at 6-months and less activated at 90-months than in the 30 and 60-month-old animals. DEG exploration in gluteal tissues revealed that immune functions were more highly activated at both 6 and 90-months, compared with 30 and 60-months. Immune system activation in the muscle and lung tissues of 30-month-old yaks may increase their resistance to infections, while decreased may be due to aging. Furthermore, the higher immune activation status in the gluteal tissues in 90-month-old yaks could be due to muscle injury and subsequent regeneration, which is supported by the fact that 5 unigenes related with muscle injury and 3 related to muscle regeneration displayed greater expression levels at 90-months than at 30 and 60-months. Overall, the present study highlights the important role of the immune system in yak development, which will facilitate future investigations.

scholarly journals 1086 Non-Linear Associations Between Depression and Sleep Duration in an International Sample of 16,997 Respondents

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A413-A413
Author(s):  
A M Bender ◽  
R Babins-Wagner ◽  
A Laughton
Keyword(s):  
Sleep Duration ◽  
The United States ◽  
Future Research ◽  
Short Sleep Duration ◽  
Major Depressive ◽  
Convenience Sample ◽  
High Prevalence ◽  
Prevalence Of Depression ◽  
Long Sleep ◽  
Age Range

Abstract Introduction Abnormal sleep duration is common in people with depression and can be both a risk-factor and a symptom of depression. Here we determine the prevalence of depression likelihood and assess associations between long and short sleep duration in an international convenience sample. Methods N=16,997 respondents (age range: 8-98y, mean age 39.7y ±13.1 SD; 43% female) completed the 10-item Harvard Department of Psychiatry National Depression Screening Day Scale (HANDS) online from October 7 to October 13, 2019. Higher total scores on the HANDS indicate higher likelihood of major depressive episode with scores >8 indicate the presence of a major depressive disorder is likely. Additional questions were added to the survey including the question “During the past two weeks, how many hours of actual sleep did you average at night?” Answer choices ranged from “less than 5 hours” to “more than 10h” in half-hour increments. Results Respondents came from 115 different countries with the majority of respondents from Canada (48%) and the United States (38%). Sixty-four percent of the sample were recommended for further evaluation for depression. Of those recommended, 66% reported <7h of sleep per night and 3% reported >9h. Those who reported 7-9h of sleep per night had the lowest depression scores (9.2 points) compared to those who reported <7h (11.8 points) and >9h (13.7 points), F(2,15366)=434.81, p<0.001. The amount of sleep associated with the lowest depression scores was 7.5h (8.6 points) with <5h associated with the highest depression scores (15.5 points). Conclusion We found a high prevalence of depression likelihood in 64% of an international convenience sample, with 69% of those not meeting the recommended 7-9h of sleep per night. Both short and long sleep were associated with higher levels of depression with 7.5h of sleep associated with the lowest depression scores. Future research on depression should focus on sleep interventions aimed at improving both short and long sleep duration. Support N/A.

scholarly journals Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease

2013 ◽  
Vol 4 (1) ◽  
pp. 53-64 ◽  
Author(s):  
Alexandra Montagner ◽  
Walter Wahli
Keyword(s):  
Skin Diseases ◽  
Acne Vulgaris ◽  
Receptor Expression ◽  
Future Research ◽  
Low Grade ◽  
Peroxisome Proliferator ◽  
Inflammatory Skin Diseases ◽  
Skin Wound Healing ◽  
Peroxisome Proliferator Activated Receptor ◽  
Health And Disease

AbstractAmong the three peroxisome proliferator-activated receptor (PPAR) transcription factors, PPARβ/δ is the isotype with the broadest expression pattern. In fact, the expression of PPARβ/δ is ubiquitous, albeit at levels that are tightly regulated. Herein, we reviewed its multiple functions in skin health and disease. PPARβ/δ has pro-differentiating effects in keratinocytes, regulates sebocyte differentiation, and promotes hair follicle growth in healthy skin. Furthermore, we reviewed novel insights into the roles of PPARβ/δ in skin wound healing, especially in inhibiting apoptosis and in modulating keratinocyte proliferation and migration. Therefore, PPARβ/δ represents a research target for the understanding and treatment of inflammatory skin diseases, such as psoriasis and acne vulgaris. In addition, PPARβ/δ is a tumor growth modifier. Epidemiological studies have established that tumor progression may be exacerbated by chronic low-grade inflammation, a condition promoting the production of the lipids that act as modulators of PPARβ/δ activity. The action of PPARβ/δ in skin cancer is ambivalent, which might be explained by this receptor’s putative highly context-specific behavior, which depends on a combination of factors ranging from receptor expression levels to co-regulator distribution, diversity and activity of the ligands produced, and other tissue-specific conditions. Given its diverse and crucial roles in many tissues and organs, PPARβ/δ will remain a major focus of future research.

scholarly journals Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Yueh-Hsia Luo ◽  
Louis W. Chang ◽  
Pinpin Lin
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Chemical Properties ◽  
Immune Functions ◽  
Adaptive Immune ◽  
Immune System Activation ◽  
Potential Applications ◽  
System Activation ◽  
Physical And Chemical ◽  
Biological And Medical Applications

Nanomaterials, including metal-based nanoparticles, are used for various biological and medical applications. However, metals affect immune functions in many animal species including humans. Different physical and chemical properties induce different cellular responses, such as cellular uptake and intracellular biodistribution, leading to the different immune responses. The goals of this review are to summarize and discuss the innate and adaptive immune responses triggered by metal-based nanoparticles in a variety of immune system models.

Somatic symptoms and high-sensitive C-reactive protein in major depression

2011 ◽  
Vol 26 (S2) ◽  
pp. 615-615
Author(s):  
G. Camardese ◽  
G. Pizi ◽  
B. Leone ◽  
L. De Risio ◽  
B. Mattioli ◽  
...  
Keyword(s):  
Immune System ◽  
Immune Activation ◽  
Gastrointestinal Symptoms ◽  
Somatic Symptoms ◽  
Sickness Behavior ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Immune System Activation ◽  
Hs Crp

AimHigh-sensitive C-reactive protein (hs-CRP) has been used to assess low-grade immune system activation. In a population-based cohort hs-CRP was associated with functional somatic symptoms (SS), particularly with general and musculoskeletal functional SS clusters.Immune system dysregulation has also been reported in depression that is frequently associated to a high burden of SS.We investigated the correlation between hs-PCR and SS in depressed patients.Methods123 outpatients (M/F = 58/65; mean age 48,6 ± 14,8) during a Major Depressive Episode were recruited at the Institute of Psychiatry of the Catholic University in Rome. Severity of depression was assessed with the HAM-D scale. The somatization factor of the HAM-D (somatic anxiety, gastrointestinal symptoms, general somatic symptoms, hypochondria, weight loss) measured SS burden. A blood sample was collected to determine hs-CRP.ResultsHs-CRP and depression severity were not correlated, while hs-CRP and SS were (r = -0,27; p = 0,001). Patients with higher (> 3) somatizazion factor had significantly lower hs-PCR values compared to patients with lower (≤3) somatization factor (2,47 mg/L ± 4.77 vs. 3.20 mg/L ± 4.44; p = 0,026).ConclusionsIn contrast with the hypothesized cytokine involvement in somatic features of sickness behavior, higher somatic burden correlates with lower immune activation.The role of sickness behavior in experiencing SS and hs-CRP's use as valid indicator of cytokine production remain uncertain. Further studies are necessary, also to explore the relationship between HPA axis dysregulation and immune activation, possibly relevant to the interpretation of our results.

Effect of Acupuncture Treatment on the Immune Function Impairment Found in Anxious Women

2007 ◽  
Vol 35 (01) ◽  
pp. 35-51 ◽  
Author(s):  
Lorena Arranz ◽  
Noelia Guayerbas ◽  
León Siboni ◽  
Mónica De la Fuente
Keyword(s):  
Immune System ◽  
Superoxide Anion ◽  
Acupuncture Treatment ◽  
Emotional Disturbances ◽  
Nk Activity ◽  
Immune Functions ◽  
Emotional Symptoms ◽  
Old Patients ◽  
Immune Parameters ◽  
Complete Treatment

It is presently accepted that emotional disturbances lead to immune system impairment, and that therefore their treatment could restore the immune response. Thus, the aim of the present work was to study the effect of an acupuncture treatment, designed specifically to relieve the emotional symptoms stemming from anxiety, on several functions (adherence, chemotaxis, phagocytosis, basal and stimulated superoxide anion levels, lymphocyte proliferation in response to phytohemagglutinin A (PHA) and natural killer (NK) activity) of leukocytes (neutrophils and lymphocytes) from anxious women. The acupuncture protocol consisted of manual needle stimulation of 19 acupoints, with each session lasting 30 min. It was performed on 34 female 30–60 year old patients, suffering from anxiety, as determined by the Beck Anxiety Inventory (BAI). Before and 72 hours after receiving the first acupuncture session, peripheral blood samples were drawn. In 12 patients, samples were also collected immediately after the first single acupuncture session and one month after the end of the whole acupuncture treatment, which consisted of 10 sessions during a year, until the complete remission of anxiety. Twenty healthy non-anxious women in the same age range were used as controls. The results showed that the most favorable effects of acupuncture on the immune functions appear 72 hours after the single session and persist one month after the end of the complete treatment. Impaired immune functions in anxious women (chemotaxis, phagocytosis, lymphoproliferation and NK activity) were significantly improved by acupuncture, and augmented immune parameters (superoxide anion levels and lymphoproliferation of the patient subgroup whose values had been too high) were significantly diminished. Acupuncture brought the above mentioned parameters to values closer to those of healthy controls, exerting a modulatory effect on the immune system.

Sign in / Sign up

Export Citation Format

Share Document