Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2

2013 ◽  
Vol 45 (6) ◽  
pp. 237-242 ◽  
Author(s):  
Shumpei Fujie ◽  
Motoyuki Iemitsu ◽  
Haruka Murakami ◽  
Kiyoshi Sanada ◽  
Hiroshi Kawano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Cardiorespiratory Fitness ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Peak Oxygen Uptake ◽  
Cross Sectional ◽  
Fatty Acid Binding

Fatty acid binding protein 2 (FABP2) Ala54Thr polymorphism is a candidate gene associated with the risk of cardiovascular disease. Habitual exercise brings higher cardiorespiratory fitness and results in the improvement of cardiovascular disease risk. However, the effect of cardiorespiratory fitness level and FABP2 Ala54Thr polymorphism on the risk of cardiovascular diseases remains unclear. In the present study, a cross-sectional investigation of 837 Japanese men and women was performed to clarify the effects of cardiorespiratory fitness on the relationship between risk of cardiovascular disease and FABP2 Ala54Thr gene polymorphism. The study subjects were divided into high-cardiorespiratory fitness (High-Fit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median value of peak oxygen uptake in each sex and decade. The FABP2 Ala54Thr polymorphism did not significantly affect carotid β-stiffness or blood pressure. In the Low-Fit group, carotid β-stiffness, systolic blood pressure, and diastolic blood pressure were higher for individuals with the Ala/Ala genotype compared with those with the Ala/Thr or Thr/Thr genotype, whereas no differences were observed in the High-Fit group. Additionally, serum triglyceride and plasma glucose levels were lower and serum high-density lipoprotein cholesterol levels were higher in the High-Fit group compared with the Low-Fit group; the FABP2 Ala54Thr polymorphism did not significantly affect these parameters. These results suggest that the higher cardiorespiratory fitness may attenuate the changes in central arterial stiffness and blood pressure that are associated with the FABP2 genotype.

scholarly journals Association of Fitness and Fatness with Clustered Cardiovascular Disease Risk Factors in Nigerian Adolescents

2020 ◽  
Vol 17 (16) ◽  
pp. 5861
Author(s):  
Danladi I. Musa ◽  
Abel L. Toriola ◽  
Daniel T. Goon ◽  
Sunday U. Jonathan
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Cvd Risk ◽  
Standardized Residuals

Purpose: This study examinedthe independent and joint association of fitness and fatness with clustered cardiovascular disease risk (CVDrs) in 11–18 year-old Nigerian adolescents. Methods: A hundred and ninety seven adolescents (100 girls and 97 boys) were evaluated forfitness, fatness and CVDrs. Fitness was evaluated with the progressive aerobic cardiovascular endurance run test while fatness was assessed using body mass index. A clustered CVDrs was computed from the standardized residuals of total cholesterol, high density lipoprotein cholesterol, Low density lipoprotein cholesterol, triglycerides, plasma glucose, systolic blood pressure, and diastolic blood pressure. Regression models controlling for waist circumference assessed the association of fitness and fatness with CVDrs. Results: Prevalence of clustered CVD risk was 7.1% (girls = 3.0%; boys = 4.1%). Based on risk factor abnormalities, 52.8% of participants had one or more CVD risk factor abnormalities with more boys (27.4%) affected. Low fitness was associated with clustered CVDrs in both girls (R2 = 9.8%, β = −0.287, p = 0.05) and boys (R2 = 17%, β = −0.406, p < 0.0005). Fatness was not associated with the CVDrs in both sexes. After controlling for all the variables in the model, only fitness (R2 = 10.4%) and abdominal fat (R2 = 19.5%) were associated with CVDrs respectively. Unfit girls were 3.2 (95% CI = 1.31–7.91, p = 0.011) times likely to develop CVD risk abnormality compared to their fit counterparts. The likelihood of unfit boys developing CVD risk abnormality was 3.9 (95% CI = 1.15–10.08, p = 0.005) times compared to their fit peers. Conclusions: Fitness but not fatness was a better predictor of CVDrs in Nigerian boys and girls. The result of this study suggests that any public health strategies aimed at preventing or reversing the increasing trends of CVD risk in adolescents should emphasize promotion of aerobic fitness.

Changes in Weight and Cardiovascular Disease Risk Factors in Monozygotic Twins: The Healthy Twin Study

2015 ◽  
Vol 18 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Yun-Mi Song ◽  
Kayoung Lee ◽  
Joohon Sung
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Environmental Correlations

We aimed to assess the non-genetic contribution to the associations between the change in weight and changes in cardiovascular disease (CVD) risk factors. This analysis included 194 Korean monozygotic (MZ) twin pairs (116 men, 272 women; mean age, 38.5 ± 6.8 years) who were first examined for weight and CVD risk factors (blood pressure (BP), glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), and low-density lipoprotein cholesterol (LDL)) between December 2005 and December 2008, and returned for a repeat examination after 2.7 ± 0.9 years. The within-pair correlations were 0.21 for the change in weight and 0.05-0.42 for the changes in CVD risk factors. Bivariate analyses showed significant environmental correlations shared between the change in weight and the changes in CVD risk factors (p < .05), except for glucose, while there were no significant genetic effects shared between the phenotypes. After adjusting for baseline values of weight, smoking, and alcohol consumption, diastolic blood pressure (DBP), TG, TC, and LDL significantly increased by 1.6 mmHg, 0.09 mmol/L, 0.10 mmol/L, and 0.09 mmol/L, respectively, per 1 kg increase in within-pair differences in weight change. In Korean MZ twins, similarity between twins for changes in weight and CVD risk factors were small to moderate, and non-genetic factors were responsible for the associations between the change in weight and changes in DBP, TG, TC, and LDL.

scholarly journals Level of physical activity, cardiorespiratory fitness and cardiovascular disease risk factors in a rural adult population in Sogn og Fjordane

2011 ◽  
Vol 20 (2) ◽  
Author(s):  
Ane Kristiansen Solbraa ◽  
Asgeir Mamen ◽  
Geir Kåre Resaland ◽  
Jostein Steene- Johannessen ◽  
Einar Ylvisåker ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Health Status ◽  
Cardiorespiratory Fitness ◽  
Disease Risk ◽  
Adult Population ◽  
Cardiovascular Disease Risk ◽  
Cvd Risk ◽  
Cross Sectional

<strong><em>Background</em>:</strong> Physical activity (PA) and high cardiorespiratory fitness (CRF) are associated with reduced risk of cardiovascular disease (CVD). Sogn og Fjordane County has the reputation of being the most healthy county in Norway. The level of PA and/or CRF may partly explain this health status. However, only one study with regional objectively measured PA data and one study with regional data on CRF currently exist. Thus, the aim of this study was to describe levels of PA, CRF and CVD risk factors in an adult population in the county of Sogn og Fjordane.<em><strong> Methods:</strong> </em>In total, 314 (♀:178 ♂:136) 40-42-year-olds and 308 (♀:175 ♂:133) 53-55-yearolds participated in this cross-sectional study. PA was measured objectively by accelerometry, while CRF was measured directly. <em><strong>Results:</strong></em> There were no sex differences in total PA level. For the 40-42-year-olds, women spent 6.0min/day [95% CI: –11.7 to –0.3] less participating in moderate PA compared to men. For the 53-55- year-olds, women were inactive for 36.0 min/day [95% CI: –55.2 to –16.8] less and they participated in light activity for 26.4 min/day [95% CI: 7.7 to 45.2] more than men. In total, 30.0% [95% CI: 24.8 to 35.2] of the 40-42-year-olds and 30.2% [95% CI: 25.0 to 35.4] of the 53-55-year-olds met the Norwegian recommendations<br />for PA. CRF was 49.0 ml·kg–1·min–1 for men and 41.6 ml·kg–1·min–1 for women for the 40-42-year-olds. For 53-55-year-olds CRF was 41.2 ml·kg–1·min–1 for men and 33.9 ml·kg–1·min–1 for women.<em><strong> Conclusions:</strong></em> These results suggest that the level of PA and CRF are higher compared to other available data. This might explain the advantageous health status in Sogn og Fjordane.

scholarly journals Cardiovascular Disease Risk Management in Persons With HIV: Does Clinician Specialty Matter?

2020 ◽  
Vol 7 (9) ◽  
Author(s):  
Nwora Lance Okeke ◽  
Katherine R Schafer ◽  
Eric G Meissner ◽  
Jan Ostermann ◽  
Ansal D Shah ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
National Commission ◽  
Cardiovascular Disease Risk Factor ◽  
Atherosclerotic Cardiovascular Disease ◽  
Southeastern Us ◽  
The Impact

Abstract Background The impact of clinician specialty on cardiovascular disease risk factor outcomes among persons with HIV (PWH) is unclear. Methods PWH receiving care at 3 Southeastern US academic HIV clinics between January 2014 and December 2016 were retrospectively stratified into 5 groups based on the specialty of the clinician managing their hypertension or hyperlipidemia. Patients were followed until first atherosclerotic cardiovascular disease event, death, or end of study. Outcomes of interest were meeting 8th Joint National Commission (JNC-8) blood pressure (BP) goals and National Lipid Association (NLA) non–high-density lipoprotein (HDL) goals for hypertension and hyperlipidemia, respectively. Point estimates for associated risk factors were generated using modified Poisson regression with robust error variance. Results Of 1667 PWH in the analysis, 965 had hypertension, 205 had hyperlipidemia, and 497 had both diagnoses. At study start, the median patient age was 52 years, 66% were Black, and 65% identified as male. Among persons with hypertension, 24% were managed by an infectious diseases (ID) clinician alone, and 5% were co-managed by an ID clinician and a primary care clinician (PCC). Persons managed by an ID clinician were less likely to meet JNC-8 hypertension targets at the end of observation than the rest of the cohort (relative risk [RR], 0.84; 95% CI, 0.75–0.95), but when mean study blood pressure was considered, there was no difference between persons managed by ID and the rest of the cohort (RR, 0.96; 95% CI, 0.88–1.05). There was no significant association between the ID clinician managing hyperlipidemia and meeting NLA non-HDL goals (RR, 0.89; 95% CI, 0.68–1.15). Conclusions Clinician specialty may play a role in suboptimal hypertension outcomes in persons with HIV.

scholarly journals PREVALENCE OF CARDIOVASCULAR DISEASE RISK FACTORSIN SEMI-URBAN COMMUNITIES OF NORTH-CENTRAL NIGERIA

2020 ◽  
Vol 8 (12) ◽  
pp. 338-345
Author(s):  
Joshua Eyitemi ◽  
◽  
Richmond Namuna ◽  
Osaze Uduebor ◽  
Michael Nwachukwu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Fasting Blood Glucose ◽  
Geographical Location ◽  
Cardiovascular Disease Risk Factors ◽  
Cross Sectional ◽  
North Central

Background:Several studies have estimated the prevalence of cardiovascular disease risk factors (CRFs) in various communities in Nigeria. However, few have investigated the prevalence patterns in semi-urban communitiesof North-Central Nigeria. We aim to determine the prevalence patterns of CRFs in this geographical location, as a result of the growing incidence of Sudden Cardiac Death (SCD) and Heart Failure (HF) in Nigeria. Methods:A cross-sectional epidemiological study was conducted. The study was conducted across nine (9) local government councils in the southern part of Benue state, one of the six (6) states that make up the North-Central region of Nigeria. Overall, 108 participants aged > 18 years participated in the study. Risk factors were estimated by collecting information about the participants age, weight, height, Body Mass Index (BMI), waist circumference, waist-hip ratio, systolic blood pressure, diastolic blood pressure, total cholesterol,HDL-cholesterol, triglyceride cholesterol, LDL-cholesterol, and fasting blood glucose. Questionnaires, results of laboratory and instrumental diagnosis were used to collect information about the variables. Results:The overall mean of age was 50.35 ± 22.02 years. Findings showed that the prevalence of the examined cardiovascular disease risk factors was as follows: hypertension – 55(52.4%), generalized obesity (BMI > 30) – 10(9.26%)abdominal obesity –35 (32.4%) diabetes –9 (8.3%), hypercholesterolemia – 17(15.7%). The result also indicated an increase in the prevalence of hypertension with an increase in age the indices of obesity increased significantly with age but later decreased slightly among the elderly. Conclusion:Findings from the study revealed that about half of the population were hypertensive. Other key risk factors were also prevalent in this population. There is a call on relevant stakeholders for important preventive and control initiatives for awareness, as this population is at high risk of the complications that arise from the underlying disease conditions.

scholarly journals ASSOCIATION OF LIPID PROFILES WITH 10-YEAR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK: STUDY AMONG SUBJECTS IN SLEMAN DISTRICT OF YOGYAKARTA INDONESIA

2017 ◽  
Vol 10 (12) ◽  
pp. 166
Author(s):  
Rita Suhadi ◽  
Dita Maria Virginia ◽  
Christianus Heru Setiawan
Keyword(s):  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cross Sectional ◽  
Lipid Ratio ◽  
Ascvd Risk

  Objectives: The subjects in the Sleman District of Yogyakarta had medium Framingham risk score (FRS) in the preceding year study. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk was a newer risk estimator than FRS. This study aimed to associate the lipid profiles with the ASCVD risk.Methods: The study was conducted with a cross-sectional design and the subjects were selected with cluster random sampling. The association of lipid profiles and ASCVD risk was analyzed with Mann–Whitney/Kruskal–Wallis tests and Spearman’s rho correlation, whereas the categorical scores within sub-groups were analyzed Chi-square statistics, respectively.Results: The eligible subjects (n=221) had the age at 51.7±8.1 years, systolic/diastolic blood pressure 136.8±22.4/85.0±12.4 mmHg, total-cholesterol (total-C), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride at 202.0±34.9 mg/dl, 52.6±12.5 mg/dl, 126.3±30.0 mg/dl, and 135.9±95.4 mg/dl, respectively; with hypertension treatment 16.7%, smoking 52.9%, diabetes 10.4%, and the median ASCVD risk at 4.4 (0.2-41.4). The ASCVD risk has significant association with non-lipid profiles, total-C, lipid ratio of triglyceride/HDL-C, total-C/HDL-C, and LDL-C/HDL-C, to a lesser extent, HDL-C, LDL-C, and triglyceride.Conclusion: The 10-year ASCVD risk of the subjects was categorized as low and had a significant association with total-C and lipid ratio of triglyceride/ HDL-C, total-C/HDL-C, and LDL-C/HDL-C.

scholarly journals Ankle-Brachial Index: Nurses Strategy To Cardiovascular Disease Risk Factors Identification

2014 ◽  
Vol 48 (2) ◽  
pp. 223-227
Author(s):  
Daniela Luisa Maggi ◽  
Leyla Regina Dal Piva de Quadros ◽  
Karina de Oliveira Azzolin ◽  
Silvia Goldmeier
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Peripheral Arterial

Elevated risk of fatal and non-fatal cardiovascular events is associated with high prevalence of peripheral arterial disease, with assessment through the ankle-brachial index (ABI). This study aimed to demonstrate that the ABI and the Edinburgh Claudication Questionnaire are tools to be used by nurses in prevention and/or treatment of CVD (cardiovascular disease). A cross-sectional study was carried out with patients from a cardiovascular clinic. The Edinburgh Claudication Questionnaire was applied and the ABI was measured with the formula (ABI= Blood Pressure Ankle/Blood Pressure Brachial). A total of 115 patients were included, most were females (57.4%), aged 60.6 ± 12.5 years. The most prevalent risk factors were hypertension (64.3%), physical inactivity (48.7%) and family history (58.3%). The study showed that abnormal ABI was frequently found and 42.6% of the patients with abnormal ABI showed intermittent claudication. The method to evaluate the ABI associated to the Edinburg Claudication Questionnaire, can be easily used by nurses in the clinical evaluation of asymptomatic and symptomatic CVD patients.

Sign in / Sign up

Export Citation Format

Share Document