scholarly journals Prefrontal Cortex Metabolome Is Modified by Opioids, Anesthesia, and Sleep

Physiology ◽  
2021 ◽  
Vol 36 (4) ◽  
pp. 203-219 ◽  
Author(s):  
Ralph Lydic ◽  
Helen A. Baghdoyan
Keyword(s):  
Prefrontal Cortex ◽  
Autonomic Dysfunction ◽  
Entry Point ◽  
Functional Metabolomics

Obtundation of wakefulness caused by opioids and loss of wakefulness caused by anesthetics and sleep significantly alter concentrations of molecules comprising the prefrontal cortex (PFC) metabolome. Quantifying state-selective changes in the PFC metabolome is essential for advancing functional metabolomics. Diverse functions of the PFC suggest the PFC metabolome as a potential therapeutic entry point for countermeasures to state-selective autonomic dysfunction.

Author response for "Remodeling of projections from ventral hippocampus to prefrontal cortex in Alzheimer's mice"

2020 ◽  
Author(s):  
Feng Xu ◽  
Munenori Ono ◽  
Tetsufumi Ito ◽  
Osamu Uchiumi ◽  
Furong Wang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ventral Hippocampus ◽  
Author Response

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

What Can You Expect From Boosting Prefrontal Cortex?

2012 ◽  
Author(s):  
Nazbanou Nozari ◽  
Sharon L. Thompsonschill
Keyword(s):  
Prefrontal Cortex
Sign in / Sign up

Export Citation Format

Share Document