scholarly journals Novel Mechanisms in the Regulation of Phosphorus Homeostasis

Physiology ◽  
2009 ◽  
Vol 24 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Theresa Berndt ◽  
Rajiv Kumar
Keyword(s):  
Critical Role ◽  
Endocrine System ◽  
Well Being ◽  
Inorganic Phosphorus ◽  
Biological Processes ◽  
Serum Concentrations ◽  
Short Term ◽  
Hormonal Factors ◽  
Fgf 23

Phosphorus plays a critical role in diverse biological processes, and, therefore, the regulation of phosphorus balance and homeostasis are critical to the well being of the organism. Changes in environmental, dietary, and serum concentrations of inorganic phosphorus are detected by sensors that elicit changes in cellular function and alter the efficiency by which phosphorus is conserved. Short-term, post-cibal responses that occur independently of hormones previously thought to be important in phosphorus homeostasis may play a larger role than previously appreciated in the regulation of phosphorus homeostasis. Several hormones and regulatory factors such as the vitamin D endocrine system, parathyroid hormone, and the phosphatonins (FGF-23, sFRP-4, MEPE) among others, may play a role only in the long-term regulation of phosphorus homeostasis. In this review, we discuss how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus.

Intraindividual Variability and Stability of Affect and Well-Being

GeroPsych ◽  
2013 ◽  
Vol 26 (3) ◽  
pp. 185-199 ◽  
Author(s):  
Christina Röcke ◽  
Annette Brose
Keyword(s):  
Age Differences ◽  
Well Being ◽  
Subjective Well Being ◽  
Emotional Experiences ◽  
Short Term ◽  
Regulatory Processes ◽  
Functional Implications ◽  
Methodological Approaches ◽  
Underlying Processes

Whereas subjective well-being remains relatively stable across adulthood, emotional experiences show remarkable short-term variability, with younger and older adults differing in both amount and correlates. Repeatedly assessed affect data captures both the dynamics and stability as well as stabilization that may indicate emotion-regulatory processes. The article reviews (1) research approaches to intraindividual affect variability, (2) functional implications of affect variability, and (3) age differences in affect variability. Based on this review, we discuss how the broader literature on emotional aging can be better integrated with theories and concepts of intraindividual affect variability by using appropriate methodological approaches. Finally, we show how a better understanding of affect variability and its underlying processes could contribute to the long-term stabilization of well-being in old age.

Positive Emotions

2009 ◽  
pp. 12-24 ◽  
Author(s):  
Michael A. Cohn ◽  
Barbara L. Fredrickson
Keyword(s):  
Positive Emotions ◽  
Well Being ◽  
Life Outcomes ◽  
Short Term ◽  
Future Success ◽  
Broaden And Build Theory ◽  
Mental And Physical Health ◽  
Very High ◽  
Future Growth

Positive emotions include pleasant or desirable situational responses, ranging from interest and contentment to love and joy, but are distinct from pleasurable sensation and undifferentiated positive affect. These emotions are markers of people's overall well-being or happiness, but they also enhance future growth and success. This has been demonstrated in work, school, relationships, mental and physical health, and longevity. The broaden-and-build theory of positive emotions suggests that all positive emotions lead to broadened repertoires of thoughts and actions and that broadening helps build resources that contribute to future success. Unlike negative emotions, which are adapted to provide a rapid response to a focal threat, positive emotions occur in safe or controllable situations and lead more diffusely to seeking new resources or consolidating gains. These resources outlast the temporary emotional state and contribute to later success and survival. This chapter discusses the nature of positive emotions both as evolutionary adaptations to build resources and as appraisals of a situation as desirable or rich in resources. We discuss the methodological challenges of evoking positive emotions for study both in the lab and in the field and issues in observing both short-term (“broaden”) and long-term (“build”) effects. We then review the evidence that positive emotions broaden perception, attention, motivation, reasoning, and social cognition and ways in which these may be linked to positive emotions' effects on important life outcomes. We also discuss and contextualize evidence that positive emotions may be detrimental at very high levels or in certain situations. We close by discussing ways in which positive emotions theory can be harnessed by both basic and applied positive psychology research.

Configurations to Superior Environmental Innovation Strategy: A Both–And Approach

2021 ◽  
pp. 108602662110316
Author(s):  
Tiziana Russo-Spena ◽  
Nadia Di Paola ◽  
Aidan O’Driscoll
Keyword(s):  
Climate Change ◽  
Value Chain ◽  
Critical Role ◽  
Well Being ◽  
Point Of View ◽  
Future Generations ◽  
Innovation Strategy ◽  
Environmental Innovation ◽  
Data Set

An effective climate change action involves the critical role that companies must play in assuring the long-term human and social well-being of future generations. In our study, we offer a more holistic, inclusive, both–and approach to the challenge of environmental innovation (EI) that uses a novel methodology to identify relevant configurations for firms engaging in a superior EI strategy. A conceptual framework is proposed that identifies six sets of driving characteristics of EI and two sets of beneficial outcomes, all inherently tensional. Our analysis utilizes a complementary rather than an oppositional point of view. A data set of 65 companies in the ICT value chain is analyzed via fuzzy-set comparative analysis (fsQCA) and a post-QCA procedure. The results reveal that achieving a superior EI strategy is possible in several scenarios. Specifically, after close examination, two main configuration groups emerge, referred to as technological environmental innovators and organizational environmental innovators.

Individual Differences in the Vitamin Model of Well-being

2021 ◽  
Author(s):  
Peter Warr
Keyword(s):  
Emotion Regulation ◽  
Individual Differences ◽  
Well Being ◽  
Attentional Focus ◽  
Short Term ◽  
Environmental Features ◽  
Individual Variations ◽  
Nonlinear Associations

Prominent among frameworks of well-being is the Vitamin Model, which emphasizes nonlinear associations with environmental features. The Vitamin Model has previously been described through average patterns for people in general, but we need also to explore inter-individual variations. For presentation, those differences can either be viewed generically, based on divergence in age, personality and so on, or through short-term episodes of emotion regulation, such as through situation-specific attentional focus and reappraisal. Both long-term and short-term variations are considered here.

Athletes Play Through Pain—What Does That Mean for Rehabilitation Specialists?

2020 ◽  
Vol 29 (5) ◽  
pp. 640-649 ◽  
Author(s):  
Amy Barrette ◽  
Katherine Harman
Keyword(s):  
Well Being ◽  
Short Term ◽  
Semistructured Interviews ◽  
Sport Organization ◽  
The University ◽  
E Mail ◽  
Competitive Nature ◽  
And Training ◽  
Insight Into

Context: Pain in sport has been normalized to the point where athletes are expected to ignore pain and remain in the game despite the possible detrimental consequences associated with playing through pain. While rehabilitation specialists may not have an influence on an athlete’s competitive nature or the culture of risk they operate in, understanding the consequences of those factors on an athlete’s physical well-being is definitely in their area of responsibility. Objective: To explore the factors associated with the experiences of subelite athletes who play through pain in gymnastics, rowing, and speed skating. Design: The authors conducted semistructured interviews with subelite athletes, coaches, and rehabilitation specialists. They recruited coach participants through their provincial sport organization. Athletes of the recruited coaches who were recovering from a musculoskeletal injury and training for a major competition were then recruited. They also recruited rehabilitation specialists who were known to treat subelite athletes independently by e-mail. Setting: An observation session was conducted at the athlete’s training facility. Interviews were then conducted either in a room at the university or at a preferred sound-attenuated location suggested by the participant. Participants: The authors studied 5 coaches, 4 subelite athletes, and 3 rehabilitation specialists. Interventions: The authors photographed athletes during a practice shortly before an important competition, and we interviewed all the participants after that competition. Our photographs were used during the interview to stimulate discussion. Results: The participant interviews revealed 3 main themes related to playing through pain. They are: Listening to your body, Decision making, and Who decides. Conclusion: When subelite athletes, striving to be the best in their sport continue to train with the pain of an injury, performance is affected in the short-term and long-term consequences are also possible. Our study provides some insight into the contrasting forces that athletes balance as they decide to continue or to stop.

Is There a Role for Therapeutic Drug Monitoring of Anti-TNF Monoclonal Antibodies in Inflammatory Bowel Disease

2015 ◽  
Vol 33 (Suppl. 1) ◽  
pp. 70-77 ◽  
Author(s):  
Filip Baert
Keyword(s):  
Monoclonal Antibodies ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Treatment Guidelines ◽  
Therapeutic Drug ◽  
Serum Concentrations ◽  
Short Term ◽  
Clear Dose Response ◽  
Inflammatory Bowel

In recent years it has become clear that therapeutic drug monitoring can be an important tool to optimize outcome and costs of anti TNF treatment including the subcutaneous and fully human monoclonal antibodies. There is a clear dose response curve between early serum concentrations of all monoclonal antibodies and response both short term and long term. The wide variations in early serum concentrations are insufficiently explained by classic pharmacokinetic factors. Low early concentrations can lead to anti-drug antibody formation and ensuing loss of response. Therapeutic drug monitoring allows to rationalize the current practice of dose optimization and the use of concomitant immunomodulator treatment. However more prospective studies are needed before strong recommendations can enter treatment guidelines.

scholarly journals Teenage mothers: a long-term view on their well-being

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
A M G van Tintelen ◽  
S H Bolt ◽  
D E M C Jansen
Keyword(s):  
Social Support ◽  
Online Survey ◽  
Well Being ◽  
Teenage Mothers ◽  
Long Term Results ◽  
Teenage Childbearing ◽  
Short Term ◽  
Lack Of Information ◽  
The Social

Abstract Background This study aims to address the lack of information about teenage mothers in different stages of their lives by exploring how they are doing in the long term and the social support they receive. Methods From December 2018 to February 2019 teenage mothers in the Netherlands were recruited by Fiom (an expert centre for unintended pregnancy), via social media and a website for teenage mothers (n = 248). Using an online survey, data were obtained to assess various outcomes, such as well-being, education, work, income, housing and social support. Respondents were divided into three groups: 0-3 years after teenage childbearing (short-term), 4-12 years (medium-term), >12 years (long-term). Results were analysed using univariate and bivariate descriptions in SPSS. Results Almost 80% of the respondents reported that they were doing well and were satisfied with their life. 63.3% had a job, and 17.0% was enrolled in education. Short-term mothers worked fewer hours per week compared to long-term mothers (p < 0.001). 85.1% of the respondents reported that they received benefits, short-term mothers receiving more benefits than long-term mothers (p < 0.001). The majority (78.2%) was satisfied with their living conditions; short-term mothers were less satisfied than long-term mothers (p = 0.031). 36.3% of the respondents smoked cigarettes. Most support was given by family (83.1%), mainly from female relatives. About 24% of the respondents received formal support. Conclusions This study shows that teenage mothers, on average, were doing well and were satisfied with their life, in both the short and long term. Regarding income and housing, short-term mothers were in a less favourable position. These results suggest that as the years pass, teenage mothers overcome difficulties. Since the association between well-being and social support on the long term is unknown, we advise investigating the effect of social support on the outcomes of teenage childbearing. Key messages Both in the short-term and the long-term, most teenage mothers were doing well and satisfied with life. Regarding housing and income, short-term mothers function less well compared to long-term mothers.

Short and Longer Term Effects of Musical Intervention in Severe Alzheimer's Disease

2012 ◽  
Vol 29 (5) ◽  
pp. 533-541 ◽  
Author(s):  
Sylvain Clément ◽  
Audrey Tonini ◽  
Fatiha Khatir ◽  
Loris Schiaratura ◽  
Séverine Samson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Facial Expressions ◽  
Emotional State ◽  
Present Finding ◽  
Well Being ◽  
Music Intervention ◽  
Short Term

in this study, we examined short and longer term effects of musical and cooking interventions on emotional well-being of severe Alzheimer's disease (AD) patients. These two pleasurable activities (i.e., listening to music, tasting sweets) that were collectively performed (i.e., playing music together, collaborative preparation of a cake) were compared in two groups of matched patients with AD (N = 14). Each intervention lasted four weeks (two sessions per week) and their effects were regularly assessed up to four weeks after the end of the intervention. We repeatedly evaluated the emotional state of both groups before, during, and after the intervention periods by analyzing discourse content and facial expressions from short filmed interviews as well as caregivers' judgments of mood. The results reveal short-term benefits of both music and cooking interventions on emotional state on all these measures, but long-term benefits were only evident after the music intervention. The present finding suggests that non-pharmacological approaches offer promising methods to improve the quality of life of patients with dementia and that music stimulation is particularly effective to produce long lasting effects on patients' emotional well-being.

scholarly journals Approach to the Pretransplant Evaluation of the Living Kidney Donor

2011 ◽  
Vol 2011 ◽  
pp. 1-8
Author(s):  
Mala Sachdeva ◽  
Madhu Bhaskaran ◽  
Ernesto P. Molmenti ◽  
Donna Dalton ◽  
Joseph Mattana
Keyword(s):  
Health And Safety ◽  
Well Being ◽  
Kidney Donor ◽  
Short Term ◽  
Complex Activity ◽  
Living Kidney Donor ◽  
Donor Evaluation ◽  
Ethical And Legal Issues ◽  
Careful Assessment

Evaluation of the potential kidney donor is a complex activity that differs substantially from other types of preoperative assessments. The well being of the donor, who derives no medical benefit from this surgery, must be assured in both the short term and long term, and the potential adverse consequences to the recipient must be determined as well. The criteria that must be met for a person to donate a kidney are rigorous and include medical, social, psychosocial, ethical, and legal issues. Donor evaluation can be divided into assessments to protect the health and safety of the donor and assessments to protect the health and safety of the recipient. This article provides an approach to evaluating a donor, focusing on the complex issues that an evaluator is faced with. A careful assessment of risks and benefits to both the donor and recipient can lead to favorable outcomes.

PROGRESS AND REGRESS: UNDERSTANDING COMPLEX SOCIAL MEASURES AND THEIR TRADE-OFFS

2017 ◽  
Vol 34 (2) ◽  
pp. 164-189
Author(s):  
Daniel Austin Green ◽  
Roberta Q. Herzberg
Keyword(s):  
Income Inequality ◽  
Social Values ◽  
Scientific Progress ◽  
Well Being ◽  
Moral Progress ◽  
Short Term ◽  
Economic Progress ◽  
Trade Offs ◽  
Global And Local

Abstract:What is progress and what is not progress? We can talk about progress in lots of different arenas; we will focus primarily on economic and scientific progress, but also make brief reference to cultural and moral progress. In our discussion, we want to distinguish, especially, between overall, long-term progress and narrower, shorter-term progress or regress. We will refer to these as “global” and “local” progress, respectively. Of course, one can also regress; therefore, we will also look at instances where progress, along some dimension, slows or even moves backwards. Generally, such regress is local, and often still in a context of broader, global progress. In scientific progress, for example, there are many instances of short-term progress which, if not completely discarded or disproved, are at least substantially modified or fundamentally challenged. And yet, those research paths, even when later abandoned, still contributed to the overall progress of the field. In that sense, the regress (that is, rejection or modification of previous theories) is corrected by, but not in conflict with, the overall progress. In the case of economic progress, the concept of regress usually takes on a different form in which things that aren’t advancing progress don’t necessarily stop it, but are simply retarding progress — that is, making the rate of progress less efficient. The consequence, we suggest, is that when talking about economic progress, objections to certain consequences of economic progress (for instance, income inequality — a type of regress, in our terminology) should not be cordoned off and dealt with independently, but should be incorporated into the way we think about economic progress itself — as instances of local regress within a context of global progress. We explore the effects of these different relations between progress and regress to suggest some of the challenges those seeking to broaden the standard measure, GDP, to incorporate other social values of well-being will face moving forward.

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