scholarly journals Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation

Physiology ◽  
2018 ◽  
Vol 33 (1) ◽  
pp. 26-38 ◽  
Author(s):  
Kevin A. Murach ◽  
Christopher S. Fry ◽  
Tyler J. Kirby ◽  
Janna R. Jackson ◽  
Jonah D. Lee ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Satellite Cell ◽  
Muscle Fiber ◽  
Satellite Cells ◽  
Skeletal Muscle Fiber ◽  
Cell Depletion ◽  
Loss Of Function ◽  
Adult Mice ◽  
Fiber Size

Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.

scholarly journals Depletion of resident muscle stem cells negatively impacts running volume, physical function, and muscle fiber hypertrophy in response to lifelong physical activity

2020 ◽  
Vol 318 (6) ◽  
pp. C1178-C1188 ◽  
Author(s):  
Davis A. Englund ◽  
Kevin A. Murach ◽  
Cory M. Dungan ◽  
Vandré C. Figueiredo ◽  
Ivan J. Vechetti ◽  
...  
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Physical Function ◽  
Satellite Cell ◽  
Muscle Fiber ◽  
Satellite Cells ◽  
Cell Depletion ◽  
Muscle Adaptation ◽  
Adult Skeletal Muscle

To date, studies that have aimed to investigate the role of satellite cells during adult skeletal muscle adaptation and hypertrophy have utilized a nontranslational stimulus and/or have been performed over a relatively short time frame. Although it has been shown that satellite cell depletion throughout adulthood does not drive skeletal muscle loss in sedentary mice, it remains unknown how satellite cells participate in skeletal muscle adaptation to long-term physical activity. The current study was designed to determine whether reduced satellite cell content throughout adulthood would influence the transcriptome-wide response to physical activity and diminish the adaptive response of skeletal muscle. We administered vehicle or tamoxifen to adult Pax7-diphtheria toxin A (DTA) mice to deplete satellite cells and assigned them to sedentary or wheel-running conditions for 13 mo. Satellite cell depletion throughout adulthood reduced balance and coordination, overall running volume, and the size of muscle proprioceptors (spindle fibers). Furthermore, satellite cell participation was necessary for optimal muscle fiber hypertrophy but not adaptations in fiber type distribution in response to lifelong physical activity. Transcriptome-wide analysis of the plantaris and soleus revealed that satellite cell function is muscle type specific; satellite cell-dependent myonuclear accretion was apparent in oxidative muscles, whereas initiation of G protein-coupled receptor (GPCR) signaling in the glycolytic plantaris may require satellite cells to induce optimal adaptations to long-term physical activity. These findings suggest that satellite cells play a role in preserving physical function during aging and influence muscle adaptation during sustained periods of physical activity.

scholarly journals Skeletal muscle fiber size and fiber type distribution in human cancer: Effects of weight loss and relationship to physical function

2016 ◽  
Vol 35 (6) ◽  
pp. 1359-1365 ◽  
Author(s):  
Michael J. Toth ◽  
Damien M. Callahan ◽  
Mark S. Miller ◽  
Timothy W. Tourville ◽  
Sarah B. Hackett ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Weight Loss ◽  
Physical Function ◽  
Muscle Fiber ◽  
Human Cancer ◽  
Fiber Type ◽  
Skeletal Muscle Fiber ◽  
Type Distribution ◽  
Fiber Size ◽  
Fiber Type Distribution

scholarly journals Skeletal Muscle Fiber Size and Gene Expression in the Oldest-Old With Differing Degrees of Mobility

2019 ◽  
Vol 10 ◽  
Author(s):  
Fabio Naro ◽  
Massimo Venturelli ◽  
Lucia Monaco ◽  
Luana Toniolo ◽  
Ettore Muti ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Oldest Old ◽  
Skeletal Muscle Fiber ◽  
Fiber Size

scholarly journals COX Inhibitor Influence on Skeletal Muscle Fiber Size and Metabolic Adaptations to Resistance Exercise in Older Adults

2016 ◽  
Vol 71 (10) ◽  
pp. 1289-1294 ◽  
Author(s):  
Todd A. Trappe ◽  
Stephen M. Ratchford ◽  
Brooke E. Brower ◽  
Sophia Z. Liu ◽  
Kaleen M. Lavin ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Resistance Exercise ◽  
Muscle Fiber ◽  
Skeletal Muscle Fiber ◽  
Metabolic Adaptations ◽  
Cox Inhibitor ◽  
Fiber Size

Automated Methods for the Analysis of Skeletal Muscle Fiber Size and Metabolic Type

2013 ◽  
pp. 275-332 ◽  
Author(s):  
Tatiana Y. Kostrominova ◽  
David S. Reiner ◽  
Richard H. Haas ◽  
Randall Ingermanson ◽  
Patrick M. McDonough
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Skeletal Muscle Fiber ◽  
Fiber Size ◽  
Metabolic Type ◽  
Automated Methods
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