scholarly journals Integration of ChREBP-Mediated Glucose Sensing into Whole Body Metabolism

Physiology ◽  
2015 ◽  
Vol 30 (6) ◽  
pp. 428-437 ◽  
Author(s):  
Floriane Baraille ◽  
Julien Planchais ◽  
Renaud Dentin ◽  
Sandra Guilmeau ◽  
Catherine Postic
Keyword(s):  
Energy Source ◽  
Glucose Metabolism ◽  
Binding Protein ◽  
Glucose Sensing ◽  
Whole Body ◽  
Element Binding Protein ◽  
Whole Body Metabolism ◽  
Responsive Element ◽  
Principal Energy

Since glucose is the principal energy source for most cells, many organisms have evolved numerous and sophisticated mechanisms to sense glucose and respond to it appropriately. In this context, cloning of the carbohydrate responsive element binding protein has unraveled a critical molecular link between glucose metabolism and transcriptional reprograming induced by glucose. In this review, we detail major findings that have advanced our knowledge of glucose sensing.

scholarly journals Correction to ‘The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility’

Open Biology ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 160237
Author(s):  
David Sillam-Dussès ◽  
Robert Hanus ◽  
Michael Poulsen ◽  
Virginie Roy ◽  
Maryline Favier ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Binding Protein ◽  
Glucose Sensing ◽  
Element Binding Protein ◽  
Responsive Element

scholarly journals The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility

Open Biology ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 160080 ◽  
Author(s):  
David Sillam-Dussès ◽  
Robert Hanus ◽  
Michael Poulsen ◽  
Virginie Roy ◽  
Maryline Favier ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Fatty Acid Synthase ◽  
De Novo ◽  
Binding Protein ◽  
Glucose Sensing ◽  
De Novo Lipogenesis ◽  
Organic Polymer ◽  
Key Factor ◽  
Element Binding Protein ◽  
Responsive Element

Termites are among the few animals that themselves can digest the most abundant organic polymer, cellulose, into glucose. In mice and Drosophila , glucose can activate genes via the transcription factor carbohydrate-responsive element-binding protein (ChREBP) to induce glucose utilization and de novo lipogenesis. Here, we identify a termite orthologue of ChREBP and its downstream lipogenic targets, including acetyl-CoA carboxylase and fatty acid synthase. We show that all of these genes, including ChREBP, are upregulated in mature queens compared with kings, sterile workers and soldiers in eight different termite species. ChREBP is expressed in several tissues, including ovaries and fat bodies, and increases in expression in totipotent workers during their differentiation into neotenic mature queens. We further show that ChREBP is regulated by a carbohydrate diet in termite queens. Suppression of the lipogenic pathway by a pharmacological agent in queens elicits the same behavioural alterations in sterile workers as observed in queenless colonies, supporting that the ChREBP pathway partakes in the biosynthesis of semiochemicals that convey the signal of the presence of a fertile queen. Our results highlight ChREBP as a likely key factor for the regulation and signalling of queen fertility.

scholarly journals Iron-responsive element-binding protein. Phosphorylation by protein kinase C.

1993 ◽  
Vol 268 (36) ◽  
pp. 27363-27370
Author(s):  
R S Eisenstein ◽  
P T Tuazon ◽  
K L Schalinske ◽  
S A Anderson ◽  
J A Traugh
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Protein Phosphorylation ◽  
Binding Protein ◽  
Iron Responsive Element ◽  
Kinase C ◽  
Element Binding Protein ◽  
Responsive Element

scholarly journals Acetylation of cAMP-responsive Element-binding Protein (CREB) by CREB-binding Protein Enhances CREB-dependent Transcription

2003 ◽  
Vol 278 (18) ◽  
pp. 15727-15734 ◽  
Author(s):  
Qing Lu ◽  
Amanda E. Hutchins ◽  
Colleen M. Doyle ◽  
James R. Lundblad ◽  
Roland P. S. Kwok
Keyword(s):  
Binding Protein ◽  
Creb Binding Protein ◽  
Element Binding Protein ◽  
Responsive Element ◽  
Camp Responsive Element Binding

scholarly journals Sequence and expression of the murine iron-responsive element binding protein

1991 ◽  
Vol 19 (22) ◽  
pp. 6333-6333 ◽  
Author(s):  
Caroline C. Philpott ◽  
Tracey A. Rouault ◽  
Richard D. Klausner
Keyword(s):  
Binding Protein ◽  
Iron Responsive Element ◽  
Element Binding Protein ◽  
Responsive Element
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