Mouse MRI: Concepts and Applications in Physiology

Physiology ◽  
2004 ◽  
Vol 19 (4) ◽  
pp. 168-175 ◽  
Author(s):  
Robia G. Pautler

The purpose of this review is to provide an introduction to the rapidly expanding field of mouse magnetic resonance imaging (MRI). It is by no means meant to be all-inclusive but rather to provide a brief introduction to the basics of MRI theory, provide some insight into the basic experiments that can be performed in mice by using MRI, and bring to light some factors to consider when planning a mouse MRI experiment.

2018 ◽  
Vol 31 (02) ◽  
pp. 155-165 ◽  
Author(s):  
Alissa Burge ◽  
Hollis Potter ◽  
Erin Argentieri

AbstractMagnetic resonance imaging (MRI) provides an effective and noninvasive means by which to evaluate articular cartilage within the knee. Existing techniques can be utilized to detect and monitor longitudinal changes in cartilage status due to injury or progression of degenerative disease. Quantitative MRI (qMRI) techniques can provide a metric by which to evaluate the efficacy of cartilage repair techniques and offer insight into the composition of cartilage and cartilage repair tissue. In this review, we provide background on MR signal generation and decay, the utility of morphologic MRI assessment, and qMRI techniques for the biochemical assessment of cartilage (dGEMRIC, T2, T2*, T1ρ, sodium, gagCEST). Finally, the description and utility of these qMRI techniques for the evaluation of cartilage repair are discussed.


1989 ◽  
Vol 2 (3) ◽  
pp. 191-195
Author(s):  
Jeffrey A. Clanton

The nuclear pharmacist works with a very specific group of drugs. These drugs generally exhibit no toxic effects and are used almost exclusively for diagnosis. In the past these have been the radioactive drugs used in nuclear medicine and the iodinated contrast agents used in radiology. However, with the advent of magnetic resonance imaging (MRI), there is an additional class of drugs used in radiology, the magnetopharmaceuticals. These drugs are designed especially for increasing diagnostic sensitivity with MRI. This article is intended to provide topical insight into the basics of MRI and magnetopharmaceuticals.


2019 ◽  
Vol 23 (04) ◽  
pp. 405-418 ◽  
Author(s):  
James F. Griffith ◽  
Radhesh Krishna Lalam

AbstractWhen it comes to examining the brachial plexus, ultrasound (US) and magnetic resonance imaging (MRI) are complementary investigations. US is well placed for screening most extraforaminal pathologies, whereas MRI is more sensitive and accurate for specific clinical indications. For example, MRI is probably the preferred technique for assessment of trauma because it enables a thorough evaluation of both the intraspinal and extraspinal elements, although US can depict extraforaminal neural injury with a high level of accuracy. Conversely, US is probably the preferred technique for examination of neurologic amyotrophy because a more extensive involvement beyond the brachial plexus is the norm, although MRI is more sensitive than US for evaluating muscle denervation associated with this entity. With this synergy in mind, this review highlights the tips for examining the brachial plexus with US and MRI.


Endoscopy ◽  
2004 ◽  
Vol 36 (10) ◽  
Author(s):  
BP McMahon ◽  
JB Frøkjær ◽  
A Bergmann ◽  
DH Liao ◽  
E Steffensen ◽  
...  

2019 ◽  
pp. 10-23
Author(s):  
T. A. Akhadov ◽  
S. Yu. Guryakov ◽  
M. V. Ublinsky

For a long time, there was a need to apply magnetic resonance imaging (MRI) technique for lung visualization in clinical practice. The development of this method is stimulated by necessity of the emergence of an alternative to computed tomography, especially when radiation and injection of iodine-containing contrast agents are contraindicated or undesirable, for example, in pregnant women and children, people with intolerance to iodinated contrast. One of the reasons why lung MRI is still rarely used is lack of elaborated standardized protocols that would be adapted to clinical needs of medical society. This publication is a current literature review on the use of MRI in lung studies.


2007 ◽  
Vol 30 (4) ◽  
pp. 41
Author(s):  
A. Dechant

On the morning of October 10, 2003, the residents of New York awoke to find that an entire page of their beloved paper, The Times, had been usurped for the sole purpose of flagrant self-promotion and protestation. On his own behalf, Dr. Raymand Damadian had purchased a one page spread bemoaning his exclusion in the Nobel Prize for Medicine that year which had previously been awarded to Paul Laterbur and Peter Mansfield for their contributions to the development of Magnetic Resonance Imaging (MRI). Over the course of the next few months, the public was to witness a series of such articles proclaiming that a shameful wrong had been committed, and that the truth would eventually prove Dr. Damadian’s accusations. That truth lay in the early theoretical and technical foundations that led to the discovery of MRI. Described just after the Second World War, nuclear magnetic resonance (NMR) was hailed as a breakthrough in physical chemistry for which Felix Bloch and Edward Purcell were awarded the Nobel Prize in Physics in 1952. Two decades later, in 1971, Dr. Damadian discovered that differences between the NMR signals of cancerous and normal tissue might provide a rapid means of cancer detection. However, Laterbur and Mansfield were the first to actually demonstrate images of live tissue using the application of magnetic gradients – the key to modern MRI. Though speculation exists that Dr. Damadian may have been excluded from the prize due to his religious beliefs or political rivalry, only time will reveal the whole truth when the Nobel files are opened 50 years hence. Bradley W. The Nobel Prize: Three Investigators Allowed but Two Were Chosen. Journal of Magnetic Resonance Imaging 2004; 19:520. Laterbur P. Image formation by induced local interactions: examples of employing nuclear magnetic resonance. Nature 1973; 242:190-191. Mansfield P, Grannell P. “NMR diffraction in solids?” Journal of Physics C: Solid State Physics 1973; 63:L433-L426.


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