scholarly journals Performance Monitoring Local Field Potentials in the Medial Frontal Cortex of Primates: Anterior Cingulate Cortex

2008 ◽  
Vol 99 (2) ◽  
pp. 759-772 ◽  
Author(s):  
Erik E. Emeric ◽  
Joshua W. Brown ◽  
Melanie Leslie ◽  
Pierre Pouget ◽  
Veit Stuphorn ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Local Field ◽  
Performance Monitoring ◽  
Local Field Potentials ◽  
Cingulate Cortex ◽  
Negative Polarity ◽  
Event Related Potential ◽  
Anterior Cingulate ◽  
Field Potentials ◽  
Macaque Monkeys

We describe intracranial local field potentials (LFP) recorded in the anterior cingulate cortex (ACC) of macaque monkeys performing a saccade countermanding task. The most prominent feature at ∼70% of sites was greater negative polarity after errors than after rewarded correct trials. This negative polarity was also evoked in unrewarded correct trials. The LFP evoked by the visual target was much less polarized, and the weak presaccadic modulation was insufficient to control the initiation of saccades. When saccades were cancelled, LFP modulation decreased slightly with the magnitude of response conflict that corresponds to the coactivation of gaze-shifting and -holding neurons estimated from the probability of canceling. However, response time adjustments on subsequent trials were not correlated with LFP polarity on individual trials. The results provide clear evidence that error- and feedback-related, but not conflict-related, signals are carried by the LFP in the macaque ACC. Finding performance monitoring field potentials in the ACC of macaque monkeys establishes a bridge between event-related potential and functional brain-imaging studies in humans and neurophysiology studies in non-human primates.

scholarly journals Dorsal anterior cingulate cortex intrinsic functional connectivity linked to electrocortical measures of error-monitoring

2020 ◽  
Author(s):  
Hayley Gilbertson ◽  
Lin Fang ◽  
Jeremy A. Andrzejewski ◽  
Joshua M. Carlson
Keyword(s):  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Flanker Task ◽  
Monitoring Network ◽  
Cingulate Cortex ◽  
Event Related Potential ◽  
Anterior Cingulate ◽  
Functional Coupling ◽  
Error Monitoring ◽  
Dorsal Anterior Cingulate Cortex

AbstractThe error-related negativity (ERN) is a response-locked event-related potential, occurring approximately 50 ms following an erroneous response at frontocentral electrode sites. Source localization and functional magnetic resonance imaging (fMRI) research indicate that the ERN is likely generated by activity in the dorsal anterior cingulate cortex (dACC). The dACC is thought to be a part of a broader network of brain regions that collectively comprise an error-monitoring network. However, little is known about how intrinsic connectivity within the dACC-based error-monitoring network contributes to variability in ERN amplitude. The purpose of this study was to assess the relationship between dACC functional connectivity and ERN amplitude. In a sample of 53 highly trait-anxious individuals, the ERN was elicited in a flanker task and functional connectivity was assessed in a 10-minute resting-state fMRI scan. Results suggest that the strength of dACC seeded functional connectivity with the supplementary motor area is correlated with the ΔERN (i.e., incorrect – correct responses) amplitude such that greater ΔERN amplitude was accompanied by greater functional coupling between these regions. In addition to the dACC, exploratory analyses found that functional connectivity in the caudate, cerebellum, and a number of regions in the error-monitoring network were linked to variability in ΔERN amplitude. In sum, ERN amplitude appears to be related to the strength of functional connectivity between error-monitoring and motor control regions of the brain.

scholarly journals A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Wei Tang ◽  
Saad Jbabdi ◽  
Ziyi Zhu ◽  
Michiel Cottaar ◽  
Giorgia Grisot ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Diffusion Magnetic Resonance Imaging ◽  
Cingulate Cortex ◽  
Retrograde Tracing ◽  
Anterior Cingulate ◽  
Resonance Imaging ◽  
Macaque Monkeys ◽  
Afferent Inputs ◽  
Rostral Anterior Cingulate Cortex ◽  
A Site

We investigated afferent inputs from all areas in the frontal cortex (FC) to different subregions in the rostral anterior cingulate cortex (rACC). Using retrograde tracing in macaque monkeys, we quantified projection strength by counting retrogradely labeled cells in each FC area. The projection from different FC regions varied across injection sites in strength, following different spatial patterns. Importantly, a site at the rostral end of the cingulate sulcus stood out as having strong inputs from many areas in diverse FC regions. Moreover, it was at the integrative conjunction of three projection trends across sites. This site marks a connectional hub inside the rACC that integrates FC inputs across functional modalities. Tractography with monkey diffusion magnetic resonance imaging (dMRI) located a similar hub region comparable to the tracing result. Applying the same tractography method to human dMRI data, we demonstrated that a similar hub can be located in the human rACC.

scholarly journals The Role of Intact Frontostriatal Circuits in Error Processing

2006 ◽  
Vol 18 (4) ◽  
pp. 651-664 ◽  
Author(s):  
Markus Ullsperger ◽  
D. Yves von Cramon
Keyword(s):  
Prefrontal Cortex ◽  
Basal Ganglia ◽  
Anterior Cingulate Cortex ◽  
Performance Monitoring ◽  
Brain Plasticity ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Cortical Circuits ◽  
Lateral Prefrontal Cortex ◽  
Error Related Negativity

The basal ganglia have been suggested to play a key role in performance monitoring and resulting behavioral adjustments. It is assumed that the integration of prefrontal and motor cortico—striato—thalamo—cortical circuits provides contextual information to the motor anterior cingulate cortex regions to enable their function in performance monitoring. So far, direct evidence is missing, however. We addressed the involvement of frontostriatal circuits in performance monitoring by collecting event-related brain potentials (ERPs) and behavioral data in nine patients with focal basal ganglia lesions and seven patients with lateral prefrontal cortex lesions while they performed a flanker task. In both patient groups, the amplitude of the error-related negativity was reduced, diminishing the difference to the ERPs on correct responses. Despite these electrophysiological abnormalities, most of the patients were able to correct errors. Only in lateral prefrontal cortex patients whose lesions extended into the frontal white matter, disrupting the connections to the motor anterior cingulate cortex and the striatum, were error corrections severely impaired. In sum, the fronto—striato—thalamo—cortical circuits seem necessary for the generation of error-related negativity, even when brain plasticity has resulted in behavioral compensation of the damage. Thus, error-related ERPs in patients provide a sensitive measure of the integrity of the performance monitoring network.

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