scholarly journals Bursting deep dorsal horn neurons: the pharmacological target for the antispastic effects of zolmitriptan?

2017 ◽  
Vol 117 (5) ◽  
pp. 1841-1843
Author(s):  
Eva Meier Carlsen ◽  
Rune Rasmussen
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Methodological Framework ◽  
Tonic Firing ◽  
Dorsal Horn Neurons ◽  
Bursting Neurons ◽  
Cord Injury ◽  
Pharmacological Target ◽  
Firing Properties

In a recent publication, Thaweerattanasinp et al. ( J Neurophysiol 116: 1644–1653, 2016) investigated spinal cord injury and firing properties of deep dorsal horn neurons during NMDA or zolmitriptan application by employing electrophysiology in an in vitro spinal cord preparation. Deep dorsal horn neurons were classified into bursting, simple, or tonic firing groups,with bursting neurons showing NMDA and zolmitriptan sensitivity. We discuss the findings in a methodological framework and propose future experiments of importance for translating the results into physiological settings.

scholarly journals Bursting deep dorsal horn neurons: the pharmacological target for the anti-spastic effects of Zolmitriptan?

2016 ◽  
Author(s):  
Eva Meier Carlsen ◽  
Rune Rasmussen
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Dorsal Horn ◽  
Methodological Framework ◽  
Dorsal Horn Neurons ◽  
Bursting Neurons ◽  
Cord Injury ◽  
Pharmacological Target ◽  
Firing Properties

AbstractIn a recent publication, Thaweerattanasinp and colleagues employed an in vitro preparation and electrophysiology to investigate firing properties of deep dorsal horn neurons following spinal cord injury during NMDA or zolmitriptan application. Deep dorsal horn neurons were classified into bursting, simple or tonic, with bursting neurons showing NMDA and zolmitriptan sensitivity. Here, we discuss the findings in a methodological framework and propose future experiments of importance for translating the results into a physiological setting.

Changes in Properties of Spinal Dorsal Horn Neurons and Their Sensitivity to Morphine after Spinal Cord Injury in the Rat

2005 ◽  
Vol 102 (1) ◽  
pp. 152-164 ◽  
Author(s):  
Jungang Wang ◽  
Mikito Kawamata ◽  
Akiyoshi Namiki
Keyword(s):  
Spinal Cord ◽  
Spontaneous Activity ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
High Threshold ◽  
Dorsal Horn Neurons ◽  
Spinal Dorsal ◽  
Cord Injury ◽  
Spinal Dorsal Horn Neurons ◽  
Wdr Neurons

Background To gain a better understanding of spinal cord injury (SCI)-induced central neuropathic pain, the authors investigated changes in properties of spinal dorsal horn neurons located rostrally and caudally to the lesion and their sensitivity to morphine in rats after SCI. Methods The right spinal cord of Sprague-Dawley rats was hemisected at the level of L2. At 10 to 14 days after the SCI, when mechanical hyperalgesia/allodynia had fully developed, spontaneous activity and evoked responses to mechanical stimuli of wide-dynamic-range (WDR) and high-threshold neurons rostral and caudal to the lesion were recorded. Effects of cumulative doses of systemic (0.1-3 mg/kg) and spinal (0.1-5 microg) administration of morphine on spontaneous activity and evoked responses to the stimuli of the neurons were evaluated. Results Spontaneous activity significantly increased in WDR neurons both rostral and caudal to the SCI site, but high-frequency background discharges with burst patterns were only observed in neurons rostral to the SCI site. Significant increases in responses to the mechanical stimuli were seen both in WDR and high-threshold neurons located both rostrally and caudally to the lesion. The responses to nonnoxious and noxious stimuli were significantly greater in caudal WDR neurons than in rostral WDR neurons. In contrast, the responses to pinch stimuli were significantly higher in rostral high-threshold neurons than those in caudal high-threshold neurons. Systemically administered morphine had a greater effect on responses to nonnoxious and noxious stimuli of rostral WDR neurons than those of caudal WDR neurons. Spinally administered morphine significantly suppressed responses of WDR neurons in SCI animals to nonnoxious stimuli compared with those in sham-operated control animals. Conclusions The findings suggest that changes in properties of spinal dorsal horn neurons after SCI are caused by different mechanisms, depending on the classification of the neurons and their segmental locations.

Membrane properties of deep dorsal horn neurons from neonatal rat spinal cord in vitro

1997 ◽  
Vol 767 (2) ◽  
pp. 214-219 ◽  
Author(s):  
Shawn Hochman ◽  
Sandra M Garraway ◽  
Susan Pockett
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Neonatal Rat ◽  
Membrane Properties ◽  
Rat Spinal Cord ◽  
Dorsal Horn Neurons

scholarly journals Monosynaptic Input to Deep Dorsal Horn Neurons from Primary Afferent A.DELTA. Fibers in the Rat Spinal Cord in vitro.

1992 ◽  
Vol 39 (4) ◽  
pp. 301-303
Author(s):  
MEGUMU YOSHIMURA ◽  
TOKO SHIMIZU ◽  
YOHICHI YAJIRI ◽  
SYOGORO NISHI
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Rat Spinal Cord ◽  
Primary Afferent ◽  
Dorsal Horn Neurons
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