Sensory-Motor Interaction in the Primate Auditory Cortex During Self-Initiated Vocalizations

2003 ◽  
Vol 89 (4) ◽  
pp. 2194-2207 ◽  
Author(s):  
Steven J. Eliades ◽  
Xiaoqin Wang
Keyword(s):  
Auditory Cortex ◽  
Cortical Neurons ◽  
Vocal Communication ◽  
Dynamic Range ◽  
Common Marmoset ◽  
Acoustic Environment ◽  
Hearing Sensitivity ◽  
Sensory Motor ◽  
Excitatory Responses ◽  
Motor Interaction

Little is known about sensory-motor interaction in the auditory cortex of primates at the level of single neurons and its role in supporting vocal communication. The present study investigated single-unit activities in the auditory cortex of a vocal primate, the common marmoset ( Callithrix jacchus), during self-initiated vocalizations. We found that 1) self-initiated vocalizations resulted in suppression of neural discharges in a majority of auditory cortical neurons. The vocalization-induced inhibition suppressed both spontaneous and stimulus-driven discharges. Suppressed units responded poorly to external acoustic stimuli during vocalization. 2) Vocalization-induced suppression began several hundred milliseconds prior to the onset of vocalization. 3) The suppression of cortical discharges reduced neural firings to below the rates expected from a unit's rate-level function, adjusted for known subcortical attenuation, and therefore was likely not entirely caused by subcortical attenuation mechanisms. 4) A smaller population of auditory cortical neurons showed increased discharges during self-initiated vocalizations. This vocalization-related excitation began after the onset of vocalization and is likely the result of acoustic feedback. Units showing this excitation responded nearly normally to external stimuli during vocalization. Based on these findings, we propose that the suppression of auditory cortical neurons, possibly originating from cortical vocal production centers, acts to increase the dynamic range of cortical responses to vocalization feedback for self monitoring. The excitatory responses, on the other hand, likely play a role in maintaining hearing sensitivity to the external acoustic environment during vocalization.

Multiparametric Corticofugal Modulation of Collicular Duration-Tuned Neurons: Modulation in the Amplitude Domain

2007 ◽  
Vol 97 (5) ◽  
pp. 3722-3730 ◽  
Author(s):  
Xiaofeng Ma ◽  
Nobuo Suga
Keyword(s):  
Auditory Cortex ◽  
Cortical Neurons ◽  
Electric Stimulation ◽  
Dynamic Range ◽  
Neural Representation ◽  
Time Duration ◽  
Multiple Parameters ◽  
Time Domains ◽  
Descending Fibers ◽  
Corticofugal Modulation

The subcortical auditory nuclei contain not only neurons tuned to a specific frequency but also those tuned to multiple parameters characterizing a sound. All these neurons are potentially subject to modulation by descending fibers from the auditory cortex (corticofugal modulation). In the past, we electrically stimulated cortical duration-tuned neurons of the big brown bat, Eptesicus fuscus, and found that its collicular duration-tuned neurons were corticofugally modulated in the frequency and time (duration) domains. In the current paper, we report that they were also corticofugally modulated in the amplitude (intensity) domain. We found the following collicular changes evoked by focal cortical electric stimulation. 1) Corticofugal modulation in the amplitude domain differed depending on whether recorded collicular neurons matched in best frequency (BF) with stimulated cortical neurons. BF-matched neurons decreased their thresholds, whereas BF-unmatched neurons increased their thresholds: the larger the BF difference between the recorded collicular and stimulated cortical neurons, the larger the threshold increase. 2) In general, the dynamic range for amplitude coding was larger in the inferior colliculus than in the auditory cortex. BF-matched neurons increased their dynamic ranges and response magnitude, whereas BF-unmatched neurons decreased them. 3) Single duration-tuned neurons were simultaneously modulated by cortical electric stimulation in the amplitude, frequency and time domains. 4) Corticofugal modulation in these three domains indicates that the contrast of the neural representation of repeatedly delivered sound stimuli is increased.

Tone Frequency Maps and Receptive Fields in the Developing Chinchilla Auditory Cortex

2005 ◽  
Vol 93 (1) ◽  
pp. 454-466 ◽  
Author(s):  
Martin Pienkowski ◽  
Robert V. Harrison
Keyword(s):  
Auditory Cortex ◽  
Receptive Fields ◽  
Sound Stimulation ◽  
Tone Frequency ◽  
Acoustic Environment ◽  
Hearing Sensitivity ◽  
Temporal Complexity ◽  
Ketamine Anesthesia ◽  
Middle Ear Disease ◽  
Cortical Receptive Fields

Single-unit responses to tone pip stimuli were isolated from numerous microelectrode penetrations of auditory cortex (under ketamine anesthesia) in the developing chinchilla ( laniger), a precocious mammal. Results are reported at postnatal day 3 (P3), P15, and P30, and from adult animals. Hearing sensitivity and spike firing rates were mature in the youngest group. The topographic representation of sound frequency (tonotopic map) in primary and secondary auditory cortex was also well ordered and sharply tuned by P3. The spectral-temporal complexity of cortical receptive fields, on the other hand, increased progressively (past P30) to adulthood. The (purported) refinement of initially diffuse tonotopic projections to cortex thus seems to occur in utero in the chinchilla, where external (and maternal) sounds are considerably attenuated and might not contribute to the mechanism(s) involved. This compares well with recent studies of vision, suggesting that the refinement of the retinotopic map does not require external light, but rather waves of (correlated) spontaneous activity on the retina. In contrast, it is most probable that selectivity for more complex sound features, such as frequency stacks and glides, develops under the influence of the postnatal acoustic environment and that inadequate sound stimulation in early development (e.g., due to chronic middle ear disease) impairs the formation of the requisite intracortical (and/or subcortical) circuitry.

scholarly journals High-field Functional Magnetic Resonance Imaging of Vocalization Processing in Marmosets

2014 ◽  
Author(s):  
Srivatsun Sadagopan ◽  
Nesibe Z Temiz ◽  
Henning U Voss
Keyword(s):  
Auditory Cortex ◽  
Auditory Processing ◽  
High Field ◽  
Vocal Communication ◽  
Common Marmoset ◽  
Cortical Region ◽  
Functional Magnetic Resonance ◽  
Temporal Pole ◽  
Vocalization Type ◽  
The Common

Vocalizations are behaviorally critical sounds, and this behavioral importance is reflected in the ascending auditory system, where conspecific vocalizations are increasingly over-represented at higher processing stages. Recent evidence suggests that, in macaques, this increasing selectivity for vocalizations might culminate in a cortical region that is densely populated by vocalization-preferring neurons. Such a region might be a critical node in the representation of vocal communication sounds, underlying the recognition of vocalization type, caller and social context. These results raise the questions of whether cortical specializations for vocalization processing exist in other species, their cortical location, and their relationship to the auditory processing hierarchy. To explore cortical specializations for vocalizations in another species, we performed high-field fMRI of the auditory cortex of a vocal New World primate, the common marmoset (Callithrix jacchus). Using a sparse imaging paradigm, we discovered a caudal-rostral gradient for the processing of conspecific vocalizations in marmoset auditory cortex, with regions of the anterior temporal lobe close to the temporal pole exhibiting the highest preference for vocalizations. These results demonstrate similar cortical specializations for vocalization processing in macaques and marmosets, suggesting that cortical specializations for vocal processing might have evolved before the lineages of these species diverged.

scholarly journals Low Basal CB2R in Dopamine Neurons and Microglia Influences Cannabinoid Tetrad Effects

2020 ◽  
Vol 21 (24) ◽  
pp. 9763
Author(s):  
Qing-Rong Liu ◽  
Ana Canseco-Alba ◽  
Ying Liang ◽  
Hiroki Ishiguro ◽  
Emmanuel S. Onaivi
Keyword(s):  
Cortical Neurons ◽  
Cannabinoid Receptors ◽  
Dynamic Range ◽  
Conditional Knockout ◽  
Dopamine Neurons ◽  
In Vivo Studies ◽  
Mouse Strains ◽  
Genotypic Differences ◽  
Mrna Levels ◽  
Selective Agonist

There are two well-characterized cannabinoid receptors (CB1R and CB2R and other candidates): the central nervous system (CNS) enriched CB1R and peripheral tissue enriched CB2R with a wide dynamic range of expression levels in different cell types of human tissues. Hepatocytes and neurons express low baseline CB1R and CB2R, respectively, and their cell-type-specific functions are not well defined. Here we report inducible expression of CB1R in the liver by high-fat and high sugar diet and CB2R in cortical neurons by methamphetamine. While there is less controversy about hepatocyte CB1R, the presence of functional neuronal CB2R is still debated to date. We found that neuron CB2R basal expression was higher than that of hepatocyte CB1R by measuring mRNA levels of specific isoform CB2A in neurons isolated by fluorescence-activated cell sorting (FACS) and CB1A in hepatocytes isolated by collagenase perfusion of liver. For in vivo studies, we generated hepatocyte, dopaminergic neuron, and microglia-specific conditional knockout mice (Abl-Cnr1Δ, Dat-Cnr2Δ, and Cx3cr1-Cnr2Δ) of CB1R and CB2R by crossing Cnr1f/f and Cnr2f/f strains to Abl-Cre, Dat-Cre, and Cx3cr1-Cre deleter mouse strains, respectively. Our data reveals that neuron and microglia CB2Rs are involved in the “tetrad” effects of the mixed agonist WIN 55212-2, CB1R selective agonist arachidonyl-2′-chloroethylamide (ACEA), and CB2R selective agonist JWH133. Dat-Cnr2Δ and Cx3cr1-Cnr2Δ mice showed genotypic differences in hypomobility, hypothermia, analgesia, and catalepsy induced by the synthetic cannabinoids. Alcohol conditioned place preference was abolished in DAT-Cnr2Δ mice and remained intact in Cx3cr1-Cnr2Δ mice in comparison to WT mice. These Cre-loxP recombinant mouse lines provide unique approaches in cannabinoid research for dissecting the complex endocannabinoid system that is implicated in many chronic disorders.

Representation of Spectral and Temporal Envelope of Twitter Vocalizations in Common Marmoset Primary Auditory Cortex

2002 ◽  
Vol 87 (4) ◽  
pp. 1723-1737 ◽  
Author(s):  
Srikantan S. Nagarajan ◽  
Steven W. Cheung ◽  
Purvis Bedenbaugh ◽  
Ralph E. Beitel ◽  
Christoph E. Schreiner ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Social Contact ◽  
Primary Auditory Cortex ◽  
Common Marmoset ◽  
Spectral Envelope ◽  
Response Patterns ◽  
Temporal Envelope ◽  
Degraded Speech ◽  
Neurophysiological Data ◽  
Narrowband Channels

Cortical sensitivity in representations of behaviorally relevant complex input signals was examined in recordings from primary auditory cortical neurons (AI) in adult, barbiturate-anesthetized common marmoset monkeys ( Callithrix jacchus). We studied the robustness of distributed responses to natural and degraded forms of twitter calls, social contact vocalizations comprising several quasi-periodic phrases of frequency and AM. We recorded neuronal responses to a monkey's own twitter call (MOC), degraded forms of their twitter call, and sinusoidal amplitude modulated (SAM) tones with modulation rates similar to those of twitter calls. In spectral envelope degradation, calls with narrowband channels of varying bandwidths had the same temporal envelope as a natural call. However, the carrier phase was randomized within each narrowband channel. In temporal envelope degradation, the temporal envelope within narrowband channels was filtered while the carrier frequencies and phases remained unchanged. In a third form of degradation, noise was added to the natural calls. Spatiotemporal discharge patterns in AI both within and across frequency bands encoded spectrotemporal acoustic features in the call although the encoded response is an abstract version of the call. The average temporal response pattern in AI, however, was significantly correlated with the average temporal envelope for each phrase of a call. Response entrainment to MOC was significantly correlated with entrainment to SAM stimuli at comparable modulation frequencies. Sensitivity of the response patterns to MOC was substantially greater for temporal envelope than for spectral envelope degradations. The distributed responses in AI were robust to additive continuous noise at signal-to-noise ratios ≥10 dB. Neurophysiological data reflecting response sensitivity in AI to these forms of degradation closely parallel human psychophysical results on the intelligibility of degraded speech in quiet and noisy conditions.

Monaural inhibition in cat auditory cortex

1995 ◽  
Vol 73 (5) ◽  
pp. 1876-1891 ◽  
Author(s):  
M. B. Calford ◽  
M. N. Semple
Keyword(s):  
Auditory Cortex ◽  
Lateral Inhibition ◽  
Cortical Neurons ◽  
Frequency Tuning ◽  
Inhibitory Response ◽  
Forward Masking ◽  
Excitatory Response ◽  
Rate Level ◽  
Wide Range ◽  
Response Area

1. Several studies of auditory cortex have examined the competitive inhibition that can occur when appropriate sounds are presented to each ear. However, most cortical neurons also show both excitation and inhibition in response to presentation of stimuli at one ear alone. The extent of such inhibition has not been described. Forward masking, in which a variable masking stimulus was followed by a fixed probe stimulus (within the excitatory response area), was used to examine the extent of monaural inhibition for neurons in primary auditory cortex of anesthetized cats (barbiturate or barbiturate-ketamine). Both the masking and probe stimuli were 50-ms tone pips presented to the contralateral ear. Most cortical neurons showed significant forward masking at delays beyond which masking effects in the auditory nerve are relatively small compared with those seen in cortical neurons. Analysis was primarily concerned with such components. Standard rate-level functions were also obtained and were examined for nonmonotonicity, an indication of level-dependent monaural inhibition. 2. Consistent with previous reports, a wide range of frequency tuning properties (excitatory response area shapes) was found in cortical neurons. This was matched by a wide range of forward-masking-derived inhibitory response areas. At the most basic level of analysis, these were classified according to the presence of lateral inhibition, i.e., where a probe tone at a neuron's characteristic frequency was masked by tones outside the limits of the excitatory response area. Lateral inhibition was a property of 38% of the sampled neurons. Such neurons represented 77% of those with nonmonotonic rate-level functions, indicating a strong correlation between the two indexes of monaural inhibition; however, the shapes of forward masking inhibitory response areas did not usually correspond with those required to account for the "tuning" of a neuron. In addition, it was found that level-dependent inhibition was not added to by forward masking inhibition. 3. Analysis of the discharges to individual stimulus pair presentations, under conditions of partial masking, revealed that discharges to the probe occurred independently of discharges to the preceding masker. This indicates that even when the masker is within a neuron's excitatory response area, forward masking is not a postdischarge habituation phenomenon. However, for most neurons the degree of masking summed over multiple stimulus presentations appears determined by the same stimulus parameters that determine the probability of response to the masker.(ABSTRACT TRUNCATED AT 400 WORDS)

Neural Responses in Primary Auditory Cortex Mimic Psychophysical, Across-Frequency-Channel, Gap-Detection Thresholds

2000 ◽  
Vol 84 (3) ◽  
pp. 1453-1463 ◽  
Author(s):  
Jos J. Eggermont
Keyword(s):  
Auditory Cortex ◽  
Cortical Neurons ◽  
Primary Auditory Cortex ◽  
Noise Burst ◽  
Gap Detection ◽  
Frequency Content ◽  
Neural Responses ◽  
Frequency Channel ◽  
Interval Representations ◽  
Onset Response

Responses of single- and multi-units in primary auditory cortex were recorded for gap-in-noise stimuli for different durations of the leading noise burst. Both firing rate and inter-spike interval representations were evaluated. The minimum detectable gap decreased in exponential fashion with the duration of the leading burst to reach an asymptote for durations of 100 ms. Despite the fact that leading and trailing noise bursts had the same frequency content, the dependence on leading burst duration was correlated with psychophysical estimates of across frequency channel (different frequency content of leading and trailing burst) gap thresholds in humans. The duration of the leading burst plus that of the gap was represented in the all-order inter-spike interval histograms for cortical neurons. The recovery functions for cortical neurons could be modeled on basis of fast synaptic depression and after-hyperpolarization produced by the onset response to the leading noise burst. This suggests that the minimum gap representation in the firing pattern of neurons in primary auditory cortex, and minimum gap detection in behavioral tasks is largely determined by properties intrinsic to those, or potentially subcortical, cells.

Taste responses of cortical neurons in freely ingesting rats

1989 ◽  
Vol 61 (6) ◽  
pp. 1244-1258 ◽  
Author(s):  
T. Yamamoto ◽  
R. Matsuo ◽  
Y. Kiyomitsu ◽  
R. Kitamura
Keyword(s):  
Cortical Neurons ◽  
Correlation Coefficients ◽  
Entropy Measure ◽  
Response Patterns ◽  
Gustatory System ◽  
Basic Taste ◽  
Quinine Hydrochloride ◽  
Excitatory Responses

1. Activities of 35 taste-responsive neurons in the cortical gustatory area were recorded with chronically implanted fine wires in freely ingesting Wistar rats. Quantitative analyses were performed on responses to distilled water, food solution, and four taste stimuli: sucrose, NaCl, HCl, and quinine hydrochloride. 2. Taste-responsive neurons were classified into type-1 and type-2 groups according to the response patterns to licking of the six taste stimuli. Type-1 neurons (n = 29) responded in excitatory or inhibitory directions to one or more of the taste stimuli. Type-2 neurons (n = 6) showed responses in different directions depending upon palatability of the liquids to rats: neurons showing excitatory (or inhibitory) responses to palatable stimuli exhibited inhibitory (or excitatory) responses to unpalatable stimuli. 3. Correlation coefficients of responses to pairs of stimuli across neurons suggested that palatable stimuli (water, food solution, sucrose, and NaCl) and unpalatable stimuli (HCl and quinine) elicited reciprocal (excitatory vs. inhibitory) responses in type-2 neurons, whereas type-1 neurons showed positively correlated responses to specific combinations of stimuli such as food solution and NaCl, sucrose and HCl, NaCl and quinine, and HCl and quinine. 4. A tendency toward equalization of effectiveness in eliciting responses among the four basic taste stimuli was detected on the cortex. The ratios of mean evoked responses in 29 type-1 neurons in comparison with spontaneous rate (4.4 spikes/s) were 1.7, 1.9, 1.8, and 1.9 for sucrose, NaCl, HCl, and quinine, respectively. 5. The breadth of responsiveness to the four basic taste stimuli was quantified by means of the entropy measure introduced by Smith and Travers (33). The mean entropy value was 0.540 for 29 type-1 neurons, which was similar to 0.588 previously reported for rat chorda tympani fibers, suggesting that breadth of tuning is not more narrowly tuned in a higher level of the gustatory system in the rat. 6. Convergent inputs of other sensory modalities were detected exclusively in type-1 neurons. Thirteen (45%) of 29 type-1 neurons also responded to cold and/or warm water, but none of 6 type-2 neurons responded to thermal stimuli. Two (7%) of 29 type-1 neurons responded to almond and acetic acid odors, but the 6 type-2 neurons did not. Two (13%) of 16 type-1 neurons responded to interperitoneal injection of LiCl, which is known to induce gastrointestinal disorders, with a latency of approximately 5 min, but 4 type-2 neurons tested were not responsive to this stimulation.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals Fast-spiking GABA circuit dynamics in the auditory cortex predict recovery of sensory processing following peripheral nerve damage

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Jennifer Resnik ◽  
Daniel B Polley
Keyword(s):  
Peripheral Nerve ◽  
Auditory Cortex ◽  
Sensory Processing ◽  
Cortical Neurons ◽  
Sensory Nerve ◽  
Intracortical Inhibition ◽  
Nerve Fibers ◽  
Nerve Damage ◽  
Inhibitory Neurons ◽  
Sound Processing

Cortical neurons remap their receptive fields and rescale sensitivity to spared peripheral inputs following sensory nerve damage. To address how these plasticity processes are coordinated over the course of functional recovery, we tracked receptive field reorganization, spontaneous activity, and response gain from individual principal neurons in the adult mouse auditory cortex over a 50-day period surrounding either moderate or massive auditory nerve damage. We related the day-by-day recovery of sound processing to dynamic changes in the strength of intracortical inhibition from parvalbumin-expressing (PV) inhibitory neurons. Whereas the status of brainstem-evoked potentials did not predict the recovery of sensory responses to surviving nerve fibers, homeostatic adjustments in PV-mediated inhibition during the first days following injury could predict the eventual recovery of cortical sound processing weeks later. These findings underscore the potential importance of self-regulated inhibitory dynamics for the restoration of sensory processing in excitatory neurons following peripheral nerve injuries.

Sign in / Sign up

Export Citation Format

Share Document