scholarly journals Modulation and transmission of peripheral inputs in monkey cuneate and external cuneate nuclei

2011 ◽  
Vol 106 (5) ◽  
pp. 2764-2775 ◽  
Author(s):  
Claire L. Witham ◽  
Stuart N. Baker
Keyword(s):  
Peripheral Nerves ◽  
Action Potentials ◽  
Conditioning Stimulus ◽  
Mechanical Stimulus ◽  
Dorsal Column ◽  
Motor Threshold ◽  
Peripheral Stimulation ◽  
Transmission Of Information ◽  
Forelimb Afferents ◽  
Stimulation Of

Somatosensory signals undergo substantial modulation in the dorsal column nuclei. We examined transmission of signals from forelimb afferents in primate cuneate and external cuneate nuclei. In anesthetized macaque monkeys, the median, ulnar, deep radial, and superficial radial nerves were electrically stimulated at 1.5–2× motor threshold with independent Poisson trains whereas extracellular recordings were made from 317 cells. Responses to peripheral stimulation included instances of both brief facilitation and long lasting suppression. A high proportion of cells (87%) responded to stimulation of two or more peripheral nerves, suggesting a large amount of convergence. Facilitated cells showed coherence with the peripheral stimulation across a broad frequency range; coherence was especially high in cells that responded with a burst of action potentials. Cells that responded with suppression also showed significant coherence, but this fell rapidly for frequencies above 25 Hz. Similar results were seen in both the main and external cuneate. When stimulation of one nerve was conditioned by a preceding nerve stimulus, the response to the second stimulus was attenuated for around 40 ms. This occurred independently of whether the first stimulus produced an initial facilitation or suppression or whether the same or a different nerve served as a conditioning stimulus. Mechanical stimulation of a receptive field suppressed responses to a second identical mechanical stimulus over a similar timescale. We conclude that the primate cuneate nucleus is capable of transmitting temporal information about stimuli with high fidelity; stimuli interact both temporally and spatially to modulate the onward transmission of information.

Spinocervical tract neurons responsive to light mechanical stimulation of the raccoon forepaw

1989 ◽  
Vol 61 (1) ◽  
pp. 138-148 ◽  
Author(s):  
H. Hirata ◽  
B. H. Pubols
Keyword(s):  
Mechanical Stimulation ◽  
Receptive Fields ◽  
Mechanical Stimulus ◽  
Dorsal Column ◽  
Glabrous Skin ◽  
Mechanical Stimuli ◽  
The Relationship ◽  
Lemniscal System ◽  
Extracellular Activity ◽  
Stimulation Of

1. The extracellular activity of 45 antidromically identified spinocervical tract (SCT) neurons responsive to light mechanical stimulation of the glabrous surfaces of the forepaw was examined in raccoons anesthetized with pentobarbital sodium. An additional seven neurons had peripheral receptive fields (RFs) located on hairy skin of the forelimb, and three had deep RFs. 2. All recording sites were histologically verified as falling within Rexed's laminae III and IV in spinal cord segments C6-T1. Antidromic conduction velocities of the 55 neurons ranged between 8.3 and 64.2 m/s. 3. Units with glabrous skin RFs were classified according to their response to a maintained mechanical stimulus as either rapidly adapting (n = 39) or slowly adapting (n = 6). Of 11 cells tested, 2 displayed enhanced responses to noxious stimuli and were classed as multireceptive. 4. RF areas were significantly smaller on digits (range = 0.4-45.0 mm2) than on palm pads (range = 5.6-76.0 mm2), and comparable in size to RF areas previously reported in raccoon cuneate nuclear cells (32). 5. RA neurons fell into three distinct categories with respect to the relationship between instantaneous spike frequency during displacement ramp stimulation, and ramp velocity, steep functions (as defined by the value of power function exponents), flat functions, and discontinuous functions; SA neurons fell into two categories, continuous, and discontinuous. 6. The results, in conjunction with those of previous studies, lead to two major conclusions: 1) raccoon and primate spinocervicothalamic systems are more similar to each other than either is to that of the cat and 2) the ability of the raccoon SCT to convey information from the glabrous skin of the forepaw regarding characteristics of light mechanical stimuli is at least as precise as that of neurons of the dorsal column-medial lemniscal system.

Epidermal Laser Stimulation of Action Potentials in the Frog Sciatic Nerve

2008 ◽  
Author(s):  
Nichole M. Jindra ◽  
Robert J. Thomas ◽  
Douglas N. Goddard ◽  
Michelle L. Imholte
Keyword(s):  
Sciatic Nerve ◽  
Action Potentials ◽  
Laser Stimulation ◽  
Frog Sciatic Nerve ◽  
Stimulation Of

scholarly journals Stimulation of dorsal column in multiple sclerosis.

BMJ ◽  
1980 ◽  
Vol 280 (6218) ◽  
pp. 889-891 ◽  
Author(s):  
C H Hawkes ◽  
M Myke ◽  
A Desmond ◽  
M I Bultitude ◽  
G S Kanegaonkar
Keyword(s):  
Multiple Sclerosis ◽  
Dorsal Column ◽  
Stimulation Of

Tetrodotoxin-resistant release of ATP from superfused rabbit detrusor muscle during electrical field stimulation in the presence of luciferin–luciferase

1984 ◽  
Vol 62 (1) ◽  
pp. 153-156 ◽  
Author(s):  
Archana Chaudhry ◽  
John W. Downie ◽  
Thomas D. White
Keyword(s):  
Action Potentials ◽  
Electrical Field Stimulation ◽  
Detrusor Muscle ◽  
Electrical Field ◽  
Stimulation Parameters ◽  
Rabbit Bladder ◽  
Firefly Luciferin ◽  
Rabbit Urinary Bladder ◽  
Stimulation Of

The present study was carried out to assess the possible role of ATP in the noncholinergic, nonadrenergic transmission in the rabbit urinary bladder. When rabbit detrusor muscle strips were superfused with medium containing firefly luciferin–luciferase and stimulated transmurally at low stimulation parameters, tetrodotoxin-sensitive contractions were obtained but no release of ATP could be detected. However, at somewhat higher stimulation parameters, release of ATP was observed. This release of ATP was not diminished by tetrodotoxin indicating that ATP was not likely released as a result of propagated action potentials in nerves. Because contractions persisted in the presence of tetrodotoxin, it is possible that the ATP might have been released as a result of direct electrical stimulation of the muscle. These results do not support the idea that ATP is released as a neurotransmitter in the rabbit bladder.

Surface anodal stimulation of human peripheral nerves

1988 ◽  
Vol 73 (3) ◽  
pp. 481-488 ◽  
Author(s):  
T. Winkler ◽  
E. St�lberg
Keyword(s):  
Peripheral Nerves ◽  
Anodal Stimulation ◽  
Stimulation Of

Control of feeding motor output by paracerebral neurons in brain of Pleurobranchaea californica

1982 ◽  
Vol 47 (5) ◽  
pp. 885-908 ◽  
Author(s):  
R. Gillette ◽  
M. P. Kovac ◽  
W. J. Davis
Keyword(s):  
Feeding Behavior ◽  
Action Potentials ◽  
Tactile Stimulation ◽  
Natural Food ◽  
Buccal Ganglion ◽  
Pleurobranchaea Californica ◽  
Feeding Rhythm ◽  
Intracellular Stimulation ◽  
Motor Rhythm ◽  
Stimulation Of

1. A population of interneurons that control feeding behavior in the mollusk Pleurobranchaea has been analyzed by dye injection and intracellular stimulation/recording in whole animals and reduced preparations. The population consists of 12-16 somata distributed in two bilaterally symmetrical groups on the anterior edge of the cerebropleural ganglion (brain). On the basis of their position adjacent to the cerebral lobes, these cells have been named paracerebral neurons (PCNs). This study concerns pme subset pf [MCs. the large, phasic ones, which have the strongest effect on the feeding rhythm (21). 2. Each PCN sends a descending axon via the ipsilateral cerebrobuccal connective to the buccal ganglion. Axon branches have not been detected in other brain or buccal nerves and hence the PCNs appear to be interneurons. 3. In whole-animal preparations, tonic intracellular depolarization of the PNCs causes them to discharge cyclic bursts of action potentials interrupted by a characteristic hyperpolarization. In all specimens that exhibit feeding behavior, the interburst hyperpolarization is invariably accompanied by radula closure and the beginning of proboscis retraction (the "bite"). No other behavorial effect of PCN stimulation has been observed. 4. In whole-animal preparations, the PCNs are excited by food and tactile stimulation of the oral veil, rhinophores, and tentacles. When such stimuli induce feeding the PCNs discharge in the same bursting pattern seen during tonic PCN depolarization, with the cyclic interburst hyperpolarization phase locked to the bit. When specimens egest an unpalatable object by cyclic buccal movements, however, the PCNs are silent. The PCNs therefore exhibit properties expected of behaviorally specific "command" neurons for feeding. 5. Silencing one or two PCNs by hyperpolarization may weaken but does not prevent feeding induced by natural food stimuli. Single PCNs therefore can be sufficient but are not necessary to induction of feeding behavior. Instead the PCNs presumably operate as a population to control feeding. 6. In isolated nervous system preparations tonic extracellular stimulation of the stomatogastric nerve of the buccal ganglion elicits a cyclic motor rhythm that is similar in general features to the PNC-induced motor rhythm. Bursts of PCN action potentials intercalated at the normal phase position in this cycle intensify the buccal rhythm. Bursts of PCN impulses intercalated at abnormal phase positions reset the buccal rhythm. The PCNs, therefore, also exhibit properties expected of pattern-generator elements and/or coordinating neurons for the buccal rhythm. 7. The PCNs are recruited into activity when the buccal motor rhythm is elicited by stomatogastric nerve stimulation or stimulation of the reidentifiable ventral white cell. The functional synergy between the PCNs and the buccal rhythm is therefore reciprocal. 8...

Electrical Stimulation of the Spinal Cord and Peripheral Nerves for Pain Control

1981 ◽  
Vol 44 (4) ◽  
pp. 207-217 ◽  
Author(s):  
Don M. Long ◽  
Donald Erickson ◽  
James Campbell ◽  
Richard North
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Peripheral Nerves ◽  
Pain Control ◽  
Stimulation Of
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