scholarly journals Linear summation in the barn owl's brainstem underlies responses to interaural time differences

2013 ◽  
Vol 110 (1) ◽  
pp. 117-130 ◽  
Author(s):  
Paula T. Kuokkanen ◽  
Go Ashida ◽  
Catherine E. Carr ◽  
Hermann Wagner ◽  
Richard Kempter
Keyword(s):  
Interaural Time Difference ◽  
Field Potential ◽  
Time Difference ◽  
Linear Summation ◽  
Interaural Time Differences ◽  
Synaptic Potentials ◽  
Binaural Stimulation ◽  
Nonlinear Responses ◽  
Model Predictions ◽  
Primary Origin

The neurophonic potential is a synchronized frequency-following extracellular field potential that can be recorded in the nucleus laminaris (NL) in the brainstem of the barn owl. Putative generators of the neurophonic are the afferent axons from the nucleus magnocellularis, synapses onto NL neurons, and spikes of NL neurons. The outputs of NL, i.e., action potentials of NL neurons, are only weakly represented in the neurophonic. Instead, the inputs to NL, i.e., afferent axons and their synaptic potentials, are the predominant origin of the neurophonic (Kuokkanen PT, Wagner H, Ashida G, Carr CE, Kempter R. J Neurophysiol 104: 2274–2290, 2010). Thus in NL the monaural inputs from the two brain sides converge and create a binaural neurophonic. If these monaural inputs contribute independently to the extracellular field, the response to binaural stimulation can be predicted from the sum of the responses to ipsi- and contralateral stimulation. We found that a linear summation model explains the dependence of the responses on interaural time difference as measured experimentally with binaural stimulation. The fit between model predictions and data was excellent, even without taking into account the nonlinear responses of NL coincidence detector neurons, although their firing rate and synchrony strongly depend on the interaural time difference. These results are consistent with the view that the afferent axons and their synaptic potentials in NL are the primary origin of the neurophonic.

Tuning to Interaural Time Difference and Frequency Differs Between the Auditory Arcopallium and the External Nucleus of the Inferior Colliculus

2009 ◽  
Vol 101 (5) ◽  
pp. 2348-2361 ◽  
Author(s):  
Katrin Vonderschen ◽  
Hermann Wagner
Keyword(s):  
Inferior Colliculus ◽  
Tuning Curve ◽  
Interaural Time Difference ◽  
Low Frequency ◽  
Steep Slope ◽  
Time Difference ◽  
Interaural Time Differences ◽  
Tuning Curves ◽  
Barn Owls ◽  
Zero Time

Barn owls process sound-localization information in two parallel pathways, the midbrain and the forebrain pathway. Exctracellular recordings of neural responses to auditory stimuli from far advanced stations of these pathways, the auditory arcopallium in the forebrain and the external nucleus of the inferior colliculus in the midbrain, demonstrated that the representations of interaural time difference and frequency in the forebrain pathway differ from those in the midbrain pathway. Specifically, low-frequency representation was conserved in the forebrain pathway, while it was lost in the midbrain pathway. Variation of interaural time difference yielded symmetrical tuning curves in the midbrain pathway. By contrast, the typical forebrain-tuning curve was asymmetric with a steep slope crossing zero time difference and a less-steep slope toward larger contralateral time disparities. Low sound frequencies contributed sensitivity to contralateral leading sounds underlying these asymmetries, whereas high frequencies enhanced the steepness of slopes at small interaural time differences. Furthermore, the peaks of time-disparity tuning curves were wider in the forebrain than in the midbrain. The distribution of the steepest slopes of best interaural time differences in the auditory arcopallium, but not in the external nucleus of the inferior colliculus, was centered at zero time difference. The distribution observed in the auditory arocpallium is reminiscent of the situation observed in small mammals. We speculate that the forebrain representation may serve as a population code supporting fine discrimination of central interaural time differences and coarse indication of laterality of a stimulus for large interaural time differences.

The Effect of Spatially Separated Sound Sources on Speech Intelligibility

1969 ◽  
Vol 12 (1) ◽  
pp. 5-38 ◽  
Author(s):  
Donald D. Dirks ◽  
Richard H. Wilson
Keyword(s):  
Speech Intelligibility ◽  
Rank Order ◽  
Interaural Time Difference ◽  
Sound Field ◽  
Spatial Separation ◽  
Spatial Location ◽  
Time Difference ◽  
Noise Sources ◽  
Sound Sources ◽  
Interaural Time Differences

A series of five experiments was conducted to investigate the effects of spatial separation of speakers on the intelligibility of spondaic and PB words in noise and the identification of synthetic sentences in noise and competing message. Conditions in which the spatial location of the speakers produced interaural time differences ranked highest in intelligibility. The rank order of other conditions was dependent on the S/N ratio at the monaural near ear. Separations of only 10° between the speech and noise sources resulted in measurable changes in intelligibility. The binaural intelligibility scores were enhanced substantially over the monaural near ear results during conditions where an interaural time difference was present. This result was observed more effectively when spondaic words or sentences were used rather than PB words. The implications of this result were related to the interaural time difference and the frequency range of the critical information in the primary message. Although the initial experiments were facilitated by recording through an artificial head, almost identical results were obtained in the final experiment when subjects were tested in the sound field.

scholarly journals Microsecond Interaural Time Difference Discrimination Restored by Cochlear Implants After Neonatal Deafness

2018 ◽  
Author(s):  
Nicole Rosskothen-Kuhl ◽  
Alexa N Buck ◽  
Kongyan Li ◽  
Jan W H Schnupp
Keyword(s):  
Cochlear Implants ◽  
Critical Period ◽  
Interaural Time Difference ◽  
Spatial Hearing ◽  
Time Difference ◽  
Interaural Time Differences ◽  
Behavioral Thresholds ◽  
Essentially Normal ◽  
High Degree ◽  
Prelingually Deaf

AbstractCochlear implants (CIs) can restore a high degree of functional hearing in deaf patients however spatial hearing remains poor, with many early deaf CI users reported to have no measurable sensitivity to interaural time differences (ITDs) at all. Deprivation of binaural experience during an early critical period is often blamed for this shortcoming. However, we show that neonatally deafened rats provided with precisely synchronized CI stimulation in adulthood can be trained to localize ITDs with essentially normal behavioral thresholds near 50 μs. Furthermore, neonatally deaf rats show high physiological sensitivity to ITDs immediately after binaural implantation in adulthood. The fact that our neonatally deaf CI rats achieved very good behavioral ITD thresholds while prelingually deaf human CI patients usually fail to develop a useful sensitivity to ITD raises urgent questions about whether shortcomings in technology or treatment may be behind the usually poor binaural outcomes for current binaural CI patients.

scholarly journals Microsecond interaural time difference discrimination restored by cochlear implants after neonatal deafness

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Nicole Rosskothen-Kuhl ◽  
Alexa N Buck ◽  
Kongyan Li ◽  
Jan W H Schnupp
Keyword(s):  
Cochlear Implant ◽  
Cochlear Implants ◽  
Early Development ◽  
Critical Period ◽  
Interaural Time Difference ◽  
Spatial Hearing ◽  
Time Difference ◽  
Interaural Time Differences ◽  
Behavioral Thresholds ◽  
Essentially Normal

Spatial hearing in cochlear implant (CI) patients remains a major challenge with many early deaf users reported to have no measurable sensitivity to interaural time differences (ITDs). Deprivation of binaural experience during an early critical period is often hypothesized to be the cause of this shortcoming. However, we show that neonatally deafened (ND) rats provided with precisely synchronized CI stimulation in adulthood can be trained to lateralize ITDs with essentially normal behavioral thresholds near 50 μs. Furthermore, comparable ND rats show high physiological sensitivity to ITDs immediately after binaural implantation in adulthood. Our result that ND CI rats achieved very good behavioral ITD thresholds while prelingually deaf human CI patients often fail to develop a useful sensitivity to ITD raises urgent questions concerning the possibility that shortcomings in technology or treatment, rather than missing input during early development, may be behind the usually poor binaural outcomes for current CI patients.

scholarly journals Disparity in interaural time difference improves the accuracy of neural representations of individual concurrent narrowband sounds in rat inferior colliculus and auditory cortex

2020 ◽  
Vol 123 (2) ◽  
pp. 695-706
Author(s):  
Lu Luo ◽  
Na Xu ◽  
Qian Wang ◽  
Liang Li
Keyword(s):  
Auditory Cortex ◽  
Inferior Colliculus ◽  
Interaural Time Difference ◽  
Critical Role ◽  
Low Frequency ◽  
Time Difference ◽  
Neural Representation ◽  
Frequency Bands ◽  
Neural Segregation ◽  
Peripheral Auditory System

The central mechanisms underlying binaural unmasking for spectrally overlapping concurrent sounds, which are unresolved in the peripheral auditory system, remain largely unknown. In this study, frequency-following responses (FFRs) to two binaurally presented independent narrowband noises (NBNs) with overlapping spectra were recorded simultaneously in the inferior colliculus (IC) and auditory cortex (AC) in anesthetized rats. The results showed that for both IC FFRs and AC FFRs, introducing an interaural time difference (ITD) disparity between the two concurrent NBNs enhanced the representation fidelity, reflected by the increased coherence between the responses evoked by double-NBN stimulation and the responses evoked by single NBNs. The ITD disparity effect varied across frequency bands, being more marked for higher frequency bands in the IC and lower frequency bands in the AC. Moreover, the coherence between IC responses and AC responses was also enhanced by the ITD disparity, and the enhancement was most prominent for low-frequency bands and the IC and the AC on the same side. These results suggest a critical role of the ITD cue in the neural segregation of spectrotemporally overlapping sounds. NEW & NOTEWORTHY When two spectrally overlapped narrowband noises are presented at the same time with the same sound-pressure level, they mask each other. Introducing a disparity in interaural time difference between these two narrowband noises improves the accuracy of the neural representation of individual sounds in both the inferior colliculus and the auditory cortex. The lower frequency signal transformation from the inferior colliculus to the auditory cortex on the same side is also enhanced, showing the effect of binaural unmasking.

Sign in / Sign up

Export Citation Format

Share Document