scholarly journals The organization of the human cerebral cortex estimated by intrinsic functional connectivity

2011 ◽  
Vol 106 (3) ◽  
pp. 1125-1165 ◽  
Author(s):  
B. T. Thomas Yeo ◽  
Fenna M. Krienen ◽  
Jorge Sepulcre ◽  
Mert R. Sabuncu ◽  
Danial Lashkari ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Functional Connectivity ◽  
Large Scale ◽  
Distributed Networks ◽  
Association Cortex ◽  
Resting State Functional Connectivity ◽  
Local Networks ◽  
Temporal Area ◽  
Hierarchical Relations ◽  
Connectivity Patterns

Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within the visual system. Other connectivity patterns, particularly among association areas, suggest the presence of large-scale circuits without clear hierarchical relations. In this study the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI. Data from 1,000 subjects were registered using surface-based alignment. A clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex. The results revealed local networks confined to sensory and motor cortices as well as distributed networks of association regions. Within the sensory and motor cortices, functional connectivity followed topographic representations across adjacent areas. In association cortex, the connectivity patterns often showed abrupt transitions between network boundaries. Focused analyses were performed to better understand properties of network connectivity. A canonical sensory-motor pathway involving primary visual area, putative middle temporal area complex (MT+), lateral intraparietal area, and frontal eye field was analyzed to explore how interactions might arise within and between networks. Results showed that adjacent regions of the MT+ complex demonstrate differential connectivity consistent with a hierarchical pathway that spans networks. The functional connectivity of parietal and prefrontal association cortices was next explored. Distinct connectivity profiles of neighboring regions suggest they participate in distributed networks that, while showing evidence for interactions, are embedded within largely parallel, interdigitated circuits. We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition.

scholarly journals Situating the left-lateralized language network in the broader organization of multiple specialized large-scale distributed networks

2020 ◽  
Vol 124 (5) ◽  
pp. 1415-1448 ◽  
Author(s):  
Rodrigo M. Braga ◽  
Lauren M. DiNicola ◽  
Hannah C. Becker ◽  
Randy L. Buckner
Keyword(s):  
Functional Connectivity ◽  
Large Scale ◽  
Distributed Networks ◽  
Task Demands ◽  
Association Cortex ◽  
Control Networks ◽  
Language Network

This research shows that a language network can be identified within individuals using functional connectivity. Organizational details reveal that the language network shares a common spatial motif with other association networks, including default and frontoparietal control networks. The language network is activated by language task demands, whereas closely juxtaposed networks are not, suggesting that similarly organized but differentially specialized distributed networks populate association cortex.

scholarly journals The organization of the human striatum estimated by intrinsic functional connectivity

2012 ◽  
Vol 108 (8) ◽  
pp. 2242-2263 ◽  
Author(s):  
Eun Young Choi ◽  
B. T. Thomas Yeo ◽  
Randy L. Buckner
Keyword(s):  
Cerebral Cortex ◽  
Functional Connectivity ◽  
Large Scale ◽  
Supplementary Motor Area ◽  
Strongly Correlated ◽  
Resting State Functional Connectivity ◽  
Tract Tracing ◽  
Motor Representation ◽  
Anatomical Studies ◽  
Functional Connectivity Mri

The striatum is connected to the cerebral cortex through multiple anatomical loops that process sensory, limbic, and heteromodal information. Tract-tracing studies in the monkey reveal that these corticostriatal connections form stereotyped patterns in the striatum. Here the organization of the striatum was explored in the human with resting-state functional connectivity MRI (fcMRI). Data from 1,000 subjects were registered with nonlinear deformation of the striatum in combination with surface-based alignment of the cerebral cortex. fcMRI maps derived from seed regions placed in the foot and tongue representations of the motor cortex yielded the expected inverted somatotopy in the putamen. fcMRI maps derived from the supplementary motor area were located medially to the primary motor representation, also consistent with anatomical studies. The topography of the complete striatum was estimated and replicated by assigning each voxel in the striatum to its most strongly correlated cortical network in two independent groups of 500 subjects. The results revealed at least five cortical zones in the striatum linked to sensorimotor, premotor, limbic, and two association networks with a topography globally consistent with monkey anatomical studies. The majority of the human striatum was coupled to cortical association networks. Examining these association networks further revealed details that fractionated the five major networks. The resulting estimates of striatal organization provide a reference for exploring how the striatum contributes to processing motor, limbic, and heteromodal information through multiple large-scale corticostriatal circuits.

scholarly journals The organization of the human cerebellum estimated by intrinsic functional connectivity

2011 ◽  
Vol 106 (5) ◽  
pp. 2322-2345 ◽  
Author(s):  
Randy L. Buckner ◽  
Fenna M. Krienen ◽  
Angela Castellanos ◽  
Julio C. Diaz ◽  
B. T. Thomas Yeo
Keyword(s):  
Cerebral Cortex ◽  
Functional Connectivity ◽  
Body Representation ◽  
Anterior Lobe ◽  
Association Cortex ◽  
Posterior Lobe ◽  
Resting State Functional Connectivity ◽  
Discovery Sample ◽  
Human Cerebellum ◽  
Functional Connectivity Mri

The cerebral cortex communicates with the cerebellum via polysynaptic circuits. Separate regions of the cerebellum are connected to distinct cerebral areas, forming a complex topography. In this study we explored the organization of cerebrocerebellar circuits in the human using resting-state functional connectivity MRI (fcMRI). Data from 1,000 subjects were registered using nonlinear deformation of the cerebellum in combination with surface-based alignment of the cerebral cortex. The foot, hand, and tongue representations were localized in subjects performing movements. fcMRI maps derived from seed regions placed in different parts of the motor body representation yielded the expected inverted map of somatomotor topography in the anterior lobe and the upright map in the posterior lobe. Next, we mapped the complete topography of the cerebellum by estimating the principal cerebral target for each point in the cerebellum in a discovery sample of 500 subjects and replicated the topography in 500 independent subjects. The majority of the human cerebellum maps to association areas. Quantitative analysis of 17 distinct cerebral networks revealed that the extent of the cerebellum dedicated to each network is proportional to the network's extent in the cerebrum with a few exceptions, including primary visual cortex, which is not represented in the cerebellum. Like somatomotor representations, cerebellar regions linked to association cortex have separate anterior and posterior representations that are oriented as mirror images of one another. The orderly topography of the representations suggests that the cerebellum possesses at least two large, homotopic maps of the full cerebrum and possibly a smaller third map.

scholarly journals Parallel Distributed Networks Resolved at High Resolution Reveal Close Juxtaposition of Distinct Regions

2018 ◽  
Author(s):  
Rodrigo M. Braga ◽  
Koene R. A. Van Dijk ◽  
Jonathan R. Polimeni ◽  
Mark C. Eldaief ◽  
Randy L. Buckner
Keyword(s):  
High Resolution ◽  
Large Scale ◽  
Spatial Separation ◽  
Distributed Networks ◽  
Association Cortex ◽  
Default Network ◽  
Network Organization ◽  
Parahippocampal Cortex ◽  
The Individual ◽  
Insight Into

Examination of large-scale distributed networks within the individual reveals details of cortical network organization that are absent in group-averaged studies. One recent discovery is that a distributed transmodal network, often referred to as the ‘default network’, is comprised of two separate but closely interdigitated networks, only one of which is coupled to posterior parahippocampal cortex. Not all studies of individuals have identified the same networks and questions remain about the degree to which the two networks are separate, particularly within regions hypothesized to be interconnected hubs. Here we replicate the observation of network separation across analytical (seed-based connectivity and parcellation) and data projection (volume and surface) methods in 2 individuals each scanned 31 times. Additionally, 3 individuals were examined with high-resolution fMRI to gain further insight into the anatomical details. The two networks were identified with separate regions localized to adjacent portions of the cortical ribbon, sometimes inside the same sulcus. Midline regions previously implicated as hubs revealed near complete spatial separation of the two networks, displaying a complex spatial topography in the posterior cingulate and precuneus. The network coupled to parahippocampal cortex also revealed a separate region directly within the hippocampus at or near the subiculum. These collective results support that the default network is composed of at least two spatially juxtaposed networks. Fine spatial details and juxta-positions of the two networks can be identified within individuals at high resolution, providing insight into the network organization of association cortex and placing further constraints on interpretation of group-averaged neuroimaging data.

scholarly journals Attention network modulation via tRNS correlates with attention gain

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Federica Contò ◽  
Grace Edwards ◽  
Sarah Tyler ◽  
Danielle Parrott ◽  
Emily Grossman ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Large Scale ◽  
Random Noise ◽  
Cognitive Capacity ◽  
Resting State Functional Connectivity ◽  
Attention Network ◽  
Transcranial Random Noise Stimulation ◽  
The Impact ◽  
Behavioral Improvement

Transcranial random noise stimulation (tRNS) can enhance vision in the healthy and diseased brain. Yet, the impact of multi-day tRNS on large-scale cortical networks is still unknown. We investigated the impact of tRNS coupled with behavioral training on resting-state functional connectivity and attention. We trained human subjects for 4 consecutive days on two attention tasks, while receiving tRNS over the intraparietal sulci, the middle temporal areas, or Sham stimulation. We measured resting-state functional connectivity of nodes of the dorsal and ventral attention network (DVAN) before and after training. We found a strong behavioral improvement and increased connectivity within the DVAN after parietal stimulation only. Crucially, behavioral improvement positively correlated with connectivity measures. We conclude changes in connectivity are a marker for the enduring effect of tRNS upon behavior. Our results suggest that tRNS has strong potential to augment cognitive capacity in healthy individuals and promote recovery in the neurological population.

scholarly journals Large-scale network integration in the human brain tracks temporal fluctuations in memory encoding performance

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Ruedeerat Keerativittayayut ◽  
Ryuta Aoki ◽  
Mitra Taghizadeh Sarabi ◽  
Koji Jimura ◽  
Kiyoshi Nakahara
Keyword(s):  
Functional Connectivity ◽  
Human Brain ◽  
Large Scale ◽  
Brain Regions ◽  
Brain Network ◽  
Time Varying ◽  
Memory Encoding ◽  
Graph Metrics ◽  
Connectivity Patterns ◽  
Network States

Although activation/deactivation of specific brain regions has been shown to be predictive of successful memory encoding, the relationship between time-varying large-scale brain networks and fluctuations of memory encoding performance remains unclear. Here, we investigated time-varying functional connectivity patterns across the human brain in periods of 30–40 s, which have recently been implicated in various cognitive functions. During functional magnetic resonance imaging, participants performed a memory encoding task, and their performance was assessed with a subsequent surprise memory test. A graph analysis of functional connectivity patterns revealed that increased integration of the subcortical, default-mode, salience, and visual subnetworks with other subnetworks is a hallmark of successful memory encoding. Moreover, multivariate analysis using the graph metrics of integration reliably classified the brain network states into the period of high (vs. low) memory encoding performance. Our findings suggest that a diverse set of brain systems dynamically interact to support successful memory encoding.

Aberrant interactions of cortical networks in chronic migraine

Neurology ◽  
2019 ◽  
Vol 92 (22) ◽  
pp. e2550-e2558 ◽  
Author(s):  
Gianluca Coppola ◽  
Antonio Di Renzo ◽  
Barbara Petolicchio ◽  
Emanuele Tinelli ◽  
Cherubino Di Lorenzo ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Chronic Migraine ◽  
Large Scale ◽  
Preventive Therapy ◽  
Cortical Networks ◽  
Executive Control Network ◽  
Acute Medication ◽  
Connectivity Patterns ◽  
Mri Scans ◽  
Group Ica

ObjectiveWe investigated resting-state (RS)-fMRI using independent component analysis (ICA) to determine the functional connectivity (FC) between networks in chronic migraine (CM) patients and their correlation with clinical features.MethodsTwenty CM patients without preventive therapy or acute medication overuse underwent 3T MRI scans and were compared to a group of 20 healthy controls (HC). We used MRI to collect RS data in 3 selected networks, identified using group ICA: the default mode network (DMN), the executive control network (ECN), and the dorsal attention system (DAS).ResultsCompared to HC, CM patients had significantly reduced functional connectivity between the DMN and the ECN. Moreover, in patients, the DAS showed significantly stronger FC with the DMN and weaker FC with the ECN. The higher the severity of headache, the increased the strength of DAS connectivity, and the lower the strength of ECN connectivity.ConclusionThese results provide evidence for large-scale reorganization of functional cortical networks in chronic migraine. They suggest that the severity of headache is associated with opposite connectivity patterns in frontal executive and dorsal attentional networks.

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