Local Field Potential Oscillations in Primate Cerebellar Cortex: Synchronization With Cerebral Cortex During Active and Passive Expectancy

2005 ◽  
Vol 93 (4) ◽  
pp. 2039-2052 ◽  
Author(s):  
Richard Courtemanche ◽  
Yves Lamarre
Keyword(s):  
Local Field ◽  
Primary Motor Cortex ◽  
Field Potential ◽  
Brain Regions ◽  
Stimulus Onset ◽  
Somatosensory Processing ◽  
Potential Oscillations ◽  
Passive Condition ◽  
Right Hand ◽  
Active Condition

Many brain regions, such as the cerebellum, primary somatosensory cortex (SI), and primary motor cortex (MI), interact to produce coordinated actions. Synchronization of local field potentials (LFPs) in sensorimotor cerebral areas has been related to motor performance, often through 10- to 25-Hz oscillatory LFPs. The macaque cerebellar paramedian lobule (PM) also shows 10- to 25-Hz LFP oscillations, which are modulated in a stimulus–response lever press task to get reward (active condition), but also, albeit differently, in a similarly timed stimulus–reward relation (passive condition). This study focuses on simultaneous LFP activity in primate SI or MI and the PM cerebellum during the active (left- or right-hand lever presses) and passive conditions. Results show a similar modulation pattern of 10- to 25-Hz oscillations in the cerebellum, MI, and SI during the active condition (left or right hand), decreasing after stimulus onset, returning, and again decreasing after movement onset. In the passive condition, when the monkey did not move but got reward, all 3 areas show an oscillatory profile where oscillations increase after stimulus onset and last until reward, denoting a role for these oscillations in passive expectancy. However, synchronization between cerebellar LFPs and SI LFPs is higher during the active condition than during the passive condition, and highest for the interested hand. This greater PM–SI synchronization, when the monkey had to press the lever, could represent a form of cerebro-cerebellar communication, perhaps to serve somatosensory processing to accomplish the task; PM–MI synchronization was less selective for the hand used and might carry a more general type of information.

Local Field Potential Oscillations in Primate Cerebellar Cortex: Modulation During Active and Passive Expectancy

2002 ◽  
Vol 88 (2) ◽  
pp. 771-782 ◽  
Author(s):  
Richard Courtemanche ◽  
Jean-Pierre Pellerin ◽  
Yves Lamarre
Keyword(s):  
Local Field ◽  
Local Field Potential ◽  
Lever Press ◽  
Field Potential ◽  
Elbow Flexion ◽  
Granule Cell Layer ◽  
Voluntary Action ◽  
Passive Condition ◽  
Flexion Extension ◽  
Active Condition

Cerebellar local field potential (LFP) oscillations were recorded in the paramedian lobule of one hemisphere, while monkeys were in two behavioral conditions: actively performing an elbow flexion-extension or a lever-press task in response to an auditory or visual stimulus to get reward (active condition), or waiting quietly for the reward to come in the same time window after the appearance of the stimulus (passive condition). The oscillations in the paramedian lobule were first characterized in four monkeys, and they showed an idiosyncratic frequency for each monkey, between 13 and 25 Hz. The granule cell layer multi-unit activity was phase-locked with the negative phase of the LFP oscillations, while Purkinje cell simple spikes were also sometimes phase-locked with the LFP. Three monkeys were trained to perform the motor tasks: the LFP oscillations were modulated, in the active condition, in a systematic manner in relation to the lever-press or elbow flexion-extension tasks. During periods when the monkey was waiting to initiate movement, LFP oscillations appeared and then stopped with movement initiation. This modulation was valid for the task being executed with either hand. Surprisingly, the LFP oscillations were also systematically modulated during the passive condition; as the monkey was waiting for the usual time to get a reward passively, oscillations appeared stronger and were stopped by the end of the usual delay, whether the monkey was rewarded or not. This type of modulation was not affected by the length of the stimulus, as long as the reward window was known to the monkey. If the monkey had not been previously trained to the active condition, the modulation appeared in the passive condition. These results show that cerebellar LFP oscillations in the paramedian lobule are reliably present when the monkey is involved in a waiting period, whether this period ends with an active or passive event. This study provides electrophysiological evidence for a specific pattern of activity in the cerebellum for the expectancy of events that are known to be bound to happen, either externally, or from voluntary action.

Detection of a Weak Somatosensory Stimulus: Role of the Prestimulus Mu Rhythm and Its Top–Down Modulation

2010 ◽  
Vol 22 (2) ◽  
pp. 307-322 ◽  
Author(s):  
Yan Zhang ◽  
Mingzhou Ding
Keyword(s):  
Field Potential ◽  
Electrical Stimulus ◽  
Stimulus Onset ◽  
Oscillatory Activity ◽  
Somatosensory Processing ◽  
Causality Analysis ◽  
Mu Rhythm ◽  
Potential Oscillations ◽  
Scalp Electroencephalogram ◽  
The Right

The ongoing neural activity in human primary somatosensory cortex (SI) is characterized by field potential oscillations in the 7–13 Hz range known as the mu rhythm. Recent work has shown that the magnitude of the mu oscillation immediately preceding the onset of a weak stimulus has a significant impact on its detection. The neural mechanisms mediating this impact remain not well understood. In particular, whether and how somatosensory mu rhythm is modulated by executive areas prior to stimulus onset for improved behavioral performance has not been investigated. We addressed these issues by recording 128-channel scalp electroencephalogram from normal volunteers performing a somatosensory perception experiment in which they reported the detection of a near-threshold electrical stimulus (∼50% detection rate) delivered to the right index finger. Three results were found. First, consistent with numerous previous reports, the N1 component (∼140 msec) of the somatosensory-evoked potential was significantly enhanced for perceived stimulus compared to unperceived stimulus. Second, the prestimulus mu power and the evoked N1 amplitude exhibited an inverted-U relationship, suggesting that an intermediate level of prestimulus mu oscillatory activity is conducive to stimulus processing and perception. Third, a Granger causality analysis revealed that the prestimulus causal influence in the mu band from prefrontal cortex to SI was significantly higher for perceived stimulus than for unperceived stimulus, indicating that frontal executive structures, via ongoing mu oscillations, exert cognitive control over posterior sensory cortices to facilitate somatosensory processing.

scholarly journals Modulation of high- and low-frequency components of the cortical local field potential via nicotinic and muscarinic acetylcholine receptors in anesthetized mice

2014 ◽  
Vol 111 (2) ◽  
pp. 258-272 ◽  
Author(s):  
Abigail Kalmbach ◽  
Jack Waters
Keyword(s):  
Muscarinic Receptors ◽  
Local Field ◽  
Local Field Potential ◽  
Basal Forebrain ◽  
Field Potential ◽  
Low Frequency ◽  
Stimulus Onset ◽  
Stimulus Offset ◽  
Frequency Power ◽  
Ach Receptors

Release of acetylcholine (ACh) in neocortex is important for learning, memory and attention tasks. The primary source of ACh in neocortex is axons ascending from the basal forebrain. Release of ACh from these axons evokes changes in the cortical local field potential (LFP), including a decline in low-frequency spectral power that is often referred to as desynchronization of the LFP and is thought to result from the activation of muscarinic ACh receptors. Using channelrhodopsin-2, we selectively stimulated the axons of only cholinergic basal forebrain neurons in primary somatosensory cortex of the urethane-anesthetized mouse while monitoring the LFP. Cholinergic stimulation caused desynchronization and two brief increases in higher-frequency power at stimulus onset and offset. Desynchronization (1–6 Hz) was localized, extending ≤ 1 mm from the edge of stimulation, and consisted of both nicotinic and muscarinic receptor-mediated components that were inhibited by mecamylamine and atropine, respectively. Hence we have identified a nicotinic receptor-mediated component to desynchronization. The increase in higher-frequency power (>10 Hz) at stimulus onset was also mediated by activation of nicotinic and muscarinic receptors. However, the increase in higher-frequency power (10–20 Hz) at stimulus offset was evoked by activation of muscarinic receptors and inhibited by activation of nicotinic receptors. We conclude that the activation of nicotinic and muscarinic ACh receptors in neocortex exerts several effects that are reflected in distinct frequency bands of the cortical LFP in urethane-anesthetized mice.

scholarly journals The functional organization of human epileptic hippocampus

2016 ◽  
Vol 115 (6) ◽  
pp. 3140-3145 ◽  
Author(s):  
Petr Klimes ◽  
Juliano J. Duque ◽  
Ben Brinkmann ◽  
Jamie Van Gompel ◽  
Matt Stead ◽  
...  
Keyword(s):  
Spatial Scale ◽  
Local Field ◽  
Medial Temporal Lobe ◽  
Slow Wave Sleep ◽  
Functional Organization ◽  
Spectral Power ◽  
Spatial Scales ◽  
Field Potential ◽  
Brain Regions ◽  
Behavioral State

The function and connectivity of human brain is disrupted in epilepsy. We previously reported that the region of epileptic brain generating focal seizures, i.e., the seizure onset zone (SOZ), is functionally isolated from surrounding brain regions in focal neocortical epilepsy. The modulatory effect of behavioral state on the spatial and spectral scales over which the reduced functional connectivity occurs, however, is unclear. Here we use simultaneous sleep staging from scalp EEG with intracranial EEG recordings from medial temporal lobe to investigate how behavioral state modulates the spatial and spectral scales of local field potential synchrony in focal epileptic hippocampus. The local field spectral power and linear correlation between adjacent electrodes provide measures of neuronal population synchrony at different spatial scales, ∼1 and 10 mm, respectively. Our results show increased connectivity inside the SOZ and low connectivity between electrodes in SOZ and outside the SOZ. During slow-wave sleep, we observed decreased connectivity for ripple and fast ripple frequency bands within the SOZ at the 10 mm spatial scale, while the local synchrony remained high at the 1 mm spatial scale. Further study of these phenomena may prove useful for SOZ localization and help understand seizure generation, and the functional deficits seen in epileptic eloquent cortex.

scholarly journals Induced cortical oscillations in turtle cortex are coherent at the mesoscale of population activity, but not at the microscale of the membrane potential of neurons

2017 ◽  
Vol 118 (5) ◽  
pp. 2579-2591 ◽  
Author(s):  
Mahmood S. Hoseini ◽  
Jeff Pobst ◽  
Nathaniel Wright ◽  
Wesley Clawson ◽  
Woodrow Shew ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Membrane Potential ◽  
Neural Activity ◽  
Visual Stimulation ◽  
Field Potential ◽  
Brain Regions ◽  
Large Trial ◽  
Population Activity ◽  
Potential Oscillations ◽  
Time Frequency

Bursts of oscillatory neural activity have been hypothesized to be a core mechanism by which remote brain regions can communicate. Such a hypothesis raises the question to what extent oscillations are coherent across spatially distant neural populations. To address this question, we obtained local field potential (LFP) and membrane potential recordings from the visual cortex of turtle in response to visual stimulation of the retina. The time-frequency analysis of these recordings revealed pronounced bursts of oscillatory neural activity and a large trial-to-trial variability in the spectral and temporal properties of the observed oscillations. First, local bursts of oscillations varied from trial to trial in both burst duration and peak frequency. Second, oscillations of a given recording site were not autocoherent; i.e., the phase did not progress linearly in time. Third, LFP oscillations at spatially separate locations within the visual cortex were more phase coherent in the presence of visual stimulation than during ongoing activity. In contrast, the membrane potential oscillations from pairs of simultaneously recorded pyramidal neurons showed smaller phase coherence, which did not change when switching from black screen to visual stimulation. In conclusion, neuronal oscillations at distant locations in visual cortex are coherent at the mesoscale of population activity, but coherence is largely absent at the microscale of the membrane potential of neurons. NEW & NOTEWORTHY Coherent oscillatory neural activity has long been hypothesized as a potential mechanism for communication across locations in the brain. In this study we confirm the existence of coherent oscillations at the mesoscale of integrated cortical population activity. However, at the microscopic level of neurons, we find no evidence for coherence among oscillatory membrane potential fluctuations. These results raise questions about the applicability of the communication through coherence hypothesis to the level of the membrane potential.

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