scholarly journals Muscle metabolic, SR Ca2+-cycling responses to prolonged cycling, with and without glucose supplementation

2007 ◽  
Vol 103 (6) ◽  
pp. 1986-1998 ◽  
Author(s):  
T. A. Duhamel ◽  
H. J. Green ◽  
R. D. Stewart ◽  
K. P. Foley ◽  
I. C. Smith ◽  
...  
Keyword(s):  
Prolonged Exercise ◽  
Vastus Lateralis ◽  
Phase 1 ◽  
Vastus Lateralis Muscle ◽  
Release Rates ◽  
Oxidation Rates ◽  
Lateralis Muscle ◽  
Blood Glucose Homeostasis ◽  
Exercise Induced ◽  
Glucose Supplementation

This study investigated the effects of prolonged exercise, with and without glucose supplementation, on metabolism and sarcoplasmic reticulum (SR) Ca2+-handling properties in working vastus lateralis muscle. Fifteen untrained volunteers [peak O2consumption (V̇o2peak) = 3.45 ± 0.17 l/min; mean ± SE] cycled at ∼60% V̇o2peakon two occasions, during which they were provided with either an artificially sweetened placebo beverage (NG) or a 6% glucose (G) beverage (∼1.00 g carbohydrate/kg body mass). Beverage supplementation started at 30 min of exercise and continued every 15 min thereafter. SR Ca2+handling, metabolic, and substrate responses were assessed in tissue extracted from the vastus lateralis at rest, after 30 min and 90 min of exercise, and at fatigue in both conditions. Plasma glucose during G was 15–23% higher ( P < 0.05) than those observed during NG following 60 min of exercise until fatigue. Cycle time to fatigue was increased ( P < 0.05) by ∼19% during G (137 ± 7 min) compared with NG (115 ± 6 min). Prolonged exercise reduced ( P < 0.05) maximal Ca2+-ATPase activity (−18.4%), SR Ca2+uptake (−27%), and both Phase 1 (−22.2%) and Phase 2 (−34.2%) Ca2+-release rates during NG. The exercise-induced reductions in SR Ca2+-cycling properties were not altered during G. The metabolic responses to exercise were all unaltered by glucose supplementation, since no differences in respiratory exchange ratios, carbohydrate and lipid oxidation rates, and muscle metabolite and glycogen contents were observed between NG and G. These results indicate that the maintenance of blood glucose homeostasis by glucose supplementation is without effect in modifying the muscle metabolic, endogenous glycogen, or SR Ca2+-handling responses.

Effects of prior exercise and a low-carbohydrate diet on muscle sarcoplasmic reticulum function during cycling in women

2006 ◽  
Vol 101 (3) ◽  
pp. 695-706 ◽  
Author(s):  
T. A. Duhamel ◽  
H. J. Green ◽  
J. G. Perco ◽  
J. Ouyang
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Atpase Activity ◽  
Vastus Lateralis ◽  
Phase 1 ◽  
Vastus Lateralis Muscle ◽  
Low Carbohydrate Diet ◽  
Hill Slope ◽  
Low Carbohydrate ◽  
Exercise Induced

The effects of exercise and diet on sarcoplasmic reticulum Ca2+-cycling properties in female vastus lateralis muscle were investigated in two groups of women following four different conditions. The conditions were 4 days of a low-carbohydrate (Lo CHO) and glycogen-depleting exercise plus a Lo CHO diet (Ex + Lo CHO) ( experiment 2) and 4 days of normal CHO (Norm CHO) and glycogen-depleting exercise plus Norm CHO (Ex + Norm CHO) ( experiment 1). Peak aerobic power (V̇o2peak) was 38.1 ± 1.4 (SE); n = 9 and 35.6 ± 1.4 ml·kg−1·min−1; n = 9, respectively. Sarcoplasmic reticulum properties measured in vitro in homogenates (μmol·g protein−1·min−1) indicated exercise-induced reductions ( P < 0.05) in maximal Ca2+-ATPase activity (0 > 30, 60 min > fatigue), Ca2+ uptake (0 > 30 > 60 min, fatigue), and Ca2+ release, both phase 1 (0, 30 > 60 min, fatigue) and phase 2 (0 > 30, 60 min, fatigue; 30 min > fatigue) in Norm CHO. Exercise was without effect in altering the Hill slope ( nH), defined as the slope of relationship between Ca2+-ATPase activity and Ca2+ concentration. No differences were observed between Norm CHO and Ex+Norm CHO. Compared with Norm CHO, Lo CHO resulted in a lower ( P < 0.05) Ca2+ uptake, phase 1 Ca2+ release (30 min), and nH. Ex + Lo CHO resulted in a greater ( P < 0.05) Ca2+ uptake and nH compared with Lo CHO. The results demonstrate that Lo CHO alone can disrupt SR Ca2+ cycling and that, with the exception of Ca2+ release, a glycogen-depleting session of exercise before Lo CHO can reverse the effects.

Manipulation of dietary carbohydrates after prolonged effort modifies muscle sarcoplasmic reticulum responses in exercising males

2006 ◽  
Vol 291 (4) ◽  
pp. R1100-R1110 ◽  
Author(s):  
T. A. Duhamel ◽  
J. G. Perco ◽  
H. J. Green
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Muscle Glycogen ◽  
Prolonged Exercise ◽  
Vastus Lateralis ◽  
Phase 1 ◽  
Phase 2 ◽  
Dietary Carbohydrates ◽  
Carbohydrate Diet ◽  
Exercise Induced ◽  
Total Muscle

The hypothesis tested was that disturbances in the sarcoplasmic reticulum (SR) Ca2+-cycling responses to exercise would associate with muscle glycogen reserves. Ten untrained males [peak O2consumption (V̇o2 peak) = 3.41 ± 0.20 (SE) l/min] performed a standardized cycle test (∼70% V̇o2 peak) on two occasions, namely, following 4 days of a high (Hi CHO)- and 4 days of a low (Lo CHO)-carbohydrate diet. Both Hi CHO and Lo CHO were preceded by a session of prolonged exercise designed to deplete muscle glycogen. SR Ca2+cycling in crude homogenates prepared from vastus lateralis samples indicated higher ( P < 0.05) Ca2+uptake (μM·g protein−1·min−1) in Hi CHO compared with Lo CHO at 30 min (2.93 ± 0.10 vs. 2.23 ± 0.12) and at 67 min (2.77 ± 0.16 vs. 2.10 ± 0.12) of exercise, the point of fatigue in Lo CHO. Similar effects ( P < 0.05) were noted between conditions for maximal Ca2+-ATPase (μM·g protein−1·min−1) at 30 min (142 ± 8.5 vs. 107 ± 5.0) and at 67 min (130 ± 4.5 vs. 101 ± 4.7). Both phase 1 and phase 2 Ca2+release were 23 and 37% higher ( P < 0.05) at 30 min of exercise and 15 and 34% higher ( P < 0.05), at 67 min during Hi CHO compared with Lo CHO, respectively. No differences between conditions were observed at rest for any of these SR properties. Total muscle glycogen (mmol glucosyl units/kg dry wt) was higher ( P < 0.05) in Hi CHO compared with Lo CHO at rest (+36%), 30 min (+53%), and at 67 min (+44%) of cycling. These results indicate that exercise-induced reductions in SR Ca2+-cycling properties occur earlier in exercise during low glycogen states compared with high glycogen states.

Ayurvedic management of Myositis Ossificans of Vastus Lateralis Muscle (Urusthamba) - A Case Study

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Vishnu Mohan ◽  
Gopikrishna BJ ◽  
Avnish Pathak ◽  
Mahesh Kumar ES ◽  
Duradundi G
Keyword(s):  
Heterotopic Ossification ◽  
Myositis Ossificans ◽  
Vastus Lateralis ◽  
Treatment Protocol ◽  
Vastus Lateralis Muscle ◽  
Satisfactory Treatment ◽  
Lateralis Muscle ◽  
Ayurvedic Treatment

Myositis ossificansis characterized by heterotopic ossification (calcification) of muscle of various etiologies. It is most commonly affected in the quadriceps of the thighs. There are many tools available for diagnosis of Myositis ossificans, but lack of satisfactory treatment. So the development of a treatment protocol for Myositis ossificans is the need of today`s era. In Ayurveda, the same can be understood as Urusthamba. The present paper discusses a case of Myositis ossificans of right vastus lateralis muscle and its Ayurvedic treatment.

Vastus lateralis muscle volume prediction in early-adolescent boys

2021 ◽  
pp. 110735
Author(s):  
Theresa Domroes ◽  
Gunnar Laube ◽  
Sebastian Bohm ◽  
Adamantios Arampatzis ◽  
Falk Mersmann
Keyword(s):  
Vastus Lateralis ◽  
Muscle Volume ◽  
Early Adolescent ◽  
Vastus Lateralis Muscle ◽  
Adolescent Boys ◽  
Lateralis Muscle

Repair of Recurrent Cleft Palate with Free Vastus Lateralis Muscle Flap

2012 ◽  
Vol 49 (2) ◽  
pp. 245-248 ◽  
Author(s):  
Jose G. Christiano ◽  
Amir H. Dorafshar ◽  
Eduardo D. Rodriguez ◽  
Richard J. Redett
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Vastus Lateralis ◽  
Muscle Flap ◽  
Free Flaps ◽  
Vastus Lateralis Muscle ◽  
Oronasal Fistula ◽  
Lateralis Muscle ◽  
Palate Repair

A 6-year-old girl presented with a large recalcitrant oronasal fistula after bilateral cleft lip and palate repair and numerous secondary attempts at fistula closure. Incomplete palmar arches precluded a free radial forearm flap. A free vastus lateralis muscle flap was successfully transferred. No fistula recurrence was observed at 18 months. There was no perceived thigh weakness. The surgical scar healed inconspicuously. Free flaps should no longer be considered the last resort for treatment of recalcitrant fistulas after cleft palate repair. A free vastus lateralis muscle flap is an excellent alternative, and possibly a superior option, to other previously described free flaps.

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