Point: Release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained hypoxic pulmonary vasoconstriction

2007 ◽  
Vol 102 (5) ◽  
pp. 2071-2072 ◽  
Author(s):  
Tom P. Robertson
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Rho Kinase ◽  
Cell Contraction ◽  
Calcium Sensitization ◽  
Pulmonary Vasoconstriction

The Mechanism(s) of Hypoxic Pulmonary Vasoconstriction: Potassium Channels, Redox O2 Sensors, and Controversies

Physiology ◽  
2002 ◽  
Vol 17 (4) ◽  
pp. 131-137 ◽  
Author(s):  
Stephen Archer ◽  
Evangelos Michelakis
Keyword(s):  
Smooth Muscle ◽  
Membrane Potential ◽  
Potassium Channels ◽  
Pulmonary Artery ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Pulmonary Vasoconstriction ◽  
Pulmonary Artery Smooth Muscle

Hypoxic pulmonary vasoconstriction matches perfusion to ventilation and optimizes systemic oxygenation. Alterations in Po2 are sensed by a vascular redox O2 sensor in the pulmonary artery smooth muscle cell, probably within the mitochondria. This creates a signal that modulates redox-sensitive K+ channels, thereby controlling membrane potential, Ca2+ entry, and tone.

1429: Upregulation of Rho-Kinase in a Human Corpus Cavernosum Smooth Muscle Cell Line in Response to Hypoxia

2004 ◽  
Vol 171 (4S) ◽  
pp. 376-377
Author(s):  
Yongmu Zheng ◽  
Shaohua Chang ◽  
Alan J. Wein ◽  
Samuel Chacko ◽  
Michael E. DiSanto
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Line ◽  
Muscle Cell ◽  
Corpus Cavernosum ◽  
Rho Kinase ◽  
Muscle Cell Line

scholarly journals Smooth muscle cell contraction increases the critical buckling pressure of arteries

2013 ◽  
Vol 46 (4) ◽  
pp. 841-844 ◽  
Author(s):  
Danika M. Hayman ◽  
Jinzhou Zhang ◽  
Qin Liu ◽  
Yangming Xiao ◽  
Hai-Chao Han
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Contraction ◽  
Critical Buckling Pressure

Optical modulation of smooth muscle cell contraction

2010 ◽  
Author(s):  
Jonghee Yoon ◽  
Myunghwan Choi ◽  
Chulhee Choi
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Optical Modulation ◽  
Cell Contraction

scholarly journals Dexamethasone induces rapid promotion of norepinephrine-mediated vascular smooth muscle cell contraction

2012 ◽  
Vol 7 (2) ◽  
pp. 549-554 ◽  
Author(s):  
TING ZHANG ◽  
WEN-LEI SHI ◽  
JEFFREY G. TASKER ◽  
JIANG-RUI ZHOU ◽  
YUN-LI PENG ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Contraction

Effect of oxidative stress on Rho kinase II and smooth muscle contraction in rat stomach

2015 ◽  
Vol 93 (6) ◽  
pp. 405-411 ◽  
Author(s):  
Othman Al-Shboul ◽  
Ayman Mustafa
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Muscle Contraction ◽  
Muscle Cell ◽  
Rho Kinase ◽  
Smooth Muscle Contraction ◽  
Enzyme Linked Immunosorbent Assay ◽  
Rat Stomach ◽  
Cell Contraction ◽  
Kinase Pathway

Recent studies have shown that both Rho kinase signaling and oxidative stress are involved in the pathogenesis of a number of human diseases, such as diabetes mellitus, hypertension, and atherosclerosis. However, very little is known about the effect of oxidative stress on the gastrointestinal (GI) smooth muscle Rho kinase pathway. The aim of the current study was to investigate the effect of oxidative stress on Rho kinase II and muscle contraction in rat stomach. The peroxynitrite donor 3-morpholinosydnonimine (SIN-1), hydrogen peroxide (H2O2), and peroxynitrite were used to induce oxidative stress. Rho kinase II expression and ACh-induced activity were measured in control and oxidant-treated cells via specifically designed enzyme-linked immunosorbent assay (ELISA) and activity assay kits, respectively. Single smooth muscle cell contraction was measured via scanning micrometry in the presence or absence of the Rho kinase blocker, Y-27632 dihydrochloride. All oxidant agents significantly increased ACh-induced Rho kinase II activity without affecting its expression level. Most important, oxidative stress induced by all three agents augmented ACh-stimulated muscle cell contraction, which was significantly inhibited by Y-27632. In conclusion, oxidative stress activates Rho kinase II and enhances contraction in rat gastric muscle, suggesting an important role in GI motility disorders associated with oxidative stress.

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