Reproducibility of the cold-induced vasodilation response in the human finger

Catherine O'Brien

doi:10.1152/japplphysiol.00859.2004

Reproducibility of the cold-induced vasodilation response in the human finger

Journal of Applied Physiology ◽

10.1152/japplphysiol.00859.2004 ◽

2005 ◽

Vol 98 (4) ◽

pp. 1334-1340 ◽

Cited By ~ 46

Author(s):

Catherine O'Brien

Keyword(s):

Blood Flow ◽

Time Course ◽

Cold Water ◽

Temperature Response ◽

Onset Time ◽

Middle Finger ◽

Warm Water ◽

Finger Temperature ◽

Nail Bed ◽

Human Finger

Cold-induced vasodilation (CIVD) is a cyclic oscillation in blood flow that occurs in the extremities on cold exposure and that is likely associated with reduced risk of cold injury (e.g., frostbite) as well as improved manual dexterity and less pain while working in the cold. The CIVD response varies between individuals, but the within-subject reproducibility has not been adequately described. The purpose of this study was to quantify the within-subject variability in the CIVD response under standardized conditions. Twenty-one volunteers resting in a controlled environment (27°C) immersed the middle finger in warm water (42°C) for 15 min to standardize initial finger temperature and then in cold water (4°C; CWI) for 30 min, on five separate occasions. Skin temperature (Tf) and blood flow (laser-Doppler; expressed as percent change from warm-water peak) responses that describe CIVD were identified, including initial nadir reached during CWI, onset time of CIVD, initial apex during CIVD, time of that apex, and overall mean during CWI. Within-subject coefficient of variation for Tfacross the five tests for the nail bed and pad, respectively, were as follows: nadir, 9 and 21%; onset, 18 and 19%; apex, 12 and 17%; apex time, 23 and 24%; mean 10 and 15%. For blood flow, these values were as follows: nadir 52 and 64%; onset, 6 and 5%; apex, 33 and 31%; apex time 9 and 8%; and mean 43 and 34%. Greater variability was found in the temperature response of the finger pad than the nail bed, but for blood flow the variability was similar between locations. Variability in onset and apex time between sites was similar for both temperature and blood flow responses. The reproducibility of the time course of CIVD suggests this methodology may be of value for further studies examining the mechanism of the response.

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Hypohydration effect on finger skin temperature and blood flow during cold-water finger immersion

Journal of Applied Physiology ◽

10.1152/japplphysiol.00678.2002 ◽

2003 ◽

Vol 94 (2) ◽

pp. 598-603 ◽

Cited By ~ 9

Author(s):

Catherine O'Brien ◽

Scott J. Montain

Keyword(s):

Blood Flow ◽

Body Weight ◽

Skin Temperature ◽

Cold Water ◽

Water Immersion ◽

Heat Exposure ◽

Onset Time ◽

Fluid Replacement ◽

Warm Water ◽

C 30

This study was conducted to determine whether hypohydration (Hy) alters blood flow, skin temperature, or cold-induced vasodilation (CIVD) during peripheral cooling. Fourteen subjects sat in a thermoneutral environment (27°C) during 15-min warm-water (42°C) and 30-min cold-water (4°C) finger immersion (FI) while euhydrated (Eu) and, again, during Hy. Hy (−4% body weight) was induced before FI by exercise-heat exposure (38°C, 30% relative humidity) with no fluid replacement, whereas during Eu, fluid intake maintained body weight. Finger pad blood flow [as measured by laser-Doppler flux (LDF)] and nail bed (Tnb), pad (Tpad), and core (Tc) temperatures were measured. LDF decreased similarly during Eu and Hy (32 ± 10 and 33 ± 13% of peak during warm-water immersion). Mean Tnb and Tpad were similar between Eu (7.1 ± 1.0 and 11.5 ± 1.6°C) and Hy (7.4 ± 1.3 and 12.6 ± 2.1°C). CIVD parameters (e.g., nadir, onset time, apex) were similar between trials, except Tpad nadir was higher during Hy (10.4 ± 3.8°C) than during Eu (7.9 ± 1.6°C), which was attributed to higher Tc in six subjects during Hy (37.5 ± 0.2°C), compared with during Eu (37.1 ± 0.1°C). The results of this study provide no evidence that Hy alters finger blood flow, skin temperature, or CIVD during peripheral cooling.

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Central and peripheral factors in thermal, neuromuscular, and perceptual adaptation of the hand to repeated cold exposures

Applied Physiology Nutrition and Metabolism ◽

10.1139/h05-007 ◽

2006 ◽

Vol 31 (2) ◽

pp. 110-117 ◽

Cited By ~ 12

Author(s):

Carla L.M Geurts ◽

Gordon G Sleivert ◽

Stephen S Cheung

Keyword(s):

Cold Water ◽

Thermal Sensation ◽

Cardiovascular Response ◽

Temperature Response ◽

Neuromuscular Function ◽

Finger Temperature ◽

Left Hand ◽

Control Right ◽

And Control ◽

Over Time

We investigated the role of central and peripheral factors in repeated cold exposure of the hand and their effects on temperature response, neuromuscular function, and subjective thermal sensation. Eleven subjects immersed their left hand repeatedly in 8 °C cold water for 30 min, 5 d/week, for 2 weeks. Before and following the 2 weeks of exposure, neuromuscular function, blood markers, thermal sensation, and temperature responses of both acclimated (left) and control (right) hands were tested. Minimum index finger temperature pre-acclimation was 10.9 ± 3.4 °C and 10.0 ± 2.0 °C in the left and right hand, respectively, and did not change significantly post-acclimation (left, 12.8 ± 4.2 °C; right, 10.2 ± 1.1 °C). Neuromuscular function was impaired with cooling, but this was significantly different neither between the hands nor over time. Central factors, measured by catecholamines and changes in temperature and cardiovascular response over time, did not change and there were no differences in responses between the exposed and non-exposed hand over time (peripheral adaptation) nor were there any differences in local factors endothelian-1 and nitric oxide. Subjective thermal comfort was improved and the discepancy that was found between the change in actual and perceived temperature may increase the risk of cold injury in partially acclimatized individuals, owing to an adjustment in behavioural thermoregulation.Key words: hand, skin temperature, cold-induced vasodilatation, neuromuscular function, manual dexterity.

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Early Temporal Characteristics of Cerebral Blood Flow and Deoxyhemoglobin Changes during Somatosensory Stimulation

Journal of Cerebral Blood Flow & Metabolism ◽

10.1097/00004647-200001000-00025 ◽

2000 ◽

Vol 20 (1) ◽

pp. 201-206 ◽

Cited By ~ 119

Author(s):

Afonso C. Silva ◽

Sang-Pil Lee ◽

Costantino Iadecola ◽

Seong-Gi Kim

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Oxygen Consumption ◽

Time Course ◽

Functional Neuroimaging ◽

Onset Time ◽

Blood Oxygenation ◽

High Temporal Resolution ◽

Somatosensory Stimulation ◽

Temporal Characteristics

The close correspondence between neural activity in the brain and cerebral blood flow (CBF) forms the basis for modern functional neuroimaging methods. Yet, the temporal characteristics of hemodynamic changes induced by neuronal activity are not well understood. Recent optical imaging observations of the time course of deoxyhemoglobin (HbR) and oxyhemoglobin have suggested that increases in oxygen consumption after neuronal activation occur earlier and are more spatially localized than the delayed and more diffuse CBF response. Deoxyhemoglobin can be detected by blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI). In the present study, the temporal characteristics of CBF and BOLD changes elicited by somatosensory stimulation in rat were investigated by high-field (9.4 T) MRI. With use of high-temporal-resolution fMRI, it was found that the onset time of the CBF response in the somatosensory cortex was 0.6 ± 0.4 seconds (n = 10). The CBF changes occurred significantly earlier than changes in HbR concentration, which responded after 1.1 ± 0.3 seconds. Furthermore, no early increases in HbR (early negative BOLD signal changes) were observed. These findings argue against the occurrence of an early loss of hemoglobin oxygenation that precedes the rise in CBF and suggest that CBF and oxygen consumption increases may be dynamically coupled in this animal model of neural activation.

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Patterns of Cerebral Blood Flow and Systemic Hemodynamics During Arithmetic Processing

Journal of Psychophysiology ◽

10.1027/0269-8803.22.2.81 ◽

2008 ◽

Vol 22 (2) ◽

pp. 81-90 ◽

Cited By ~ 21

Author(s):

Natalie Werner ◽

Neval Kapan ◽

Gustavo A. Reyes del Paso

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Time Course ◽

Doppler Sonography ◽

Transcranial Doppler Sonography ◽

Systemic Hemodynamics ◽

Heart Period ◽

Blood Flow Velocities ◽

Flow Velocities

The present study explored modulations in cerebral blood flow and systemic hemodynamics during the execution of a mental calculation task in 41 healthy subjects. Time course and lateralization of blood flow velocities in the medial cerebral arteries of both hemispheres were assessed using functional transcranial Doppler sonography. Indices of systemic hemodynamics were obtained using continuous blood pressure recordings. Doppler sonography revealed a biphasic left dominant rise in cerebral blood flow velocities during task execution. Systemic blood pressure increased, whereas heart period, heart period variability, and baroreflex sensitivity declined. Blood pressure and heart period proved predictive of the magnitude of the cerebral blood flow response, particularly of its initial component. Various physiological mechanisms may be assumed to be involved in cardiovascular adjustment to cognitive demands. While specific contributions of the sympathetic and parasympathetic systems may account for the observed pattern of systemic hemodynamics, flow metabolism coupling, fast neurogenic vasodilation, and cerebral autoregulation may be involved in mediating cerebral blood flow modulations. Furthermore, during conditions of high cardiovascular reactivity, systemic hemodynamic changes exert a marked influence on cerebral blood perfusion.

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Predicting cold-water bleaching in corals: role of temperature, and potential integration of light exposure

Marine Ecology Progress Series ◽

10.3354/meps13336 ◽

2020 ◽

Vol 642 ◽

pp. 133-146

Author(s):

PC González-Espinosa ◽

SD Donner

Keyword(s):

Coral Bleaching ◽

Cold Water ◽

Light Exposure ◽

Light Attenuation ◽

Florida Keys ◽

Cold Temperature ◽

Warm Water ◽

Coral Tissue ◽

Effect Of Temperature ◽

Type I

Warm-water growth and survival of corals are constrained by a set of environmental conditions such as temperature, light, nutrient levels and salinity. Water temperatures of 1 to 2°C above the usual summer maximum can trigger a phenomenon known as coral bleaching, whereby disruption of the symbiosis between coral and dinoflagellate micro-algae, living within the coral tissue, reveals the white skeleton of coral. Anomalously cold water can also lead to coral bleaching but has been the subject of limited research. Although cold-water bleaching events are less common, they can produce similar impacts on coral reefs as warm-water events. In this study, we explored the effect of temperature and light on the likelihood of cold-water coral bleaching from 1998-2017 using available bleaching observations from the Eastern Tropical Pacific and the Florida Keys. Using satellite-derived sea surface temperature, photosynthetically available radiation and light attenuation data, cold temperature and light exposure metrics were developed and then tested against the bleaching observations using logistic regression. The results show that cold-water bleaching can be best predicted with an accumulated cold-temperature metric, i.e. ‘degree cooling weeks’, analogous to the heat stress metric ‘degree heating weeks’, with high accuracy (90%) and fewer Type I and Type II errors in comparison with other models. Although light, when also considered, improved prediction accuracy, we found that the most reliable framework for cold-water bleaching prediction may be based solely on cold-temperature exposure.

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Independent and combined impact of hypoxia and acute inorganic nitrate ingestion on thermoregulatory responses to the cold

European Journal of Applied Physiology ◽

10.1007/s00421-021-04602-x ◽

2021 ◽

Vol 121 (4) ◽

pp. 1207-1218

Author(s):

Josh T. Arnold ◽

Stephen J. Bailey ◽

Simon G. Hodder ◽

Naoto Fujii ◽

Alex B. Lloyd

Keyword(s):

Blood Flow ◽

Cooling Rate ◽

Skin Blood Flow ◽

Rectal Temperature ◽

Onset Time ◽

Rate Of Change ◽

Vascular Control ◽

Delta Change ◽

Core Cooling ◽

The Impact

Abstract Purpose This study assessed the impact of normobaric hypoxia and acute nitrate ingestion on shivering thermogenesis, cutaneous vascular control, and thermometrics in response to cold stress. Method Eleven male volunteers underwent passive cooling at 10 °C air temperature across four conditions: (1) normoxia with placebo ingestion, (2) hypoxia (0.130 FiO2) with placebo ingestion, (3) normoxia with 13 mmol nitrate ingestion, and (4) hypoxia with nitrate ingestion. Physiological metrics were assessed as a rate of change over 45 min to determine heat loss, and at the point of shivering onset to determine the thermogenic thermoeffector threshold. Result Independently, hypoxia expedited shivering onset time (p = 0.05) due to a faster cooling rate as opposed to a change in central thermoeffector thresholds. Specifically, compared to normoxia, hypoxia increased skin blood flow (p = 0.02), leading to an increased core-cooling rate (p = 0.04) and delta change in rectal temperature (p = 0.03) over 45 min, yet the same rectal temperature at shivering onset (p = 0.9). Independently, nitrate ingestion delayed shivering onset time (p = 0.01), mediated by a change in central thermoeffector thresholds, independent of changes in peripheral heat exchange. Specifically, compared to placebo ingestion, no difference was observed in skin blood flow (p = 0.5), core-cooling rate (p = 0.5), or delta change in rectal temperature (p = 0.7) over 45 min, while nitrate reduced rectal temperature at shivering onset (p = 0.04). No interaction was observed between hypoxia and nitrate ingestion. Conclusion These data improve our understanding of how hypoxia and nitric oxide modulate cold thermoregulation.

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Failure of prostaglandins to modulate the time course of blood flow during dynamic forearm exercise in humans

Journal of Applied Physiology ◽

10.1152/jappl.1996.81.4.1516 ◽

1996 ◽

Vol 81 (4) ◽

pp. 1516-1521 ◽

Cited By ~ 50

Author(s):

J. K. Shoemaker ◽

H. L. Naylor ◽

Z. I. Pozeg ◽

R. L. Hughson

Keyword(s):

Blood Flow ◽

Brachial Artery ◽

Time Course ◽

Forearm Blood Flow ◽

Voluntary Contraction ◽

Double Blind ◽

Rate Of Increase ◽

Forearm Exercise ◽

Blind Manner ◽

Exercise In Humans

Shoemaker, J. K., H. L. Naylor, Z. I. Pozeg, and R. L. Hughson. Failure of prostaglandins to modulate the time course of blood flow during dynamic forearm exercise in humans. J. Appl. Physiol. 81(4): 1516–1521, 1996.—The time course and magnitude of increases in brachial artery mean blood velocity (MBV; pulsed Doppler), diameter ( D; echo Doppler), mean perfusion pressure (MPP; Finapres), shear rate (γ˙ = 8 ⋅ MBV/ D), and forearm blood flow (FBF = MBV ⋅ π r 2) were assessed to investigate the effect that prostaglandins (PGs) have on the hyperemic response on going from rest to rhythmic exercise in humans. While supine, eight healthy men performed 5 min of dynamic handgrip exercise by alternately raising and lowering a 4.4-kg weight (∼10% maximal voluntary contraction) with a work-to-rest cycle of 1:1 (s/s). When the exercise was performed with the arm positioned below the heart, the rate of increase in MBV and γ˙ was faster compared with the same exercise performed above the heart. Ibuprofen (Ibu; 1,200 mg/day, to reduce PG-induced vasodilation) and placebo were administered orally for 2 days before two separate testing sessions in a double-blind manner. Resting heart rate was reduced in Ibu (52 ± 3 beats/min) compared with placebo (57 ± 3 beats/min) ( P < 0.05) without change to MPP. With placebo, D increased in both arm positions from ∼4.3 mm at rest to ∼4.5 mm at 5 min of exercise ( P < 0.05). This response was not altered with Ibu ( P > 0.05). Ibu did not alter the time course of MBV or forearm blood flow ( P > 0.05) in either arm position. The γ˙ was significantly greater in Ibu vs. placebo at 30 and 40 s of above the heart exercise and for all time points after 25 s of below the heart exercise ( P < 0.05). Because PG inhibition altered the time course ofγ˙ at the brachial artery, but not FBF, it was concluded that PGs are not essential in regulating the blood flow responses to dynamic exercise in humans.

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The Effect of Caffeine on Digital Haemodynamics

Journal of Hand Surgery (European Volume) ◽

10.1016/0266-7681(94)90076-0 ◽

1994 ◽

Vol 19 (3) ◽

pp. 301-302 ◽

Cited By ~ 4

Author(s):

B. BARTON ◽

J. M. KLEINERT

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Room Temperature ◽

Systolic Pressure ◽

Middle Finger ◽

Distal Phalanx ◽

Normal Volunteers ◽

Pulse Volume ◽

Digital Pressure ◽

Digital Blood Flow

Caffeine has been shown to increase mean blood pressure, but studies documenting the effect of caffeine on digits are lacking. We evaluated the effect of caffeine on digital blood pressure and pulse volume in normal volunteers. In the first part of the study, 24 subjects were given water containing either 200 mg of caffeine or placebo. Bilateral brachial and middle finger digital pressures were measured at room temperature before ingestion and at 30 and 60 minutes after ingestion. In the second part of the study, pulse volume recordings (PVRs) were obtained in 24 subjects at the level of the distal phalanx of the middle finger of one hand immediately prior to beverage ingestion and at 10 minute intervals for 90 minutes. Differences in mean digital systolic pressure, digital/brachial index, or PVR amplitude between the control and caffeine groups were not statistically significant. The administration of caffeine was found not to alter the haemodynamics of digital blood flow or digital pressure in this population.

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Nailbed repair and patient satisfaction in children

Annals of The Royal College of Surgeons of England ◽

10.1308/003588410x12664192075891 ◽

2010 ◽

Vol 92 (6) ◽

pp. 483-485 ◽

Cited By ~ 6

Author(s):

S Pearce ◽

RJI Colville

Keyword(s):

Patient Satisfaction ◽

Complication Rate ◽

Parent Satisfaction ◽

Middle Finger ◽

Outcome Data ◽

General Anaesthetic ◽

Nail Bed ◽

Telephone Interviews ◽

High Satisfaction Rate

INTRODUCTION We performed an audit to assess frequency of injury to the nail bed and outcomes after repair in a busy paedi-atric hand trauma clinic. SUBJECTS AND METHODS This retrospective study examines 46 consecutive nail bed repairs over a 6-month period. All notes were reviewed for patient demographics, details of the injury including the operation and aftercare. Telephone interviews were used to assess patient/parent satisfaction and complications. RESULTS The commonest mechanism of injury was trapping a finger in a door. The accident usually occurred indoors and most frequently affected the middle finger. The majority of repairs were carried out under general anaesthetic, by registrars, using absorbable synthetic sutures, within 24 h of the injury as a day-case. Outcome data with a minimum of 15 months follow-up, showed a high satisfaction rate (8.9/10) and low complication rate (7%), none of which required further surgery. There was a high failure rate of attendance in the follow-up clinic whilst the outcomes of those attending were good. CONCLUSIONS Outcomes and patient satisfaction were good with a low complication rate resulting in a change of practice in our unit to an ‘opt-in’ system for follow-up.

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