Effects of simulated microgravity on closed-loop cardiovascular regulation and orthostatic intolerance: analysis by means of system identification

2004 ◽  
Vol 96 (2) ◽  
pp. 489-497 ◽  
Author(s):  
Xinshu Xiao ◽  
Ramakrishna Mukkamala ◽  
Natalie Sheynberg ◽  
S. Marlene Grenon ◽  
Michael D. Ehrman ◽  
...  
Keyword(s):  
System Identification ◽  
Simulated Microgravity ◽  
Closed Loop ◽  
Orthostatic Intolerance ◽  
Bed Rest ◽  
Model Parameters ◽  
Primary Concern ◽  
Loop Model ◽  
Before And After ◽  
Coupling Mechanisms

Microgravity-induced orthostatic intolerance (OI) continues to be a primary concern for the human space program. To test the hypothesis that exposure to simulated microgravity significantly alters autonomic nervous control and, thus, contributes to increased incidence of OI, we employed the cardiovascular system identification (CSI) technique to evaluate quantitatively parasympathetic and sympathetic regulation of heart rate (HR). The CSI method analyzes second-to-second fluctuations in noninvasively measured HR, arterial blood pressure, and instantaneous lung volume. The coupling mechanisms between these signals are characterized by using a closed-loop model. Parameters reflecting parasympathetic and sympathetic responsiveness with regard to HR regulation can be extracted from the identified coupling mechanisms. We analyzed data collected from 29 human subjects before and after 16 days of head-down-tilt bed rest (simulated microgravity). Statistical analyses showed that parasympathetic and sympathetic responsiveness was impaired by bed rest. A lower sympathetic responsiveness and a higher parasympathetic responsiveness measured before bed rest identified individuals at greater risk of OI before and after bed rest. We propose an algorithm to predict OI after bed rest from measures obtained before bed rest.

System identification of closed-loop cardiovascular control: effects of posture and autonomic blockade

1997 ◽  
Vol 272 (1) ◽  
pp. H448-H461 ◽  
Author(s):  
T. J. Mullen ◽  
M. L. Appel ◽  
R. Mukkamala ◽  
J. M. Mathias ◽  
R. J. Cohen
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
System Identification ◽  
Closed Loop ◽  
Cardiac Contraction ◽  
Loop Model ◽  
Physiological Mechanisms ◽  
Arterial Blood ◽  
Autonomic Blockade ◽  
Coupling Mechanisms

We applied system identification to the analysis of fluctuations in heart rate (HR), arterial blood pressure (ABP), and instantaneous lung volume (ILV) to characterize quantitatively the physiological mechanisms responsible for the couplings between these variables. We characterized two autonomically mediated coupling mechanisms [the heart rate baroreflex (HR baroreflex) and respiratory sinus arrhythmia (ILV-HR)] and two mechanically mediated coupling mechanisms [the blood pressure wavelet generated with each cardiac contraction (circulatory mechanics) and the direct mechanical effects of respiration on blood pressure (ILV⇢ABP)]. We evaluated the method in humans studied in the supine and standing postures under control conditions and under conditions of beta-sympathetic and parasympathetic pharmacological blockades. Combined beta-sympathetic and parasympathetic blockade abolished the autonomically mediated couplings while preserving the mechanically mediated coupling. Selective autonomic blockade and postural changes also altered the couplings in a manner consistent with known physiological mechanisms. System identification is an “inverse-modeling” technique that provides a means for creating a closed-loop model of cardiovascular regulation for an individual subject without altering the underlying physiological control mechanisms.

Changes in size and compliance of the calf after 30 days of simulated microgravity

1989 ◽  
Vol 66 (3) ◽  
pp. 1509-1512 ◽  
Author(s):  
V. A. Convertino ◽  
D. F. Doerr ◽  
S. L. Stein
Keyword(s):  
Simulated Microgravity ◽  
Orthostatic Intolerance ◽  
Bed Rest ◽  
Calf Muscle ◽  
Venous Compliance ◽  
Cross Sectional ◽  
Percent Change ◽  
Long Duration ◽  
Before And After ◽  
Muscle Compartment

Increased leg venous compliance may contribute to postflight orthostatic intolerance in astronauts. We reported that leg compliance was inversely related to the size of the muscle compartment. The purpose of this study was to test the hypothesis that reduced muscle compartment after long-duration exposure to microgravity would cause increased leg compliance. Eight men, 31–45 yr old, were measured for vascular compliance of the calf and serial circumferences of the calf before and after 30 days of continuous 6 degrees head-down bed rest. Cross-sectional areas (CSA) of muscle, fat, and bone compartments in the calf were determined before and after bed rest by computed tomography. From before to after bed rest, calculated calf volume (cm3) decreased (P less than 0.05) from 1,682 +/- 83 to 1,516 +/- 76. Calf muscle compartment CSA (cm2) also decreased (P less than 0.05) from 74.2 +/- 3.6 to 70.6 +/- 3.4; calf compliance (ml.100 ml-1.mmHg-1.100) increased (P less than 0.05) from 3.9 +/- .7 to 4.9 +/- .5. The percent change in calf compliance after bed rest was significantly correlated with changes in calf muscle compartment CSA (r = 0.72, P less than 0.05). The increased leg compliance observed after exposure to simulated microgravity can be partially explained by reduced muscle compartment. Countermeasures designed to minimize muscle atrophy in the lower extremities may be effective in ameliorating increased venous compliance and orthostatic intolerance after spaceflight.

A NEW MODEL FOR THE ROLE OF INDIVIDUAL PREDISPOSITION IN ORTHOSTATIC INTOLERANCE BEFORE AND AFTER EXPOSURE TO SIMULATED MICROGRAVITY.

2004 ◽  
Vol 52 ◽  
pp. S384-S385
Author(s):  
S. M. Grenon ◽  
N. Sheynberg ◽  
X. Xiao ◽  
C. D. Ramsdell ◽  
S. Hurwitz ◽  
...  
Keyword(s):  
Simulated Microgravity ◽  
Orthostatic Intolerance ◽  
New Model ◽  
Before And After

scholarly journals Effect of intermittent hypoxic training on orthostatic tolerance in humans before and after simulated microgravity

2020 ◽  
Author(s):  
VP Katuntsev ◽  
TV Sukhostavtseva ◽  
AN Kotov ◽  
MV Baranov
Keyword(s):  
Orthostatic Intolerance ◽  
Bed Rest ◽  
Daily Basis ◽  
Tilt Test ◽  
Control Group ◽  
Orthostatic Tolerance ◽  
Pronounced Increase ◽  
Intermittent Hypoxic Training ◽  
Hypoxic Training ◽  
Before And After

Reduced orthostatic tolerance (OT) is a serious concern facing space medicine. This work sought to evaluate the effects of intermittent hypoxic training (IHT) on OT in humans before and after 3 days of head-down bed rest (HDBR) used to model microgravity. The study was carried out in 16 male volunteers aged 18 to 40 years and included 2 series of experiments with 11-day and 21-day IHT administered on a daily basis. During the first IHT session, the concentration of oxygen in the inspired gas mixture was 10%; for other sessions it was adjusted to 9%. OT was assessed by a 20-minute-long orthostatic tilt test (OTT) conducted before and after HDBR. Before HDBR, orthostatic intolerance was observed in 3 participants, while after HDBR, it was observed in 9 of 16 volunteers (p < 0.05). During OTT conducted after HDBR, the heart rate (HR) exceeded control values by 26.8% (p < 0.01). Preexposure to any of the applied IHT regimens led to a reduction in the number of volunteers with orthostatic intolerance. After the 11-day IHT program, there was a less pronounced increase in HR during OTT before HDBR; with the extended IHT regimen, less pronounced changes were observed for HR, systolic, diastolic and mean blood pressure (BP). The increase in HR during OTT after HDBR was significantly lower in the group that had completed the 11-day IHT program, while BP remained stable. The changes in HR and systolic BP were less pronounced in the group that had completed the 21-day IHT program than in the control group (p < 0.05). Thus, IHT reduced the risk of orthostatic disorders and mitigated changes in cardiovascular parameters during the orthostatic test.

46 A NEW MODEL FOR THE ROLE OF INDIVIDUAL PREDISPOSITION IN ORTHOSTATIC INTOLERANCE BEFORE AND AFTER EXPOSURE TO SIMULATED MICROGRAVITY.

2004 ◽  
Vol 52 (Suppl 2) ◽  
pp. S384.6-S385
Author(s):  
S. M. Grenon ◽  
N. Sheynberg ◽  
X. Xiao ◽  
C. D. Ramsdell ◽  
S. Hurwitz ◽  
...  
Keyword(s):  
Simulated Microgravity ◽  
Orthostatic Intolerance ◽  
New Model ◽  
Before And After

Pseudo-random binary sequence closed-loop system identification error with integration control

2009 ◽  
Vol 223 (6) ◽  
pp. 877-884 ◽  
Author(s):  
Z Ren ◽  
G G Zhu
Keyword(s):  
System Identification ◽  
Closed Loop ◽  
Binary Sequence ◽  
Open Loop ◽  
Loop System ◽  
Loop Model ◽  
Closed Loop System ◽  
Identification Error ◽  
Closed Loop Identification ◽  
Integral Controller

This paper studies the closed-loop system identification (ID) error when a dynamic integral controller is used. Pseudo-random binary sequence (PRBS) q-Markov covariance equivalent realization (Cover) is used to identify the closed-loop model, and the open-loop model is obtained based upon the identified closed-loop model. Accurate open-loop models were obtained using PRBS q-Markov Cover system ID directly. For closed-loop system ID, accurate open-loop identified models were obtained with a proportional controller, but when a dynamic controller was used, low-frequency system ID error was found. This study suggests that extra caution is required when a dynamic integral controller is used for closed-loop system identification. The closed-loop identification framework also has significant effects on closed-loop identification error. Both first- and second-order examples are provided in this paper.

Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance

2007 ◽  
Vol 103 (6) ◽  
pp. 1964-1972 ◽  
Author(s):  
Donald E. Watenpaugh ◽  
Deborah D. O'Leary ◽  
Suzanne M. Schneider ◽  
Stuart M. C. Lee ◽  
Brandon R. Macias ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Acute Exercise ◽  
Treadmill Exercise ◽  
Orthostatic Intolerance ◽  
Lower Body Negative Pressure ◽  
Bed Rest ◽  
Orthostatic Tolerance ◽  
Lower Body ◽  
Before And After ◽  
Head Up Tilt

Orthostatic intolerance follows actual weightlessness and weightlessness simulated by bed rest. Orthostasis immediately after acute exercise imposes greater cardiovascular stress than orthostasis without prior exercise. We hypothesized that 5 min/day of simulated orthostasis [supine lower body negative pressure (LBNP)] immediately following LBNP exercise maintains orthostatic tolerance during bed rest. Identical twins (14 women, 16 men) underwent 30 days of 6° head-down tilt bed rest. One of each pair was randomly selected as a control, and their sibling performed 40 min/day of treadmill exercise while supine in 53 mmHg (SD 4) [7.05 kPa (SD 0.50)] LBNP. LBNP continued for 5 min after exercise stopped. Head-up tilt at 60° plus graded LBNP assessed orthostatic tolerance before and after bed rest. Hemodynamic measurements accompanied these tests. Bed rest decreased orthostatic tolerance time to a greater extent in control [34% (SD 10)] than in countermeasure subjects [13% (SD 20); P < 0.004]. Controls exhibited cardiac stroke volume reduction and relative cardioacceleration typically seen after bed rest, yet no such changes occurred in the countermeasure group. These findings demonstrate that 40 min/day of supine LBNP treadmill exercise followed immediately by 5 min of resting LBNP attenuates, but does not fully prevent, the orthostatic intolerance associated with 30 days of bed rest. We speculate that longer postexercise LBNP may improve results. Together with our earlier related studies, these ground-based results support spaceflight evaluation of postexercise orthostatic stress as a time-efficient countermeasure against postflight orthostatic intolerance.

scholarly journals Vascular adaptation to microgravity: what have we learned?

2001 ◽  
Vol 91 (6) ◽  
pp. 2415-2430 ◽  
Author(s):  
Li-Fan Zhang
Keyword(s):  
Structure Function ◽  
Rat Model ◽  
Animal Studies ◽  
Simulated Microgravity ◽  
Orthostatic Intolerance ◽  
Peripheral Resistance ◽  
Bed Rest ◽  
Cerebral Vasculature ◽  
Future Studies ◽  
Vascular Adaptation

Findings from recent bed rest and spaceflight human studies have indicated that the inability to adequately elevate the peripheral resistance and the altered autoregulation of cerebral vasculature are important factors in postflight orthostatic intolerance. Animal studies with rat model have revealed that simulated microgravity may induce upward and downward regulations in the structure, function, and innervation of the cerebral and hindquarter vessels. These findings substantiate in general the hypothesis that microgravity-induced redistribution of transmural pressures and flows across and within the arterial vasculature may well initiate differential adaptations of vessels in different anatomic regions. Understanding of the mechanisms involved in vascular adaptation to microgravity is also important for the development of multisystem countermeasures. However, future studies will be required to further ascertain the peripheral effector mechanism of postflight cardiovascular dysfunction.

scholarly journals Orthostatic Intolerance Is Independent of the Degree of Autonomic Cardiovascular Adaptation after 60 Days of Head-Down Bed Rest

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jiexin Liu ◽  
Yongzhi Li ◽  
Bart Verheyden ◽  
Zhanghuang Chen ◽  
Jingyu Wang ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Orthostatic Intolerance ◽  
Low Frequency ◽  
Systolic Arterial Pressure ◽  
Bed Rest ◽  
Progressive Increase ◽  
Tilt Test ◽  
Sinus Arrhythmia ◽  
Before And After ◽  
Low Frequency Power

Spaceflight and head-down bed rest (HDBR) can induce the orthostatic intolerance (OI); the mechanisms remain to be clarified. The aim of this study was to determine whether or not OI after HDBR relates to the degree of autonomic cardiovascular adaptation. Fourteen volunteers were enrolled for 60 days of HDBR. A head-up tilt test (HUTT) was performed before and after HDBR. Our data revealed that, in all nonfainters, there was a progressive increase in heart rate over the course of HDBR, which remained higher until 12 days of recovery. The mean arterial pressure gradually increased until day 56 of HDBR and returned to baseline after 12 days of recovery. Respiratory sinus arrhythmia and baroreflex sensitivity decreased during HDBR and remained suppressed until 12 days of recovery. Low-frequency power of systolic arterial pressure increased during HDBR and remained elevated during recovery. Three subjects fainted during the HUTT after HDBR, in which systemic vascular resistance did not increase and remained lower until syncope. None of the circulatory patterns significantly differed between the fainters and the nonfainters at any time point. In conclusion, our data indicate that the impaired orthostatic tolerance after HDBR could not be distinguished by estimation of normal hemodynamic and/or neurocardiac data.

Self-Sensing Active Magnetic Dampers for Vibration Control

2009 ◽  
Vol 131 (6) ◽  
Author(s):  
Angelo Bonfitto ◽  
Xavier De Lépine ◽  
Mario Silvagni ◽  
Andrea Tonoli
Keyword(s):  
Vibration Control ◽  
Closed Loop ◽  
Flexible Structures ◽  
Open Loop ◽  
System Response ◽  
Model Parameters ◽  
Loop Model ◽  
Single Degree Of Freedom ◽  
Luenberger Observer ◽  
Model Response

The aim of this paper is to investigate the potential of a self-sensing strategy in the case of an electromagnetic damper for the vibration control of flexible structures and rotors. The study has been performed in the case of a single degree of freedom mechanical oscillator actuated by a couple of electromagnets. The self-sensing system is based on a Luenberger observer. Two sets of parameters have been used: nominal ones (based on simplifications on the actuator model) and identified ones. In the latter case, the parameters of the electromechanical model used in the observer are identified starting from the open-loop system response. The observed states are used to close a state-feedback loop with the objective of increasing the damping of the system. The results show that the damping performance are good in both cases, although much better in the second one. Furthermore, the good correlation between the closed-loop model response and the experimental results validates the modeling, the identification procedure, the control design, and its implementation. The paper concludes on a sensitivity analysis, in which the influence of the model parameters on the closed-loop response is shown.

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