scholarly journals Creatine (methyl-d3) dilution in urine for estimation of total body skeletal muscle mass: accuracy and variability vs. MRI and DXA

2018 ◽  
Vol 124 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Richard V. Clark ◽  
Ann C. Walker ◽  
Ram R. Miller ◽  
Robin L. O’Connor-Semmes ◽  
Eric Ravussin ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Dual Energy ◽  
Intraindividual Variability ◽  
Whole Body ◽  
Dilution Method ◽  
X Ray ◽  
Spot Urine ◽  
Spot Urine Sample ◽  
Liquid Chromatography Tandem Mass ◽  
Total Body

A noninvasive method to estimate muscle mass based on creatine ( methyl-d3) (D3-creatine) dilution using fasting morning urine was evaluated for accuracy and variability over a 3- to 4-mo period. Healthy older (67- to 80-yr-old) subjects ( n = 14) with muscle wasting secondary to aging and four patients with chronic disease (58–76 yr old) fasted overnight and then received an oral 30-mg dose of D3-creatine at 8 AM ( day 1). Urine was collected during 4 h of continued fasting and then at consecutive 4- to 8-h intervals through day 5. Assessment was repeated 3–4 mo later in 13 healthy subjects and 1 patient with congestive heart failure. Deuterated and unlabeled creatine and creatinine were measured using liquid chromatography–tandem mass spectrometry. Total body creatine pool size and muscle mass were calculated from D3-creatinine enrichment in urine. Muscle mass was also measured by whole body MRI and 24-h urine creatinine, and lean body mass (LBM) was measured by dual-energy X-ray absorptiometry (DXA). D3-creatinine urinary enrichment from day 5 provided muscle mass estimates that correlated with MRI for all subjects ( r = 0.88, P < 0.0001), with less bias [difference from MRI = −3.00 ± 2.75 (SD) kg] than total LBM assessment by DXA, which overestimated muscle mass vs. MRI (+22.5 ± 3.7 kg). However, intraindividual variability was high with the D3-creatine dilution method, with intrasubject SD for estimated muscle mass of 2.5 kg vs. MRI (0.5 kg) and DXA (0.8 kg). This study supports further clinical validation of the D3-creatine method for estimating muscle mass. NEW & NOTEWORTHY Measurement of creatine ( methyl-d3) (D3-creatine) and D3-creatinine excretion in fasted morning urine samples may be a simple, less costly alternative to MRI or dual-energy X-ray absorptiometry (DXA) to calculate total body muscle mass. The D3-creatine enrichment method provides estimates of muscle mass that correlate well with MRI, and with less bias than DXA. However, intraindividual variability is high with the D3-creatine method. Studies to refine the spot urine sample method for estimation of muscle mass may be warranted.

Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method

2002 ◽  
Vol 76 (2) ◽  
pp. 378-383 ◽  
Author(s):  
Jaehee Kim ◽  
ZiMian Wang ◽  
Steven B Heymsfield ◽  
Richard N Baumgartner ◽  
Dympna Gallagher
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Dual Energy ◽  
Mass Estimation ◽  
X Ray ◽  
Total Body

scholarly journals Ethnic Differences in the BMI-%BF Relationships between Young Japanese and Australian-Caucasian Males Living in Australia Using Dual-Energy X-ray Absorptiometry

2003 ◽  
Vol 15 (1_suppl) ◽  
pp. S27-S32 ◽  
Author(s):  
M Kagawa ◽  
D Kerr ◽  
C Binns
Keyword(s):  
Ethnic Differences ◽  
World Health Organisation ◽  
Dual Energy ◽  
The Body ◽  
World Health ◽  
Asia Pacific ◽  
Whole Body ◽  
X Ray ◽  
Total Body

The Body Mass Index (BMI) has been used worldwide as an indicator of fatness. However, the universal cut-off points by the World Health Organisation (WHO) classification may not be appropriate for every ethnic group when consider the relationship with their actual total body fatness (%BF). The application of population-specific classifications to assess BMI may be more relevant to public health. Ethnic differences in the BMI-%BF relationship between 45 Japanese and 42 Australian-Caucasian males were assessed using whole body dual-energy X-ray absorptiometry (DXA) scan and anthropometry using a standard protocol. Japanese males had significantly ( p<0.05) greater %BF at given BMI values than Australian males. When this is taken into account the newly proposed Asia-Pacific BMI classification of BMI >23 as overweight and >25 as obese may better assess the level of obesity that is associated increased health risks for this population. To clarify the current findings, further studies that compare the relationships across other Japanese populations are recommended.

scholarly journals Estimation of body composition from bioelectrical impedance of body segments: Comparison with dual-energy X-ray absorptiometry

1993 ◽  
Vol 69 (3) ◽  
pp. 645-655 ◽  
Author(s):  
S. P. Stewart ◽  
P. N. Bramley ◽  
R. Heighton ◽  
J. H. Green ◽  
A. Horsman ◽  
...  
Keyword(s):  
Body Composition ◽  
Muscle Mass ◽  
Bioelectrical Impedance ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Whole Body ◽  
Simple Method ◽  
Creatinine Excretion ◽  
X Ray ◽  
Body Segments

In twenty-eight healthy subjects, ten men and eighteen women, with a range in body mass index (BMI) of 17.9–31.6 kg/m2 and an age range 20–60 years, body composition was estimated by dual-energy X-ray absorptiometry (DEXA), skinfold anthropometry (SFA) and bioelectrical impedance analysis (BIA) of the ‘whole body’and body segments. In thirteen subjects muscle mass was also estimated by 24 h urinary creatinine excretion. The relationship between fat-free mass (FFM) determined by DEXA and the impedance index of each body segment (calculated as Iength2/impedance (Z)) was analysed. The strongest correlation was between FFM (DEXA) and height2/‘whole-body’Z (Zw) (r 0.97 for the combined sexes, standard error of estimate (SEE) 2.72 kg). Separate prediction equations were found to be necessary for males and females when estimating FFM from BIA measurement of the arm (for men, r 0.93, SEE 1.98 kg; for women, r 0.75, SEE 2.87 kg). Muscle mass derived from 24 h creatinine excretion showed weak correlation with FFM (DEXA) (r 0.57, P = 0.03) and no correlation with FFM (SFA). FFM (SFA) correlated well with both FFM (DEXA) (r 0.96, SEE = 3.12 kg) and with height2/Zw (r 0.92, SEE 4.52 kg). Measurement of the impedance of the arm offers a simple method of assessing the composition of the whole body in normal individuals, and it appears comparable with other methods of assessment.

scholarly journals Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents

2006 ◽  
Vol 84 (5) ◽  
pp. 1014-1020 ◽  
Author(s):  
Jaehee Kim ◽  
Wei Shen ◽  
Dympna Gallagher ◽  
Alfredo Jones ◽  
ZiMian Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Children And Adolescents ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Dual Energy ◽  
Mass Estimation ◽  
X Ray ◽  
Total Body

scholarly journals The Association of Muscle Mass Measured by D3-Creatine Dilution Method With Dual-Energy X-Ray Absorptiometry and Physical Function in Postmenopausal Women

2021 ◽  
Author(s):  
Kexin Zhu ◽  
Jean Wactawski-Wende ◽  
Heather M Ochs-Balcom ◽  
Michael J LaMonte ◽  
Kathleen M Hovey ◽  
...  
Keyword(s):  
New York ◽  
Physical Function ◽  
Postmenopausal Women ◽  
Muscle Mass ◽  
Dual Energy ◽  
Community Dwelling ◽  
Dilution Method ◽  
Blood Draw ◽  
Anthropometric Measures ◽  
X Ray

Abstract Background The D3-creatine (D3Cr) dilution method provides a direct measure of skeletal muscle. The aim of this study was to compare the association of D3Cr muscle mass with lean body mass (LBM) measured by dual-energy x-ray absorptiometry (DXA) and examine its relation with physical function in postmenopausal women. Methods Seventy-four community-dwelling women (mean age 82.3 ± 5.4) participated in this pilot study from the Buffalo, New York clinical site of the Women’s Health Initiative (WHI). Participants attended a clinic visit which included anthropometric measures, blood draw, DXA scan, measures of physical function, and initiated the D3Cr protocol. Physical function was evaluated using hand grip strength, short physical performance battery (SPPB), and RAND-36 physical function scale. Descriptive statistics and logistic regression models were used to examine the associations of D3Cr muscle mass with functional outcomes. Results D3-creatine muscle mass was moderately correlated with DXA LBM (r = 0.50) and DXA appendicular lean mass (ALM) (r = 0.50). Individuals with high D3Cr muscle mass (%) had higher physical function compared to individuals with low muscle mass (%), indicated by high scores on SPPB (odds ratio [OR] = 5.24; 95% confidence interval [CI]: 1.40, 19.58). We observed stronger relationships between high D3Cr and physical function than either DXA LBM (OR = 3.40; 95% CI: 0.88, 13.11) or DXA ALM (OR = 4.15; 95% CI: 1.10, 15.68) and physical function. Conclusions Our findings provide strong preliminary data for the associations of D3Cr muscle mass with measures of physical function in older women. These findings support and extend prior work on D3Cr muscle mass in older men.

scholarly journals Relationship between Dual-Energy X-Ray Absorptiometry-Derived Appendicular Lean Tissue Mass and Total Body Skeletal Muscle Mass Estimated by Ultrasound

2013 ◽  
Vol 04 (06) ◽  
pp. 283-286 ◽  
Author(s):  
Takashi Abe ◽  
Nicole C. Dabbs ◽  
Vinayak K. Nahar ◽  
M. Allison Ford ◽  
Martha A. Bass ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Dual Energy ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Lean Tissue Mass ◽  
X Ray ◽  
Total Body

scholarly journals Estimation of Total Body Skeletal Muscle Mass in Chinese Adults: Prediction Model by Dual-Energy X-Ray Absorptiometry

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53561 ◽  
Author(s):  
Xinyu Zhao ◽  
ZiMian Wang ◽  
Junyi Zhang ◽  
Jianming Hua ◽  
Wei He ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Prediction Model ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Dual Energy ◽  
Chinese Adults ◽  
X Ray ◽  
Total Body

Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass

1999 ◽  
Vol 87 (4) ◽  
pp. 1513-1520 ◽  
Author(s):  
Marjolein Visser ◽  
Thomas Fuerst ◽  
Thomas Lang ◽  
Loran Salamone ◽  
Tamara B. Harris ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Elderly Persons ◽  
X Ray ◽  
Total Body Fat ◽  
The Mean ◽  
Leg Muscle ◽  
The Difference ◽  
Total Body

The aim of the study was to examine the accuracy of fan-beam dual-energy X-ray absorptiometry (DEXA) for measuring total body fat-free mass (FFM) and leg muscle mass (MM) in elderly persons. Participants were 60 men and women aged 70–79 yr and with a body mass index of 17.5–39.8 kg/m2. FFM and MM at four leg regions were measured by using DEXA (Hologic 4500A, v8.21). A four-compartment body composition model (4C) and multislice computed tomography (CT) of the legs were used as the criterion methods for FFM and MM, respectively. FFM by DEXA was positively associated with FFM by 4C ( R 2 = 0.98, SE of estimate = 1.6 kg). FFM by DEXA was higher [53.5 ± 12.0 (SD) kg] than FFM by 4C (51.6 ± 11.9 kg; P < 0.001). No association was observed between the difference and the mean of the two methods. MM by DEXA was positively associated with CT at all four leg regions ( R 2 = 0.86–0.96). MM by DEXA was higher than by CT in three regions. The results of this study suggest that fan-beam DEXA offers considerable promise for the measurement of total body FFM and leg MM in elderly persons.

scholarly journals Novel lateral whole‐body dual‐energy X‐ray absorptiometry of lumbar paraspinal muscle mass: results from the SarcoSpine study

2021 ◽  
Author(s):  
Sang Yoon Lee ◽  
Dong Hyun Kim ◽  
Sang Joon Park ◽  
Jinhee Park ◽  
Sun Gun Chung ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Dual Energy ◽  
Paraspinal Muscle ◽  
Whole Body ◽  
X Ray
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