scholarly journals Effects of pacing modality on noninvasive assessment of heart rate dependency of indices of large artery function

2016 ◽  
Vol 121 (3) ◽  
pp. 771-780 ◽  
Author(s):  
Isabella Tan ◽  
Hosen Kiat ◽  
Edward Barin ◽  
Mark Butlin ◽  
Alberto P. Avolio
Keyword(s):  
Heart Rate ◽  
Arterial Stiffness ◽  
Pulse Pressure ◽  
Wave Reflection ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Large Artery ◽  
Rate Dependency ◽  
Wave Reflections

Studies investigating the relationship between heart rate (HR) and arterial stiffness or wave reflections have commonly induced HR changes through in situ cardiac pacing. Although pacing produces consistent HR changes, hemodynamics can be different with different pacing modalities. Whether the differences affect the HR relationship with arterial stiffness or wave reflections is unknown. In the present study, 48 subjects [mean age, 78 ± 10 (SD), 9 women] with in situ cardiac pacemakers were paced at 60, 70, 80, 90, and 100 beats per min under atrial, atrioventricular, or ventricular pacing. At each paced HR, brachial cuff-based pulse wave analysis was used to determine central hemodynamic parameters, including ejection duration (ED) and augmentation index (AIx). Wave separation analysis was used to determine wave reflection magnitude (RM) and reflection index (RI). Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV). Pacing modality was found to have significant effects on the HR relationship with ED ( P = 0.01), central aortic pulse pressure ( P = 0.01), augmentation pressure ( P < 0.0001), and magnitudes of both forward and reflected waves ( P = 0.05 and P = 0.003, respectively), but not cfPWV ( P = 0.57) or AIx ( P = 0.38). However, at a fixed HR, significant differences in pulse pressure amplification ( P < 0.001), AIx ( P < 0.0001), RM ( P = 0.03), and RI ( P = 0.03) were observed with different pacing modalities. These results demonstrate that although the HR relationships with arterial stiffness and systolic loading as measured by cfPWV and AIx were unaffected by pacing modality, it should still be taken into account for studies in which mixed pacing modalities are present, in particular, for wave reflection studies.

Cardiovascular Effects of Aerobic Exercise With Self-Selected or Predetermined Intensity in Adolescents With Obesity

2021 ◽  
pp. 1-7
Author(s):  
Tércio A.R. Barros ◽  
Wagner L. do Prado ◽  
Thiago R.S. Tenório ◽  
Raphael M. Ritti-Dias ◽  
Antônio H. Germano-Soares ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Heart Rate ◽  
Pulse Pressure ◽  
Exercise Intensity ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Cardiovascular Effects ◽  
Heart Rate Reserve ◽  
Central Pulse Pressure

This study compared the effects of self-selected exercise intensity (SEI) versus predetermined exercise intensity (PEI) on blood pressure (BP) and arterial stiffness in adolescents with obesity. A total of 37 adolescents, 14.7 (1.6) years old, body mass index ≥95th percentile were randomly allocated into SEI (n = 18; 12 boys) or PEI (n = 19; 13 boys). Both groups exercised for 35 minutes on a treadmill, 3 times per week, for 12 weeks. The SEI could set the speed at the beginning of the sessions and make changes every 5 minutes. The PEI adolescents were trained at an intensity set at 60% to 70% of heart rate reserve. Brachial and central BP, pulse pressure, augmentation index, and carotid–femoral pulse wave were determined at baseline and after 12 weeks. Both groups reduced brachial systolic BP (SEI, Δ = −9 mm Hg; PEI, Δ = −4 mm Hg; P < .01), central systolic BP (SEI, Δ = −4 mm Hg; PEI, Δ = −4 mm Hg; P = .01), and central pulse pressure (SEI, Δ = −4 mm Hg; PEI, Δ = −3 mm Hg; P = .02) without differences between groups. No changes in the augmentation index and carotid–femoral pulse wave were observed in either group. The SEI induced similar changes in various cardiovascular outcomes compared with PEI in adolescents with obesity.

Volume status and arterial blood pressures are associated with arterial stiffness in hemodialysis patients

2018 ◽  
Vol 41 (7) ◽  
pp. 378-384 ◽  
Author(s):  
Alper Erdan ◽  
Abdullah Ozkok ◽  
Nadir Alpay ◽  
Vakur Akkaya ◽  
Alaattin Yildiz
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Pressure ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Mean Blood Pressure ◽  
Aortic Blood ◽  
Aortic Blood Pressure

Background: Arterial stiffness is a strong predictor of mortality in hemodialysis patients. In this study, we aimed to investigate possible relations of arterial stiffness with volume status determined by bioimpedance analysis and aortic blood pressure parameters. Also, effects of a single hemodialysis session on these parameters were studied. Methods: A total of 75 hemodialysis patients (M/F: 43/32; mean age: 53 ± 17) were enrolled. Carotid-femoral pulse wave velocity, augmentation index, and aortic pulse pressure were measured by applanation tonometry before and after hemodialysis. Extracellular fluid and total body fluid volumes were determined by bioimpedance analysis. Results: Carotid-femoral pulse wave velocity (9.30 ± 3.30 vs 7.59 ± 2.66 m/s, p < 0.001), augmentation index (24.52 ± 9.42 vs 20.28 ± 10.19, p < 0.001), and aortic pulse pressure (38 ± 14 vs 29 ± 8 mmHg, p < 0.001) significantly decreased after hemodialysis. Pre-dialysis carotid-femoral pulse wave velocity was associated with age (r2 = 0.15, p = 0.01), total cholesterol (r2 = 0.06, p = 0.02), peripheral mean blood pressure (r2 = 0.10, p = 0.005), aortic-mean blood pressure (r2 = 0.06, p = 0.02), aortic pulse pressure (r2 = 0.14, p = 0.001), and extracellular fluid/total body fluid (r2 = 0.30, p < 0.0001). Pre-dialysis augmentation index was associated with total cholesterol (r2 = 0.06, p = 0,02), aortic-mean blood pressure (r2 = 0.16, p < 0.001), and aortic pulse pressure (r2 = 0.22, p < 0.001). Δcarotid-femoral pulse wave velocity was associated with Δaortic-mean blood pressure (r2 = 0.06, p = 0.02) and inversely correlated with baseline carotid-femoral pulse wave velocity (r2 = 0.29, p < 0.001). Pre-dialysis Δaugmentation index was significantly associated with Δaortic-mean blood pressure (r2 = 0.09, p = 0.009) and Δaortic pulse pressure (r2 = 0.06, p = 0.03) and inversely associated with baseline augmentation index (r2 = 0.14, p = 0.001). In multiple linear regression analysis (adjusted R2 = 0.46, p < 0.001) to determine the factors predicting Log carotid-femoral pulse wave velocity, extracellular fluid/total body fluid and peripheral mean blood pressure significantly predicted Log carotid-femoral pulse wave velocity (p = 0.001 and p = 0.006, respectively). Conclusion: Carotid-femoral pulse wave velocity, augmentation index, and aortic pulse pressure significantly decreased after hemodialysis. Arterial stiffness was associated with both peripheral and aortic blood pressure. Furthermore, reduction in arterial stiffness parameters was related to reduction in aortic blood pressure. Pre-dialysis carotid-femoral pulse wave velocity was associated with volume status determined by bioimpedance analysis. Volume control may improve not only the aortic blood pressure measurements but also arterial stiffness in hemodialysis patients.

scholarly journals Leukocyte telomerase concentration is inversely associated with central wave reflection in patients with hypertension

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
O S Pavlova ◽  
T L Denisevich ◽  
M I Belskaya ◽  
E V Shafranovskaya ◽  
S E Ogurtsova ◽  
...  
Keyword(s):  
Family History ◽  
Cardiovascular Diseases ◽  
Arterial Stiffness ◽  
Telomere Length ◽  
Pulse Pressure ◽  
Wave Reflection ◽  
Augmentation Index ◽  
History Of ◽  
The Mean ◽  
Depressive Episodes

Abstract Introduction Telomere length and telomerase are biomarkers of aging and cardiovascular diseases. Arterial stiffness is associated with vascular age and higher risk of cardiovascular diseases. Decreased reparative cell's potential may cause vascular ageing and predispose to the progression of hypertension. Objective To determine association leukocyte telomerase concentration (TC) and relative telomere length (RTL) with arterial stiffness in hypertensive patients. Material and methods The study included 120 people (70 patients with uncomplicated arterial hypertension (AH) and 50 normotensive individuals). Mean age of hypertensives was 54.8±9.3 and of normotensives was 50.2±9.73 years. Dietary habits, smoking, level of physical activity, body mass index, waist circumference, presence of obesity, blood pressure (BP) level, family history of cardiovascular deseases, depressive episodes and psychological stress according the international questionnaires, glucose; cholesterol, angiotensin II, renin and aldosteron in blood were assessed in the participants. Aortic BP, aortic pulse pressure, augmentation index (AIx), AIx adjusted for heart rate 75 beats per minute (Aix@HR75), pulse wave velocity (PWV) were determined by the applanation tonometry. RTL of peripheral blood leukocytes was performed by real-time PCR. The leukocyte TC was measured using the enzyme immunoassay. Results There were no differences between patients with AH and normotensives in both leukocyte TC (4.9 (4.0; 8.0) versus 6.2 (4.1; 9.4), p=0.281) and RTL (0.94 (0.86; 1.0) versus 0.96 (0.83; 1.0), p=0.978). In hypertensive and normotensive groups the mean systolic aortic BP were 130.6±17,7 and 109.9±11.7 mmHg (p&lt;0.001), aortic pulse pressure – 41.5±9,7 and 33.6±10,4 mmHg (p&lt;0.001), Aix@HR75 – 16.0 (7.0; 28.0) and 27.0 (13.0; 35.0)% (p=0.004), PWV –7.9±1.4 and 8.1±1,7 m/s (p=0.409) respectively. In patients with AH the mean leukocyte TC was lower with an increased Aix@75 (&gt;25%) in contrast to the group of patients with normal Aix@75 (4.45 (3.9; 7.8) versus 7.97 (4.6; 10.0) ng/ml; p=0.043). Based on the multivariate logistic regression analysis independent factors influencing on the Aix@75 were leukocyte TC &lt;5 ng/ml with the family history of AH (OR=1.9, 95% CI: 1.1–3.4; p=0.036), the degree of AH combined with decreased salt sensitivity (OR=3.1; 95% CI: 1.3–7.5; p=0.010) and age (OR=1.2; 95% CI: 1.1–1.2; p=0.001). Conclusions Decrease of the leukocyte telomerase concentration associated with the raise of augmentation index in patient with uncomplicated AH. As a parameter of central wave reflection the augmentation index may considered as an early sign of biological and vascular aging in hypertension. FUNDunding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The state program of scientific research “Fundamental and applied sciences for medicine”

scholarly journals Insulin Increases Central Aortic Stiffness in Response To Hyperglycemia in Healthy Humans: A Randomized Four-Way Crossover Study

2021 ◽  
Author(s):  
William B Horton ◽  
Linda A Jahn ◽  
Lee M Hartline ◽  
Kevin W Aylor ◽  
James T Patrie ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Diastolic Blood Pressure ◽  
Wave Velocity ◽  
Wave Reflection ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Healthy Humans

Abstract Introduction: Increasing arterial stiffness is a feature of vascular aging that is accelerated by conditions that enhance cardiovascular risk, including diabetes mellitus. Multiple studies demonstrate divergence of carotid-femoral pulse wave velocity and augmentation index in persons with diabetes mellitus, though mechanisms responsible for this are unclear.Materials and Methods: We tested the effect of acutely and independently increasing plasma glucose, plasma insulin, or both on hemodynamic function and markers of arterial stiffness (including carotid-femoral pulse wave velocity, augmentation index, forward and backward wave reflection amplitude, and wave reflection magnitude) in a four-arm, randomized study of healthy young adults.Results: Carotid-femoral pulse wave velocity increased only during hyperglycemic-hyperinsulinemia (+0.36 m/s; p=0.032), while other markers of arterial stiffness did not change (all p>0.05). Heart rate (+3.62 bpm; p=0.009), mean arterial pressure (+4.14 mmHg; p=0.033), central diastolic blood pressure (+4.16 mmHg; p=0.038), and peripheral diastolic blood pressure (+4.09 mmHg; p=0.044) also significantly increased during hyperglycemic-hyperinsulinemia.Conclusions: We conclude that the acute combination of moderate hyperglycemia and hyperinsulinemia preferentially stiffens central elastic arteries. This effect may be due to increased sympathetic activity. (ClinicalTrials.gov number NCT03520569; registered 9 May 2018).

Abstract WP383: The Effect of Stretching on Pulse Wave Velocity

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Jeongok G Logan ◽  
Suk-Sun Kim ◽  
Mijung Lee ◽  
SeonAe Yeo
Keyword(s):  
Heart Rate ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Whole Body ◽  
Large Artery ◽  
Long Term Effects ◽  
Cardiovascular Morbidity And Mortality ◽  
Trunk Flexibility

Introduction: Large-artery stiffness is an independent predictor of hypertension which is a leading cause of excess cardiovascular morbidity and mortality. Carotid-femoral pulse wave velocity (cf-PWV) is considered the ‘gold-standard’ measure of arterial stiffness because it measures along the aorto-iliac pathway, which makes the largest contribution to the arterial buffering function. While there is well-documented evidence on the health benefits of aerobic and resistance exercise, the information for the effect of stretching on arterial stiffness is limited. Previous studies have shown that arterial stiffness is associated with trunk flexibility. Stretching exercise targeted to improve flexibility may exert a beneficial effect on reducing arterial stiffness. Purpose: This study aimed (1) to determine the association between trunk flexibility and arterial stiffness and (2) to examine whether one bout of stretching exercise will increase trunk flexibility and decrease arterial stiffness. Methods: Thirty healthy women (mean age = 44.37 years) were instructed to follow a 20-minute DVD demonstration of whole-body stretching. Before and after stretching, cf-PWV and trunk flexibility were measured by using the SphygmoCor system and by sit-and-reach test, respectively, as well as systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) by using a Welch Allyn Monitor. All data were measured after taking a 10-minute rest in a supine position. Results: cf-PWV was not related to trunk flexibility, however, cf-PWV was significantly decreased after stretching compared with before stretching (mean difference [MD]=.63, , p=.01). Trunk flexibility was also significantly increased after stretching (MD=-3.08, p=.00). Furthermore, while SBP and DBP did not change significantly, HR was significantly reduced after stretching compared with before stretching (MD=3.12, p=.00). Conclusions: Our results showed that one bout of stretching exercise had significant effects on reducing arterial stiffness and heart rate. Further testing of long-term effects of stretching exercise is warranted for development of preventative interventions to reduce arterial stiffness, an important subclinical biomarker of cardiovascular disease.

scholarly journals Insulin Increases The Central-To-Peripheral Arterial Stiffness Gradient in Response To Hyperglycemia in Healthy Humans: A Randomized Four-Way Crossover Study

2020 ◽  
Author(s):  
William B Horton ◽  
Linda A Jahn ◽  
Lee M Hartline ◽  
Kevin W Aylor ◽  
Eugene J Barrett
Keyword(s):  
Heart Rate ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Crossover Study ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Healthy Humans ◽  
Subendocardial Viability Ratio ◽  
Peripheral Arterial

Abstract Background: Increasing arterial stiffness is a physiological feature of vascular aging that is accelerated by conditions that enhance cardiovascular risk, including diabetes mellitus. Emerging evidence demonstrates that reversal of the normal central-to-peripheral arterial stiffness gradient predicts adverse cardiovascular consequences, including target organ damage. Preferential stiffening of central over peripheral arteries has been reported in type 2 diabetes, though mechanisms for this remain unclear.Methods: We tested the effect of acutely increasing plasma glucose, plasma insulin, or both on central arterial stiffness (carotid-femoral pulse wave velocity) and peripheral arterial stiffness (radial artery augmentation index) in a randomized, four-way, crossover study of 19 healthy young adults. We also measured myocardial oxygen supply-demand (subendocardial viability ratio) and hemodynamic function. Results: Carotid-femoral pulse wave velocity increased during hyperglycemic-hyperinsulinemia (+0.4 m/s; p=0.02) but not with euglycemia, hyperglycemia, or euglycemic-hyperinsulinemia. There were no significant changes in radial artery augmentation index within any protocol (all p>0.05), though this value trended lower with hyperglycemic-hyperinsulinemia (opposite of the observed effect on carotid-femoral pulse wave velocity). No changes were observed in subendocardial viability ratio within any protocol. Heart rate significantly increased only during hyperglycemic-hyperinsulinemia (+3.62 bpm; p=0.02). There was a significant inverse correlation between peripheral and arterial stiffness during hyperglycemic-hyperinsulinemia. Conclusions: We conclude that combined hyperglycemia and hyperinsulinemia acutely increases aortic stiffness, diminishes the normal central-to-peripheral arterial stiffness gradient, and increases heart rate in healthy humans. (ClinicalTrials.gov number NCT03520569; registered 9 May 2018).Clinical Trial Information: ClinicalTrials.gov identifier NCT03520569 (registered 9 May 2018).

scholarly journals Acute Effect of Moderate-Intensity Aerobic Exercise on Arterial Stiffness in Fine Particulate Matter Environment: A Pilot Study

2021 ◽  
Vol 30 (2) ◽  
pp. 257-263
Author(s):  
Jin-Su Kim ◽  
Moon-Hyon Hwang
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Fine Particulate Matter ◽  
Moderate Intensity ◽  
Fine Particulate ◽  
Pm2.5 Exposure

PURPOSE:This study aimed to examine the effect of one bout of moderate-intensity aerobic exercise on arterial stiffness under ambient fine particulate matter (PM2.5) exposure.METHODS: In a randomized crossover design, seven healthy young men performed 30 minutes of treadmill running at 70% of heart rate peak under high PM2.5 and low PM2.5 exposure. Arterial stiffness was assessed by measuring the carotid-femoral pulse wave velocity and augmentation index, a measure of pulse wave reflection before and after each exercise intervention.RESULTS: Regardless of the PM2.5 exposure, brachial systolic blood pressure and heart rate increased in response to one bout of moderate-intensity aerobic exercise (<i>p</i><.05). However, the augmentation index adjusted at a heart rate of 75 beats/min, central diastolic blood pressure, central mean arterial pressure, and brachial diastolic blood pressure were increased after one bout of moderate-intensity aerobic exercise under the high PM2.5 condition (<i>p</i><.05).CONCLUSIONS: Moderate-intensity aerobic exercise at the high PM2.5 level may result in acute negative arterial stiffness and blood pressure responses even in healthy young men.

scholarly journals FRI0256 ADVANCED MICROCIRCULATORY DAMAGE IS ASSOCIATED WITH INCREASED PULSE WAVE REFLECTIONS IN PATIENTS WITH SSC

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 712.1-712
Author(s):  
E. Pagkopoulou ◽  
S. Soulaidopoulos ◽  
E. Triantafyllidou ◽  
N. Katsiki ◽  
G. Kitas ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Arterial Stiffness ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Risk Index ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Wave Reflections ◽  
Cross Sectional ◽  
Fibrotic Process

Background:In systemic sclerosis (SSc), inflammation and microvascular damage are fundamental in the progressive fibrotic process. Although the presence of accelerated atherosclerosis in SSc is not as well-described as in other systemic disorders namely rheumatoid arthritis, it appears that individuals suffering from the disease are at higher risk for cardiovascular events. Nailfold Video Capillaroscopy (NVC) is a non-invasive and reproducible imaging technique of the capillary vascular bed, used in the evaluation of microvascular involvement in SSc. Previous data on the association between micro- and macrovascular damage are scarce.Objectives:The aim of this study was to examine the association between micro- and macrovascular involvement in patients with SSc.Methods:This is a cross-sectional study including consecutive SSc patients attending to a Scleroderma Outpatient Clinic between March and September 2018. All the study participants underwent NVC and the findings were classified in one of the following qualitative patterns: early, active, and late NVC pattern. Capillary’s density was evaluated in the distal row of each finger, based on the number of capillaries per 1 mm and the mean capillaroscopic skin ulcer risk index (CSURI) was automatically calculated with software image analysis. Carotid intima-media thickness (cIMT) was measured in the common carotid artery bilaterally, according to the relevant guidelines. Aortic blood pressure (BP), heart rate adjusted augmentation index [AIx(75)] and carotid-femoral pulse wave velocity (PWV) were evaluated with applanation tonometry (Sphygmocor).Results:Sixty-four (95,3% women) SSc individuals with mean age 57.54±12.99 years were included in this analysis. AIx(75) was significantly associated with CSURI (r=0.261; p=0.038) and inversely associated with the number of capillaries (r=-0.271; p=0.030) suggesting a link between the degree of microvascular disease and arterial stiffening. Regarding SSc-specific NVC patterns, AIx(75) were marginally lower in patients with early compared to active or late patterns (25.95±11.27 vs 32.50±11.17 vs 31.62±10.32%; p=0.081 and p=0.083) confirming a trend between progressive microvasculopathy and arterial stiffness. Mean cIMT was negatively correlated with enlarged capillary loops. Brachial or aortic systolic BP (SBP) and pulse pressure (PP) levels were not correlated with any of the studied NVC parameters.Conclusion:Microvascular vasculopathy is associated with higher wave reflections, indicating an association between atherosclerotic disease and microvascular injury in SSc patients. Such observations may provide possible explanations for the excessive cardiovascular and mortality risk in this population.References:[1]Soulaidopoulos, S., Pagkopoulou, E., Katsiki, N. et al. Arterial stiffness correlates with progressive nailfold capillary microscopic changes in systemic sclerosis: results from a cross-sectional study. Arthritis Res Ther 21, 253 (2019)[2]Jung K-H, Lim MJ, Kwon SR, Kim D, Joo K, Park W. Nailfold capillary microscopic changes and arterial stiffness in Korean systemic sclerosis patients. Mod Rheumatol. 2015;25:328–31.[3]Aviña-zubieta JA, Man A, Yurkovich M, Huang K, Sayre EC. Early cardiovascular disease after the diagnosis of systemic sclerosis. Am J Med. 2015;129:324–31Disclosure of Interests:Eleni Pagkopoulou: None declared, Stergios Soulaidopoulos: None declared, Eva Triantafyllidou: None declared, Niki Katsiki: None declared, Georeg Kitas: None declared, Asterios Karagiannis: None declared, Alexandros Garyfallos Grant/research support from: MSD, Aenorasis SA, Speakers bureau: MSD, Novartis, gsk, Theodoros Dimitroulas: None declared

scholarly journals Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Kaspar Tootsi ◽  
Jaak Kals ◽  
Mihkel Zilmer ◽  
Kaido Paapstel ◽  
Aare Märtson
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Selection Procedure ◽  
Applanation Tonometry ◽  
Serum Adiponectin ◽  
Large Artery ◽  
Cardiovascular Comorbidity ◽  
Matrix Metalloproteinase 3 ◽  
End Stage

Objective.Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality. Evidence is lacking about whether arterial stiffness is involved in OA. The objective of our study was to find out associations between OA, arterial stiffness, and adipokines.Design.Seventy end-stage knee and hip OA patients (age62±7years) and 70 asymptomatic controls (age60±7years) were investigated using the applanation tonometry to determine their parameters of arterial stiffness. Serum adiponectin, leptin, and matrix metalloproteinase 3 (MMP-3) levels were determined using the ELISA method. Correlation between variables was determined using Spearman’s rho. Multiple regression analysis with a stepwise selection procedure was employed.Results.Radiographic OA grade was positively associated with increased carotid-femoral pulse wave velocity (cf-PWV) (r=0.272,p=0.023). We found that OA grade was also associated with leptin and MMP-3 levels (rho=-0.246,p=0.040andrho=0.235,p=0.050, resp.). In addition, serum adiponectin level was positively associated with augmentation index and inversely with large artery elasticity index (rho=0.293,p=0.006andrho=-0.249,p=0.003, resp.).Conclusions.Our results suggest that OA severity is independently associated with increased arterial stiffness and is correlated with expression of adipokines. Thus, increased arterial stiffness and adipokines might play an important role in elevated cardiovascular risk in end-stage OA.

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