scholarly journals Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release

2013 ◽  
Vol 304 (8) ◽  
pp. G732-G740 ◽  
Author(s):  
Yong Ji ◽  
Yasuhisa Sakata ◽  
Xiaoming Li ◽  
Chao Zhang ◽  
Qing Yang ◽  
...  
Keyword(s):  
Histamine Release ◽  
Protein Secretion ◽  
Diamine Oxidase ◽  
Fold Increase ◽  
Fat Absorption ◽  
Histamine Concentration ◽  
Oxidative Breakdown ◽  
Release Histamine ◽  
Relationship Of ◽  
The Relationship

Diamine oxidase (DAO) is abundantly expressed in mammalian small intestine catalyzing the oxidative breakdown of polyamines and histamine. The aim of this study was to determine the relationship between stimulation of intestinal diamine oxidase secretion with intestinal fat absorption and histamine release. Conscious intestinal lymph fistula rats were used. The mesenteric lymph ducts were cannulated and intraduodenal tubes were installed for the infusion of Liposyn II 20% (an intralipid emulsion). Lymphatic DAO activity and protein secretion were analyzed by radiometric assay and Western blot, respectively. Lymphatic histamine concentration was measured by ELISA. Infusion of Liposyn II (4.43 kcal/3 ml) resulted in a ∼3.5-fold increase in lymphatic DAO protein secretion and DAO activity, peaking at 1 h and lasting for 3 h. Liposyn II infusion also increased the lymphatic histamine release, a substrate for DAO. To determine the relationship of DAO release with histamine release, histamine was administered intraperitoneally (10 mg/kg) in fasting rats and resulted in a significant doubling in lymphatic DAO activity, supporting a link between histamine and DAO. In addition, ip administration of the histamine H4 receptor antagonist JNJ7777120 significantly reduced the Liposyn II-induced DAO output by 65.9%, whereas H1 (pyrilamine maleate), H2 (ranitidine), and H3 (thioperamide maleate) receptor antagonists had little effect. We conclude that DAO secretion may contribute to the catabolism of histamine released during fat absorption and this is probably mediated through the histamine H4 receptor.

Triiodothyronine (T3), inflammation and mortality risk in patients with acute myocardial infarction

2022 ◽  
Author(s):  
Salman Razvi ◽  
Avais Jabbar ◽  
Arjola Bano ◽  
Lorna Ingoe ◽  
Peter Carey ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Confidence Interval ◽  
Mortality Risk ◽  
Fold Increase ◽  
Lower Serum ◽  
Reactive Protein ◽  
All Cause Mortality ◽  
Relationship Of ◽  
The Relationship

Objectives: To study the relationship between serum free T3 (FT3), C-reactive protein (CRP), and all-cause mortality in patients with acute myocardial infarction (AMI). Design: Prospective multicentre longitudinal cohort study. Methods: Between December 2014 and December 2016, thyroid function and CRP were analysed in AMI (both ST- and non-ST-elevation) patients from the ThyrAMI-1 study. The relationship of FT3 and CRP at baseline with all-cause mortality up to June 2020 was assessed. Mediation analysis was performed to evaluate if CRP mediated the relationship between FT3 and mortality. Results: In 1919 AMI patients [29.2% women, mean (SD) age 64.2 (12.1) years and 48.7% STEMI] followed over a median (inter-quartile range) period of 51 (46 to 58) months, there were 277 (14.4%) deaths. Overall, lower serum FT3 and higher CRP levels were associated with higher risk of mortality. When divided into tertiles based on levels of FT3 and CRP, the group with the lowest FT3 and highest CRP levels had 2.5-fold increase in mortality risk [adjusted hazard ratio (95% confidence interval) of 2.48 (1.82 to 3.16)] compared to the group with the highest FT3 and lowest CRP values. CRP mediated 9.8% (95% confidence interval 6.1 to 15.0%) of the relationship between FT3 and mortality. Conclusions: In AMI patients, lower serum FT3 levels on admission are associated with a higher mortality risk, which is partly mediated by inflammation. Adequately designed trials to explore potential benefits of T3 in AMI patients are required.

scholarly journals KOMPLIKASI KEHAMILAN DAN PERSALINAN PADA KEHAMILAN REMAJA

2021 ◽  
Vol 3 (2) ◽  
pp. 138
Author(s):  
Faqihati Husna ◽  
Muhammad Ilham Aldika Akbar ◽  
Rize Budi Amalia
Keyword(s):  
Teenage Pregnancy ◽  
Sampling Technique ◽  
Fold Increase ◽  
P Value ◽  
Cross Sectional ◽  
Labor Complications ◽  
Adolescent Pregnancies ◽  
Relationship Of ◽  
The Relationship ◽  
And Child Health

AbstrakLatar Belakang: Menurut UNICEF, setiap lima kelahiran bayi terdapat satu bayi lahir dari ibu dengan usia dibawah 19 tahun. Kehamilan pada remaja usia 15-19 tahun di negara berkembang mencapai angka 21 juta. Kehamilan remaja merupkan masalah yang tersebar di seluruh dunia dan berdampak terhadap kesehatan ibu dan anak. (Mukhopadhyay, 2010), secara luas kematian yang disebabkan oleh kehamilan merupakan penyebab utama kematian anak perempuan usia 15-19 tahun (WHO, 2017). Remaja memiliki risiko komplikasi kehamilan yang tinggi, salah satunya adalah persalinan prematur,  IUGR dan pre-eklamsia. (Baker, 2007).Terjadi peningkatan risiko komplikasi sebesar 2 kali lipat pada kehamilan remaja dibandingkan kehamilan pada wanita usia 20-an (Utomo I. D., 2013), Penelitian ini bertujuan untuk mencari hubungan kehamilan remaja dengan komplikasi kehamilan dan persalinan. Metode: Penelitian ini menggunakan metode analitik observasional dengan pendekatan retrospektif cross sectional dengan jumlah sampel 40 dan diambil dengan teknik cosecutive sampling. Hasil: Komplikasi pada kehamilan remaja mencapai 60%. Hasil analisis hubungan kehamilan remaja dengan komplikasi kehamilan (p value= 0,0100 OR = 6), anemia ( p value 0,013 OR=7,364), defisiensi gizi p value=0,400), prekalmisa/eklamsia (p value =0,300), komplikasi persalinan (p value =1,000), persalinan SC (p value=1,000) dan KPD (p value =1,000). Kesimpulan: Pada penelitian ini kehamilan remaja berpengaruh pada komplikasi kehamilan dengan penyulit  dominan anemia dan tidak berpengaruh pada komplikasi persalinan.AbstractBackgrounds: According to UNICEF, every five babies born there is one baby born to a mother under the age of 19 years. Pregnancy in adolescents aged 15-19 years in developing countries reaches 21 million. Teenage pregnancy was a problem that spread throughout the world and had an impact on maternal and child health. (Mukhopadhyay, 2010), widely deaths caused by pregnancy are the main cause of death for girls aged 15-19 years (WHO, 2017). Adolescents had a high risk of pregnancy complications, one of which is premature labor, IUGR and pre-eclampsia. (Baker, 2007). There has been a 2-fold increase in the risk of complications in adolescent pregnancies versus pregnancies in women in their 20s (Utomo I. D., 2013). Methods: This study were observational analytic method with a retrospective cross sectional approach with 40 samples and was taken by cosecutive sampling technique. Results: Complications in adolescent pregnancy reach 60%. The results of the analysis of the relationship of adolescent pregnancies with complications of pregnancy showed (p value= 0,0100 OR = 6), anemia ( p value 0,013 OR=7,364), nutritional deficiency (p value=0,400), preeclampsia/eclampsia (p value =0,300), labor complications (p value =1,000), sectio caesaria (p value=1,000) dan premature rupture of membrane (p value =1,000)

scholarly journals Chemical basis for beef charqui meat texture

2007 ◽  
Vol 50 (4) ◽  
pp. 719-724 ◽  
Author(s):  
Elza Y. Youssef ◽  
Carlos Eduardo Rocha Garcia ◽  
Fábio Yamashita ◽  
Massami Shimokomaki
Keyword(s):  
Mathematical Modeling ◽  
Chemical Composition ◽  
Moisture Content ◽  
Shear Force ◽  
Vastus Lateralis ◽  
Fold Increase ◽  
Raw Material ◽  
Water Molecules ◽  
Relationship Of ◽  
The Relationship

This work evaluated the relationship of charqui meat (CHM) chemical composition with the tenderness throughout its production. CHM was prepared from beef Vastus lateralis of 4-5 years old. Shear force of fresh CHM showed an approx. 3-fold increase in toughness compared to the raw material while, in the case of cooked CHM it was 6-fold increased in relation to the raw charqui. The moisture content decreased by 39.0 and 58.0% (p<0.05) for uncooked and cooked CHM, respectively, in relation to the raw material. Mathematical modeling of the influence of these meat components showed that shear force increased exponentially with the loss of moisture. The texture of CHM was the result of a multitude of factors involving myofibril proteins which promoted dynamic biochemical events such as the binding of water molecules. It was the amount of the latter which ultimately determine the final charqui meat texture.

scholarly journals Relationship of intestinal histology with the resistance to Trichostrongylus colubriformis infection in three breeds of sheep

2007 ◽  
Vol 27 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Alessandro F.T. Amarante ◽  
Raquel A. Rocha ◽  
Patrizia A. Bricarello
Keyword(s):  
Cellular Response ◽  
Inflammatory Cell ◽  
Inflammatory Cells ◽  
Intestinal Histology ◽  
Trichostrongylus Colubriformis ◽  
Histamine Concentration ◽  
Tissue Samples ◽  
Intestine Mucosa ◽  
Relationship Of ◽  
The Relationship

The study was carried out to evaluate the relationship of inflammatory intestinal cells with the resistance to Trichostrongylus colubriformis infections in three breeds of sheep (Santa Ines, Suffolk and Ile de France), naturally infected. Mast cells, eosinophils, and globule leucocytes were enumerated in intestinal mucosa. Histamine concentration was estimated in intestinal tissue samples and the length of male and female specimens were determined. The three breeds of sheep showed similar cellular response in the small intestine mucosa (P>0.05). There was extensive variation among sheep in the parasitological and inflammatory cell variables, even in lambs of the same breed. In general, animals presenting less inflammatory cells had a larger worm burden, higher fecal egg counts, and larger T. colubriformis worms. The inflammatory cells possibly impaired the parasite's establishment, development, and survival.

Calcium mediates gastrin-induced gastric histamine release in the rat

1993 ◽  
Vol 264 (1) ◽  
pp. G51-G56
Author(s):  
A. K. Sandvik ◽  
E. Brenna ◽  
H. L. Waldum
Keyword(s):  
Histamine Release ◽  
Fold Increase ◽  
Ionized Calcium ◽  
Channel Blockers ◽  
Tetraacetic Acid ◽  
Rat Stomach ◽  
Acetoxymethyl Ester ◽  
Transmembrane Flux ◽  
Release Histamine ◽  
Messenger System

This study examined the second messenger system responsible for gastrin-induced histamine release from the rat stomach. We examined the effect of different concentrations of ionized calcium, the calcium-channel blockers verapamil and nicardipine, and the intracellular calcium-chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid/acetoxymethyl ester (BAPTA/AM) on gastrin-stimulated histamine release in the totally isolated vascularly perfused rat stomach. Moreover, the effect on baseline histamine release of caffeine as well as of forskolin and 3-isobutyl-1-methylxanthine (IBMX) was tested. Gastrin induced an immediate 10- to 15-fold increase in venous histamine. Perfusate ionized calcium in the 0.25-1.25 mM range did not affect histamine release; histamine release was attenuated by the 0.00 and 1.75 mM calcium concentrations. Verapamil, nicardipine, and BAPTA/AM inhibited gastrin-stimulated histamine release. Caffeine stimulated the release, whereas forskolin and IBMX had no effect. We conclude that gastrin-induced histamine release from the rat stomach is mediated by calcium, probably both from the intracellular pool and by transmembrane flux from the extracellular space.

scholarly journals The Relationship between CRP at Admission and Thorax CT Findings in Patients Diagnosed with COVID-19

2021 ◽  
Author(s):  
Engin Beydoğan ◽  
Pınar Yürük Atasoy
Keyword(s):  
Emergency Department ◽  
Fold Increase ◽  
Rt Pcr ◽  
Reactive Protein ◽  
Ct Findings ◽  
Ct Density ◽  
Thorax Ct ◽  
Relationship Of ◽  
The Relationship ◽  
Negative Imaging

Introduction: The current study aims to evaluate the relationship between C-reactive protein (CRP) levels, thorax CT findings and CT-SS in patients presenting to the emergency department with COVID-19. Methods: Patients diagnosed with COVID-19 by nasopharyngeal rt-PCR (+) in the emergency department were included in the study. In addition to the CRP, ferritin and D-dimer examinations of patients at admission, thorax CT involvement findings and CT-SS results were recorded. The relationship of CRP value with CT-SS and clinical outcome was evaluated. Results: A total of 974 COVID-19 patients, 572 males (58.7%) and 402 females (41.3%), with a mean age of 59.64±17.34 years, were included in the study. The CRP values of the patients who needed intensive care and needed respiratory support were also significantly higher at admission (95.1 mg/dL vs. 31.05 mg/dL) (p<0.001). The CRP values of the patients who developed any complications during the treatment of COVID-19 were higher (79.9 mg/dL vs. 41.85 mg/dL) (p<0.001). In the case of CRP >124.5, a thorax CT density score 7.35 times higher was determined to be severe. In addition, it was determined that there was a 9.09-fold increase in the incidence of negative imaging findings in terms of COVID-19 in cases where the CRP value was <12.5 mg/dL. Conclusion: The CRP levels of COVID-19 patients measured upon admission to the emergency room are correlated with the severity of lung involvement and are an important predictor of clinical outcomes.

The relationship of the scleractinian corals to the rugose corals

Paleobiology ◽  
1980 ◽  
Vol 6 (02) ◽  
pp. 146-160 ◽  
Author(s):  
William A. Oliver
Keyword(s):  
Critical Points ◽  
Scleractinian Corals ◽  
Convincing Evidence ◽  
Early Triassic ◽  
Rugose Corals ◽  
History Of ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship ◽  
Biologic Factors

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.

Skeletal elements of crinoid echinoderms: High-resolution structural and microanalytical results

1983 ◽  
Vol 41 ◽  
pp. 194-195
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor
Keyword(s):  
High Resolution ◽  
Marine Invertebrates ◽  
Sea Urchins ◽  
Structural Features ◽  
Sea Stars ◽  
High Resolution Tem ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.

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