(Invited) Deep Tissue Fluorescence Imaging in the Second Near-Infrared Window (NIR-II Window) Using Carbon Nanotubes

2016 ◽  
Keyword(s):  
Carbon Nanotubes ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Deep Tissue ◽  
Tissue Fluorescence ◽  
Infrared Window

scholarly journals Numerical Simulation of a Scanning Illumination System for Deep Tissue Fluorescence Imaging

2019 ◽  
Vol 5 (11) ◽  
pp. 83
Author(s):  
Qimei Zhang ◽  
Anna M. Grabowska ◽  
Philip A. Clarke ◽  
Stephen P. Morgan
Keyword(s):  
Fluorescence Imaging ◽  
Spatial Resolution ◽  
Near Infrared ◽  
Scanning System ◽  
Deep Tissue ◽  
Full Field ◽  
Infrared Wavelength ◽  
Tissue Optical Properties ◽  
Illumination System ◽  
Tissue Fluorescence

The spatial resolution and light detected in fluorescence imaging for small animals are limited by light scattering, absorption and autofluorescence. To address this, novel near-infrared fluorescent contrast agents and imaging configurations have been investigated. In this paper, the influence of the light wavelength and imaging configurations (full-field illumination system and scanning system) on fluorescence imaging are compared quantitatively. The surface radiance for both systems is calculated by modifying the simulation tool Near-Infrared Fluorescence and Spectral Tomography. Fluorescent targets are embedded within a scattering medium at different positions. The surface radiance and spatial resolution are obtained for emission wavelengths between 620 nm and 1000 nm. It was found that the spatial resolution of the scanning system is independent of the tissue optical properties, whereas for full-field illumination, the spatial resolution degrades at longer wavelength. The full width at half maximum obtained by the scanning system is 25% lower than that obtained by the full-field illumination system when the targets are located in the middle of the phantom. The results indicate that although imaging at near-infrared wavelength can achieve a higher surface radiance, it may produce worse spatial resolution.

Acceptor Engineering of Small Molecule Fluorophores for NIR-II Fluorescent and NIR-I Photoacoustic Imaging

2021 ◽  
Author(s):  
Yaxi Li ◽  
Hongli Zhou ◽  
Renzhe Bi ◽  
Xiuting Li ◽  
Menglei Zha ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Small Molecule ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Infrared Window

Fluorescence imaging in the second near-infrared window (NIR-II) has been an emerging technique in diverse in vivo applications with high sensitivity/resolution and deep tissue penetration. To date, the designing principle...

Gram-scale synthesis of a neodymium chelate as a spectral CT and second near-infrared window imaging agent for visualizing the gastrointestinal tract in vivo

2021 ◽  
Author(s):  
Pengrui Zhuang ◽  
Ke Xiang ◽  
Xiangxi Meng ◽  
Guohe Wang ◽  
Ziyuan Li ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Fluorescence Imaging ◽  
Large Scale ◽  
Near Infrared ◽  
Imaging Agent ◽  
Spectral Ct ◽  
Green Method ◽  
Infrared Window

A facile and green method was developed to fabricate Nd-DTPA on a large scale without byproducts for CT/spectral CT and NIR II fluorescence imaging of the gastrointestinal tract in vivo.

scholarly journals 3D Tissue Reconstruction by using Deep Tissue Fluorescence Imaging System and FLIM

2014 ◽  
Vol 106 (2) ◽  
pp. 400a
Author(s):  
Sohail Jahid ◽  
Alexander S. Dvornikov ◽  
Michelle Digman ◽  
Enrico Gratton
Keyword(s):  
Fluorescence Imaging ◽  
Imaging System ◽  
Deep Tissue ◽  
Tissue Reconstruction ◽  
Fluorescence Imaging System ◽  
Tissue Fluorescence
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