A Newly Developed Electrochemical Method for the Simultaneous Determination of Camylofin and Analgine in Pharmaceutical Preparation and Biological Fluids

2019 ◽  
Vol 166 (13) ◽  
pp. B1217-B1225 ◽  
Author(s):  
Shimaa A. Atty ◽  
Ola M. Abdallah ◽  
Mona A. Abdelrahman ◽  
Ahmed M. Abdel-Megied
Keyword(s):  
Simultaneous Determination ◽  
Electrochemical Method ◽  
Biological Fluids ◽  
Pharmaceutical Preparation

scholarly journals Automatic continuous on-line monitoring of salicylic acid and acetylsalicylic acid in pharmaceuticals

1990 ◽  
Vol 12 (6) ◽  
pp. 263-266 ◽  
Author(s):  
J. M. López Fernández ◽  
M. D. Luque de Castro ◽  
M. Valcárcel
Keyword(s):  
Salicylic Acid ◽  
Acetylsalicylic Acid ◽  
Simultaneous Determination ◽  
Pharmaceutical Preparation ◽  
Pharmaceutical Preparations ◽  
Sampling Frequency ◽  
The Other ◽  
Dissolution Test ◽  
On Line

An asymmetrical FIA merging-zones manifold based on the dual injection of two sample microvolumes was developed for the simultaneous determination of salicylic acid and acetylsalicylic acid in pharmaceutical preparations at a sampling frequency of 30/h. The complex formed between the Fe(III) reagent continuously introduced in the system and salicylic acid was monitored photometrically at 520 nm. One of the sample plugs was prehydrolysed on injection into an NaOH stream and was circulated through a longer channel than the other plug. This yielded two FIA peaks corresponding to salicylic acid and the overall content, respectively. The proposed manifold was successfully used to control the dissolution test of a pharmaceutical preparation.

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