A Glucose Biosensor Based on a 3D Nanostructured Gold Electrode

2012 ◽  
Vol 160 (1) ◽  
pp. B1-B5 ◽  
Author(s):  
Chung-Che Tsai ◽  
Gou-Jen Wang
2012 ◽  
Author(s):  
Azila Abd. Aziz

Satu biosensor glukosa separa telah dibina menggunakan satu lapisan dalaman yang selektif, satu lapisan enzim dan satu elektrod emas. Kedua–dua lapisan membran tersebut adalah berasaskan polivinil alcohol (PVA) tersambung silang. Prestasi biosensor glukosa tersebut telah dinilai terutamanya prestasi terhadap gangguan asetaminofen, yang merupakan molekul tak ionik. Sensitiviti enzim tersekat gerak tersebut terhadap glukosa adalah tinggi tetapi ianya tidak mencukupi untuk melawan gangguan asetaminofen. Kehadiran lapisan dalaman PVA yang hanya sederhana selektif tidak menyebabkan kesan yang ketara pada gangguan. Satu model matematik kemudiannya digunakan untuk menganalisis prestasi biosensor yang lengkap. Satu lapisan luar ditambah secara simulasi kepada dua lapisan terdahulu. Model matematik tersebut meramalkan bahawa penambahan satu lapisan luar yang mempunyai kebolehtelapan yang rendah terhadap bahan larut mampu memperbaiki prestasi sensor. Kata kunci: Biosensor glukosa; model matematik; asetaminofen; gangguan elektrokimia; polivinil alkohol tersambung silang A partial glucose biosensor was constructed using a selective internal layer, an enzyme layer and a gold electrode. Both membrane layers are based on cross–linked polyvinyl alcohol (PVA). The performance of the partial glucose biosensor was analyzed particularly with respect to the interfering effects of acetaminophen, a non–ionic molecule. The sensitivity of the immobilized enzyme to glucose was high but it was not high enough to counter acetaminophen interference. The addition of the moderately selective PVA internal layer did not seem to have a significant effect on interference. A mathematical model was then used to analyze the performance of a completed biosensor. A simulated external layer was added to the two layers. The mathematical model predicted that the addition of an external layer with lowered permeability to solutes could improve the performance of the sensor. Key words: Glucose biosensor; mathematical modeling; acetaminophen; electrochemical interference; cross-linked polyvinyl alcohol


RSC Advances ◽  
2015 ◽  
Vol 5 (52) ◽  
pp. 41786-41794 ◽  
Author(s):  
Rachna Sharma ◽  
R. K. Sinha ◽  
Ved Varun Agrawal

A one-step electrochemical route for the synthesis, functionalization and deposition of Au nanostructures and for the bi-enzyme functionalization of a Au electrode has been proposed.


2006 ◽  
Vol 8 (12) ◽  
pp. 1825-1829 ◽  
Author(s):  
Liang Wang ◽  
Junyue Bai ◽  
Pengfei Huang ◽  
Hongjing Wang ◽  
Liying Zhang ◽  
...  

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