In Vitro Evaluation of Osteoblast-Like Cell Adhesion and Proliferation on Titanium Oxide Film Formed by Sand-Blasted Titanium Anode Treatment Process

The bioactivities of titanium oxide film on titanium surface received from different chemical treatment methods were studied in SBF in vitro and mechanically and histologically investigated in vivo. Three groups of titanium specimens were prepared: untreated titanium(S), acid-alkali treated titanium (H), and acid-alkali and heat-treated titanium(X). The oxide film of X surface resulted in more apatite formation and significantly higher strength of the interface between the samples and bone than those of the other titanium groups. The surface of the acid-alkali treated titanium and that further treated by heat treatment had higher bioactivity and stronger bone-bonding ability.

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In Vitro Studies of Inflammation and Contact Activation of Titanium Oxide Film

Key Engineering Materials - Bioceramics 19 ◽

10.4028/0-87849-422-7.729 ◽

2007 ◽

pp. 729-732

Author(s):

An Sha Zhao ◽

Ping Yang ◽

Yong Xiang Leng ◽

Jun Ying Chen ◽

Jin Wang ◽

...

Keyword(s):

Oxide Film ◽

Titanium Oxide ◽

In Vitro Studies ◽

Contact Activation ◽

Titanium Oxide Film

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In Vitro Studies of Inflammation and Contact Activation of Titanium Oxide Film

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.330-332.729 ◽

2007 ◽

Vol 330-332 ◽

pp. 729-732

Author(s):

An Sha Zhao ◽

Ping Yang ◽

Yong Xiang Leng ◽

Jun Ying Chen ◽

Jin Wang ◽

...

Keyword(s):

Reference Material ◽

Oxide Film ◽

Titanium Oxide ◽

Medical Devices ◽

Contact Activation ◽

Host Reaction ◽

Titanium Oxide Film ◽

Inflammatory Molecule ◽

Good Biocompatibility

Ti-O film is a kind of potential biomaterial may be applied in medical devices. But the mechanism of its good biocompatility is not so clear. This study revealed that when Titanium oxide contact with macrophage and plasma, the activation, adhesion and secretion of inflammatory molecule MCP-1 of macrophage is lower than reference material. Ti-O film also show minor contact activation to plasma. So reducing the host reaction including contact activation and inflammation may be the important reason for the good biocompatibility of Ti-O film.

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Characterization of an Amorphous Titanium Oxide Film Deposited onto a Nano-Textured Fluorination Surface

Materials ◽

10.3390/ma9060429 ◽

2016 ◽

Vol 9 (6) ◽

pp. 429 ◽

Cited By ~ 5

Author(s):

Pei-Yu Li ◽

Hua-Wen Liu ◽

Tai-Hong Chen ◽

Chun-Hao Chang ◽

Yi-Shan Lu ◽

...

Keyword(s):

Oxide Film ◽

Titanium Oxide ◽

Titanium Oxide Film

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Preparation of nano-structured titanium oxide film for biosensor substrate by wet corrosion process

Current Applied Physics ◽

10.1016/j.cap.2009.06.051 ◽

2009 ◽

Vol 9 (4) ◽

pp. e266-e269 ◽

Cited By ~ 11

Author(s):

So-Yoon Lee ◽

Madoka Takai ◽

Hyun-Min Kim ◽

Kazuhiko Ishihara

Keyword(s):

Oxide Film ◽

Titanium Oxide ◽

Corrosion Process ◽

Titanium Oxide Film

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Titanium Oxide Film Deposition by Low-Power APS Equipment Using Air Working Gas and Rechargeable Lead Battery

Renewable Energy and Sustainable Buildings - Innovative Renewable Energy ◽

10.1007/978-3-030-18488-9_73 ◽

2019 ◽

pp. 879-888

Author(s):

Zine Elabidine Ettayebi ◽

Yoshimasa Noda ◽

Yasutaka Ando ◽

Mitsumasa Iino

Keyword(s):

Oxide Film ◽

Low Power ◽

Titanium Oxide ◽

Film Deposition ◽

Titanium Oxide Film ◽

Lead Battery

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Three-Dimensional Bone Substitutes for Oral and Maxillofacial Surgery: Biological and Structural Characterization

Journal of Functional Biomaterials ◽

10.3390/jfb9040062 ◽

2018 ◽

Vol 9 (4) ◽

pp. 62 ◽

Cited By ~ 8

Author(s):

Gianluca Turco ◽

Davide Porrelli ◽

Eleonora Marsich ◽

Federica Vecchies ◽

Teresa Lombardi ◽

...

Keyword(s):

Cell Adhesion ◽

Clinical Performance ◽

Maxillofacial Surgery ◽

Chemical Characterization ◽

Bone Substitutes ◽

Human Cell Line ◽

Structural Features ◽

Oral And Maxillofacial Surgery ◽

Cell Adhesion And Proliferation

Background: Bone substitutes, either from human (autografts and allografts) or animal (xenografts) sources, suffer from inherent drawbacks including limited availability or potential infectivity to name a few. In the last decade, synthetic biomaterials have emerged as a valid alternative for biomedical applications in the field of orthopedic and maxillofacial surgery. In particular, phosphate-based bone substitution materials have exhibited a high biocompatibility due to their chemical similitude with natural hydroxyapatite. Besides the nature of the biomaterial, its porous and interconnected architecture is essential for a correct osseointegration. This performance could be predicted with an extensive characterization of the biomaterial in vitro. Methods: In this study, we compared the biological, chemical, and structural features of four different commercially available bone substitutes derived from an animal or a synthetic source. To this end, µ-CT and SEM were used to describe the biomaterials structure. Both FTIR and EDS analyses were carried out to provide a chemical characterization. The results obtained by these techniques were correlated with cell adhesion and proliferation of the osteosarcoma MG-63 human cell line cultured in vitro. Results: The findings reported in this paper indicate a significant influence of both the nature and the structure of the biomaterials in cell adhesion and proliferation, which ultimately could affect the clinical performance of the biomaterials. Conclusions: The four commercially available bone substitutes investigated in this work significantly differed in terms of structural features, which ultimately influenced in vitro cell proliferation and may so affect the clinical performance of the biomaterials.

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