Potentiostatic Nucleation of Zinc on a Pyrolitic Carbon Electrode from a Zincate Electrolyte Containing Polymeric Tetraalkylammonium Salt as an Additive

Background:: new and selective electrochemical sensor was developed for the determination of levocetirizine dihydrochloride, which is an antihistaminic drug. Method:: The investigation was performed by using cyclic, differential pulse and square wave voltammetric methods on the β-cyclodextrin modified glassy carbon electrode. It is thereby planned to obtain information about levocetirizine determination and its mechanism. Result:: The efficiency of experimental parameters including pH, scan rate, and accumulation potential and time on the anodic response of levocetirizine dihydrochloride was studied. By employing the developed method and under optimized conditions, the current showed linear dependence with a concentration in the range between 2 × 10-8 M and 6 × 10-6 M in pH 2.0 Britton Robinson (BR) buffer. Conclusion:: The achieved limits of detection and quantification were found as 3.73 × 10-10 M and 1.24 × 10-9 M, respectively. In addition, the possibility of applying the developed sensor for real sample analysis was investigated, so β-cyclodextrin modified glassy carbon electrode was used to determine levocetirizine dihydrochloride in Xyzal® tablet dosage form. Finally, this sensor was successfully applied to the real sample as a selective, simple, reproducible, repeatable electrochemical sensor.

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Simultaneous Determination of Epinephrine and Tyrosine Using a Glassy Carbon Electrode Amplified with ZnO-Pt/CNTs Nanocomposite

Current Analytical Chemistry ◽

10.2174/1573411014666180313115001 ◽

2019 ◽

Vol 15 (2) ◽

pp. 166-171 ◽

Cited By ~ 9

Author(s):

Ali Samadzadeh ◽

Iran Sheikhshoaie ◽

Hassan Karimi-Maleh

Keyword(s):

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Simultaneous Analysis ◽

Urine Samples ◽

Carbon Electrode ◽

Linear Dynamic ◽

Biological Compounds ◽

Blood And Urine Samples ◽

Human Blood And Urine

Background: Simultaneous analysis of epinephrine and tyrosine as two effective and important biological compounds in human blood and urine samples are very important for the investigation of human health. Objective: In this research, a highly effective voltammetric sensor fabricated for simultaneous analysis of epinephrine and tyrosine. The sensor was fabricated by the modification of glassy carbon electrode with ZnO-Pt/CNTs nanocomposite (ZnO-Pt/CNTs/GCE). The synthesized nanocomposite was characterized by SEM method. The ZnO-Pt/CNTs/GCE showed two separated oxidation signals at potential ~220 mV and 700 mV for epinephrine and tyrosine, respectively. Also, we detected linear dynamic ranges 0.5-250.0 µM and 1.0-220 µM with a limit of detections 0.1 µM and 0.5 µM for the determination of epinephrine and tyrosine, respectively. The ZnO-Pt/CNTs/GCE was used for the determination of epinephrine and tyrosine in blood serum and human urine samples.

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Solar Exfoliated Graphene Oxide: A Platform for Electrochemical Sensing of Epinephrine

Current Analytical Chemistry ◽

10.2174/1573411015666190104110928 ◽

2020 ◽

Vol 16 (4) ◽

pp. 393-403 ◽

Cited By ~ 1

Author(s):

Renjini Sadhana ◽

Pinky Abraham ◽

Anithakumary Vidyadharan

Keyword(s):

Cyclic Voltammetry ◽

Graphene Oxide ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Simultaneous Detection ◽

Differential Pulse ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Reduced Graphene ◽

Pulse Voltammetry

Introduction: In this study, solar exfoliated graphite oxide modified glassy carbon electrode was used for the anodic oxidation of epinephrine in a phosphate buffer medium at pH7. The modified electrode showed fast response and sensitivity towards Epinephrine Molecule (EP). The electrode was characterized electrochemically through Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV). Area of the electrode enhanced three times during modification and studies reveal that the oxidation process of EP occurs by an adsorption controlled process involving two electrons. The results showed a detection limit of 0.50 ± 0.01μM with a linear range up to 100 μM. The rate constant calculated for the electron transfer reaction is 1.35 s-1. The electrode was effective for simultaneous detection of EP in the presence of Ascorbic Acid (AA) and Uric Acid (UA) with well-resolved signals. The sensitivity, selectivity and stability of the sensor were also confirmed. Methods: Glassy carbon electrode modified by reduced graphene oxide was used for the detection and quantification of epinephrine using cyclic voltammetry and differential pulse voltammetry. Results: The results showed an enhancement in the electrocatalytic oxidation of epinephrine due to the increase in the effective surface area of the modified electrode. The anodic transfer coefficient, detection limit and electron transfer rate constant of the reaction were also calculated. Conclusion: The paper reports the determination of epinephrine using reduced graphene oxide modified glassy carbon electrode through CV and DPV. The sensor exhibited excellent reproducibility and repeatability for the detection of epinephrine and also its simultaneous detection of ascorbic acid and uric acid, which coexist in the biological system.

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Glassy carbon electrode activation – A way towards highly active, reproducible and stable electrode surface

Electrochimica Acta ◽

10.1016/j.electacta.2019.01.066 ◽

2019 ◽

Vol 299 ◽

pp. 963-970 ◽

Cited By ~ 5

Author(s):

Tomas Bystron ◽

Eva Sramkova ◽

Filip Dvorak ◽

Karel Bouzek

Keyword(s):

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Electrode Surface ◽

Carbon Electrode ◽

Highly Active

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