Cathodic Adsorptive Stripping Voltammetric Behavior and Determination of Tricyclic Antidepressant Drug Nortriptyline Hydrochloride in Bulk Form and Pharmaceutical Formulation

2019 ◽  
Vol 13 (20) ◽  
pp. 21-46
Author(s):  
Rajeev Jain ◽  
Radhapyari Keisham
Keyword(s):  
Antidepressant Drug ◽  
Tricyclic Antidepressant ◽  
Pharmaceutical Formulation ◽  
Voltammetric Behavior ◽  
Nortriptyline Hydrochloride

Determination of tricyclic antidepressant, clomipramine (Anafranil), in plasma by a specific radioimmunoassay procedure.

1978 ◽  
Vol 24 (1) ◽  
pp. 36-40 ◽  
Author(s):  
G F Read ◽  
D Riad-Fahmy
Keyword(s):  
Bovine Serum Albumin ◽  
Active Metabolite ◽  
Antidepressant Drug ◽  
Tricyclic Antidepressant ◽  
Chromatographic Purification ◽  
Throughput Rate ◽  
Specific Radioimmunoassay ◽  
Pharmacologically Active ◽  
Good Agreement

Abstract A radioimmunoassay is reported for the tricyclic antidepressant drug, clomipramine (Anafranil, Geigy). Antisera generated in rabbits to clomipramine conjugated to bovine serum albumin at positions 10 and 11 were specific, cross reacting less than 5% with the pharmacologically active metabolite, desmethylclomipramine. Specificity was confirmed by the good agreement in titres observed when the samples were assayed with and without a pre-assay thin-layer chromatographic purification. Intra- and inter-assay variations were less than 8 and 13%, respectively, with a sensitivity of 175 ng/liter. Results obtained agreed well with those reported by other groups using double radioisotope derivative assays. The method has a high throughput rate, one technician can assay 200 samples in duplicate in a working week; and it is sufficiently precise, sensitive, and specific for use in routine minitoring of the drug in plasma and for checking patient compliance with dosage regimen.

scholarly journals Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Pankaj Soni ◽  
Deepak Sinha ◽  
Rajmani Patel
Keyword(s):  
Antidepressant Drug ◽  
Pharmaceutical Preparations ◽  
Correlation Coefficients ◽  
Molar Absorptivity ◽  
Tricyclic Antidepressant ◽  
Simple Approach ◽  
Colour Intensity ◽  
Pharmaceutical Dosage Forms ◽  
Uv Visible

The paper describes a new and simple approach for spectrophotometric determination of tricyclic antidepressant drug amitriptyline. Enhancement of the colour intensity of the Fe(III)-SCN−complex on addition of the drug amitriptyline forms the basis of the proposed method. The value of molar absorptivity of the Fe(III)-SCN−amitriptyline ion pair complex in terms of the drug lies in the range of (2.82–3.36) × 103 L·mol−1·cm−1at the absorption maximum 460 nm. The detection limit of the method was 0.3 μg·mL−1. The slope, intercept, and correlation coefficients for the present method were found to be 0.008, 0.002, and +0.998, respectively. The effect of analytical variables on the determination of the drug and the composition of the complex are discussed in the paper. The method is applicable in the determination of amitriptyline in pharmaceutical preparations.

Voltammetric behavior and determination of antidepressant drug paroxetine at carbon-based electrodes

Ionics ◽  
2015 ◽  
Vol 21 (8) ◽  
pp. 2345-2354 ◽  
Author(s):  
Mariola Brycht ◽  
Sławomira Skrzypek ◽  
Nurgul Karadas-Bakirhan ◽  
Sylwia Smarzewska ◽  
Burcin Bozal-Palabiyik ◽  
...  
Keyword(s):  
Antidepressant Drug ◽  
Voltammetric Behavior ◽  
Carbon Based

Extractive Spectrophotometric Method for the Determination of Glibenclamide by Ion-Pair Complex in Pure Form and Pharmaceutical Formulation

2019 ◽  
Vol 9 (o3) ◽  
Author(s):  
RUAA MUAYAD MAHMOOD ◽  
HAMSA MUNAM YASSEN ◽  
SAMAR , NAJWA ISSAC ABDULLA AHMED DARWEESH ◽  
NAJWA ISSAC ABDULLA
Keyword(s):  
Spectrophotometric Method ◽  
Molar Absorptivity ◽  
Ion Pair ◽  
Pharmaceutical Formulation ◽  
Ratio Method ◽  
Colored Complex ◽  
Colored Product ◽  
Method Of Continuous Variation ◽  
Job's Method

Simple, rapid and sensitive extractive spectrophotometric method is presented for the determination of glibenclamide (Glb) based on the formation of ion-pair complex between the Glb and anionic dye, methyl orange (MO) at pH 4. The yellow colored complex formed was quantitatively extracted into dichloromethane and measured at 426 nm. The colored product obeyed Beer’s law in the concentration range of (0.5-40) μg.ml-1. The value of molar absorptivity obtained from Beer’s data was found to be 31122 L.mol-1.cm-1, Sandell’s sensitivity value was calculated to be 0.0159 μg.cm-2, while the limits of detection (LOD) and quantification (LOQ) were found to be 0.1086 and 0.3292 μg.ml-1, respectively. The stoichiometry of the complex created between the Glb and MO was 1:1 as determined via Job’s method of continuous variation and mole ratio method. The method was successfully applied for the analysis of pharmaceutical formulation.

Evaluation of Myocardial Cell Damage by In-111-Monoclonal Antimyosin Antibodies in Patients Under Chronic Tricyclic Antidepressant Drug Treatment

Circulation ◽  
1995 ◽  
Vol 91 (6) ◽  
pp. 1619-1623 ◽  
Author(s):  
Vicens Martí ◽  
Manel Ballester ◽  
Claudi Udina ◽  
Ignasi Carrió ◽  
Enric Alvarez ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Cell Damage ◽  
Antidepressant Drug ◽  
Myocardial Cell ◽  
Tricyclic Antidepressant ◽  
Antidepressant Drug Treatment ◽  
Myocardial Cell Damage

scholarly journals Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution

2021 ◽  
Vol 152 (2) ◽  
pp. 185-192
Author(s):  
Jelena Lović ◽  
Jelena Lađarević ◽  
Nemanja Trišović ◽  
Filip Andrić ◽  
Aleksandar Mladenović ◽  
...  
Keyword(s):  
Gold Electrode ◽  
Electrochemical Determination ◽  
Pharmaceutical Formulation
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